Tumor Heterogeneity

• 7499 Genetic evolution of sarcomatoid/rhabdoid de differentiation in renal cancers. Natalie R. Abuelsamen, Kate I. Glennon, Mustafa Soytas, Madeleine Arseneault, Peixi Liu, eleonora scarlata, fadi brimo, Simon Tanguay, Yasser Riazalhosseini
• 7500 · PDF Dependent lineage regulatory programs in TP53-mutated acute myeloid leukemia revealed through deep single-cell multi-omic profiling of patient samples Felix A. Radtke, Bijay S. Jaiswal, Gonzalo Lopez, Junfei Zhao, Sagnik Banerjee, Daiane Hemerich Brennan, Yilin Zhao, Verena Körber, Marlen Metzner, Rachel Moore, Bilyana Stoilova, Batchimeg Usukhbayar, David Cruz Hernandez, Maria Ortiz Estevez, Aimee O’Donohue, Daniel Lopes de Menezes, Rajasekhar NVS Suragani, Anita K. Gandhi, Paresh Vyas
• 7502 · PDF Spindle assembly checkpoint integrity determines sensitivity to KIF18A inhibition in small-cell lung cancer Chiori Tabe, Rajesh Kumar, Yang Zhang, Yue Huang, Ajit Kumar Sharma, Roshan L. Shrestha, Anish Thomas
• 7503 · PDF Spatio-temporal analysis of EGFR inhibitor resistant tumor epithelial clusters Shuichi Watanabe, Yoshiyuki Suehara, Masachika Ikegami, Soohwan Park, Yo Kimura, Toshihide Ueno, Takuo Hayashi, Hiroyuki Mano, Kazuya Takamochi, Shinji Kohsaka
• 7504 · PDF Do secondary MSH3/MSH6 alterations define an immune-modulatory subtype of MSI gastric cancer? Marika Milan, Daniela Conticelli, Marco Volante, Claudia Orrù, Emanuela Boccuni, Simona Corso, Silvia Giordano
• 7505 · PDF Single-cell transcriptomics identifies distinct EPCAM-low and EPCAM-negative epithelial populations with aggressive phenotypes in hormone-receptor positive breast cancer Élise Di Lena, Alyssa Victoria Francis, Atilla Omeroglu, Sarkis Meterissian, Luke McCaffrey
• 7506 · PDF CEACAM1-dominant molecular program drives immune escape in EGFR-mutant lung adenocarcinoma Jianyu Li, Qinglin Wang, Tongyan Liu, Siwei Wang, Rong Yin
• 7507 · PDF Genomic evolution and heterogeneity of von Hippel-Lindau (VHL)-associated clear cell renal cell carcinoma revealed by multi-region whole-genome sequencing Francesca Corea, Husayn A. Pallikonda, Scott T. C. Shepherd, Isaline Rowe, Alessandro Larcher, Andrea Salonia, Samra Turajlic, Thomas J. Mitchell, Rosa Bernardi, Umberto Capitanio
• 7509 · PDF A spatiotemporal cancer cell trajectory underlies glioblastoma heterogeneity Grant De Jong, Fani Memi, Tannia Gracia, Olga Lazareva, Richard Mair, Sam Behjati, Oliver Stegle, Omer Bayraktar
• 7510 · PDF Molecular and clinical correlates of extrachromosomal DNA in oral squamous cell carcinoma Lucas Penny, Hugh Kim, Jeffrey Bruce, Matthew Waas, Meinusha Govindarajan, Christopher Yao, Thomas Kislinger, Laurie Ailles, Scott V. Bratman
• 7511 · PDF Extrachromosomal MDM2 amplifications define an ecDNA-permissive tumor cell state that impacts intercellular tumor heterogeneity and treatment response across cancers Rachel Schmargon, Giulia Montuori, Elias Rodriguez-Fos, Lotte Brückner, Dennis Gürgen, Anton George Henssen, Jan-Rafael Dörr
• 7513 · PDF Integrated clonal and single-cell analyses uncover progenitor-driven tumor diversification in early-stage endometrioid endometrial carcinoma Suguru Miyata, Hiroshi Yoshida, Toyoyuki Hanazawa, Masahito Kawazu
• 7514 · PDF Spatial multimodal and functional dissection reveal a UCHL1-driven malignant program in clear cell renal cell carcinoma Yize Li, Wagma Caravan, Xiyi Wei, Kapur B. Dhami, Kazuhito Sato, Xiangwei Fang, Preet Lal, Hongyi Liu, Lijun Chen, Cody Weimholt, Hui Zhang, Li Ding, Feng Chen
• 7515 · PDF Uncovering transdifferentiation mechanisms underlying heterogeneity in neuroblastoma Michele Tomanelli, Jennifer Hoti, Ilaria Medici, Chaimae Sellak, Tullio Florio, Aldo Pagano

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