Spatial Protein Profiling and Multi-Modal Mapping of Tumor and Circulating Ecosystems

• 789 PaintScape TM enables in situ, single cell spatial multiomic visualization of 3D genome organization in fresh frozen colorectal carcinoma tissue in spatially resolved tissue microenvironments Shyamtanu Chattoraj, Pamela Flatley, Stacy Elliott, David Castillo, Kenny Chung, Doug Werner, Jude Dunne, Huy Nguyen
• 790 Cellular decomposition and metabolic profiling of the tumor microenvironment tumor-stroma interface using high-dimensional spatial proteomics and image analytics Arutha Kulasinghe, Felicia Roland, Michelle Poulin, Ritu Mihani, Katherine Hales, Daniel Winkowski
• 791 · PDF Novel tools for spatial profiling of protein glycosylation in cancer biology Shuhui Chen, Erika Leonard, Shamali Roy
• 792 A standardized pan-cancer framework for spatial profiling of the tumor microenvironment using multiplex immunofluorescence Sidney van der Zande, Outi H. J. Hasu, Zhiying He, Katja E. Välimäki, Tuomas Mirtti, Antti S. Rannikko, Heini J. Lassus, Ari P. Ristimaki, Pia Osterlund, Tero A. Aittokallio, Lassi Paavolainen, Mikko J. Loukovaara, Olli P. Kallioniemi, Ralf C. Bützow, Teijo S. Pellinen
• 793 · PDF Multiplexed spatial profiling of the tumor microenvironment in syngeneic mouse models using Cell DIVE imaging Jeremy Fisher, Emily Quann Alonzo, Vasundhara Agrawal, Sophie Struble, Richard A. Heil-Chapdelaine, Natasha F. Diaz Granados, Arindam Bose
• 794 Spatial analysis of the DLBCL tumor microenvironment via the novel SignalStar® multiplex immunohistochemistry assay Jennifer Ziello, Jason Weirather, Derek Papalegis, Lily Vu, Gabriella Spang, Sizun Jiang, Giorgio Ga. Inghirami
• 795 Integrating spatial transcriptomics and Imaging Mass Cytometry™ for multi-omic mapping of hepatocellular carcinoma Atefeh Khakpoor, Qanber Raza, Merrin Mary Eapen, Dina Kazemi, Erin Coll, Liang Lim, Christina Loh, Nick Zabinyakov, Ling Qiao, Anna Di Bartolomeo, Helen McGuire, Jacob George, Ankur Sharma
• 796 Digital spatial profiling reveals immune heterogeneity across tumor and stromal compartments in hepatocellular carcinoma Min Qing, Qibiao Wu, Xuesong Lyu, Tao Chen, Mingxuan Xia, Joshua J. Rusbuldt, Denis Smirnov, Flora Berisha, Longen Zhou, Chia-Jui Yen
• 797 Integrating hematoxylin & eosin histology with multiplexed imaging mass cytometry for spatial proteomic profiling of antibody-drug conjugate targeted biomarkers Nick Zabinyakov, Qanber Raza, Liang Lim, James Mansfield, Christina Loh
• 798 Tumor-associated neutrophil density and cancer cell interaction in microsatellite stable and unstable gastric cancer using multiplex immunofluorescence Soo Kyung Nam, Seo Hwan Yu, Sun Young Ahn, Yujun Park, Yoonjin Kwak, Sujin Oh, Kyoung Un Park, Hye Seung Lee
• 799 · PDF Integrated spatial multiomics pipeline for visualizing protein interactions in the tumor microenvironment Anushka Dikshit, Josh Brownlee, Ge-Ah Kim, Sonali Deshpande, Diane Robirds, Anne Hellebust
• 801 Genomic and spatial single-cell profiling reveals BRCA-linked tumor microenvironment signatures in high-grade serous ovarian carcinoma Jue young Kim, Hayeon Shin, Yoon Joo Kim, Yookyung Lee, Jae-Hoon Kim
• 802 · PDF Multi-omic profiling maps the immune multicellular environment of renal cell carcinoma Thao Tran, Máikel L. Colli, Nathan H. Patterson, Qanber Raza, Liang Lim, Lauren Tracey, Alice Ly, Sanja Bajovic, James Mansfield, Christina Loh, Marc Claesen
• 803 A spatial profiling approach to evaluating the prognostic impact of heterogeneity in the triple-negative breast cancer immune microenvironment Prerana Sensharma, Huidan Zuo, Melanie Dawe, Megan Hopkins, Zeynep Baskurt, Osvaldo Espin-Garcia, Philippe L. Bedard, Melanie Spears, Susan J. Done
• 804 Distinct cellular phenotypes and spatial neighborhoods constitute the heterogeneous microenvironment of desmoplastic small round cell tumor Kevin A. Murgas, Jiaqian Fan, Diana Shamsutdinova, Khalida Wani, Davis R. Ingram, Alexander J. Lazar, Danh D. Truong, Joseph A. Ludwig
• 805 Fluorescence-guided multi-sampling and spatial multi-omics reveal functional lipid vulnerabilities in glioblastoma Adele-Asia Ponzoni, Evangelos Liapis, Lea Anne T. Maristela, Elizabeth E. Ginalis, Linda Szymanski, Kar Fai Chow, Kangmin Lee, George J. Kaptain, Claire L. Carter
• 806 Tumor microenvironment of ampulla of Vater cancer reveals distinct spatial niche of CAF, TIL, and TAM and their correlation with clinicopathologic features Yesul Jeong, Se Jun Park, Sung Hak Lee*, Younghoon Kim*
• 807 Integrated transcriptomic and proteomic characterization of the lung tumor microenvironment using BD®OMICS-One-Protein-Panels for CITE-seq Samuel X. Shi, Cynthia Sakofsky, Hye-won Song, Manish Thakran, Tamiyo Kobayashi, Aruna Ayer
• 808 Single cell spatial multiomics of TCR and BCR repertoires using CosMx® SMI to characterize immune cell dynamics in PBMCs and tumors Margaret L. Hoang, Rachel Liu, Dan McGuire, Ashley Heck, Kimberly Young, Megan Vandenberg, Claire Williams, Martin Shelton, Prajan Divakar, Patrick Danaher, Erin Piazza, Joseph M. Beechem
• 809 Spatially resolved multiomics profiling of glioblastoma reveals molecular signatures of neuropathology and immuno-oncology architecture using CosMx SMI Yi Cui, Claire Williams, Chia-Ying Lee, Chi Phan, Sierra Mckinzie, Shanshan He, Ashley Heck, Kimberley Young, Lidan Wu, John Lyssand, PRAJAN DIVAKAR, Joseph M. Beechem
• 810 · PDF Multi-omic spatial analysis reveals a distinct pattern of cellular neighborhood in gastric cancer Takashi Semba, Huaitao Wang, Atsuko Yonemura, Yilin Tong, Takatsugu Ishimoto
• 812 · PDF Spatial architecture of head and neck squamous cell carcinoma (SCCHN): An IMMUcan/EORTC analysis Lucas Michon, Athénaïs van der Elst, Daniel Herrero-Saboya, Marie Morfouace, Preethi Devanand, Robin Liechti, Daniel Schulz, Maya Persoons, Sylvie Rusakiewicz, Nils Eling, Paul-Antoine Nicolas, Stephanie Renaud-Tissot, Bernd Bodenmiller, Henoch Hong, Rachel Galot, Paolo bossi, Julio Oliveira, Florian Estrade, Caroline Even, Sophie E. Lucas, Loredana Martignetti, Céline Lefebvre, jean-pascal Machiels, Pierre Saintigny
• 813 Linking tumor-infiltrating immune cells from tissue and peritoneal cytology to molecular markers in endometrial cancer Seungmee Lee, Jin-Young Kim, Shin-Wha Lee, Eun Ji Nam, Ji Hae Seo, Sojin Shin
• 814 · PDF Lymphatic exudate is a novel source of tumor-associated immune cells Seka Lazare, Michael A. Harmon, Ashley Tellis, Zachary Costliow, Zhuosheng Gu, Adam Benson, Samuel Espinoza, Abbey Crittenden, Megan Rivera, Michael Abern, Sunil Patel, Kamal Pohar, Gautum Agarwal, Rohann Correa, Wendy Winckler
• 815 · PDF Simultaneous spatial transcriptome and epigenome profiling in fresh frozen and FFPE tissues with spatial CoPro Katelyn Noronha, Molly Wetzel, Abigail Chang, Jennifer M. Garbarino, Jiaying Chen, Jeffrey Sabina, Colin Ng
• 816 · PDF Spatial metabolic gradients drive epigenetic reprogramming in human glioblastoma Sankha Subhra Chakrabarty, Yilin Xu, Shannon Coy, Jia-Ren Lin, Dimitrius Tansini Pramio, Pilar Baldominos, Clement Bodineau, Nathalie Y. R. Agar, Judith Agudo, Marcos Simoes-Costa, Keith L. Ligon, Peter Karl Sorger, Sandro Santagata
• 817 Spatial characterization, of T-cell receptors at subcellular resolution using in situ sequencing-by-synthesis and spatial protein detection on the same tissue section Hansueli Meyer, Robert Pinard, Ryan Hindman, Emily Neil, Chris Nehme, Sameh Soliman, Dongju Park, Rebecca C. Hennessey, Jinling Wang, Alex Makrigiorgos, John Lee, Seiyu Hosono, Matthias Wahl, Dominic Mangiardi, Mong Marma, Hsu-yi Lee, Andreas Bosio
• 818 · PDF Simultaneous spatial transcriptome and methylation profiling in fresh frozen and FFPE tissues Katelyn Noronha, Molly Wetzel, Jennifer M. Garbarino, Jiaying Chen, Jeffrey Sabina, Colin Ng

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