Novel Models of Immunotherapy Response

• 6973 · PDF B-NDG hIL15, FcgammaR KO mice: An optimized humanized model for evaluating T cell-modulating antibodies Jiyue Chen, Yanhui Nie, Dexuan Huang, Qingqing Xu, Qiang Liu, Xiaofei Zhou
• 6974 · PDF A CD3/CD19 double-humanized mouse model for preclinical evaluation of CD19-targeted T-cell engagers Shuang Li, Lei Ci, Yi Li, Ruilin Sun
• 6975 · PDF Endogenous retrovirus-derived neoantigens enable a personalized cancer vaccine strategy for glioblastoma Megan Campbell Benz, Kenan Zhang, David M. Ashley, Christian Garde, Kirit Singh, Ohrt Andersen Rasmus, Birgitte Rønø, Daniela Kleine-Kohlbrecher, Stine Friis Thorsen, Kelly M. Hotchkiss, Jose R. Conejo-Garcia, Mustafa Khasraw
• 6976 · PDF B-CDG mice: A novel severe immunodeficient model suitable for radiotherapeutic and radiopharmaceutical evaluation Qiurong Wang, Yanhui Nie, Ruili Lv, Chengzhang Shang, Meiqi Zhang, Qingqing Xu
• 6977 · PDF B-NDG MHC I/II DKO mice plus: A refined humanized model for evaluating T cell engager efficacy and toxicity Kelvin Yin, Yanhui Nie, Zhi Zhang, Meiqi Zhang, Yanling Wang, Qiang Liu
• 6978 · PDF HIS models lacking FcgammaR provide increased predictability and facilitate study design for evaluation of immuno-oncology therapeutics Monika Buczek, Philip Dube, Nicholas Smith, Janell Richardson, Louise Baskin, Esther Andino, Debra Freer, Kathleen Bott
• 6979 · PDF An immune-competent, durable MB49-Luc orthotopic bladder cancer model demonstrates bladder-specific tumor immunity for translational immunotherapy research Melanie He, Mirian Sifuentes, Neo Wang, Zhigang Peng, Minqi Huang
• 6980 · PDF PDX ovo : Avian embryos as hosts for rapid and quantitative modelling of immunotherapy responses in patient-derived xenografts Olivia R. Grafinger, Kabir A. Khan, Esther Matus, Ping Xu, Sara Mar, Yan Li, David E. Goertz, Wilder Scott, Jean Gariepy, Katarzyna J. Jerzak, Robert S. Kerbel, Hon S. Leong
• 6981 · PDF Involvement of type I interferon signaling in anti-PD-1-induced tumor rejection in a novel humanized NOG-FcgammaR⁻/⁻ mouse model Tatsuhito Ii, Ting-Wei Yu, Katsutoshi Sato, Hirotaka Inoue, Ayumu Tsubosaka, Miwako Kakiuchi, Daisuke Komura, Ikumi Katano, Nao Suzuki, Iyo Ootsuka, Motohito Goto, Misa Mochizuki, Kenji Kawai, Shumpei Ishikawa, Masami Suzuki, Takeshi Takahashi
• 6982 · PDF Patient-derived uveal melanoma organoids reveal HLA-I-restricted tumor antigens and tumor-reactive T cells Alexander Lim, Wei Tian, Zhuoning Li, Mara Monetti, Alexander Noor Shoushtari, James Smithy, Samuel Tischfield, Mark Donoghue, David A. Scheinberg, Chenyang Zhan
• 6983 · PDF A novel syngeneic model for evaluating the efficacy of MYC-driven liver cancer targeted and immunotherapy Lei Ci, Kai Zhou, Jiangyan Liu, Ruilin Sun
• 6984 · PDF Modeling late-stage ovarian cancer and validating oncolytic adenoviral tools for transgene expression and tumor monitoring Lakshmi Kadkol, Eric Gauchat, Maria Jose Godoy Calderon, Manali Patwardhan, VK Gadi
• 6985 · PDF Overcoming pancreatic ductal adenocarcinoma immunoresistance: Microfluidic-primed organoid interacting lymphocytes demonstrate superior infiltration, cytotoxicity, and tumor suppression in patient-derived models Eleftherios Makris, Damian Hutchins, Tiefu Liu, Adam Hall, Lance Miller, Shay Soker, Konstantinos Votanopoulos

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