Immune Cell Biology and Tumor-Immune Crosstalk

• 158 · PDF PI3Kdelta in CD4⁺ T cells protects against lung metastases through IFNgamma-induced tumor senescence Leqi Tang, Grace Cooper, Linsey Porter, Seung joon Kim, Erick Armingol, Oliver Burton, James E. Thaventhiran, Walid T. Khaled, Roser Vento-tormo, Rahul Roychoudhuri, Klaus Okkenhaug
• 159 · PDF Itaconate promotes memory CD8 + T cell development by epigenetic modification and glucose flux redirection in viral infection and cancer Xiao Yang, Mengyao Su, Jiacheng Wang, Yue Deng, Lingyi Kong, Kunyu Yang, Chao Wan
• 160 · PDF FGFR3 impairs DC1s/CD8 + T cell clustering in bladder cancer preventing the PD-1/PD-L1 blockade-induced CD8 + T cell phenotypes associated with immunotherapy efficacy Andrea Ziblat, Ken Hatogai, Anthony A. Fernald, Danny E. Kim, Hyunsik Lee, Alexander T. Pearson, Madeleine S. Torcasso, Randy F. Sweis
• 161 · PDF Adenosine signaling promotes double-negative t-cell anticancer responses in conditions of CD8 t-cell lymphopenia Brionna King, Zhi Huang, Laura Naldi, Lucio Miele, Giulia Monticone
• 162 · PDF Early CD8 + T and NK cell interactions orchestrate preemptive immunosurveillance to potentiate optimal cytotoxicity that blocks tumor antigen-escape variants Thanigaivelan Kanagasabai, Salvador Gonzalez Ochoa, Roman V. Uzhachenko, Maria Teresa P. de Aquino, Harshana Rajakaruna, Muna A. Mohammed, Jane Tonello, Maria Johnson Irudayam, Alla V. Ivanova, Anil Shanker
• 163 · PDF Allogeneic double-negative T cells induce an innate-like cytotoxic function in CD8 + T cells against acute myeloid leukemia Leanne Palichuk, Enoch Tin, Pauline Douglas, Ruzena Filandrova, David Schriemer, Juan Arteaga, Michele Nawata, Sandeep Kaur, Sonia Cerquozzi, Michelle Geddes, Lynn Savoie, Jongbok Lee
• 164 · PDF Restoring TUSC2 function boosts NK cell cytotoxicity and antitumor immunity in vivo and in vitro Muna Ahmed Eltayeb A. Mohammed, Salvador Gonzalez Ochoa, Jane Tonello, Thanigaivelan Kanagasabai, Mark S. Berger, Alla Ivanova, Anil Shanker
• 165 · PDF Role of SRC-3 in regulatory T cells as a modulator of activation and immunological memory Davis A. Graham, Yan Xia, Subhashree Pradhan, Amrit Koirala, Xiaobin Yu, Adam M. Dean, Bryan C. Nikolai, Aiden L. Moser, Jianming Xu, Cristian Coarfa, Bert W. O'Malley, David M. Lonard
• 166 · PDF Rewiring the dendritic cell: Regulatory T cell axis sensitizes prostate cancer to immunotherapy Jessica C. Hill, Kade R. Copple, Collin Jugler, Phuong Nguyen, Nilika Bhattacharya, Jessica N. Lancaster, Casey R. Ager
• 167 · PDF Preclinic study of src3-ko regulatory T cells in mouse breast cancer model Yan Xia, Yosef Gilad, Davis Graham, Bert W. O'Malley, David M. Lonard
• 168 · PDF Harnessing TLS-derived B cells through STING and LTbetaR activation reveals a novel opportunity to antibody-mediated immunotherapy in pancreatic cancer Maxwell Duah, Yasuhiro Kikuchi, Fumiaki Kanamori, Tomoko Stansel, Gabrielle Brown, Masanobu Komatsu
• 169 · PDF A TNF-producing neutrophil subset drives age-dependent hepatotoxicity Jin Lee, Yiming Gao, Yufei Zhang, Aaron Havas, Peter Adams, Gerald S. Shadel, Susan M. Kaech, Gen-Sheng Feng
• 170 Biphasic, time-dependent neutrophil biology in glioblastoma revealed by in vivo survival and flow cytometry with single-cell transcriptomic corroboration Matthew Alexander Abikenari, John Choi, Justin Liu, Adam Sjoholm, George Nageeb, James Poe, Brandon Hwa-Lin Bergsneider, Andrew Tran, David Bakalov, Ravi Medikonda, Lily Kim, Rohit Verma, Caren Wu, Kwang Bog Cho, Matei Banu, Michael Lim
• 171 KEAP1 loss-of-function suppresses immunogenic ferroptosis and limits PD-1 blockade efficacy through an NRF2-FSP1 pathway Xinfeng Wang, Yuxin Yao, Tomi Jun, Kuan-lin Huang, Nan Sun, Jie He
• 172 · PDF Investigating how host TLR5 signaling modulates FLT3 ligand therapeutic efficacy for ovarian cancer Cara Hatzinger, Mitchell McGinty, Simona Bajgai, Mika Poblete, Akshita Mirani, Audrey Putelo, Mirna Perusina Lanfranca, Una Miagkov, Melanie Rutkowski
• 173 · PDF Targeting tumoral GLI1 in triple-negative breast cancer: A novel strategy to reverse the immunosuppressive microenvironment Aidan Gray, Qiang Shen, Wanda Marini, Kiichi Murakami, Pamela Ohashi, Michael Reedijk
• 174 · PDF Tumor-reactive CD8 lymphocyte isolated from melanoma brain metastasis show that a subset of the total population is better at controlling tumor growth after adoptive transfer into a xenograft model Jeffrey Wu, Mike Beymer, Rebekka Duhen, Venkatesh Rajamanickam, Colin Thalhofer, Prakash Ambady, Andrew D. Weinberg
• 176 · PDF Intrinsic failure of immune activation in NRAS -mutant melanoma reveals a targetable mechanism of checkpoint resistance Inyoung Cho, Sung Eun Kim, Joong-Bae Ahn, Sang Joon Shin
• 177 · PDF In vivo CRISPR screening uncovers Folr1-mediated metabolic remodeling that sensitizes colorectal cancer to PD-1 blockade Boping Jing, Feng Guo, Tadahito Yasuda, Mayu Yasuda, Hudie Li, Fabio Mello, Jay Paul Overholser, Pravin Kaumaya, Yaoqi Alan Wang
• 178 · PDF Exploring the role of catecholamine signaling in CD8+ T cell immunity to neuroblastoma Mark B. Chudnovsky, Daniela Vega-Mendoza, Elinor L. DeCleene, Jose Almeida-Santos, Naomei Lidman, Mingkee Achom, Jared H. Rowe

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