Hypoxic and Proteotoxic Stress Response

• 7289 Activation of toll-like receptors promotes the expression of XBP1s in CLL cells Chih-Hang Anthony Tang, Chih-Chi Andrew Hu
• 7290 · PDF Tumor treating fields (TTFields) enhance chemotherapy-induced proteotoxic stress in pancreatic cancer cells Rubén M. Muñoz, Naama Flint-Brodsly, Yaara Porat, Daniel D. Von Hoff, Haiyong Han
• 7291 · PDF Hypoxia selects for early PI3K pathway alterations and drives clonal complexity in HPV-positive oropharyngeal cancer Bill Diplas, Xin Pei, Yingjie Zhu, Shu Yazaki, Luc G.T. Morris, Richard J. Wong, Sean M. McBride, Heiko Schoder, Yao Yu, Alan L. Ho, Eric Sherman, Nora Katabi, Nancy Lee, Nadeem Riaz
• 7292 · PDF Hypoxia-driven HIF-1alpha/YAP-AXL signaling drives adaptive resistance to TKIs in NSCLC Yuki Katayama, Tadaaki Yamada, Tomoko Yasuhiro, Ryohei Kozaki, Shigekuni Hosogi, Eishi Ashihara, Koichi Takayama
• 7293 · PDF The impact of oxygen exposure on clinical biomarkers - an underrecognized source of pre-analytic variability Ruizhong Wang, Adedeji Adebayo, Stephanie Adama, Steven M. Westphal, Hala Fatima, Carla S. Fisher, Hongyu Gao, Yunlong Liu, Ryla G. House, GEORGE SANDUSKY, Sean D. McCabe, Zhongping He, Jamunabai M. Prakash, Amber Roberts, Matt E. Thomas, Mohammad Al-Haddad, Sujani Yadlapati, Pam Rockey, William Berry, Mary B. James, Rana German, Emily M. G. Nelson, April M. Giron, Troy Moeller, Noah Xique, Kathy D. Miller, Harikrishna Nakshatri
• 7294 · PDF SDHA isoform expression modulates reverse electron flow during hypoxia Kaveri Goel, Katie Pepper Lee, Nicholas Hill, Weiqi Lee, Neil Pfister
• 7295 The role of PHD2 inhibition in melanoma progression, metabolic adaptation, and therapy resistance Claire Erdaje Palma, Stephen M. F. Jamieson, Tet-Woo Lee, Dean Singleton
• 7296 · PDF A KRAS G12V-mutant patient-derived organoid model of brain metastasis as a target discovery platform Dena Panovska, Yao Lulu Xing, Maria Dolan, Helena C. M. Oft, Alexa Gwyn, Emon Nasajpour, Michitaka Nakano, John Newman, Calvin Kuo, Pardes Habib, Claudia K. Petritsch
• 7297 · PDF HIF-1alpha pathway is a therapeutic vulnerability in mucinous colorectal cancer Yoojeong Seo, Jinho Jang, Kyung-Pil Ko, Jie Zhang, Sohee Jun, Jae-Il Park
• 7298 · PDF Extracellular acidosis modulates calcium signaling and adaptive resistance mechanisms in acute myeloid leukemia Eva Gez, Sofia Titah, Aurélie Guillemette, Céline Berthon, Laure Goursaud, Nathalie Jouy, Loic Lemonnier, Salomon Manier, Carine Brinster, Suman Mitra, Bruno Quesnel, Yasmine Touil
• 7299 · PDF A new approach to lung cancer treatment: Targeting endoplasmic reticulum stress Chang Zou, Huibin Song, Sixiao He
• 7300 SMARCA4 loss in endometrial cancer induces cell fate chaos concomitant with the senescence associated secretory phenotype and aberrant regulation of mTOR Hannah Plummer-Doherty, Mackenzie Coatham, Julia Vassalakis, Farzaneh Afzali, Bianca Dauber, Einav Renert, Tyler Cooper, Ivan Topisirovic, Cheng Han-Lee, Lynne-Marie Postovit
• 7301 · PDF Effect of chronic exposure to acidic pH on the MOLM-13 acute myeloid leukemia cell line Aurélie Guillemette, Eva Gez, Sofia Titah, Céline Berthon, Laure Goursaud, Nathalie Jouy, Loic Lemonnier, Salomon Manier, Carine Brinster, Suman Mitra, Bruno Quesnel, Yasmine TOUIL
• 7302 · PDF Critical involvement of PRELID2 in the regulation of mitochondrial homeostasis in renal carcinogenesis Renpei Kato, Daiki Ikarashi, Shigekatsu Maekawa, Mitsugu Kanehira, Yosuke Matsushita, Tetsuro Yoshimaru, Tomoya Fukawa, Toyomasa Katagiri, Wataru Obara
• 7303 Activation of HIF1ɑ drives oxidative stress and promotes deep senescence in EGFR -mutant NSCLC drug tolerant persister cells Radhika Koranne, Avishai Wizel, Aimee J. Gleason, Justine Bellier, Heidie Cabanos, Sarah Reeves, Luke Boland, Yotam Drier, Aaron N. Hata
• 7304 · PDF Lactate mediated suppression of tumor intrinsic type I interferon response in luminal breast cancer cells Yaminisree Nagidi, Aidan Moriarty, Min Yu
• 7305 · PDF Evaluating the unfolded protein response as a therapeutic target in clear cell renal cell carcinoma patients Timothy Shaw, Thushara Madanayake, Darwin Chang, Jay Mandula, Alyssa Obermayer, George J. Weiner, Dan Spakowicz, Bodour Salhia, Martin McCarter, Susanne Arnold, Aakrosh Ratan, Sheri L. Holmen, Stephen B. Edge, Julian Acevedo, Ayanambakkam Attanathi, Robert J. Rounbehler, Michelle Churchman, Ahmad Tarhini, Jose R. Conejo-Garcia, Brandon J. Manley, Paulo C. Rodriguez
• 7306 · PDF Does ribosomal protein haploinsufficiency induce cell competition in mammalian epithelia? Neha Joshi, Nicholas Baker, Eyemen Kheir
• 7307 · PDF Cyclin-dependent kinase 5 (CDK5) contributes to Bruton tyrosine kinase inhibitor (BTKI) resistance via IRE1alpha/Xbp1s axis in mantle cell lymphoma (MCL) Sonia Rodriguez-Rodriguez, Keika Yan, Andrew Chen, Dan Voung, Carly Roleder, Haifeng Shen, Tycel Phillips, Alexey Danilov
• 7308 Older statins reduce metastatic potential in ccRCC: Mechanistic validation of SIM (selective inhibitor of metastasis) development Lily Wu, Junhui Hu, Moe Ishihara, Glen Brodie, Aino Siltari, Jimin Kim, Stuart Conway, Robert Damoiseaux, Teemu J. Murtola, Michael E. Jung
• 7309 · PDF Chronic extracellular acidosis drives metabolic plasticity and adaptive survival in multiple myeloma Hua-Ling Chen, Pei-Chu Tsai, Sheng-Chieh Lin, Fang-Yu Tsai, Shih Sheng Jiang, Chieh-Lin J. Teng, Wun-Shaing Wayne Chang
• 7310 · PDF Interplay between HIF-1alpha and HIF-2alpha modulates TNBC phenotypes Aleksandra K. Kurowska, Long Chi Nguyen, Madeline Henn Bungert, Marsha Rich Rosner
• 7311 · PDF Characterization of PERK-positive polyploid-like breast cancer cells and their association with unfolded protein response signatures LUIS DEL POZO-YAUNER, Veronica Ramirez-Alcantara, Elba A. Turbat-Herrera, Hector Chavarria Bernal, Maha Babker, Huseyin Kilic, Rosetta Campbell, Bahaaeldin Youssef, Ajay Singh, Julio Isael Perez-Carreon, Wei Yang, Guillermo A. Herrera

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