Late-Breaking Research: Immunology 2

• LB136 · PDF Flotillin-2 suppresses CD8⁺T cell anti-tumor function by restricting T cell receptor nanoclustering and activation Sookjin Moon, Fei Zhao, Peer Karmaus, Michael Fessler
• LB137 E-selectin ligand engineering overcomes trafficking barriers to potentiate adoptive T-cell and BiTE therapies Yingqin Hou, Peng Wu
• LB138 Natural killer cell-based signaling in EGFR-targeted KIR-CAR T overcomes CD3-based CAR T functional deficits to eliminate resistant glioblastomas in vivo Jun Xu, Radhika Thokala, Yibo Yin, Chong Xu, Alina C. Boesteanu, Alexandria P. Cogdill, Zev A. Binder, Logan Zhang, Jiasi Vicky Zhang, Enxiu Wang, Carl H. June, Donald M. O'Rourke, Michael C. Milone, Laura A. Johnson
• LB139 · PDF Nanobody adaptor-directed CAR T cells enable precise and safe targeting of solid tumors Yoo-Shin Kim, Yogindra Vedvyas, Aroshi Mitra, Nathaniel Fredette, Irene Min, Yanping Yang, Moonsoo Jin
• LB140 · PDF B7H3 CAR T cell therapy across immunocompetent ovarian cancer models with evidence of transferable anti-tumor immunity Thu Huyen Pham, Elizabeth Allen, Supreeti Tallapragada, Justine Chan, Naiara Martinez Velez, Elena Sotillo, Crystal L. Mackall, Oliver Dorigo
• LB141 · PDF High-throughput screening of chimeric RNA-binding proteins for improved CAR T cell function Courtney Kernick, Oliver Takacsi-Nagy, Austin Hartman, Lujing Wu, Christie Chang, Ansuman Satpathy, Theodore Roth
• LB142 · PDF The inhibitory VISTA LRIG1 axis impairs the persistence and function of CAR T cells Dia Roy, Keman Zhang, Amin Zakeria, Elizabeth Delaney, Hieu Minh Ta, Paolo Elguera Grandez, Lily Wang
• LB143 · PDF Modulation of G3BP1 influences the functional efficacy of CAR T cells against glioblastoma Donghyun Lee, Yoo-Shin Kim, Yogindra Vedvyas, Nathaniel Fredette, Moonsoo Jin, Irene Min
• LB144 · PDF OBX-115 membrane-bound IL15 (mbIL15)-expressing engineered tumor-infiltrating lymphocytes (TIL) overcome target cell immune evasion related to major histocompatibility complex (MHC) silencing through both direct killing and transactivation of NK cells in patient-derived autologous non-small cell lung cancer (NSCLC) models Adam J. Schoenfeld, Alonso Villasmil Ocando, Zheng Ao, Rachel Burga, Alicia Adamovich, Hansini Wadan, Sarah Cascarino, Dhruv K. Sethi, Giridharan Ramsingh, Matthew Bott
• LB145 · PDF Lentiviral-based hematopoietic stem cell platform for macrophage-specific expression in glioma immunotherapy Jianzhong Zhang, Edward J. Allen, Víctor A. Arrieta, Heba Ali, Ningjia Zhou, Venkatanagasai Raju Alluri, Michael D. McRaven, Sergio Barajas, Adam M. Sonabend, Amy B. Heimberger, Yan Liu, Ajit Chande, Atique U. Ahmed, Jason M. Miska, Catalina Lee-Chang, Peng Zhang, Thomas J. Hope, Crismita Dmello
• LB146 · PDF Integrating a fasting mimicking diet to augment antitumor immunity following adoptive cell transfer in breast cancer Evangelia Pavlou, Olga Blazevits, Giulia Salvadori, Sara Martone, Valter Longo
• LB148 · PDF Cryo-immune vaccination (CIV):A nontoxic locoregional multicomponent immunotherapeutic approach that can systemically eradicate disseminated metastatic cancers James B. DuHadaway, Alexander J. Muller, Lisa D. Laury-Kleintop, U. Margaretha Wallon, Marie Webster, Jason R. Williams, Gabriela R. Rossi, Mario R. Mautino, Charles J. Link, George C. Prendergast
• LB149 · PDF Progenitor-to-intermediate differentiation of exhausted CD8+T cells is enhanced by HPK1 inhibition during anti-PD-1 therapy Yong Joon Lee, Seung Hyuck Jeon, Seungmook Lim, Minwoo Jeon, Heejin Nam, A Yeong Park, Boeun Gu, Jee Ye Kim, Seung Il Kim, Jeon Yeob Jang, Chul-Ho Kim, Shin Hwang, Gi-Won Song, Jae-Ho Cheong, Byung Soh Min, Su-Hyung Park, Seong Il Seo, Jinhwa Lee, Minyong Kang, Jae Eun Kim, Eui-Cheol Shin
• LB150 Senescence as an immune tolerance breaker: Inhibitors of mitotic kinases TTK (Mps1) and AURKA induce pro-immunogenic senescence that primes the tumor microenvironment for immunotherapy via cGAS-STING signaling Marina Capece, Evdokiya Reshetnikova, Yinchong Wang, Arjun Mittra, Anna E. Vilgelm
• LB151 · PDF Liposomal doxorubicin potentiates anti-tumor immune response in oral cavity squamous cell carcinoma Jennifer L. Anderson, Fabio H. Brasil Da Costa, Allison Nipper, Nicolas Oltean, Laxman Devkota, Rohan Bhavane, Ratna Veeramachaneni, Sofia Cortes, Neeraja Dharmaraj, Sarah L. Latka, Andrew Badachhape, Renuka T. R. Menon, Prajwal Bhandari, Sujuan Yang, Ansam Sinjab, Humam Kadara, Roberto Rangel, Faye M. Johnson, Jeffrey N. Myers, Ketankumar B. Ghaghada, Simon Young, Ananth V. Annapragada, Andrew G. Sikora
• LB152 · PDF ACR-368 synergizes with PD-L1 blockade by coordinated activation of adaptive and innate immunity pathways to achieve robust anti-tumor efficacy Amira Elbakry, Taronish Dubash, Joelle Baddour-Sousounis, Jessica Hopkins, Subodh Kumar, Ahmed Youssef, Yingchun Spring Liu, Kate Rappard, Calvin Yang, Ignacio Arribas Diez, Marc Isaksson, Luka Romero, Zachary Best, Nina Lipjankic, Sofija Skoric, Courtney Cooper, Emma Ahrman, Valentina Siino, Portia Lombardo, Corey Xu, Magnus E. Jakobsson, Helen Nilsson, Lei Shi, Ayesha Murshid, Michail Shipitsin, Joon Jung, David Proia, Erick Gamelin, Kristina Masson, Peter Blume-Jensen
• LB153 · PDF A quantitative MDSC infiltration assay in a tumor organoid-stromal microenvironment for immuno-oncology candidate evaluation Bo Eun Lee, Wookyeom Yang, Yoon-Ha Go, Phuong Lan Nguyen, Dong-Uk Lim
• LB154 · PDF Anti-GARP reverts immune suppression and extends overall survival in a MASH-HCC murine model resistant to anti-PDL1+anti-VEGFA therapy Julia Huguet-Pradell, David Camell-Raventos, Elisa Fernández-Martínez, Anthony Lozano, Tiago de Castro, Marcus Zeitlhoefler, Ugne Balaseviciute, Albert Gris-Oliver, Daniela Sia, Roser Pinyol, Josep M Llovet
• LB155 · PDF Durable anti-tumor immunity through in vivo CAR T cell engineering using the RetroT all-RNA genome integration platform Jian Ding, Meghan Harris, Edward Cochran, Thach Ty, Glen Leary, Jason Rodriguez, Jerome Chal, Yuxiao Wang, Daniel Getts, Robert Hofmeister, Philippe Kieffer-Kwon

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