Developmental Origins, Drivers, and Heterogeneity in Pediatric Cancer

• 622 · PDF Infant KMT2A::AFF1 acute lymphoblastic leukemia stem cell model reveals early impact on the proteome Alexandra Prosser-Dombrowski, Irina Pushel, Priyanka Prem Kumar, Thomas Gremminger, Michaella Rekowski, Midhat S. Farooqi, Michael Washburn, Jay L. Vivian, John M. Perry
• 623 · PDF Targeting PAX3::FOXO1 condensates in fusion-positive alveolar rhabdomyosarcoma via disordered-region mimetic peptides Michael Di Martino, Yanghao Zhong, Shasha Chong
• 625 · PDF Early tumor priming in Li-Fraumeni Syndrome muscle using a rhabdomyosarcoma model Ashby Kissoondoyal, Paula Rosanna Quaglietta, Brianne Laverty, David Malkin
• 626 TLX3 represses IKZF2 to activate PI3K/AKT signaling: A novel transcriptional axis driving leukemia initiation Gisele Rodrigues, Julie Hixon, Hila Winer, Timothy Gower, Francisco Lobo, Nathan Wong, Erica Matich, Steven Hsu, Emma Wachter, Elijah Edmondson, Maggie Cam, Caroline Andrews, Sarah Cramer, Wenqing Li, Scott Durum
• 627 · PDF Investigating ATRT cell of origin and tumor heterogeneity via hiPSC-derived models Clark G. Wang, Qi Wang, Nidhi Nathwani, Bryan K. Li, Takayuki Morimoto, Alison D. Parisian, G. Praveen Raju, Frank B. Furnari
• 628 · PDF Investigating the role of BRCA2 in the development of pediatric rhabdomyosarcoma Phillip Adam Weinstein, Elif Asik, Pagna Sok, Cem Ozdemir, Wei-Che Tseng, Ryan Zabriskie, Aniko Sabo, Philip J. Lupo, Alison A. Bertuch, Kyle Miller, Sharon E. Plon
• 629 SMARCD3-regulated Purkinje cell migration underlies cerebellar development and group 3 medulloblastoma metastasis Yash Patel, Han Zou, Allen Zheng, Anjali Talluru, Nirja Divekar, Chaim Sneiderman, Meghana Dodda, Katie Dietrich, Siheng Chao, Sameer Agnihotri, Gary Kohanbash, Antony Michealraj, Ian Pollack, Baoli Hu
• 630 · PDF Elucidation of PAX3::FOXO1 tumor initiation mechanisms in human induced pluripotent stem cell models Bradley T. Stevens, Yang Zhang, Brian J. Abraham, Mark E. Hatley
• 631 Trans-species analysis of central nervous system developmental-specific replication repair deficiency reveals differential patterns of gliomagenesis and response to immunotherapy Zoya Aamir, Melissa A. Galati, Emma Gattoni, Owen Crump, Nemanja Ilic, Anirban Das, Nicholas R. Fernandez, Angel K. Q. Wong, Lucie Stengs, Jose R. Dimayacyac, Yuan Chang, Vanessa Bianchi, Melissa Edwards, David Malkin, Cynthia Hawkins, Nuno M. Nunes, Uri Tabori
• 632 · PDF Dynamic characterization of tumor-microenvironment factors that drive pediatric low-grade gliomas Jenna Robinson, Joohee Lee, Sarah Reel, Shriya Rangaswamy, Michelle Boisvert, John Doench, David TW Jones, Timothy Phoenix, Pratiti Bandopadhayay
• 633 AVIL's dependency on YAP as a key mediator of oncogenic activity offers a therapeutic opportunity in rhabdomyosarcoma Martyna Glowczyk-Gluc, Robert Cornelison, Zhongqiu Xie, Julie Fanburg-Smith, Robin D. LeGallo, Eyas Alzayadneh, Hui Li
• 634 Subpopulations of CAF contribute to chemotherapy resistance in tumors through different MYCN-dependent and independent mechanisms Kevin Louault, Laurence Sarte, Liron D. Grossmann, Bruce Pawel, John M. Maris, Shahab Asgharzadeh, Yves Albert DeClerck
• 635 · PDF Defining the intertumoral and intratumoral transcriptional heterogeneity of EWS::FLI1 in Ewing sarcoma Rachael Hinshaw, Zachary P. Tolstyka, Susan M. Kitchen-Goosen, Seneca Kinn-Gurzo, Rebecca Kaufman, Maggie Chasse, Elizabeth Wilson, Gretchen Lam, Stephanie The, Elissa Boguslawski, Patrick J. Grohar
• 636 · PDF Dissecting the complex ecosystem of intracranial germ cell tumors by spatial RNA and protein analysis Torsten Pietsch, Verena Dreschmann, Pia Zapka, Evelyn Dörner, Christian Vokuhl
• 637 · PDF CyTOF analysis of heterogeneity between Ewing sarcoma cell lines in vitro and in vivo Piper Harrell, Lily Golzar, Kenzie Wells, Poornima Gourabathini, Kimberly Q. McKinney, Erin M. Trovillion, Javier Oesterheld, Kaitlyn H. Smith
• 638 Spatial organization of epithelial- and neural-like tumor phenotypes and their cellular neighborhoods in desmoplastic small round cell tumors Jiaqian Fan, Kevin Murgas, Diana Shamsutdinova, Davis Ingram, Alexander Lazar, Danh Truong, Joseph A. Ludwig
• 639 · PDF Distinct microenvironments define subtypes of neuroblastoma Joseph Seamus Toker, Katherine Elizabeth Masih, Noemi Kedei, Zahin Islam, Ben J. Somerville, Amir Jassim, Michail Mamalakis, Aysen Yuksel, Daniel R. Catchpoole, Li Zhou, Paul Aiyetan, Yong Yean Kim, David Milewski, Shaoli Das, Xinyu Wen, Yong Song, Jun Wei, Richard J. Gilbertson, Javed Khan
• 640 · PDF Multiomic profiling reveals endothelial cell plasticity in metastatic osteosarcoma Ying Wu, Julian Burks, Demond Williams, Carly Sayers, Vidhur Daulatabad, Neeraja Syed, John F. Shern, Troy A. McEachron
• 641 Identifying vulnerabilities through an elucidation of the tumor-host interplay that drives osteosarcoma lung colonization Fatemeh Yazarlou, Matthew Cannon, Yogesh Budhathoki, Amy C. Gross, Leyre Jimenez Garcia, James Reinecke, Ryan D. Roberts
• 642 · PDF Extracellular viscosity modulates spheroid formation in SMARCB1-deficient brain tumor cells Yihsuan Chen, Long-Sheng Lu, Yu-Chun Lin
• 643 · PDF The Sean Karl Cohort: An international single-cell RNAseq study of paired patient Ewing sarcoma specimens Abbe Pannucci, Elina Mukherjee, Jessica D. Daley, Shireen Sita Ganapathi, Elissa Boguslawski, Lea Surrey, Lauren Gutstein, Patrick Azar, Emily Stockfisch, Azfar Neyaz, Ivy John, Jennifer Picarsic, Yutaro Tanaka, Byron Butaney, Riaz Gillani, Brian D. Crompton, Katherine A. Janeway, Jaclyln Taroni, Jessica Davis, Damon Reed, Adam Shlien, Theodore W. Laetsch, Rajen Mody, Clémence Henon, Thomas G. Grünewald, Elizabeth R. Lawlor, Filemon Dela Cruz, Patrick J. Grohar, Jovana Pavisic, Ally Hawkins, Anthony R. Cillo, Kelly M. Bailey
• 644 · PDF Evaluating GD2-targeting antibody-drug conjugates for DIPG using human organoid-based preclinical platforms Zhikun Wang, Emily Miller, Wei Huang, Satoru Kawakita, Lauren Vanderpool, Francisco Bustamante, Uijin Kim, Zhaohui Wang
• 645 · PDF Enhancement of antigen presentation restores immune recognition in rhabdomyosarcoma Maya Groff, David Milewski, Hsien-Chao Chou, Vineela Gangalapudi, Alexandra Urbanek, Young Song, Meijie Tian, Yong Yean Kim, Jun Wei, Javed Khan
• 646 · PDF Exploring actionable therapeutic targets associated with SMARCB1 deficiency in Epithelioid sarcoma Jiyeon Park, Ryo Miyamoto, David G. Kirsch
• 647 · PDF EWSR1::FLI1 suppresses ribosome biogenesis and creates a targetable vulnerability in Ewing sarcoma Matteo Colombo, Jason Sims, Christoph Dotter, Hana Bernhardova, Sanskriti Balaji, Jonathan Levi, Aleksandra S. Anisimova, Anja Wagner-Schrittwieser, Tamina Stelzer, Aikaterini M. Formouzi, Bernadette Liegl-Atzwanger, Marita Koelz, Anke Scharrer, Markus Schosserer, Peter Schlögelhofer, Thomas G. P. Grunewald, G. Elif Karagöz, Alice Soragni, Eleni M. Tomazou
• 648 · PDF PP2A reactivation upregulates FGA gene in neuroblastoma Nazia Nazam, Shamza Manzoor, Maryam Ghufran, Morgan L. Brown, Ali M. Eakes, Pranava Nande, Joel C. Opara, Abdulraheem Kaimari, Michael Ohlmeyer, Elizabeth A. Beierle
• 649 · PDF Site-specific phospho-regulatory collapse of PML governs RTK hyperactivation in high-risk pediatric malignancy. Sreenidhi Mohanvelu, Poorvi Subramanian, Natarajan Aravindan

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