PO.CH01.06 · 化学

利用Pioneer抗体发现平台快速生成先导物

Rapid lead generation with the Pioneer Antibody Discovery Platform

编号 2402 展板 10 时间 4/20 09:00–12:00 区域 Section 38 主讲 Birthe Jessen-Park

分会场 Antibodies, Antibody-Drug Conjugates, and Nucleic Acids

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作者与单位 Authors & Affiliations

Birthe Jessen-Park¹, Sarah-Jane Kellmann², Mateusz Putyrski², Manuel Cavada², Hanh Hanuschka², Christian Frisch², Achim Knappik², Francisco Ylera²

¹Bio-Rad Laboratories, Hercules, CA,²Bio-Rad Laboratories, Munich, Germany

摘要 Abstract

中文摘要

Pioneer™抗体发现平台是Bio-Rad公司的生物治疗抗体生成服务，以Pioneer抗体文库为核心——它是最大的功能性Fab文库之一（2250亿条独特序列）。该文库借鉴了超过18年的噬菌体展示专业经验，针对治疗性抗体筛选进行了优化。它整合了SpyDisplay（一种基于SpyTag的专有筛选系统）和TrailBlazer（一个用于快速格式组装的模块化平台）。我们展示了针对IL-6R、C5aR和CXCR4的抗体筛选数据，证明Pioneer平台能够为难成药靶点产生多样化、高亲和力和功能性的先导物。这些候选物在关键参数上表现出与临床开发或已上市抗体相当或更优的性能。

查看英文原文 English abstract

The Pioneer™ Antibody Discovery Platform is Bio-Rad's biotherapeutic antibody generation service, centered around the Pioneer Antibody Library-one of the largest functional Fab libraries (225 billion unique sequences). Informed by over 18 years of phage display expertise, the library is optimized for therapeutic antibody selection. It integrates SpyDisplay, a proprietary SpyTag-based selection system, and TrailBlazer, a modular platform for rapid format assembly. We showcase data on antibody selection against IL-6R, C5aR, and CXCR4, demonstrating that the Pioneer Platform yields diverse, high-affinity, and functional leads for difficult targets. These candidates show comparable or superior performance to clinically developed or marketed antibodies across key parameters.

利益披露 Disclosure

B. Jessen-Park, None.. S. Kellmann, None.. M. Putyrski, None.. M. Cavada, None.. H. Hanuschka, None.. C. Frisch, None.. A. Knappik, None.. F. Ylera, None.

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