PO.CL07.01 · 临床研究

Illuminating the kinase starmap in NSCLC via tyrosine phosphoproteomics

编号 2521 展板 28 时间 4/20 09:00–12:00 区域 Section 43 主讲 AIJUAN YU

分会场 Data-Driven Approaches to Precision Oncology

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作者与单位

Jinfeng Yuan¹, Ying Hu², Yilin Wang¹, Tianhui Zhang³, Aijuan Yu⁴, Yi Liu⁴, Hui Zhou⁴, Chao Zhou⁴, Junjie Hou⁴, Yinyin Xu⁴, Xinxin Xu⁵, Huan Ding⁴, Yuxin Zhang⁴, Rujie Zhong¹, Mengjia Yang¹, Chunyan Chang¹, Hongxuan Yan¹, Yuanyuan Shang¹, Weicong Ren¹, Shanshan Li¹, Hongdong Zhong⁴, Yun Xiao⁴, Zhang Zhang⁵, Naizhong Zheng⁴, Ming Han⁶, Yu Pang¹

¹Department of Bacteriology and Immunology, Beijing Chest Hospital, Capital Medical University/Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, China,²Department of Medical Oncology, Beijing Chest Hospital, Capital Medical University/Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, China,³Department of Thoracic Surgery, Beijing Chest Hospital, Capital Medical University/Beijing Tuberculosis and Thoracic Tumor Research Institute,, Beijing, China,⁴DeepKinase Biotechnologies Ltd., Beijing, China,⁵State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou, China,⁶Department of Thoracic Surgery, Beijing Chest Hospital, Capital Medical University/Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, China

摘要 Abstract

In lung cancer treatment, understanding kinase activity, particularly tyrosine phosphorylation, is crucial but incomplete. We studied tyrosine phosphoproteomics in 74 patients with non-small-cell lung cancer (NSCLC) using SH2-Superbinder and data-independent acquisition mass spectrometry. We constructed a tyrosine phosphorylation starmap, This starmap is presented as an interactive force-directed network, providing dynamic visualization of intricate signaling pathways that are active in tumor tissues or normal adjacent tissues (NATs). Unlike the dense, unstructured distribution observed in NATs, the tumors showed four well-defined subnetwork constellations: adherens junctions, cytoskeletal dynamics, immune signaling, and blood. Subsequently, patients were stratified by kinase activity for multiple precision medicine perspectives.

利益披露 Disclosure

J. Yuan, None.. Y. Hu, None.. Y. Wang, None.. T. Zhang, None.. A. Yu, None.. Y. Liu, None.. H. Zhou, None.. C. Zhou, None.. J. Hou, None.. Y. Xu, None.. X. Xu, None.. H. Ding, None.. Y. Zhang, None.. R. Zhong, None.. M. Yang, None.. C. Chang, None.. H. Yan, None.. Y. Shang, None.. W. Ren, None.. S. Li, None.. H. Zhong, None.. Y. Xiao, None.. Z. Zhang, None.. N. Zheng, None.. M. Han, None.. Y. Pang, None.

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