Antibody Technologies and Platforms 1

• 1642 · PDF A pan-RASi antibody-drug conjugate platform with high activity in RAS-mutant cancers Graham A. E. Garnett, Victoria K. Harman-McKenna, Taixiang Wang, Jodi Wong, Truman Hirkala-Schaefer, Michael G. Brant, Mark E. Petersen, Catalina Suarez, Khushi Lodaya, Rehan Higgins, Jesse H. Leblanc, Linglan Fu, Cathy Fu, Sara Weeres, Manuel Lasalle, Kaylee J. Wu, Vidhi Khanna, Sam Lawn, Kurt Stahl, Vincent Fung, Raffaele Colombo, Stuart D. Barnscher, Jamie R. Rich
• 1643 · PDF Targeting LANCL1 with a humanized monoclonal antibody suppresses tumorigenesis in hepatocellular carcinoma Chui-Yee Diana O, Yu-Man Tsui, Irene Oi-Lin Ng
• 1646 · PDF Maximizing therapeutic index using fully Fc-silent antibody platform Kihwan Chang
• 1647 RenNano platform enables efficient discovery of fully human VHH antibodies Frank An, Xun Xu, Jun Du, Yiqing Hu, Baihong Liu, Guan Wang, Hao Cai, Lijun Zhang, Huizhen Zhao, Jiawei Yao, Chengzhang Shang, Qiuhong Yu, Xueyuan Jiang, Fengping Yao, Jing Huang, Gao An, Yi Yang
• 1648 · PDF Real-time imaging for quantitative assessment of antibody-drug conjugate internalization Tian Wang, Yunfei Pu, Ryan Raver, Xiaoyu Zhang, Peifang Ye, Nancy Li
• 1649 · PDF FcRn humanized mice with an immunodeficient background can be used to evaluate the pharmacokinetics of antibody drugs while avoiding anti-drug antibodies Hannah Horton, Ruili Lv, Suman Zhao, Qingqing Xu, Xiaofei Zhou
• 1650 · PDF MPSA-AB5000: A high-throughput cell-based membrane protein screening array for accurate early-stage off-target assessment to accelerate safer antibody therapeutic development Liping Wang, Guoqian Wang, Yao Peng, Jinying Ning, Feng Hao
• 1651 · PDF Automated imaging-based verification of monoclonality in single-cell cloning confirms higher efficiency of the Pala single cell sorter and dispenser compared to limiting-dilution assays Ahmed Shaaban, Benjamin Werdelmann, Anna Willms, Matthias Pirsch, Sebastian Kollenda, Aleks Guledani, Ankit Vaghasiya, Susanne Sebens, Ryan McComb, Reinhild Geisen
• 1652 · PDF Binding to bridging: Complete suite of FcgammaR assay tools accelerates antibody therapeutic development Julia K. Gilden, Denise Garvin, Kristin Riching, Brock F. Binkowski, Richard Moravec, Pete Stecha, Rod Flemming, Becky Godat, Kai Hillman, Marjeta Urh, Mei Cong, Jamison Grailer
• 1653 · PDF FcRn humanized rats for pharmacokinetics assessment of antibody drugs Kelvin Yin, Suman Zhao, Zhi Zhang, Yanling Wang
• 1654 · PDF Bioluminescent and cell-based assays for comprehensive characterization of antibody-drug conjugate mechanisms of action Mei Cong, Yitong Li, virginia Kincaid, Morten Seirup, Christopher Eggers, Rod Flemming, Jim Hartnett, Kristin Riching, Jamison Grailer, Julia K. Gilden
• 1655 Building a recombinant Factor C assay to enable sustainable endotoxin testing in antibody development Yingjie Liu, Peter Hsueh, An Ouyang, Spencer Chiang, YuehChun Hsieh
• 1656 · PDF Luminescent assay platforms accelerate therapeutic antibody development in veterinary immuno-oncology Jun Wang, Denise Garvin, Ildiko Kasza, Jim Hartnett, Mei Cong, Jamison Grailer
• 1657 · PDF BCG015:A first-in-class antibody-drug conjugate targeting TM4SF5 for the treatment of hepatocellular carcinoma Guan Wang, Zhi Qi, Yu Qi, Gao An, Cong Shen, Yanan Guo
• 1658 · PDF Preclinical study of NW008, a novel dual-functional anti-MICA/B antibody-drug conjugate Afang Zhou, Juanjuan Li, Changcheng Li, Xueying Zhong, Yiran Wu, Li Liu, Gang Liu, Jiaoyi Zhong, Lijia Yang, Junkui Yang, Dan Mi, Jiabao Liu, Yaolan Dai, Yan Gao, Zhijian Li, Bin Liu, Zhigang Guo, Wenting Luo
• 1659 · PDF Development of a novel PSCA-targeting antibody-drug conjugate with high potency and stability for prostate cancer therapy Yanyang Cao, Evelyn A. Kono, Robert E. Reiter
• 1660 · PDF Design of a synthetic non-natural antibody (NoNabody) against GRP as a new therapy for small cell lung cancer Pablo Garrido Rodriquez, Jahaziel Gasperin Bulbarela, Alexei Fedorovish Licea Navarro, Alfredo Martínez
• 1661 · PDF Preclinical characterization of XB773, a novel anti-DLL3 antibody-drug conjugate Marlene Hennessy, Ganapathy Sarma, Yutaka Matsuda, Jenny Chang, Suprit Deol, Zhenzhen Mo, Yan Hu, Maoyin Li, Rajesh Kumar, Hui Zhao, Brian A. Mendelsohn, Minjong Park, Summer Park, Janice Kim, Ragadeepthi Tunduguru, Kathleen R. Gogas, Seema Kantak
• 1662 · PDF GSPT1 degrader antibody conjugate, BLB-201, for the treatment of high-risk acute myeloid leukemia Rakesh Bam, Wenjian Qian, John Liu, Peipei Zheng, Haoyang Wang, Jinna Yu, Wenfeng Hou, Xiaoying Wei, Dengqi Xue, Wen Zhang, David Yi, Alice Chen
• 1663 · PDF Monoclonal antibodies targeting the B-cell receptor complex directly induce widespread kinase inhibition and B-cell killing for the treatment of leukemia and lymphoma Rachel Welt, Virginia Raymond, David Kostyal, Sydney Welt
• 1664 · PDF Novel GPC3-targeting antibody-drug conjugate using novel payload or dual payloads to treat hepatocellular carcinoma and non-small-cell lung cancer Suk Lee, John Liu, Alice Juang, Aastha Jain, Xiaoying Wei, Wen Zhang, David Yi, Alice Chen
• 1665 · PDF Preclinical characterization of IPN60300, a first-in-class ITGA2 antibody-drug conjugate for cancer therapy Aurélie Courtin, Benjamin Beaufils, Karl Brendel, Sophie Colombo, Isabel Esteves, Marie-Odile Galcera, Thierry Guyon, Pei Han, Feng He, Wei Li, Weihong Nian, Vincent Martin, Lou-Amélia Revellin, Sylvain Roqueviere, Pierre Roubert, Yu Song, Amath Thiongane, Catherine CL Wong, Chuanying Xu, Qing Zhou, Mary Jane Hinrichs, Elisabetta Leo
• 1666 · PDF Targeting the extra-cellular matrix in the tumor microenvironment with a novel antibody-drug conjugate Matthew J. Edwards, Kovilen Sawmynaden, Aurelie Michelet, Edward Long, Rachel Evans, Dhruv Chauhan, Cecilia Pennica, Nafia Guljar, Cherie Akpotor, Luca Frenguelli, Gareth Muirhead, Sam Cooper, Athiva Shankar, TuVinh Luong, Emma Huang, Giuseppe Mazza, Chris Stevenson
• 1667 Antibody encapsulated drug: Tr-ACT2 for targeted treatments of various cancers C. J. Yu, Linrong Li, leslie Wang, Kinsley Wang, Mengmeng Liu, Faqing Huang, Warren A. Chow, Xiaojiang Cui
• 1668 · PDF MAC-8001: A KRAS-targeting molecular glue-antibody conjugate with robust antitumor activity in KRAS-mutant cancers Feilong Sun, Shuaishuai Chi, Carlos Chai, Yi Chen, Xuan Zhang
• 1669 · PDF S DUAL™: An Advanced Bispecific Antibody Platform Delivering Practical Manufacturability and Enhanced Therapeutic Efficacy Jina Kim, Wooseok Yang, Kihong Kim, Hyunbum Kim, Siwon Park, Haewon Ahn, Hyebeen Hong, Hyunseung Sun, Soyeon Lee, Gwangsu Shin, Jihoon Kim, Seonkyeong Jeong, Hyunsik Lee, Sungjin Han, Joseph H. Jeong, Yeumin Kim, Brian Hosung Min

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