Physicochemical Modulation of Cancer Ecosystems: Mechanical Forces, Hypoxia, and Acidosis

• 756 Matrix stiffness induces Ca²⁺-DCLK1-PIP5K1A mechanotransduction as a biomechanical checkpoint in pancreatic cancer progression and chemotherapy resistance Haoxiang Zhang, Chuanbin Zhao, Jiaoshun Chen, Xiaoqing Hu, Jianwei Bai, Long He, Zanglong Deng, Tao Yin
• 757 · PDF Matrix stiffness encoded mechanical memory maintains proliferative dominance in tumor metastasis Yusheng Luo, Yuxi Pan, Xiaorong Lin, Shuo Fang
• 758 · PDF ECM mimicking tunable 3D hydrogels to model Ewing sarcoma Aakanksha Jha, Cole DeForest, Elizabeth Lawlor
• 759 Mechanical remodeling of the tumor microenvironment promotes breast cancer and neutrophil-ssociated immunosuppression through ERG3-ALOX5 signaling Lingpeng Tang, Liangyu Wei, Jinpeng Lu, Haoxiang Zhang, Songsong Wu
• 761 Collagen turnover is dominated by fibrogenesis in lung adenocarcinoma and fibrolysis in lung squamous cell carcinomas Victoria Batto, Marselina Arshakyan, Rasmus Sund Pedersen, Neel Ingemann Nissen, Enrico Almici, Noemi Reguart, Morten Karsdal, Nicholas Willumsen, Jordi Alcaraz
• 762 A tunable 3D organoid model reveals stiffness-dependent stromal activation and cytokine signaling in pancreatic cancer Carolyn M. Ruiz-Rivera, Ba Xuan Hoang, Jamel Ali, Thomas D. Schmittgen, Bo Han
• 763 · PDF Bridging the translational gap: Critical TME differences between human PDAC and mouse models Rachael Guenter, Libby A. Boykin, Khidr Kishan K. Budhwani, Brahma Mubarak K. Budhwani, Chelsea L. Crawford, J. Bart Rose, Karim I. Budhwani
• 764 · PDF Mig-6 deficiency accelerates fibrotic tumor microenvironment formation in P ten -deficient endometrial tumors Shamsun Nahar, Kyeong A So, Keun Chen Kim, Jung Yoon Yoo, Jiyoung Yu, Kyunggon Kim, Eunhee M Jeong, Da-Hye Kang, Tae Hoon Kim, Jae-Wook Jeong
• 765 · PDF Tumor extracellular matrix drivesEMT and cellular reprogrammingin Wilms tumor Wilson Yeung, Matthew E. Thornton, Hripsime Chomoyan, David Koos, Justin Sunwoo, Brendan H. Grubbs, Roger E. De Filippo, Stefano Da Sacco, Laura Perin, Astgik Petrosyan
• 766 · PDF Physically driven chromosome instabilities spur macrophages to attack cooperatively Dennis Discher, Markus Sprenger, Joanna Georgiou, Tristan Marchena, Jude Khatib
• 767 Tumor stiffness as a functional biomarker of KRAS-mutant NSCLC: Insights from the ARTIDIS prospective clinical cohort Jordi Alcaraz, Elba Marin, Héctor Sanz-Fraile, Marina Querol, Paula Gausa, Keat Neal, Marselina Arshakyan, Marc Rico-Pastó, Marc Boada, David Sanchez, Carolina Ortiz Velez, Reinier Oropesa Nunez, Gitika Srivastava, Ahmed Jizawi, Sara Nizzero, Tobias Appenzeller, Philipp Oertle, Marko Loparic, Marija Plodinec, Noemi Reguart
• 768 · PDF Modeling the triple-negative breast cancer extracellular matrix in a 3d tumor scaffold Katherine Hebert, Thomas Cheng, Sophie Dietrich, Mackenzie Hawes, W. Todd Monroe, Jorge Belgodere, Elizabeth Martin
• 769 · PDF Matrix mechanics modulate cancer cell plasticity and drug responses Chantal Kopecky, Elvis Pandzic, Morgan Hamon, Sean Porazinski, Justin Gooding, Kristopher A. Kilian
• 771 ECM stiffness and glutamine availability rewire metabolic and immune phenotypes in 3D Co-culture models of pancreatic cancer and cancer-associated fibroblasts Jonathan Barajas, Carolyn Ruiz, Zhi Yang, Bo Han, Edward Agyare, Xueyou Zhu, Saun-Joo Yoon
• 773 Single-cell and spatial transcriptomic profiling reveal fibrosis-related tumor states in lung squamous cell carcinoma associated with idiopathic pulmonary fibrosis KENTA MANABE, Atsushi Matsuoka, Kazuhiko Shien, Shuta Tomida, Hidejiro Torigoe, Kazuya Hisamatsu, Ryota Fujiwara, Kosei Ishimura, Shunsuke Mori, Ryunosuke Fujii, Asuka Mimata, Kazuhiro Okada, Ryo Yoshichika, Mao Yoshikawa, Yuma Fukumoto, Haruchika Yamamoto, Kumi Nakajima, Shin Tanaka, Ken Suzawa, Kentaroh Miyoshi, Mikio Okazaki, Seiichiro Sugimoto, Shinichi Toyooka
• 774 · PDF Aligned ECM influences neuroblastoma cell plasticity via YAP-WT1 association Vic Zamloot, Chandra Kaladhar Vemula, Antonios Chronopoulos, JinSeok Park
• 775 · PDF Matrix stiffness remodels the immunosuppressive tumor microenvironment via the PIEZO1-DCLK1-STAT5B pathway Liangyu Wei, Lingpeng Tang, Jinpeng Lu, Ting Hu, Shi Chen, Zuwei Wang, Haoxiang Zhang
• 776 A cancer cell intrinsic program for matrix remodeling and CAF recruitment in slow growing, poor prognosis colorectal cancers Claudio Isella, Anna Cassisa, Consalvo Petti, Alexandra Ambra Ulla, Jie Zhou, Carlo Leonardi, Roberta Porporato, Daniela Cantarella, Letizia Franco, Cinzia Benetti, Jill Carol Rubinstein, Jessica Erriquez, Mariangela Russo, Francesco Sassi, Elena Grassi, Ymera Pignochino, Alberto Puliafito, Ivan Molineris, Rebecca Senetta, Andrea Bertotti, Livio Trusolino, Jeffrey H. Chuang, Alberto Bardelli, Enzo Medico
• 777 An ATP-grasp superfamily enzyme induced under serum starvation and hypoxia as a potential biomarker for pancreatic cancer diagnosis Katsuya Takenaka, Yukako Komori, Yoshiyasu Nakamura, Shiro Koizume, Yohei Miyagi
• 778 · PDF Hypoxia shapes tumor immune microenvironment through cell-type dependent responses in diffuse astrocytomas Aliisa Tiihonen, Iida Salonen, Iina Koivisto, Anni Ritamäki, Serafiina Jaatinen, Tanja Hyvärinen, Johanna Tilvis, Joose Kreutzer, Masi Valkonen, Göktug Karabiyik, Sonja Mäntylä, Maryam Mohammadlou, Miina Hoikka, Jürgen Beck, Roland Rölz, Mikael Marttinen, Matti Nykter, Joonas Haapasalo, Pekka Ruusuvuori, Seppo Parkkila, Pasi Kallio, Sanna Hagman, Juha Kesseli, Vidhya Madapusi Ravi, Hannu Haapasalo, Arja Jukkola, Kevin Joseph, Kirsi Rautajoki
• 779 · PDF Hypoxia-driven epithelial reprogramming elevates CD46 and promotes vasculogenic mimicry in immune-desert NSCLC Minyeop Kim, Youwon Lee, Seung Yeon Oh, Eun Ji Lee, Ji Hyung Moon, Ji Ae Ko, Ji Woo Lim, Sujin Choi, Jae-Hwan Kim, Jii Bum Lee, Min Hee Hong, Sun Min Lim, Byoung Chul Cho, Mi Ran Yun
• 780 · PDF Tumor cell adaptation to nutrient stress via metabolic change due to fibronectin/integrin internalization Arin Nam, Tasha Nguyen, Tami von Schalscha, Sara M. Weis, David A. Cheresh
• 782 · PDF Tolerance to extracellular acidic pH facilitates tumor plasticity Manami Hasegawa, Bo Xu, FeiFei Cai, Runmei Cui, Ritsuko Ando, Ken Matsumoto, Chisato Iwabuchi-Yoshida, Kazuyuki Yamagata, Rika Tsuchida, Tsuyoshi Osawa
• 783 · PDF Exploring landscapes of T cell activation in acidic environment for tumor immunotherapy Minkyeong Ro, Youngjun Park
• 785 · PDF Elucidating the molecular regulation of superdark transmembrane protein 184C (TM184C) Shraddha ChandThakuri, Jennifer Arcuri, Daniel Isom

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