Structural and Chemical Biology

• 2412 · PDF Malic enzyme inhibition as a strategy to exploit metabolic reprogramming in cancer: A structure-based approach Ben Andrew Krinkel, Yuliana Yosaatmadja, Mark Daniel Slayton, Jin Heon Jeon, Jack Copping, Jack Flanagan, Sofia Merajver, Chris Squire, Kerry Loomes
• 2413 · PDF Insights in CYP2E1-mediated ferroptosis in hepatocellular carcinoma Kristy L. Thomas, Kylie R. Driggers, Hyland C. Gonzalex, Jessica H. Hartman
• 2414 · PDF Targeting the interferon-inducible isoform, p150 of ADAR1 for the treatment of oral squamous cell carcinoma (OSCC) Annie Wai Yeeng Chai, Pei San Yee, Xavier Wezen Chee, Stephanie Hao Ling Cheah, Jie Ying Teo, Keng Yoon Yeong, Siew Kit Ng, Siaw San Hwang, Sok Ching Cheong
• 2415 First-in-class stabilizing inhibitor of CHD4 that traps and disassembles the NuRD complex Anthony Sanchez, Minkyu Kim, Ivan Babic, Kyle Miller, Elmar Nurmemmedov
• 2416 · PDF Analyzing non-cancerous and cancerous protein structure using a novel Elliptical Dichroism Spectrometer Tommy Gao, Dali Sun
• 2417 · PDF Proteome-wide target engagement and ternary complex mapping of molecular glues using LiP-MS Martin Soste, Polina Shichkova, Matevz Stefancic, Daniel Redfern, Francesca Cavallo, Lorna Charge, Ka Ying Lee, Ricardo Canavate del Pino, Denise Swift, Roland Hjerpe, Stuart Thomson, Allan Jordan, Yuehan Feng
• 2418 · PDF Non-covalent small molecule probe discovery of large intrinsically disordered protein Yichen Xiang, Marc Ramos Sala, Jose I. Vergara Panzone, Nancy Jiang, Diya Rana, Eliot Ebert, Angela N. Koehler
• 2419 Synthesis and evaluation of novel functionalized beta-lactams as potent anti-melanoma agents targeting PI3K/MAPK and JAK/STAT pathways Joy Temiloluwa Folahan, Ojasvi Dutta, Tolulope Omole, B. Donji, Konstantin Kousoulas, Timothy Beng, Jean Christopher Chamcheu
• 2421 · PDF Combining deep mutational scanning and next-generation protein sequencing to harness dominant protein variants to develop DNA repair inhibitors Nigel O'Neil, Lina Ma, Anthony Oppedisano, Esteban Lenoir, Philip Hieter, Peter C. Stirling
• 2422 · PDF Next-generation chemical biology: Mapping the Purinome druggable space reveals genotype-specific vulnerabilities via phenotypic screening Ali Khateb, Ritika Gangaraju, Eric Gonzalez, Maizie Lee, Akshat K. Nigam, Jessica San Juan, Agnes Tan, Imran S. Haque, Thilo J. Heckrodt, Jack D. Sadowsky, Stig K. Hansen, Raymond V. Fucini
• 2423 · PDF Evaluation of novel small molecule inhibitors targeting Polycomb repressive complex 1 as chemical probes Geoffrey Hewett, Haiqing He, Yiwu Yao, Se Ra Park, Sydney Musser, Trupta Purohit, Jolanta Grembecka, Tomasz Cierpicki
• 2424 · PDF Evaluating the biochemical activity and endogenous engagement of covalent small molecule inhibitors of NSD1 and NSD3 in cancer cell lines Joshua Ray, Bradley Clegg, Sergei Zari, Kibum Kim, Se Ra Park, Jolanta Grembecka, Tomasz Cierpicki
• 2426 · PDF The cryo-EM structure of ADGRL4 provides functional insights into its mechanism of activation David M. Favara, Qingchao Chen, Anastasiia Gusach, Aurora Diamante, Jayesh C. Patel, Patrcia C. Edwards, Christopher G. Tate
• 2427 Optimizing the detection of pH-dependent conformational changes in pH-low insertion peptides using microfluidic modulation spectroscopy (MMS) Emma Sanderson, Ryan Bynum, Happy Agarwal, Lacey McNally
• 2428 · PDF Structural proteomics and AI powers PROTAC rational design Nitzan Simchi, Michal Ran Shchory, Joseph Rinberg, Alon Shtrikman, Yaron Ben Shoshan-Galeczki, Gali Arad, Katharina Lange, Sagie Brodsky, Anjana Shenoy, Dimitri Kovalerchik, Yonatan Kedem, Iris Alchanati, Galina Otonin, Noam Cohen, Kirill Pevzner, Eran Seger
• 2429 · PDF Nanoformulation enabling repurposing of niclosamide for the treatment of pancreatic cancer: Rapidly soluble oral formulation for enhanced bioavailability Bhoomi Mukeshbhai Dholariya, Ketankumar Patel

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