Data-Driven Approaches to Precision Oncology

• 2494 · PDF Prospective organoid drug profiling and clinical response correlation for patients with primary or recurrent ovarian carcinoma (OC) in the PROSPERITY study Elizabeth M. Swisher, Payel Chatterjee, Isabel Rodriguez, Kalyan Banda, Faith Beers, Asal Patterson, Enna Manhardt, Mayumi Rubin-Saika, Emiko Oshima, Melanie Dillon, Rachele Rosati, Vaishnavi Pallem, Lauren R. Appleyard, Alex C. Rajewski, Shalini Pereira, Soledad Jorge, Renata R. Urban, Elise J. Simons, John B. Liao, Barbara Goff, Carla Grandori, Christopher J. Kemp
• 2495 · PDF Rapid clinical diagnostic classification and risk stratification in acute myelogenous leukemia (AML) using whole genome sequencing (WGS) Wayne M. Jepsen, Jonathan J. Keats, Sara A. Byron, Cherie Wesley, Bryce Turner, Christophe Legendre, Tyler Izatt, Tracey White, Amy Stouffer, Lucy Ghoda, Yeneka Campana, Courtney Holden, Jonathan Beteran, Michelle Afkhami, Anthony Stein, Tibor Kovacsovics, Guido Marcucci, Jeffrey Trent
• 2496 · PDF In silico screening of therapeutics candidates targeting minimal residual disease in glioblastoma Harrshavasan Congivaram, Shashwat Tripathi, Mateo Gomez, Katy McCortney, Ching Man Wai, Ruochen Du, Thomas K. Sears, Jianzhong Zhang, Daniel J. Brat, Craig M. Horbinski, Mark W. Youngblood, Jared T. Ahrendsen, Adam M. Sonabend, Stephen T. Magill, Matthew C. Tate, Maciej S. Lesniak, Sean Sachdev, Timothy Sita, Priya Kumthekar, Karan Dixit, Robin Buerki, Ditte Primdahl, Mustafa Khasraw, John de Groot, David A. Reardon, Rimas V. Lukas, Roger Stupp, Amy B. Heimberger
• 2498 · PDF OncoKB™, MSK's precision oncology knowledge base: 2025 updates Sarah Phillips Suehnholz, Ritika Kundra, Moriah Heller Nissan, Calvin Lu, Nicole Fernandez, Kelly Cavender, Kinisha Gala, Benjamin Preiser, Reshma Ramaiah, John Konecny, Xiang Li, Subhiksha Nandakumar, Kseniya Petrova-Drus, Mark Ewalt, Nikita Mehta, Yonina R. Murciano-Goroff, James Du, Anoop Balakrishnan Rema, Aijazuddin Syed, A. Rose Brannon, Ahmet Dogan, Diana Mandelker, Zsofia K. Stadler, Alexander Drilon, David B. Solit, Ross L. Levine, Maria E. Arcila, Marc Ladanyi, Michael F. Berger, Jianjiong Gao, Nikolaus Schultz, Debyani Chakravarty
• 2499 · PDF Single-cell transcriptomic comparison of tumor before and after chemotherapy reveals therapeutic vulnerabilities in chemo-tolerant osteosarcoma cells Parisa Vahidi Ferdowsi, Kenny Yeo, Tiruneh Adane, Qian Wang, Nisitha Jayatilleke, Sin Wi Ng, Janith Seneviratne, Daniel R Carter, Antoinette Anazodo, Richard Boyle, Paul Stalley, Maurice Guzman, Daniel Franks, Belamy B. Cheung, Glenn Marshall
• 2500 · PDF CMTR2 deficiency defines a novel RNA splicing-driven subtype of lung adenocarcinoma with therapeutic vulnerabilities Takashi Nakaoku, Shigenari Nukaga, Kouya Shiraishi, Akifumi Mochizuki, Hamaguchi Yu, Hitomi Nishinakamura, Yoshihisa Kobayashi, Ayako Ui, Yasushi Goto, Shun-ichi Watanabe, Yasushi Yatabe, Hiroyoshi Nishikawa, Ryuji Hamamoto, Takashi Kohno
• 2501 · PDF Epigenetic screening in organoids identify KMT5A inhibition as a therapeutic strategy via PGK1in endometrial cancer Jingyao Chen, Yinhua Tan, Zhichang Liu, Tong Wang, Kai Xiao, Feifei Na
• 2503 · PDF Lung cancer organoid-based diagnostic response prediction (CODRP) for predicting anticancer drug response and progression-free survival Seung Joon Kim, Sang-Yun Lee, Yu-Jeong Seong, Yongki Hwang, Hyobin Won, Eunyoung Lee, Dong Woo Lee
• 2504 · PDF Activation of alternative receptor by CCL5 is associated with non-small cell lung cancer disparities Briana Alicia Brock, Murugesh Eswaran, Hina Mir, Shailesh Singh
• 2505 · PDF Dual siRNAs for precision targeting of synthetic lethal vulnerabilities in Diffuse Pleural Mesothelioma Yelixza I. Avila, Anand Singh, Vivek Singh, So-Hyun Yoon, Smrity Sahu, Nathanael Pruett, Chuong D. Hoang
• 2506 · PDF Genomic-driven targeted therapy evaluation using patient-derived organoids and xenografts in gastric cancer Honyong Zhang, Nicole Halmai, Jasmine Diaz Sezati, Ana Estrada, Luis G. Carvajal-Carmona
• 2507 · PDF Causal machine learning personalizes endocrine therapy selection for ductal carcinoma in situ Emma Graham Linck, Alex Spicer, Marina N. Sharifi, Guanhua Chen, Mark Craven, Nataliya Uboha, Mark Burkard, Matthew Churpek
• 2508 · PDF New precision treatments for glioblastoma Lateef Owolabi Anifowose, Zhi Sheng
• 2509 · PDF Building a Precision Therapeutics program at a tertiary care Children's Hospital Anish Ray, Luke Hamilton, Riyaz M. Basha, Kelly L. Vallance, Diana Carrasco, Kaitlin Smith, Aly Anthony, Alejandra Dominguez, Megan Gibbs, Danielle Miller, Heidi Trinkman
• 2510 · PDF Comprehensive genomic profiling drives precision oncology and expands accessibility to targeted therapies in Uzbek populations Zilola Olimova, Gowhar Shafi, Djuraev Farrukh, Yashodhara Bhattacharya, Aarthi Ramesh, Sandhya Iyer, Mohan Uttarwar, Hrishita Kothavade, Alain D'Souza, Bhagwat Jadhav, Sangeeta Prajapati, Madhura Basavalingegowda, Kanchan Hariramani
• 2511 · PDF Ranking therapeutic recommendations of Molecular Tumor Board with an evidence-based algorithm to deliver optimal care and improve outcomes for cancer patients- continuous study Yuliang Sun, Rachel Elsey, Crystal Hattum, Bing Xu, Tobias Meissner
• 2512 · PDF A real time imaging based functional precision medicine (FPM) assay for glioblastoma Thomas Quinn, Anand Panigrahy, Dina ElHarouni, Mariam A. Oumelloul, Smitha Yerrum, Kin-Hoe Chow, Sonam Bhatia, Keith L. Ligon
• 2513 Exploring Ziziphus jujuba phytochemicals against oral cancer: Network-based profiling and molecular dynamics analyses Abdullah A. Assiri, Ahmad Alamri, Najeeb Khan
• 2514 · PDF Patient-driven multi-omic longitudinal research study reveals novel insights into uveal melanoma progression Amber Smith, Ben Kamphaus, Katie Campbell, Robin Kageyama, Benjamin G. Vincent, Christopher Heery, Christine N. Spencer, Marshall Thompson
• 2515 Preserving predictive power with minimal PDOs: Accelerated drug testing for personalized therapy in metastatic CRC Yasmine Abouleila, Roel Verkerk, Mayke Doorn, Timo Voskuilen, Gakuro Harada, Masahiko Watanabe, Lidwien Smabers, Hideaki Kyan, Takahiko Kumagai, Yuichi Hikichi, Rene Overmeer, Jeanine Roodhart, Kiyotaka Matsuno, Carla S. Verissimo, Robert G. J. Vries, Sylvia F. Boj
• 2516 Genomic landscape and patterns of homologous recombination deficiency in Indian ovarian cancer: Clinical implications for precision therapy Rahul Katara, Sourabh Kumar, Aditi Agarwal, Kiran Kumar, Deepak K. Sharma, Yuvaraj M, Hardeep Singh, Vipin Kumar, Shivani Sharma
• 2517 · PDF Real-world clinical performance of a combinatorial functional precision platform, Optim.AI™, in hematological malignancies Masturah Rashid, Weng Tong Ho, Jhin Jieh Lim, Sharon Pei Yi Chan, William YK Hwang, Edward Kai-Hua Chow
• 2518 · PDF Feasibility study of an ex vivo functional precision medicine platform, Optim.AI™, in guiding treatment for gynecological cancers Masturah Rashid, Jhin Jieh Lim, Sharon Pei Yi Chan, Manavi Sachdeva, Hidayah Nabillah Nasit, Natalie Ngoi, John Chia, David Tan, Edward Kai-Hua Chow
• 2519 · PDF Characterization of BRAF fusions and their therapeutic and resistance implications in NSCLC Kai Wang, Chao Yi, Xiong Ning, Dalin Xiong, Song Wang, Xiaoying Wu, Hua Bao, Haimeng Tang, Xue Wu, Yuan Jiang, Hongyu Deng, Faqing Tang
• 2520 · PDF Clinical impact of the personalized medicine for neuroblastoma patients: Six years of experience of the PREME program Francesca Parisi, Eleonora Ciampi, Veronica Bensa, Federica Serafino, Matilde Tirelli, Laura De Rosa, Vito A. Lasorsa, Mario Capasso, Chiara Brignole, Loredana Amoroso, Massimo Conte, Mirco Ponzoni, Fabio Pastorino
• 2521 · PDF Illuminating the kinase starmap in NSCLC via tyrosine phosphoproteomics Jinfeng Yuan, Ying Hu, Yilin Wang, Tianhui Zhang, Aijuan Yu, Yi Liu, Hui Zhou, Chao Zhou, Junjie Hou, Yinyin Xu, Xinxin Xu, Huan Ding, Yuxin Zhang, Rujie Zhong, Mengjia Yang, Chunyan Chang, Hongxuan Yan, Yuanyuan Shang, Weicong Ren, Shanshan Li, Hongdong Zhong, Yun Xiao, Zhang Zhang, Naizhong Zheng, Ming Han, Yu Pang
• 2522 · PDF Exploring the impact of RAS mutations in abdominopelvic Rosai Dorfman disease on responsiveness to targeted therapies: A case control study Rebecca Denson, Fnu Amisha, David Pottinger, Ling Zhang, Lubomir Sokol, Samuel Benjamin Reynolds

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