CAR T Cell Targets and TME Reprogramming

• 1519 · PDF AI-designed immune sensor-enhanced CAR-T cells for potent solid tumor immunotherapy Zoya Alteber, Jitka Sagiv, Reut Nave, Gil Friedman, Dor Shimon, Maayan Shamsian, Megi Cemel David, Dina Listov, Sharon Avkin Nachum, Ofer Levy, Michal Golan Mashiach
• 1520 · PDF Improving BCMA-targeted CAR-T cell therapy of myeloma using TGF-beta resistance and inducible production of IL-18 Sandhya Rai, Shijing Wang, Bin Sun, Tyce Kearl, Peiman Hematti, Joseph Zenga, Heather Himburg, Musaddiq Awan, Deepak Parashar, Binod Dhakal, Siegfried Janz, Fumou Sun
• 1521 · PDF Concurrent targeting of tumors and their microenvironment using CAR-T cells specific for fibroblast activation protein alpha Larina Tzu-Wei Shen, Afsana Islam, Daiki Fujita, Kenji Nakamaru, Dan Macleod
• 1522 · PDF FMNL1 overexpression enhances tumor-specific TIL and CAR-T cell accumulation and therapeutic efficacy in solid tumors Jeffrey W. Chung, Jessica Olivas-Corral, Ashley M. Wood, Ashton L. Sigler, Edward Ning, Michelle E. Allen, Kayla Fairweather, Jordan Jacobelli
• 1523 · PDF Galectin-3 blockade reprograms the tumor microenvironment and improves CAR T-cell therapy in pediatric cancers Enrique Conde-Gallastegi, Karin Straathof, Sergio Quezada
• 1524 · PDF Collagen-binding IL-12-armored STEAP1 CAR-T cells for advanced prostate cancer Koichi Sasaki, Vipul Bhatia, Yuta Asano, Jakob Bakhtiari, Pooja Kaur, Chuyi Wang, Takumi Matsuo, Olivier Dubois, Po-Chuan Chiu, Donny Gun, Charanjit Singh, Ioanna Panagi, Laurine Noblecourt, Maria Nikolaidi, Truman Chong, Gerardo Javier, Saul J. Priceman, Aude G. Chapuis, John K. Lee, Jun Ishihara
• 1525 · PDF Optimized CART cell therapy to remodel the tumor microenvironment and eliminate GI malignancies Omar L. Gutierrez Ruiz, Jennifer Feigin, Brooke Kimball, R. Leo Sakemura, Elizabeth L. Siegler, Dominic A. Skeele, Ateka Saleh, Claudia Manriquez Roman, Ismail Can, Olivia Sirpilla, Kun Yun, Carli M. Stewart, Mehrdad Hefazi, Yoh Yamaguchi, Lionel Aurelien Kankeu Fonkoua, Long K. Mai, Truc Huynh, Sophia Y. Goldberg, Grace E. DeFranco, Sara Foote, Ekene Johnkennedy Newton Ogbodo, Hong Xia, Michael Redig, Matthew L. Matthew, Tamiel Nichole Turley, Skyeler Klinge, John Alton Copland, Saad J. Kenderian
• 1526 · PDF Nanobody-based, DLL3-directed FAST-CAR T-cell therapy for small cell lung cancer (SCLC) Qi Dong, Wenjie Yin, Xiangling Dai, Tao Wang, Guangyao Zhu, Manli Yin, Yu Zou, Yu Yang, Di Wu, Mark Cobbold, Lianjun Shen
• 1527 · PDF Conformal external beam radiation increases B7-H3 expression in a murine model of pancreatic cancer liver metastases and promotes CAR T cell function Megan C. Purl, Alexandria Shick, Annaiz Grimm, Hind Abdallat, Cyrus J. Sholevar, Makan Karimzadeh, Natalie M. Liu, Jinhwan Kim, Cameron E. Gaskill, Edward J. Kim, Arta M. Monjazeb, William J. Murphy, Robert J. Canter, Sean J. Judge
• 1528 · PDF AZD5851, a TGF-beta-resistant GPC3 CAR-T cell product, prolongs animal survival times in patient derived orthotopic xenograft models of medulloblastoma and atypical teratoid rhabdoid tumor Milagros Suarez, Aalaa Abdallah, Xin Zhai, Zilu Huang, Yuchen Du, Nitin Wadhwani, Alicia Lenzen, Jee Young Kwon, Steven B. Neuhauser, Timothy Stearns, Jeffrey H. Chuang, Emily L. Jocoy, Carol J. Bult, Beverly Teicher, Malcolm A. Smith, Xiao Nan Li
• 1529 · PDF ST6GAL1 enhanced CAR-T cells improve persistence and antitumor efficacy in DLBCL Lee Seng Mari Lau, Maria Suarez, Brandon Fernandez, Aiza Berdalinova, Joseph Souchack, Aristotelis Antonopoulos, Anne Dell, Stuart Haslam, Avery D. Posey, Charles J. Dimitroff
• 1530 · PDF Comprehensive preclinical evaluation of CAR-T cell therapeutics in organoid-fibroblast co-cultures Yijie Ren, Tomas Veenendaal, Puxin Wang, Jiawen Gao, Jiawei Meng, Danting Yan, Yingying Li, Meng Zhang, Michelle Kop, Ashgard Weterings, Marten Hornsveld, Gera Goverse, Ludovic Bourre, Peng Wang, Jun Zhou
• 1531 · PDF Obesity exacerbates cytokine release syndrome (CRS) toxicity associated with chimeric antigen receptor (CAR) T cell therapy in preclinical models Wahed A. Firoz, Craig P. Collins, Logan V. Vick, Michael K. Sheng, Ryan N. Nielsen, Spencer Rosario, Robert J. Canter, Arta M. Monjazeb, Sean J. Judge, Anthony E. Zamora, Shuchi Gulati, William J. Murphy
• 1532 · PDF In vivo genome-wide CRISPR screens in human T cells to enhance T cell therapy for solid tumors Qi Liu, Peixin(Amy) Chen, Esha Urs, Shimin Zhang, Maya M. Arce, Charlotte H. Wang, Zhongmei Li, Jin Seo, Nupura Kale, Taylor N. LaFlam, Fanglue Peng, Eric Shifrut, Greg Allen, Justin Eyquem, Katherine C. Fuh, Stacie E. Dodgson, Jason Cyster, Alexander Marson, Julia Carnevale
• 1533 · PDF A universal and switchable CAR T cell therapy platform (zCART) targeting tumor antigens and the immunosuppressive microenvironment Ki Hyun Kim, Soohwan Kim, Eun-Hoe Lee, Soo-Youn Lim, Tack-Jin Yoo, Sung Min Kim, E-Young Kim, Ji-Hun Park, Hyun-Jong Lee, Seong Yeol Kim, Min Yoon, Youngha Lee, In-Sik Hwang, Yoon Lee, Jong-Hoon Kim, Jong-Seo Lee, Junho Chung
• 1534 · PDF OriC613: A novel therapeutic strategy for gastric and pancreatic cancers utilizing dual-targeting CAR-T cells against MSLN and CLDN18.2 with a favorable safety profile and potent efficacy Xiaowen He, Shasha Yang, Hao Guo, Huajing Wang, Xuefeng Kong, Zhongjun Shi
• 1535 · PDF Preclinical evaluation of allogeneic BCMA/CD70 Dual CAR T cells for high-risk multiple myeloma Mark K. O'Dair, David Qu, Duy Nguyen, Kristen Zhang, Zachary Roberts, Elvin Lauron, Cesar Sommer
• 1536 · PDF CADM1-CAR T cells targeting neuroendocrine subtypes of small cell lung cancer Shiva Krishna Katkam, Sergei Chuikov, Zhefan Wang, Venkateshwar Keshamouni
• 1537 · PDF Anti GPC3 CAR T lymphocytes effectively target NSCLC, including chemoresistant stem like cells Lucilla Minori, Alessia Proment, Francesca Napoli, Luisella Righi, Gabriella Doronzo, Elisa Vigna, Katherine Chaney, Woo Jin Shim, John Stone, Paolo Bironzo, Ashley Hamilton, Silvia Novello, Dario Sangiolo
• 1538 · PDF Oncostatin-M ligand-based CAR T-cell therapy targets and eliminates lung adenocarcinoma Kayla Klatt, Daniel Feinberg, Reshmi Parameswaran
• 1539 Harnessing NOPE: A key oncofetal protein driving beta-catenin signaling through peptidic antigen receptor macrophages in hepatocellular carcinoma Carmen Oi Ning Leung, Rainbow Wing Hei Leung, Terence Kin-Wah Lee
• 1540 · PDF Development of EPHA2 car t cell therapy for solid tumors Ali Cihan, Daoqi You, Armaan Siddiquee, Kristina Guillan, Tamar Feinberg, Erin Burns, Jasmine Um, Samantha Brosius, Joan Rou-En Choo, Andrew L. Kung, Anthony F. Daniyan, Filemon S. Dela Cruz
• 1541 · PDF Development of MUC4-directed CAR-T cells against chemoresistant colorectal carcinoma Avik Chattopadhyay, Erin O’Connor, Anna Tingler, Kristi L. Helke, Melinda A. Engevik, Leonardo M. R. Ferreira
• 1542 · PDF ALK expression identifies a therapeutically targetable subset of Merkel cell carcinomas responsive to ALK.CAR-T cell therapy alone or in combination with ALK inhibitors Alessandro Gasparetto, Jasna Metovic, Elisa Landoni, Carmen Mecca, Gabriele Saccu, Simone Piane, Nirmala Tilija Pun, Umberto Mortara, Chiara Anselmo, Marco Campisi, Haley Ohlson, Maria Vittoria Di Marco, Giulia Mura, Mauro Papotti, Rebecca Senetta, Claudia Voena, Gianpietro Dotti, Elisa Bergaggio, Roberto Chiarle
• 1543 · PDF B-cell activating factor plays a critical role in CAR-T cell-associated cytokine release syndrome Claire Fritz, Leland Metheny, David N. Wald, Paolo Caimi, Reshmi Parameswaran

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