Metabolic Vulnerabilities in Pancreatic, Hepatic, and Renal Cancers

• 7315 Polysulfides contribute to persulfidation of FSCN-1 to accelerate development of pancreatic ductal adenocarcinoma Makoto Suematsu, Takehiro Yamamoto, Minako Takizawa, Chiyoko Nishime, Masami Suzuki, Nobuyoshi Hiraoka
• 7316 · PDF Targeting sulfatide metabolism as a therapeutic vulnerability in pancreatic pre-cancer lesions Riccardo Ballarò, Yihui Chen, Marta Sans, Fredrik Ivar Thege, Rongzhang Dou, Jimin Min, Michele Yip-Schneider, Jianjun Zhang, Ranran Wu, Ehsan Irajizad, Yuki Makino, Kimal Rajapakshe, Mark Hurd, Ricardo A. León-Letelier, Jody Vykoukal, Jennifer B. Dennison, Kim-Anh Do, Samir M. Hanash, Robert Wolff, Paola A. Guerrera, Michael Paul Kim, C. Max Schmidt, Anirban Maitra, Johannes Fahrmann
• 7317 Dual targeting of SLC6A14 and autophagy/macropinocytosis enhances therapeutic efficacy in pancreatic ductal adenocarcinoma Mosharaf Mahmud Syed, Devaraja Rajasekaran, Souad R. Sennoune, Tanima Sharker, Oscar Sanchez, Mary Katherine Jurek, Longfa Kou, Ruijie Chen, Vadivel Ganapathy, Yangzom D. Bhutia
• 7318 · PDF Pancreatic ductal adenocarcinoma causes altered whole-body iron distribution Amit Roopan, Subin Pyo, Yichi Zhang, Anna Barbeau, ChiHin Feng, Matthew G. Vander Heiden
• 7319 · PDF Targeting HDAC1 activity presents vulnerabilities in pancreatic cancer metabolism Don-Gerard C. B. Conde, Evan J. Zhou, Soren Jensen, Maximillian Farma, Chiamaka Joy Ezeh, Alexander N. Behram, Phuong T. N. Pham, Nabila N. Binti, Laiba Shiekh, Matthew C. Cheung, Zeribe Nwosu
• 7320 · PDF KRAS-PIP5K1A-SDC1 axis regulates nutrient scavenging in pancreatic cancer Sommer H. Ramos, Oisun Jung, Suyong Choi
• 7321 · PDF The link between metabolism and inflammation in Black African pancreatic ductal adenocarcinoma patients Nnenna Elebo, Dupe Ojo, Jones A.O. Omoshoro-Jones, Stefano Cacciatore, John Devar, Ekene E. Nweke
• 7322 · PDF Vav1 promotes pancreatic tumor cell invasion via GLS1-dependent glutamine metabolism Mustafa Emre Gedik, Omar L. Gutierrez-Ruiz, Katherine M. Johnson, Ella Rose D. Chianis, Jing Chen, Alex Bittner, Adam Zahm, Ankit Chhoda, Taro Hitosugi, Mark A. McNiven, Gina Razidlo
• 7323 · PDF ACADS-dependent fatty acid oxidation drive mitochondrial remodeling in pancreatic cancer cells Madison Brown-Blackshear, Divine Asamoah, Nadiya Harris, Mengistu Lemecha
• 7324 · PDF HER3 mediates metabolic reprogramming in metastatic colorectal and pancreatic cancer Moeez Ghani Rathore, Chao Wei, Kimberly Curry, Mehrdad Zarei, Zhenghe Wang, Jordan Winter, Rui Wang
• 7325 · PDF Cytosolic transport of citrate protects nutrient-austere pancreatic cancer from ferroptosis Adam Kneebone, Kailey Lindaur, Ata Abbas, Joel Cassel, Sarah Graff, Caudia Rose Keating, Gerard Abood, Xianzhong Ding, William Small, Clodia Osipo, Wei Qiu, Curtis Tatsuoka, Simone Sidoli, Costas Andreas Lyssiotis, Joseph M. Salvino, Ali Vaziri-Gohar
• 7326 · PDF PU-H71 alters metabolism to suppress growth in pancreatic cancer Chiamaka J. Ezeh, Darren Binder, Leo Li, Zeribee C. Nwosu
• 7327 · PDF Dissecting lysosomal metabolic dependencies in pancreatic cancer through functional genomics Caleb Cheng, Ruya Pakkan, Jasmine Wisniewski, Sydney Peters, Yuanyuan Qiao, Costas Andreas Lyssiotis, Arul Chinnaiyan
• 7328 · PDF EPR imaging of oxygen consumption driven by NQO1-activated compounds in FH-deficient renal tumors Yuki Shibata, Shun Kishimoto, Ye Yang, Ming-Hui Wei, Julia Medina-Velazquez, Burchelle Blackman, Jeeva Munasinghe, Viraj Chegu, Vaishnavi S. Srirama, Tyler A. On, Nallathamby Devasahayam, Chandramouli V. Gadisetti, Jeffrey R. Brender, Murali C. Krishna, Daniel R. Crooks, William Marston Linehan
• 7329 · PDF Host organ environment shapes clear cell renal cell carcinoma metastatic metabolism X. Alex Guo, Lina P. Calderon, Andrea L. Sanmiguel, Anirudh Sridharan, A. Ari Hakimi, Ed Reznik
• 7330 · PDF Hypoxia enhances sensitivity to RAS inhibition in PDAC Anna Shevzov-Zebrun, Darius Sinha, Muhammad Bin Munim, Keene Abbott, Matthew G. Vander Heiden
• 7331 · PDF Hepatic proton conductance as a bioenergetic vulnerability and therapeutic target in MASH-associated HCC Elizabeth Rachel Marie Zunica, Kim Pedersen, Anan L. Cole, Analisa L. Taylor, Elizabeth C. Heintz, Megan D. Dousay, Bolormaa Vandanmagsar, Monika Sharma, Odinakhon Shamieva, Lucas Kniess Debarba, Marcus DaSilva Goncalves, Tomislav Jelesijevic, Rees G. Matthew, Jennifer A. Roth, Martin J. Ronis, Christopher L. Axelrod, John P. Kirwan
• 7332 Targeting a DYRK1A-regulated lipogenesis-STING axis alleviates hepatic metabolic dysfunction and lipotoxicity in metabolic steatohepatitis Wen Yan Huang, Kyunghee Noh
• 7333 · PDF Disrupting tumor lipid homeostasis by MUFA depletion drives cell death in HCC Justyna J. Gleba, Victoria N. Rios, Brian M. Necela, Skyeler M. Klinge, Matt L. Pawlush, Mike J. Redig, Aylin Alasonyalilar-Demirer, Han W. Tun and John A. Copland III
• 7334 · PDF Mitochondrial creatine kinase promotes hepatocellular carcinoma progression Nusrat Israr Khan, Luke Jordan, Olayinka David, Shreya Pattisapu, Kyle Schachtschneider, Kejia Cai, Ron Gaba, Lobna Elkhadragy
• 7335 · PDF Spatio-temporal interactome of fructose-1,6-bisphosphate aldolase B in hepatocellular carcinoma XIANGNAN CHEN, Hongfei WANG, Shanshan Zhong, Huiyong YIN
• 7336 Harnessing lipid metabolism to treat drug-tolerant persister cells Mumina Sadullozoda, Patrick Jonker, Erin Szuromi, Asha Bozicevich, Alexander Muir
• 7337 · PDF Estrogen-related receptor gamma maintains oxidative metabolism via glutamine-derived anaplerosis Samantha A. McLaughlin, Zelia M. Correa, J. William Harbour, Daniel Pelaez
• 7338 Elucidating the interplay between phospholipid biosynthesis and oxidative stress responses in the tumorigenesis of Clear Cell Renal Cell Carcinoma Rento Ito, Renpei Kato, Yosuke Matsushita, Toyomasa Katagiri, Wataru Obara
• 7339 Transcriptomic features associated with tumoral metabolites characterizing the immune microenvironment in clear cell renal cell carcinoma Sei Naito, Takafumi Narisawa, Hiromi Ito, Norihiko Tschiya
• 7340 · PDF Exploring the role of PNPLA3 I148M in cancer using the selective small molecule degrader NUV-244 Katrin Juenemann, Patrick Steigemann, Ralf Lesche, Tamara Kanashova, Hanna Meyer, Claudia Noack, Barbara Nicke, Peter Staller, Charlotte Kopitz, Martin Lange

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