Genomic Dissection to Define Novel Therapeutic Strategies

• 489 Multi-omic single-cell combinatorial indexing of gRNA, epitopes, and transcriptome uncovers modulators of drug sensitivity in K562 cells Sangwon Kang, Su-Hyeon Lee, Byungjin Hwang
• 490 High-throughput pooled CRISPR screening with high-capacity single cell analysis of the protein kinome using a dual inducible Cas9 system Clarence Mills, Anna Sheydina, Jesse Stombaugh, Emily Feldman, Josien Levenga, Kevin Taylor
• 491 · PDF A 100 million cell single cell atlas enabling mechanistic and genotype-specific drug response discovery Aisling Sinclair, Joey Pangallo, Vuong Tran, Efthymia Papalexi, Simone Marrujo, Bryan Hariadi, Crina Curca, Olivia Kaplan, Sarah Schroeder, Ajay Sapre, Guillermo Gallareta Olivares, Maria Nigos, Oliver Sanderson, Hoai Hguyen, Alec Salvino, John Thompson, Ryan Koehler, Sam You, Gokhan Demirkan, Charles Roco, Alexander Rosenberg
• 492 · PDF Uncovering therapeutically targetable mutations from The Cancer Genome Atlas (TCGA) whole-genome datasets Ryul Kim, Chunyang Bao, Hansol Park, Gang-Hee Lee, Won-Chul Lee, Jonghoon Lee, Yoonsuh Lee, Beomki Lee, David Lehotzky, Ron Solan, Antonia Kowalewski, Xavi Loinaz, Vasuki Narasimha Swamy, David I. Heiman, Samantha Van Seters, Saveliy Belkin, Sam Wiseman, Andrew D. Cherniack, Luis Antonio Corchete Sanchez, Brian P Danysh, Zachary Everton, Chip Stewart, Haruna Tomono, Gengchao Wang, Esther Rheinbay, Gad Getz, Young Seok Ju
• 493 · PDF Genomic landscape of targetable drivers in lung cancer Olivia Lee, Soo-Ryum Yang, Wei Zhao, Huu Phuc Hoang, Tongwu Zhang, Maria Teresa Landi
• 494 · PDF Multi-omics patient-derived organoid embeddings predict targeted therapy response and KRAS inhibitor sensitivity Lelia Polit, Nico Trummer, Rafal Pietrzak, Mateo Longarini, Alexis Finkbeiner, Anna-Rose Gryspeert, Jean Bouteiller, Jérome Caron, Fanny Jaulin, Gustave Ronteix
• 495 · PDF Single-cell multiomic drug response profiling of PRISM-multiplexed cancer cell lines sequenced with SBX Houlin Yu, Guoping Wang, Stephanie Yaung, Heejo Choi, Megan Rogers-Peckham, Michael Kartje, Matthew Rees, Paul Lund, Brian Haas, Charlotte Yang, Laura Doherty, Lacey McGee, Kendall Berg, Cynthia Cech, Salka Barrett, Anasha Arryman, Joanne Leadbetter, Taylor Lehmann, John Mannion, Chen Zhao, Marc Prindle, Melud Nabavi, Carolyn Morrison, Peter Smibert, Kit Nazor, Todd Golub, Catarina D. Campbell, Jennifer Roth, Niall Lennon, Victoria Popic, Dean Procter, Kokoris Mark, Aziz M. Al'Khafaji
• 496 · PDF Oncolinkage: Discovery of tumor-selective surface targets for cancer therapy McKensie A. Collins, Benjamin T. Hallisey, Andrew Astley, Rick Nicoletti, Murray O. Robinson
• 497 · PDF Transcriptomic predictors of therapy response across age groups in an omani breast cancer cohort Muna Al Dlali, Habiba El Keraby, Hamza Zaidom, Radiya Al ajmi, Cheryl Crozier, Jane Bayani, Sirin A. Adham
• 498 · PDF The perturbation data gap: Accelerating discovery with CRISPR screening Elena Vialetto, Ronay Cetin, Sebastian Süsser, Simran Rastogi, Angela Hinchie, Jessica Martyn, Martin Wegner, Manuel Kaulich
• 499 · PDF Integrated genomic and spatial analyses elucidate the origins and vulnerabilities of urachal carcinoma Toru Imai, Tatsunori Shimoi, Akiko Maeshima, Jumpei Kashima, Ibuki Tsuru, Hisashi Hashimoto, Jun Takahashi, Eijiro Nakamura, Yoshiyuki Matsui, Hiroyuki Mano, Kan Yonemori, Yosuke Tanaka
• 500 · PDF Co-occurrence of gene fusions and microsatellite instability (MSI) defines a clinically distinct subtype of colorectal cancer Scott Kulm, Sebastià Franch-Expósito, Paul Fields, Catherine Igartua
• 501 · PDF Integrated multiomic profiling reveals SWI-SNF subunit-specific pathway alterations and targetable vulnerabilities Clemence Astier, Jorge Bretones Santamarina, Marlène Garrido, Léo Colmet-Daage, Thibault Delobel, Marcos Bolanos, Marianne Chasseriaud, Elodie Anthony, Daphné Morel, Roman M. Chabanon, Theo Roumeliotis, Mercedes Pardo, Elaine Del Nery, Jyoti Choudhary, Annabelle Ballesta, Sophie Postel-Vinay
• 502 Comparison of MTAP loss by immunohistochemistry (IHC) and MTAP homozygous deletion by next-generation sequencing (NGS) and DNA fluorescence in-situ hybridization (FISH) Lisa Huang, Lauren Giampapa, Paige Montanaro, Ishwarya Krishna, Shannon Chilewski, Haeun Hwangbo, Wen-Chi Chou, Sarah Jamerson, Lynn Dong, Olufemi Adelakun, Juliana Coculo, John Rassa, Jonathan Baden, Travis Hollmann, Igor Katsyv
• 503 · PDF Assessing paralog dependency in ovarian cancer to drive target discovery Amy R. Lowe, Siobhan O'Brien, Marissa Fujimoto, Alice H. Berger
• 504 · PDF Interferon enriched gene expression signatures are associated with ADAR1 dependency in oral squamous cell carcinoma Pei San Yee, Jie Ying Teo, Shi Mun Yee, Shiyin Ooi, Yee Hua Tan, Mathew J Garnett, Siew Kit Ng, Annie Wai Yeeng Chai, Sok Ching Cheong
• 505 · PDF Molecular Standard of Care Sam Phillips, Eric Collisson
• 506 High content CRISPR activation screens identified synthetically lethal RNA-based mechanisms to sensitize cancer cells to targeted T cell cytotoxicity Jeehyun Yoe, Reece V. Akana, Olivia Laveroni, Chang Sun, Young-Min Kim, Livnat Jerby

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