Methods to Measure Tumor Evolution and Heterogeneity

• 685 · PDF eTRACER illuminates the spatiotemporal landscape of immune escape in EGFR-mutant lung adenocarcinoma Hongbin Ji, Zheng Hu, Jinhua Yang, Liangzhen Hou, Xue Wang
• 686 · PDF Dissecting colorectal cancer heterogeneity and microbiota interactions using murine and patient-derived organoids Markus Tschurtschenthaler, Valentina Brunner, Nicholas Bodenstein, Expedito M. Diógenes, Lisa Niedermeier, Nicole A. Schmid, Miguel G. Silva, Moritz Jesinghaus, Roland Rad, Bärbel Stecher, Julius Fischer, Dieter Saur
• 687 · PDF In situ KRAS -mapping and spatial -omics characterization in lung premalignancy Amanda Lindberg, Bartosz Sobocki, Patrick Micke, Carina Strell
• 688 · PDF Pan-cancer mapping of genetic immune escape evolutionary trajectories Shengqing Gu, Wenjie Chen, Toby Baker, Zhihui Zhang, Huw A. Ogilvie, Peter Van Loo
• 689 · PDF Significance of prostaglandin E₂ signaling in the carcinogenesis of ulcerative colitis Tatsunari Fukuoka, Masakazu Yashiro, Hiroaki Kasashima, Nobuhiro Naito, Iguru Omori, Yasuhiro Fukui, Yuki Seki, Kenji Kuroda, Yuichiro Miki, Mami Yoshii, Tatsuro Tamura, Masatsune Shibutani, Takahiro Toyokawa, Kiyoshi Maeda
• 690 Hierarchical mixed effects cubic spline modeling of methylation-based tumor fraction dynamics for pan-cancer assessment of treatment response and outcomes in immunotherapy patients Christopher Pretz, Amar Das, Carin Espenschied, Sara Wienke, Samantha I. Liang, Christopher Cabanski
• 691 Visualizing differential prostate cancer lesion growth in longitudinal MRIs of patients on active surveillance: Quantitative mapping by Habitat Risk Score and digital pathology Sandra M. Gaston, Yuwei Zhang, Veronica M. Wallaengen, Amanda Galvez, Leonard Salcedo, Adrian L. Breto, Ahmad Algohary, Noah C. Lowry, Jakub Karczmarzyk, Gupta R. Rajarsi, Erich Bremer, Tahsin Kurc, Benjamin O. Spieler, Oleksandr N. Kryvenko, Alan Pollack, Sanoj Punnen, Joel Saltz, Radka Stoyanova
• 692 Novel single cell and bulk NGS assays for improved assessment of MRD (measurable residual disease) and clonal dynamics in acute myeloid leukemia (AML) Crystal Zhou, Ruwan Gunaratne, Emily Yang, Rachel Agoglia, Diwash Jangam, Charu Tiwari, Kailee Tanaka, Tsoyu Chiang, Chandler Ho, Sydney Lu, James L. Zehnder, Bing Melody Zhang, Henning Stehr, Tian Yi Zhang
• 693 · PDF ET-resistant cell populations in ER positive breast cancer: From profiling to therapeutic targeting Svetlana Semina, Rosemary Huggins J. Huggins, Huiping Zhao, Virgilia Macias, Leo Feferman, Andre A. Kajdacsy-Balla, Debra A. Tonetti, Kent F. Hoskins, Geoffrey L. Greene, Jonna M. Frasor, Jonathan Coloff
• 694 · PDF Spatially resolved genomics reveals evolutionary modes and imaging correlates in glioblastoma You Jin Song, Yelyzaveta Miller-Michlits, Karl-Heinz Nenning, Christoph Bock, Ji Yoon Lee, Jiwon Kim, Jisoo Hong, Dayoung Lee, Namsung Moon, Harim Koo, Jason K. Sa, Adelheid Woehrer
• 696 · PDF In vivo clonal lineage tracing using methylation barcodes in the protocadherin gene cluster Christopher T. Boniface, Samuel Hackett, Adriana V. A. Fonseca, Akemi Ramos-Yamasaki, Caroline Watson, Joanna Baxter, Jyoti Nangalia, Sadik Esener, Hisham Mohammed, Jamie Blundell
• 697 · PDF Label-free spatial profiling of the melanoma tumor microenvironment using metasurface-enhanced Raman spectroscopy Kai Chang, Mamatha Serasanambati, Feven Naba, Priyanuj Bordoloi, Antony Georgiadis, Emma Wagner, Hamish Carr Delgado, Chih-Yi Chen, Varun Dolia, Baba Ogunlade, Remi Dado, Ariel Stiber, Jack Hu, Amanda R. Kirane, Jennifer Dionne
• 698 · PDF Novel reporter tool for visualization of neuroblastoma cell state Samantha Turk, Melody Allensworth, Justina McEvoy, Marybeth Lupo, Jackie Norrie, Michael A. Dyer
• 699 Dynamic adaptation and heterogeneity in tumor patient-derived organoids: Insights into cancer evolution and drug resistance Javier Frias Aldeguer, Jasmin Pourfarzad, Alessandro Gregory, Farzin Pourfarzad, Rene Overmeer, Robert G. J. Vries, Sylvia F. Boj
• 700 · PDF Feasibility to detect genomic loss of HLA alleles by One Lambda LABType products combined with novel data analysis algorithm Svetlana Argounova, Bernabe Valdez, Kevin Lam, Hanna Bennett, Anna Chikova
• 701 Patient-derived organoid biobanks preserve tumor heterogeneity and molecular signatures Rene Overmeer, Farzin Pourfarzad, Alejandra Hernandez Segura, Merel Derksen, Carla Verissimo, Robert G. J. Vries, Sylvia F. Boj
• 702 · PDF Harnessing clonal dynamics to overcome resistance: An adaptive therapy framework in colorectal cancer Harley I. Richker, Bailey Sierra Kane, Gissel Marquez Alcaraz, Ellie Pahl, Ryan Carr, Nagarajan Kannan, Carlo C. Maley
• 703 · PDF Tracking tumor evolution and heterogeneity in fusion-driven sarcomas through cell-free DNA analysis Tom T. Fischer, Panna Lajer, Konstantin Okonechnikov, Anke King, Karla Catacora, Katharina Bauer, Iris Oezen, Tanja Jutzi, Katherine Kelly, Calvin Hans Setiadi, Waqar Hussain, Kendra K. Maass, Roland Imle, Anja Speicher, Kamelia Soleiman-Masihi, Nadine Volk, Birgit Besenbeck, Robert Kuechler, Anu Mathews, Editha Gnutzmann, Julia Ketzer, Daniela Richter, Daniel Huebschmann, Ana Banito, Claudia Ball, Kathrin Schramm, David T. W. Jones, Jan-Philipp Mallm, Uta Dirksen, Sabine Stegmaier, Monika Sparber-Sauer, Richard F. Schlenk, Hanno Glimm, Stefan Froehling, Stefan M. Pfister, Supat Thongjuea, Kristian W. Pajtler, Daniel B. Lipka
• 704 · PDF Full-range genomic analysis at single-cell resolution reveals genetic, epigenetic, and parallel evolution of melanoma subclones Chi-Ping Day, Yuelin Liu, Anton Goretsky, Ayse Keskus, Salem Malikic, Eva Perez-Guijarro, Glenn Merlino, Eytan Ruppin, Suleyman Cenk Sahinalp, Mikhail Kolmogorov
• 706 · PDF Beyond a single core biopsy: Spatial genomic profiling improves therapeutic target detection in glioblastoma Enmar Harfoush, Taylor Weiskittel, Mylan Blomquist, Dustin Grief, Aadel A. Chaudhuri, Leland S. Hu, Nhan L. Tran, Shannon Fortin-Ensign
• 707 · PDF Phylogenetic and machine learning analyses of simulated ancestral sequences reveals heterogeneous ccRCC evolution Nic Fisk, Christopher Cross, Brian M. Shuch, Jeffrey Peter Townsend

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