Microenvironmental Determinants of Therapy Response and Resistance 2

• 7417 Immune system state shapes clinical response to CAR-T therapy in mantle cell lymphoma Vivian Jiang, Qingsong Cai, Hong Kim, Lei Nie, Chengtai Yu, Yang Liu, Yijing Li, Jovanny Vargas, Michael Wang
• 7418 · PDF Evaluation of chemo-radiation therapy's effect on the senescence status of tumor microenvironment of HNSCC Lan Gao, Alanna Sun, Ruomin Xin, Daniel John, Wei Tse Li, Weg M. Ongkeko
• 7419 Comprehensive profiling of primary and metastatic prostate tumors reveals distinct tumor and fibroblast cell states associated with androgen resistance Aleksandar Obradovic, Kwangmin Yoo, Chang Liu, Patrick McCann, Casey R. Ager, Matthew C. Dallos, Samir Zaidi
• 7420 · PDF Mechanistic study of CX3CL1 promoting T cell exhaustion in ESCC via the JAK/STAT3 axis Jiayi Huang, Beilei Liu, Licheng Tan, Hongyu Zhou, Bowen Yao, Shuang Zhang, Xin-Yuan Guan
• 7421 · PDF Palmatine modulates tumor microenvironment and improves gemcitabine efficacy in PDAC via HOXA10-STAT3 axis suppression Meagan Marie Ybarra, Xiaoyu Yang, Siri Borra, Chia-Nung Hung, John Baer, Ramya Chengalvala, Rolando Trevino Jr, Shaye Hagler, Sung-Jen Wei, Joel Michalek, Zhao Zhang, Sukeshi A. Patel, Danielle Fritze, Glenn Halff, Zhao Lai, Yuji Ikeno, Yidong Chen, Rita Ghosh, Addanki Pratap Kumar
• 7422 Investigation of acquired resistance to atezolizumab-bevacizumab in hepatocellular carcinoma: Paired tumor microenvironment analysis in a mouse model and human subjects Tsung-Hao Liu, Li-Chun Lu, Yu-Yun Shao, Shu-Han Yang, Chi-Yuan Yao, Chia-Lang Hsu, Ying-Chun Shen, Ann-Lii A. Cheng, Chih-Hung Hsu
• 7423 · PDF Longitudinal tumor microenvironment analysis to predict immunochemotherapy response in salivary duct carcinoma Boseung Choi, Hyunsu Kim, Dongryul Oh, Myung-Ju Ahn, Hyun Ae Jung, Junhun Cho, Han-Sin Jeong, Se-Hoon Lee, Kyungmi Yang, Nayeon Choi, Eun-hye Kim, Sehhoon Park
• 7424 · PDF Longitudinal and spatial heterogeneity of intra-tumoral TCR repertoires during immunotherapy in metastatic cancers Asimina Zoitou, Stefan Velculescu, Gavin Pereira, Archana Balan, Mimi Najjar, Amna Jamali, James R. White, Rachel Karchin, Noushin Niknafs, Hyunseok Kang, Patrick M. Forde, Christine L. Hann, Jody E. Hooper, Julie R. Brahmer, Valsamo (Elsa) Anagnostou
• 7425 Histologic and tumor microenvironmental features as prognostic markers in mantle cell lymphoma: A digital pathology-based study Hyungjin Kim, Sei Na, Jeong-Ok Lee, Ji Yun Lee, Sang-A Kim, Jin Ho Paik
• 7427 Genomic analysis of microenvironment composition by breast cancer molecular subtype using an integrated single-cell RNA sequencing cohort Constandina (Dina) E. O'Connell, Alexander V. Lobanov, Kevin R. Mott, Daniel P. Hollern, Brian C. Miller, Charles M. Perou
• 7428 · PDF Tumors induce a NR4A1 transcriptional program in dendritic cells leading to immune tolerance and cancer progression Michael P. Plebanek, Mahere Rezazade Bazaz, Y-Van Nguyen, Balamayooran Theivanthiran, Brent A. Hanks
• 7429 Characterizing the spatial tumor microenvironments of therapy-induced and hereditary mismatch-repair-deficient hypermutated gliomas Chae Yun (Kate) Cho, Bo Zhao, Lingqun Ye, Inés Martín-Barrio, Yonathan Lissanu, Kadir C. Akdemir
• 7430 Transcriptional programs of precursor-exhausted CD8⁺ T cells associated with checkpoint blockade response in NSCLC Ethan Daniel Littlestone, Md Roungu Ahmmad, Xiaoli Zhang
• 7431 Metabolic correlates of measurable residual disease following high dose melphalan conditioning for autologous stem cell transplant in multiple myeloma Qualia Hooker, Timothy Triche
• 7432 Spatial protein profiling of irradiated ER positive breast cancer lymph nodes suggests nodal irradiation modulates immune function Stephanie O. Dudzinski, Elizve N. Barrientos-Toro, Benjamin D. Smith, Simona F. Shaitelman, Sharia Hernandez, Alejandra Serrano, Khan Khaja, Larisa Kostousov, Wei Lu, Rensi Zacharia, Nathan Comeaux, Solis M. Luisa, Aysegul A. Sahin, Maria Gabriela Raso, Jing Wang, Karen Hoffman, Wendy A. Woodward
• 7433 · PDF Dual stromal and tumoral origins of TWEAK drive CSC maintenance in ovarian cancer relapse Mikella Robinson, Luisjesus S. Cruz, Carrie House
• 7434 · PDF Metabolic dependence of prostate cancer subtypes and its association with the tumor-immune microenvironment Tonatiuh A. Gonzalez, Anisha Tehim, Inna Serganova, Roberta Zappasodi, Ekta Khurana
• 7435 · PDF Spatial transcriptomics unveils tumor microenvironment changes in murine glioblastoma upon EGFRvIII suppression Fabio de Mello, David Eisenbarth, Feng Guo, Yamei Chen, Kun Huang, Chunhai Hao, Y. Alan Wang
• 7436 · PDF Dissecting the spatial architecture of plasmacytoid urothelial carcinoma to inform therapeutic strategies Kathryn H. Gessner, Jeffrey S. Damrauer, Siyao Liu, Mi Zhou, David Corcoran, Sara E. Wobker, William Kim
• 7437 Decoding tumor microenvironment heterogeneity through spatial microdomains and network biology to predict immunotherapy outcomes A. Burak Tosun, Raymond Yan, Brian Falkenstein, Filippo Pullara, S. Chakra Chennubhotla
• 7438 · PDF Residual disease on a dish: A practical approach to deep intrinsic resistance in melanoma Balraj Singh, Vanessa N. Sarli, Nikil Erry, Anthony Lucci
• 7439 · PDF SPP1 positive macrophage spatial feature correlation to stage III-IV colon cancer multiple pathology parameters Shaojun Xu, Hongzhe Sun, Shuo Han, Lin Zhu, Yan Wu, Qisong Zhang, Aiwen Wu, Zhifu Zhang, Enkai Zhang, Na Li, Zhongwu Li
• 7440 Characterization of the metastatic TIME via spatial transcriptomics reveals unique cellular phenotypes post anti-CSF-1R and immuno-chemotherapy Diego Armando Pedroza, Sung Wook Kang, Xiang H.-F. Zhang, Bora Lim, Hyun-Sung Lee, Jeffrey M. Rosen
• 7441 · PDF Mapping immune clonotypes in prostate cancer using spatial V(D)J to resolve cancer vaccine response Eirik Høye, Karishma Sajnani, Reetta Nätkin, Sini Hakkola, Antti Kiviaho, Thomas Cecchetto, Anthony Mathelier, Matti Nykter, Wolfgang Lilleby, Sini Eerola, Alfonso Urbanucci, Tapio Visakorpi, Heini Kallio
• 7442 Cancer chemotherapy-induced accelerated aging is mitigated by activation of the altruistic stem cell defense response Lekhika Pathak, Partha Jyoti Saikia, Upasha Sarmah, Rupam Das, Chayanika Das, Tulika Sarma, Bikul Das
• 7443 Low hypoxia microenvironment and impaired T cell maturation drive immunotherapy resistance in premenopausal triple negative breast cancer Vidya Prasad Nimbalkar, Snijesh V P, Anupama CE, Mahalakshmi S, Annie Alexander, Rakesh Ramesh, Srinath BS, Jyothi S. Prabhu
• 7444 · PDF Tetraspanin-driven metabolic plasticity and chemoresistance in disseminated breast cancer cells Alexia Brunel*, Kristin Decker*, Suvendu Das, Praveen Neel, Asad Ullah, Jasmin Meier, Ganesan Ramamoorthi, Flavio Palma, Jacob Torrez, Duy Nguyen, Marcelo Bonini, Brian Czerniecki, Thordur Oskarsson
• 7445 Effector regulatory T-cell infiltration, ARID1A status, and Ex Vivo anti-PD-1 response in ovarian clear cell carcinoma: Insights from a comparative high-grade serous ovarian cancer cohort Junsik Park, Eun Kyung Kim, Jung Chul Kim, Nari Kim, JooHyang Lee, Sunghoon Kim, Sang Wun Kim, Yong Jae Lee, Jung-Yun Lee
• 7446 · PDF Inflammation and chemotherapy induce immune mimicry in PDAC and promote crosstalk between fibroblasts and tumor cells Carson Cable, Qinlin Jiang, Kourosh Kouhmareh, Richard L. Klemke, Ryan Matthew Shepard, Alejandro D. Campos, Sara M. Weis, David A. Cheresh

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