Innate Immunity in Cancer

• 1580 · PDF Virus like particles enable targeted gene engineering and pooled CRISPR screening in primary human myeloid cells Hyuncheol Jung, Pascal Devant, Carter Ching, Minetoa Ota, Jennifer Hamilton, Zachary Steinhart, Wayne Ngo, Luis Sandoval, Jae Hyung Jung, Da Xu, Merui An, Esha Urs, Peixin Amy Chen, Vincent Allain, Takuya Tada, James K. Nuñez, Nathaniel R. Landau, David R. Liu, Justin Eyquem, Jennifer A. Doudna, Alexander Marson, Julia Carnevale
• 1581 · PDF Driver and mechanism of t-cell dysfunction and immune cold microenvironment in deadly developmental tumor in infants Poorvi Subramanian, Sreenidhi Mohanvelu, Sheeja Aravindan, Sabir Salim, Sivasubramani Narayanan, Natarajan Aravindan
• 1582 · PDF Integrative functional and multi-omics profiling reveals divergent natural killer cell responses and tumor cell plasticity in breast and ovarian cancer Jennifer C. Wischhusen, Rebecca Weber, Syed A. Ali, Brenda Besemer, David Palmero-Canton, Viktoria Sokolova, Christina Köhler, Elisa Donato, Andreas Trumpp
• 1583 · PDF Galectin9 targeted therapy for aiming cure in oncogenic driver alterations-positive non-small cell lung cancer Takanori Kondo, Toshiyuki Minami, Hidemi Kitai, Yoko Higashiguchi, Takashi Kandori, Naoki Kawamura, Misa Murakami, Jotaro Kiyota, Mayuko Tokuda, Tomoki Higashiyama, Akio Tada, Yoshiki Negi, Kazue Yoneda, Daichi Fujimoto, Taiichiro Otsuki, Koji Mikami, Ryo Takahashi, Kozo Kuribayashi, Takashi Kijima
• 1584 Metastasis associated macrophages drive immunosuppression and fibrosis in gastric peritoneal carcinomatosis Lilia Turcios, Neelima Hosamani, Ellen Beswick, Maria Carey, Joseph Kim, Mautin Barry-Hundeyin
• 1585 · PDF Kinetic profiling of ILC and ILTC responses during early hepatocellular carcinoma development reveals IL-15-ILC1 axis Patrick Huang, Rajiv Trehan, Benjamin Ruf, Chi Ma, Dana Soika, Lorenz Kocheise, Gabriel B. Prata, Tim F. Greten, Firouzeh Korangy
• 1586 · PDF Surgery-induced long term innate immune changes facilitate tumor progression Zhengyi He, Hamza O. Yazdani, Tony Haykal, Ruiqi Yang, Celine Tohme, Rihito Kanamaru, Krish Wasson, Anthony Gebran, Silvia Liu, David A. Geller, Jian-Hua Luo, Samer Tohme
• 1587 In Vivo CRISPR screen of dendritic cells identifies Traf2 as a critical regulator of anti-tumor immunity via modulation of non-canonical NF-kB pathway Chang Yoon Moon, Meriem Belabed, Steven Chen, Jessica Le Berichel, Alexander Tepper, Camillia Azimi, Natalie Vaninov, Prerna Suri, Adam Marks, Alessandra Gurtner, Matthew D. Park, Alessia Baccarini, Brian Brown, Miriam Merad
• 1588 TOX functions as a cytotoxicity checkpoint in human NK cells and is reversibly regulated by SLAMF7 receptor Yasser Ali Aldhamen, Rana K. Alrabiah, Maram Alshuwaymi, Rita Alonaizan
• 1589 · PDF Spatial and molecular profiling of multinucleated giant macrophages in pancreatic ductal adenocarcinoma Marika Viatore, Rebecca Polidori, Anna Rita Putignano, Arturo Bonometti, Silvia Uccella, Silvia Bozzarelli, Gianluca Basso, Marco Erreni, Capretti Giovanni, Vincenzo Corbo, Alberto Mantovani, Massimo Locati, Federica Marchesi
• 1590 · PDF The oncometabolite D2HG reprograms macrophages to drive immunosuppression in IDH1-mutant cholangiocarcinoma Sara E. Young, Emma Kartalia, Johnathan DeBetta, James Leatherman, Kayla J. Bendinelli, Tamara Lopez-Vidal, Edwin Y. He, Mark Yarchoan, Daniel J. Zabransky
• 1591 · PDF microRNA-25 drives initial resistance to immune checkpoint therapy by repressing innate and humoral immunity via Syndecan3 Zhouting Zhu, Wenyan Han, Yufei Deng, Zhaoyang Jia, Lujing Wu, Shweta Jakhmola, Gulshanbir Baidwan, Tongyun Wang, Dhenugen Logeswaran, Amanda Y. Sun, Bill Bray, Na Li, Lingling Wang, Hui Hui, Jiaqian Wu, Sandip Pravin Patel, Tariq M. Rana
• 1592 · PDF Age-driven changes in tumor-associated macrophages contribute to slower tumor growth in murine melanoma and breast cancer models. Manasa Suresh, Marie Durr, Bryan Weselman, Xintang Li, Francisco Tapia Belmonte, Sonia Sebaoui, Adhithi Rajesh, Katherine Fisher, Megan Winakur, Matias Hepp, Alexis Salas-Burgos, Satish Noonepalle, Alejandro Villagra
• 1593 · PDF Mitochondrial enzyme A promotes macrophage-dependent antitumor responses in colorectal cancer Lin Chung, Shi-Chuen Miaw
• 1594 · PDF Cyproheptadine and its derivatives inhibit tumor growth by eliciting NK cell-mediated anti-tumor responses in bladder cancer Himani Kumari, Chin Pui Chan, Ciao-Ni Chen, Hsin-An Shih, Tsung-Yu Tseng, Chao-Ling Yao, Steven Lin, Cheng-Huang Shen, Michael W.Y. Chan
• 1595 · PDF Combining DNA methylation inhibition and STING agonist in the treatment of metastatic triple-negative breast cancer Sofiane Berrazouane, Rhea Dumitrescu, Xiaoting You, Jack Su, Margarita Bartish, Marios Langke, Benjamin Lebeau, Young Im, Valérie Sabourin, Sonia del Rincon, Josie Ursini-Siegel, Michael R. Witcher
• 1597 · PDF A spontaneous arthritis mouse model driven by TNF-alpha overexpression Qingqing Qi, Shuang Li, Xiaolei Qiu, Yi Li, Ruilin Sun
• 1598 · PDF Preclinical efficacy of a bispecific NK cell engager studied using a humanized multiple myeloma mouse model Mari I. Suominen, Katja M. Fagerlund, Mervi Ristola, Justyna Zdrojewska, Yumei Diao, Carina Norström, Kristina Witt-Mulder, Ellen Santangelo, Thorstein Boxaspen, Hannah Cuthbertson Husbyn, Kim A. Giang, Caterina Heinz, Silje Z. Krokeide, Fredrik Schjesvold, Per-Åke Nygren, Ebba Sohlberg, Karl-Johan Malmberg, Stefan Svensson Gelius, Jukka P. Rissanen, Jenni H. E. Mäki-Jouppila
• 1600 · PDF Improved humanization of peripheral blood mononuclear cells in NSG-SGM3xIl15xDKO (SDKO) over that of NSG-MHC I/II DKO mice for immuno-oncology modeling Leandro Salati D'Abronzo, Xiaoqing (Nancy) Zheng, Beau Parry, Guoxiang Yang, Destanie Rose, Li-Chin Yao, James Keck, Jiwon Yang
• 1601 · PDF A novel preclinical tool to unlock the potential of IL-18 in cancer immunotherapy: genO-hIL-18-hIL-18R mice Angela Pappalardo, Gaëlle H. Martin, Patricia Isnard-Petit, Fabiane Sonego, Kader Thiam
• 1602 · PDF Quaking regulates macrophage MHC II-mediated antigen presentation and immune function in glioblastoma Spring Yewon Hwang
• 1603 · PDF Opposing control of MHC-II antigen presentation by FAK and PYK2: Implications for therapeutic intervention Terrance James Haanen, Xiao Lei Chen, David D. Schlaepfer
• 1604 · PDF PTEN-L/CD68 axis regulates diet-induced obesity, monocyte-to-macrophage polarization, and signaling via IL-4 and AKT pathways Tiphaine C. Martin, Sait Ozturk, Benjamin Kepecs, Nicolas de Azevedo, Ivan Reyes-Torres, Royce Zhou, Kaitlyn Bosch, Emily Gallagher, Miriam Merad, Ang Cui, Alexander Tsankov, Ramon Parsons
• 1605 · PDF Motif neoepitopes demonstrate immunogenic signal in CCL21-gene modified dendritic cell vaccination trial (NCT03546361) Amy Lauren Cummings, Andy Han, Michael Oh, Camelia Dumitras, Seung J. Park, Sai S. Kollapaneni, Daniel Li, Arjan Gower, Maria Antonia Velez Velez, Aaron Lisberg, Monica Cappelletti, Steven M. Dubinett, Bin Liu, Edward B. Garon
• 1606 · PDF Transcriptional regulation of human NK cells: TAL1 as a modulator Baomou Feng, Dandan Wang, Subramaniam Malarkannan

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