PO.CH01.06 · 化学
Antibodies, Antibody-Drug Conjugates, and Nucleic Acids
- 2393 2393 DXC016：一种新型cMET靶向双载荷抗体偶联药物，展现出强效抗肿瘤活性和有利于皮下给药的药代动力学 DXC016, a novel cMET-targeting dual payload antibody-drug conjugate, demonstrates potent antitumor activity and favorable PK for potential subcutaneous use Yong Du, Jiaojiao Yu, Huihui Guo, Lingli Zhang, Xiaoqiang Xie, Jialei Hu, Xiafen Wu, Yunxia Zheng, Yuanyuan Huang, Junxiang Jia, Wei Liu, Zhouyang Zhou, Qingliang Yang, Robert Y. Zhao
- 2394 2394 一种新型2+2 IgG样双特异性抗体偶联药物，靶向EBV GP220/350和EGFR，用于鼻咽癌的选择性治疗 A novel 2+2 IgG-like bispecific antibody-drug conjugate targeting EBV GP220/350 and EGFR for selective treatment of nasopharyngeal carcinoma Saihong Yu, Yunxia Zheng, Junxiang Jia, Xiangfei Kong, Juan Wang, Yi Luo, Hangbo Ye, Xueqing Ma, Qingliang Yang, Robert Y. Zhao
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- 2396 2396 一种新型携带双载荷的2+2 IgG样双特异性抗体偶联药物，用于异质性胃肠道癌症的靶向治疗 A novel 2+2 IgG-like bispecific antibody-drug conjugate with dual payloads for targeted therapy of heterogeneous gastrointestinal cancers Wei Zheng, Junxiang Jia, Xiaolei Liu, Gengxiang Zhao, Yongxiang Chen, Xia Zhou, Simin Zhao, Qingliang Yang, Robert Y. Zhao
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- 2399 2399 ZL-6201的发现：一种用于治疗肉瘤和上皮性实体瘤的新型靶向LRRC15的抗体药物偶联物（ADC） Discovery of ZL-6201, a novel LRRC15-targeting antibody drug conjugate (ADC) for the treatment of sarcomas and epithelial solid tumors He Xu, Zengxia Li, Jiaqing Yi, Wilson Peng, Qiuping Ye, Xinchao Xia, Lei Wang, Xinchuan Dai, Yue Ge, Donghui Li, Ziruo Wen, Changwei Lv, Joshua Zeng, Qidong Hu, Lina Wang, Jelveh Lameh, Nathan Ihle, Bing Wan, Linda N. Liu
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- 2401 2401 开发单B细胞平台以加速抗体发现与筛选 Developing a single B cell platform to accelerate antibody discovery and screening Spencer Chiang, Wenlin Ren, An Ouyang, Yu Sun, Xiaoli Li
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- 2406 2406 一种新型BRD4降解剂-HER2靶向抗体药物偶联物（DAC）克服HER2阳性癌症中的德曲妥珠单抗（trastuzumab deruxtecan）耐药 A novel BRD4 degrader-HER2-targeting antibody-drug conjugate (DAC) overcomes trastuzumab deruxtecan resistance in HER2-positive cancers Xin Yu, Bin Yang, Wendi Ni, Haibo Liu, Jan Willem Theunissen, Jesse Chen, Jin Wang
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