Targeted Radiopharmaceuticals and Combination Strategies in Cancer Therapy

• 7182 Development and evaluation of a novel high affinity PSMA-targeted radioligand 177 Lu-PSMA-3D1015 for prostate cancer Lu Hou, Quanpeng Wang, Haitian Fu, Chuang Xi, Wanggui Yang, Fangqiang Tang, Qing Gao, Lan Qin, Wenhua Huang, Henry Ho, Chunjing Yu, John Gong
• 7183 SCN-PYTA: A new bifunctional chelator (BFC) for trivalent radiometals to develop target-specific radiopharmaceuticals for imaging and therapy Shankar Vallabhajosula, Nikki A. Thiele, Kyu J. Son, Vicente Navarro, Md Faizul Islam, Alex Brown, Neil H. Bander, Phillip W. Kantoff
• 7184 GT-008: A monoclonal antibody enabling selective radionuclide delivery to a tumor-associated glycosylation form of CD24 - Preclinical proof-of-concept study Johanna Gellert, Andreas Franz, Manon Weis, Evelyn Hartung, Stephanie Gurka, Lydia Verlaat, Sophie Marinoff, Antje Danielczyk, Patrik Kehler, Dirk Pleimes
• 7185 ²²⁵Ac-RAX104: A novel PSMA-targeted radioligand optimized for actinium-225 demonstrates enhanced tumor retention and superior efficacy Xupeng Hu, Yang Cao, Min Hong, Shuanglong Liu, Guangzhou Han, Gang Chen
• 7186 · PDF Characterization of LY4257496, a novel GRPR antagonist radiolabeled with lutetium-177 Shreyas Lingadahalli, Gabriela Krivdova, Kate Huang, David Rodriguez, Matt Alteen, Chun Ping Yu, Chantal Trieu, Loredana Puca, Robin Hallet
• 7187 Preclinical evaluation of BRP-020063, a first-in-class peptide based radiopharmaceutical for the treatment of nectin4-positive cancers Maoyi Lei, Lei Peng, Bo Shan
• 7188 Theranostics targeting the calcitonin gene-related peptide receptor (CGRPR) demonstrate efficacy in a preclinical mouse model of human cancer Prabhakar Eeka, Darpan N. Pandya, Andrew F. Russo, Yusuke Shiozawa, Thaddeus J. Wadas
• 7189 · PDF Innovative theranostic Trop2 antibody-radionuclide conjugates (ARCs) for precision medicine Shih-Hsien Chuang, Wei-Ting Sun, Michael Evans, Haibo Xu
• 7190 · PDF Novel peptide radioligands targeting CAIX for theranostic applications in clear cell renal cell carcinoma (ccRCC) Weiliang (Timo) Xu, Jin Zhang
• 7191 6-thio-dG enhances standard-of-care radiation therapy by reprogramming the tumor microenvironment in glioblastoma multiforme Anthony Alexander Grichuk, Merve Yilmaz, Summer Barron, Priya Darbha, Shannon M. McCabe, Jerry W. Shay, Kristin Huntoon
• 7192 · PDF FLASH reduces radiation-induced oral mucositis in a mouse model of Fanconi anemia Phoebe Loo, Margaret Pan, Man Zhao, Stavros Melemenidis, Dixin Chen, Kerriann M. Casey, Michael Epperly, Joel S. Greenberger, Billy W. Loo, Erinn Rankin
• 7193 Short exposure to TTFields potentiates radiation response in glioblastoma via downregulation of DNA repair pathways Anat Klein-Goldberg, Tali Voloshin, Aviv Meir, Efrat Zemer-Tov, Hila Ene, Lena Lifshitz, Kerem Wainer-Katsir, Adi Haber, Moshe Giladi, Uri Weinberg, Yoram Palti
• 7194 Inhibiting glutamine metabolism in combination with radiation disrupts mitochondrial function and impairs homologous recombination Scott Bright, Yogesh Rai, Rishab Kolachina, Hadil Elldakli, Mark D. Wasley, Gabriel O. Sawakuchi
• 7195 · PDF Blocking hERG1 enhances radiation sensitization in glioblastoma Hannah E. Goen, Naya Ohuabunwa, Jonathan D. Rodgers Gochicoa, Tingting Huang, Kelli B. Pointer
• 7196 Detection of radiopharmaceuticals and their cold surrogates by Imaging Mass Cytometry enables assessment of single-cell functional response, therapeutic biodistribution, and modulation of the immune microenvironment Jennifer L. Gorman, Felix B. Salazar, Kevin Wyszatko, Michael J. Geuenich, Smriti Kala, Thom G. A. Reuvers, Matthew Watson, Daniel Majonis, Hang Zhou, Bao Ying Chen, Christopher Heskett, Marjolijn Hameetman, Qanber Raza, Sheila Singh, Christina Loh, James Mansfield, Julie Nonnekens, Erik de Blois, Kieran R. Campbell, Saman Sadeghi, Anna M. Wu, Hartland W. Jackson
• 7197 Molecular characteristics of MP0712, a clinical stage ²¹²Pb-based Radio-DARPin candidate for targeted anti-DLL3 radiotherapy of small cell lung cancer (SCLC) Stefanie Riesenberg, Amal Saidi, Francesca Malvezzi, Aaron Schatzmann, Christian Reichen, Tania Stallons, Nicole Pina, Aline Eggenschwiler, Amy Wong, Madlaina Mettier, Jitka Rantanen, Marcela Guzman-Ayala, Julien Torgue, Daniel Steiner
• 7198 Synergistic effects of next-generation Tumor-Treating Fields technology and cinnamaldehyde/cinnamon oil on apoptosis, cell cycle arrest and growth suppression in triple-negative breast cancer cells Saqib N. Peracha, Joseph M. Rohde, Margaux A. Santos, Emma C. Higgins, Lexa M. Campbell, Wageesha T. Mallehevidana, Juliana R. Seide, Aidan Hollister, Therese M. Annulis, Abdu Mohammed, Kiran Khurshid, Noor U. Huda, Aaron P. Provenzano, Jason R. Henderson, Daniel Kuebler, Joseph A. Pathakamuri, John J. O'Connell
• 7199 · PDF From simulation to reality: Evidence supporting safe high-dose TTFields delivery with the LB10000 Ze'ev Bomzon, Scott Krywick, Matthew Travers, Kenneth L. Watkins, Martin Pribula, Michael Winegar, Peter Travers
• 7200 · PDF High-dose adaptive tumor treating fields (TTFields): Expanding the boundaries of electric field therapy Ze'ev Bomzon, Scott Krywick, Matthew Travers, Kenneth L. Watkins, Martin Pribula, Michael Winegar, Peter Travers
• 7201 Preclinical evaluation of click-cleavable radioimmunoconjugates for enhanced treatment efficacy in radioimmunotherapy Marleen H. M. E. van Stevendaal, Kim E. de Roode, Luc H. M. Zijlmans, Jenne T. Meinema, Hendrina M. de Wert-Wattimury, Renate C. van Daalen-Bruens, Bianca Matthee, Mark W. Konijnenberg, James Nagarajah, Raffaella Rossin, Marc S. Robillard
• 7202 Comparative evaluation of 225 Ac-PSMA-Trillium with other 225 Ac-PSMA-SMOL assets in a preclinical prostate cancer xenograft model Urs B. Hagemann, Maria Spelling, Shankari Nair, Martin Kohs, Meike Fehder, Stefan Stargard, Sabine Zitzmann-Kolbe, Dmitry Zubov, Ming Xu
• 7203 212 Pb-based CEA pretargeted radioimmunotherapy demonstrates tumor targeting and potent TGI in immunodeficient and humanized mouse models, informing a FIH study in mCRC Sofia H. L. Frost, Alexandre Pichard, Annabelle Mouchotte, Agnès Colmont, Sara Colombetti, Alexander Haas, Hans Peter Grimm, Birgit Kittel, Stephen Fowler, Bernhard Reis, Vincent Wolowski, Uta Sweere, Michael Hettich, Wolfgang Jacob, Frederic Prince, Christian Klein, Pablo Umana, Julien Torgue, Axel Boehnke
• 7205 · PDF A universal duplex sequencing approach for accurate detection of somatic mutations Shuvro Prokash Nandi, Yuhe Cheng, Shams Al-azzam, Safa Saeed, Isabella R Stuewe, Zichen Jiang, Luka Culibrk, Maria Zhivagui, Xiaoxu Yang, Rachel M. Wise, Foster C. Jacobs, Bérénice Chavanel, Michael Korenjak, Mia PETLJAK, Silvia Balbo, Laurie G. Hudson, Ke Jian Liu, Jiri Zavadil, Joseph G. Gleeson, Ludmil B. Alexandrov

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