Late-Breaking Research: Molecular/Cellular Biology and Genetics 1

• LB093 · PDF PHIP suppresses NuRD to enable the growth of SWI/SNF-mutant cancers Hayden A. Malone, Jacqueline A. Myers, Emma G. Gruss, Marc A. Morgan, Jake D. Friske, Tabitha C. McCarty, John J. Navarro, Sarah Robinson, Rebecca L. Halliburton, Sandra J. Kietlinska, Francisca N. De Luna Vitorino, Baranda S. Hansen, Shondra M. Pruett-Miller, Benjamin A. Garcia, Martine F. Roussel, Janet F. Partridge, Charles W. M. Roberts
• LB094 Epigenetic destabilization of chromatin compartments defines chromosomal weak links enriched for driver mutations in head and neck squamous cell carcinoma Ashley Ramos-López, Sebastián Rodríguez-Torres, Laura Palmieri, Yanira González-Rodríguez, Amanda García-Negrón, Guie Beeu Guerrero-Hunt, Adhi Guerrero-Thillet, Mariana Brait, David Sidransky, Rafael Guerrero-Preston
• LB095 Chromosomal weak links in cancer: A/B compartment rewiring coupled to global DNA methylation alterations in gastric tumorigenesis Ashley Ramos-López, Sebastián Rodríguez-Torres, Laura Palmieri, Yanira González-Rodríguez, Robert Gilman, Martha H. Jahuira-Arias, Jaime Cok, Juan Combe, Gloria Vargas, William Prado, Mariana Brait, David Sidransky, Rafael Guerrero-Preston
• LB096 · PDF ACTL6A, subunit of SW/SNF chromatin remodeling complex, drives immune evasive phenotype in head and neck squamous cancers SrinivasVinod Saladi, Nana Chen
• LB097 HDAC inhibition sensitizes pancreatic cancer to DNA-damaging therapies via genome-wide redistribution of transcriptional machinery Gaoyang Liang, Hung V. T. Nguyen, Jonathan Zhu, Hervé Tiriac, Hadiqa Zafar, Daniel Y. Cao, Gabriela Estepa, Dylan C. Nelson, Yang Dai, Tae Gyu Oh, Christopher Liddle, Ruth T. Yu, Andrew M. Lowy, Weiwei Fan, Morgan L. Truitt, Annette R. Atkins, Jeremiah A. Johnson, Michael Downes, Ronald M. Evans
• LB099 · PDF Whole-genome analysis identifies novel molecular subtypes and driver structural variants in Japanese ovarian cancer Osamu Gotoh, Takaki Ishizuka, Norio Tanaka, Tetsuo Noda, Seiichi Mori
• LB100 · PDF Cervical cancer in Guatemala: Molecular mechanisms of carcinogenesis by rare HPV types Tawnjerae Joe, Sonam Tulsyan, Hong Lou, Michael Dean
• LB101 · PDF ​​Whole-genome sequencing reveals distinct mutational mechanisms across endometrial cancer subtypes Jian Sang, Mengyan Zhang, Thomas Veith, Yewon Kim, Sergio Chavez, Weiyin Zhou, Wen Luo, Adriana Morales Miranda, Jens Luebeck, Vineet Bafna, Stephen J. Chanock, Tongwu Zhang
• LB102 Evaluating the therapeutic and diagnostic utility of clinical whole-genome sequencing in comparison with cancer gene panel testing Norio Tanaka, Osamu Gotoh, Ippei Fukada, Arisa Ueki, Takayuki Ueno, Shunji Takahashi, Seiichi Mori, Tetuso Noda
• LB103 Whole-genome sequencing of driver-negative renal cell carcinoma with African ancestry identifies MET structural variations missed by targeted panel sequencing Setor Amuzu, Sean A. Fletcher, Srinivas R. Viswanathan, Jie-Fu Chen, Jian Carrot-Zhang
• LB104 Marker-based tumor-normal haplotypes matching reveals genome-wide recombination and haplotype specific somatic structural variation discovery using GIAB de novo pancreatic tumor-normal assemblies Chunlin Xiao, Justin Wagner, Jennifer McDaniel, Francoise Thibaud-Nissen, Justin Zook
• LB105 Translational analyses from the randomized phase 3 DREAM3R trial: DuRvalumab with chEmotherapy as first line treAtment in advanced pleural Mesothelioma Valsamo (Elsa) Anagnostou, Anna K. Nowak, Chris Brown, Brett G. M. Hughes, Noushin Niknafs, Tracy Hoang, Jaime Wehr, Connull Leslie, Qiong Meng, Asimina Zoitou, Kennet J. O’Byrne, Wee L. Chin, Thomas John, Peter Illei, Sonia Yip, Nick Pavlakis, Julie Brahmer, Martin R. Stockler, Patrick M. Forde, Alistair Cook
• LB107 A novel short isoform of adhesion GPCR BAI3, originated from an alternative promoter, reverses the EMT process, and confers survival benefit in glioblastoma multiforme (GBM) Rashed Rezwan Parag, Virginea De Araujo Farias, Haifa A. Alsharif, Md Simul Bhuiya, Jesse Stillwell, Yuki Kuranaga, Maryam Ahmadian Elmi, Naoki Hama, Masakazu Kamata, Sushant Bhatnagar, Erwin G. Van Meir
• LB108 · PDF Peptides targeting PIP4K2A : A novel therapeutic strategy for PTEN-deficient cancer Jinhee Kim, Yong-Jun Kwon, Yong Jae Shin, Jeeyun Lee

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