AACR Project GENIE: Predictive Models and AI

• 1 · PDF Synapse.org as a foundational platform supporting multicenter cancer data coordination, benchmarking, and broad community reuse Adam Taylor, Gaia Andreoletti, Robert Allaway, Jineta Banerjee, Orion Banks, Angie Bowen, Kevin Boske, Aditi Gopalan, Ashley Clayton, Xindi Guo, Savitha Sangameswaran, Amber Nelson, Aditya Nath, Milen Nikolov, Anh Nguyet Vu, Ziwei Pan, Alex Paynter, Chelsea Nayan, Thomas Yu, Bishoy Kamel, Serghei Mangul, Alberto Pepe, Luca Foschini, Susheel Varma
• 2 · PDF Variant interpretation web services for precision oncology: Genome Nexus and reVUE Xiang Li, Alexandria Dymun, Benjamin Preiser, Reshma Ramaiah, Allison Richards, Walid Chatila, Moriah Nissan, Amanda Dhaneshwar, Sara E. DiNapoli, Erika Gedvilaite, Thomas Y. Cong, Hongxin Zhang, Bryan Lai, Selcuk Onur Sumer, Aditi Gopalan, Tonatiuh Gonzalez, Madelaine Rangel, Trevor J. Pugh, Rose Brannon, Michael Berger, Debyani Chakravarty, Nikolaus Schultz, Jianjiong Gao, Ino de Bruijn
• 3 · PDF Evaluation of an agentic LLM chatbot for clinico-genomic analysis of AACR GENIE BPC data Likhita Thiriveedi, Kenneth L. Kehl
• 4 · PDF A multi-agent conversational artificial intelligence ecosystem for real-time integration of clinical, genomic, and social determinants of health data in colorectal cancer precision oncology Enrique Velazquez-Villarreal, Brigette Waldrup
• 5 · PDF Artificial intelligence-driven precision medicine identifies prognostic WNT pathway alterations in African American colorectal cancer patients treated with FOLFOX Tsion Z. Minas, Brigette Waldrup, Francisco G. Carranza, Sophia Manjarrez, Enrique Velazquez-Villarreal
• 6 · PDF Empowering populations at risk through conversational artificial intelligence: a framework for patient advocacy and precision oncology Araceli Estrada, Brigette Waldrup, Francisco G. Carranza, Sophia Manjarrez, Enrique Velazquez-Villarreal
• 7 · PDF Molecularly-informed prediction of treatment efficacy in the GENIE BPC NSCLC cohort using computational reasoning Barbara Vodicska, Eniko Kispeter, Dora Lakatos, Gabor Gy Kalmar, Robert Doczi, Dora Gorog-Tihanyi, Anna Dirner, Reka Szalkai-Denes, William T. Beck, Arkadiusz Z. Dudek, Christophe Le Tourneau, Istvan Petak
• 8 · PDF Using in vitro models to predict imatinib responses in PDGFRA-mutant gastrointestinal stromal tumor Homma M. Khosroyani, Alina Teuber, Ajia Town, Lillian Klug, Denisse Evans, Jerry Call, Sara Rothschild, Neeta Somaiah, Prapassorn Thirasastr, Ping Chi, Marion Liu, Peter Hohenberger, Piotr Rutkowski, Patrick Schoffski, Abbas Agaimy, Mehdi Brahmi, Carol Beadling, Sebastian Bauer, Johanna Falkenhorst, Michael C. Heinrich
• 9 · PDF ShinyEvents: Harmonizing real-world longitudinal data for clinical insights and survival analytics Alyssa Obermayer, Joshua Davis, Roger Li, Rodrigo Rodrigues Pessoa, Brandon J. Manley, G. Daniel Grass, Aik Choon Tan, Dung-Tsa Chen, Timothy Shaw
• 10 · PDF A continuous modeling framework for age-dependent selection on melanoma driver mutations Yihan Liu, Moein Rajaei, Jeffrey D. Mandell, Jorge Alfaro-Murillo, Jeffrey P. Townsend
• 11 · PDF Artificial intelligence-based spatial analysis of the local tumor microenvironment in relation to c-MET expression in non-small cell lung cancer Ji-Hyang Lee, Joshua Littrell, Chiyoon Oum, Taebum Lee, Sanghoon Song, Yoojoo Lim, Chang Ho Ahn, Jim Christian, Seokwhi Kim, Siraj M. Ali
• 12 · PDF Integrative spatial multi-omics profiling enhanced by artificial intelligence reveals ancestry-associated molecular features in early-onset colorectal cancer among Southern California patients Francisco G. Carranza, Brigette Waldrup, Yuxin Jin, Yonatan Amzaleg, David Craig, John Carpten, PE-CGS Network, Enrique I. Velazquez Villarreal
• 13 · PDF Integrating transcriptomic data to improve multi-omic tumor-of-origin classification Pranav Gadde, Naga Mudda, Pratayanch Sav, Krithik Senthilkumar, Aadarsh Sivaraman, Krithik Mudda
• 14 · PDF Mutational profiling of chondrosarcoma across multicenter cohorts Luyuan Li, Wensi Tao, Robert L. Walker, Manish KC, Darshan Gundala, Josiane E. Eid, Zhenfeng Duan, Jonathan C. Trent

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