High-Dimensional Immune Profiling and Preclinical Modeling for Cancer Immunotherapy

• 6954 Comprehensive immune profiling using a validated high-parameter flow cytometry assay to advance pharmacodynamic biomarker discovery for solid tumor immuno-oncology clinical trials Angelina Bisconte, Vaishali Shinde, Jackie Benko, Jorge Pardo, Samantha Splitt, Rachel Owen, Deborah J. Phippard
• 6955 Development of a 32-color spectral flow cytometry panel for comprehensive immunophenotyping of PBMCs from cancer patients receiving immunotherapy and radiotherapy Yao-Hui Sun, Logan Vick, Jonathan E. Van Dyke, Andrea L. Gompers, Sohan Dhar, Emanual M. Maverakis, Sean J. Judge, Robert J. Canter, Megan E. daly, William J. Murphy, Arta M. Monjazeb
• 6956 A 61-parameter CyTOF panel for comprehensive profiling of human PBMC to characterize immune activation, checkpoint expression and cytokine signatures with applications in cancer immunology Michael Cohen, Stephen Li, Lauren Janette Tracey, Katrina Thomson, Christina Loh
• 6957 GAS-Luc2 reporter cell lines enable sensitive detection of interferon-gamma signaling for immune activation and CAR-T evaluation across 2D and 3D systems Hyeyoun Chang, John G. Foulke, Luping Chen, Catherine McManus, Meghan Sikes, Fang Tian
• 6958 Donor source-dependent B cell receptor repertoire patterns visualized by the pGen-SHM plot reveal differences in adaptive immune reconstitution after hematopoietic stem cell transplantation Sakuya Matsumoto, Yohei Funakoshi, Kimikazu Yakushijin, Goh Ohji, Takaji Matsutani, Hidetomo Takakura, Yuri Okazoe-Hirakawa, Rina Sakai, Yumiko Inui, Taiji Koyama, Yoshiaki Nagatani, Keiji Kurata, Shiro Kimbara, Shinichiro Kawamoto, Naomi Kiyota, Hironobu Minami
• 6959 Functional evaluation of immuno-oncology drug candidates targeting lymphoid and myeloid cells using in vitro assays Christoph Schifflers, Martijn Vlaming, Sofie Pattyn
• 6960 · PDF Improving immune checkpoint blockade efficacy using combination therapy with bioactive molecules Dhanir Tailor, Arpit Dheeraj, Sushil Kumar, Wendy Li, Bailey F. Keefe, Annah S. Rolig, Shivaani Kummar, Lisa M. Coussens, Sanjay V. Malhotra
• 6961 Patient matched organoid-immune co-culture model as a predictive platform for immunotherapy response in precision oncology Maryam Nakhjiri, Sraboni Chaudhury, Youssel Kriko, Mohamad Orabi, Liwei Bao, Mary Horn, Rudnick Avery, Albana Grajqevci, Andrew Chang, David Odell, Udit Singhal, Rishindra M. Reddy, Tudor Borza, Tasha Hughes, Michael Sabel, Lesly Dossett, Joshua Piche, William Aibinder, Sofia Merajver, Nathan Merrill
• 6962 · PDF Expanding multiplexing capabilities with TrailBlazer StarBright Dye antibody conjugation kits Sharon Sanderson, Leon Huang, Yoon-Tae Kang, Ryan Mendoza, Errile Pusod, Michael Blundell, Tracey Long
• 6963 · PDF Empowering IL-2 therapy development: A novel humanized mouse model with functional IL-2 and IL-15 receptors Fengqian Chen, Zhenlan Niu, Zhi Zhang, Linlin Wang, Xiaofei Zhou
• 6964 A novel NSG-SGM3xIL15xDKO-based PBMC humanized mouse model to evaluate efficacy and cytokine release of immunotherapies Xiaoqing (Nancy) Zheng, Guoxiang Yang, Beau Parry, James G. Keck, Li-Chin Yao
• 6965 · PDF Utilizing a humanized CD8 mouse model for non-clinical studies of cancer immunotherapy Hannah Horton, Zhi Zhang, Zhiyuan Shen, Zhenlan Niu, Xiaofei Zhou
• 6966 · PDF A novel humanized mouse model for evaluating anti-human IL23R drugs Qiurong Wang, Chun Wang, Chong Li, Xiaofei Zhou, Linlin Wang, Jing Guo
• 6967 · PDF Humanized HLA-A11.1 mice: A preclinical platform for novel vaccine evaluation Qiurong Wang, Zhenlan Niu, Shuaiqiang Zhang, Xiaofei Zhou
• 6968 · PDF Preclinical assessment of cell, gene, and antibody therapies using humanized mice Audrey Wetzel, Emilie Bayon, Sebastien Tabruyn, Dan Georgess
• 6969 Analysis of 1000 secreted proteins in functional genomics and compound screens reveals cytotoxic and immunomodulatory targets Nathaniel Robichaud, Amy Johnson, Alistaire Sherman, Eric Miller, Narges Rashidi, Milad Dagher

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