PO.CL07.01 · 临床研究
Data-Driven Approaches to Precision Oncology
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2494 · PDF PROSPERITY研究中对原发性或复发性卵巢癌(OC)患者进行前瞻性类器官药物筛选及临床反应相关性分析 Prospective organoid drug profiling and clinical response correlation for patients with primary or recurrent ovarian carcinoma (OC) in the PROSPERITY study Elizabeth M. Swisher, Payel Chatterjee, Isabel Rodriguez, Kalyan Banda, Faith Beers, Asal Patterson, Enna Manhardt, Mayumi Rubin-Saika, Emiko Oshima, Melanie Dillon, Rachele Rosati, Vaishnavi Pallem, Lauren R. Appleyard, Alex C. Rajewski, Shalini Pereira, Soledad Jorge, Renata R. Urban, Elise J. Simons, John B. Liao, Barbara Goff, Carla Grandori, Christopher J. Kemp
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2495 · PDF 应用全基因组测序(WGS)对急性髓系白血病(AML)进行快速临床诊断分类和风险分层 Rapid clinical diagnostic classification and risk stratification in acute myelogenous leukemia (AML) using whole genome sequencing (WGS) Wayne M. Jepsen, Jonathan J. Keats, Sara A. Byron, Cherie Wesley, Bryce Turner, Christophe Legendre, Tyler Izatt, Tracey White, Amy Stouffer, Lucy Ghoda, Yeneka Campana, Courtney Holden, Jonathan Beteran, Michelle Afkhami, Anthony Stein, Tibor Kovacsovics, Guido Marcucci, Jeffrey Trent
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2496 · PDF 针对胶质母细胞瘤微小残留病灶的候选治疗药物的计算机模拟筛选 In silico screening of therapeutics candidates targeting minimal residual disease in glioblastoma Harrshavasan Congivaram, Shashwat Tripathi, Mateo Gomez, Katy McCortney, Ching Man Wai, Ruochen Du, Thomas K. Sears, Jianzhong Zhang, Daniel J. Brat, Craig M. Horbinski, Mark W. Youngblood, Jared T. Ahrendsen, Adam M. Sonabend, Stephen T. Magill, Matthew C. Tate, Maciej S. Lesniak, Sean Sachdev, Timothy Sita, Priya Kumthekar, Karan Dixit, Robin Buerki, Ditte Primdahl, Mustafa Khasraw, John de Groot, David A. Reardon, Rimas V. Lukas, Roger Stupp, Amy B. Heimberger
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2498 · PDF OncoKB™,MSK的精准肿瘤学知识库:2025年更新 OncoKB™, MSK's precision oncology knowledge base: 2025 updates Sarah Phillips Suehnholz, Ritika Kundra, Moriah Heller Nissan, Calvin Lu, Nicole Fernandez, Kelly Cavender, Kinisha Gala, Benjamin Preiser, Reshma Ramaiah, John Konecny, Xiang Li, Subhiksha Nandakumar, Kseniya Petrova-Drus, Mark Ewalt, Nikita Mehta, Yonina R. Murciano-Goroff, James Du, Anoop Balakrishnan Rema, Aijazuddin Syed, A. Rose Brannon, Ahmet Dogan, Diana Mandelker, Zsofia K. Stadler, Alexander Drilon, David B. Solit, Ross L. Levine, Maria E. Arcila, Marc Ladanyi, Michael F. Berger, Jianjiong Gao, Nikolaus Schultz, Debyani Chakravarty
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2499 · PDF 化疗前后肿瘤的单细胞转录组比较揭示化疗耐受性骨肉瘤细胞的治疗弱点 Single-cell transcriptomic comparison of tumor before and after chemotherapy reveals therapeutic vulnerabilities in chemo-tolerant osteosarcoma cells Parisa Vahidi Ferdowsi, Kenny Yeo, Tiruneh Adane, Qian Wang, Nisitha Jayatilleke, Sin Wi Ng, Janith Seneviratne, Daniel R Carter, Antoinette Anazodo, Richard Boyle, Paul Stalley, Maurice Guzman, Daniel Franks, Belamy B. Cheung, Glenn Marshall
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2500 · PDF CMTR2缺陷定义了一种由RNA剪接驱动、具有治疗弱点的肺腺癌新亚型 CMTR2 deficiency defines a novel RNA splicing-driven subtype of lung adenocarcinoma with therapeutic vulnerabilities Takashi Nakaoku, Shigenari Nukaga, Kouya Shiraishi, Akifumi Mochizuki, Hamaguchi Yu, Hitomi Nishinakamura, Yoshihisa Kobayashi, Ayako Ui, Yasushi Goto, Shun-ichi Watanabe, Yasushi Yatabe, Hiroyoshi Nishikawa, Ryuji Hamamoto, Takashi Kohno
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2501 · PDF 类器官表观遗传学筛选发现抑制KMT5A可通过PGK1成为子宫内膜癌的治疗策略 Epigenetic screening in organoids identify KMT5A inhibition as a therapeutic strategy via PGK1in endometrial cancer Jingyao Chen, Yinhua Tan, Zhichang Liu, Tong Wang, Kai Xiao, Feifei Na
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2503 · PDF 基于肺癌类器官的诊断性反应预测(CODRP)用于预测抗癌药物反应和无进展生存期 Lung cancer organoid-based diagnostic response prediction (CODRP) for predicting anticancer drug response and progression-free survival Seung Joon Kim, Sang-Yun Lee, Yu-Jeong Seong, Yongki Hwang, Hyobin Won, Eunyoung Lee, Dong Woo Lee
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2504 · PDF CCL5激活替代受体与非小细胞肺癌的差异相关 Activation of alternative receptor by CCL5 is associated with non-small cell lung cancer disparities Briana Alicia Brock, Murugesh Eswaran, Hina Mir, Shailesh Singh
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2505 · PDF 双siRNA精准靶向弥漫性胸膜间皮瘤的合成致死脆弱性 Dual siRNAs for precision targeting of synthetic lethal vulnerabilities in Diffuse Pleural Mesothelioma Yelixza I. Avila, Anand Singh, Vivek Singh, So-Hyun Yoon, Smrity Sahu, Nathanael Pruett, Chuong D. Hoang
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2506 · PDF 利用患者来源类器官和异种移植物评估胃癌的基因组驱动靶向治疗 Genomic-driven targeted therapy evaluation using patient-derived organoids and xenografts in gastric cancer Honyong Zhang, Nicole Halmai, Jasmine Diaz Sezati, Ana Estrada, Luis G. Carvajal-Carmona
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2507 · PDF 因果机器学习为导管原位癌个体化选择内分泌治疗 Causal machine learning personalizes endocrine therapy selection for ductal carcinoma in situ Emma Graham Linck, Alex Spicer, Marina N. Sharifi, Guanhua Chen, Mark Craven, Nataliya Uboha, Mark Burkard, Matthew Churpek
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2508 · PDF 胶质母细胞瘤的新型精准治疗 New precision treatments for glioblastoma Lateef Owolabi Anifowose, Zhi Sheng
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2509 · PDF 在一家三级医疗儿童医院建立精准治疗项目 Building a Precision Therapeutics program at a tertiary care Children's Hospital Anish Ray, Luke Hamilton, Riyaz M. Basha, Kelly L. Vallance, Diana Carrasco, Kaitlin Smith, Aly Anthony, Alejandra Dominguez, Megan Gibbs, Danielle Miller, Heidi Trinkman
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2510 · PDF 全面基因组分析推动精准肿瘤学发展并扩大乌兹别克人群对靶向治疗的可及性 Comprehensive genomic profiling drives precision oncology and expands accessibility to targeted therapies in Uzbek populations Zilola Olimova, Gowhar Shafi, Djuraev Farrukh, Yashodhara Bhattacharya, Aarthi Ramesh, Sandhya Iyer, Mohan Uttarwar, Hrishita Kothavade, Alain D'Souza, Bhagwat Jadhav, Sangeeta Prajapati, Madhura Basavalingegowda, Kanchan Hariramani
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2511 · PDF 采用循证算法对分子肿瘤委员会的治疗建议进行排序,以为癌症患者提供最佳诊疗并改善预后——持续性研究 Ranking therapeutic recommendations of Molecular Tumor Board with an evidence-based algorithm to deliver optimal care and improve outcomes for cancer patients- continuous study Yuliang Sun, Rachel Elsey, Crystal Hattum, Bing Xu, Tobias Meissner
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2512 · PDF 一种基于实时成像的胶质母细胞瘤功能性精准医学(FPM)检测 A real time imaging based functional precision medicine (FPM) assay for glioblastoma Thomas Quinn, Anand Panigrahy, Dina ElHarouni, Mariam A. Oumelloul, Smitha Yerrum, Kin-Hoe Chow, Sonam Bhatia, Keith L. Ligon
- 2513 2513 探索枣(Ziziphus jujuba)植物化学成分抗口腔癌作用:基于网络的分析与分子动力学研究 Exploring Ziziphus jujuba phytochemicals against oral cancer: Network-based profiling and molecular dynamics analyses Abdullah A. Assiri, Ahmad Alamri, Najeeb Khan
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2514 · PDF 患者主导的多组学纵向研究揭示葡萄膜黑色素瘤进展的新见解 Patient-driven multi-omic longitudinal research study reveals novel insights into uveal melanoma progression Amber Smith, Ben Kamphaus, Katie Campbell, Robin Kageyama, Benjamin G. Vincent, Christopher Heery, Christine N. Spencer, Marshall Thompson
- 2515 2515 以最少的PDO保留预测能力:为转移性CRC个体化治疗加速药物检测 Preserving predictive power with minimal PDOs: Accelerated drug testing for personalized therapy in metastatic CRC Yasmine Abouleila, Roel Verkerk, Mayke Doorn, Timo Voskuilen, Gakuro Harada, Masahiko Watanabe, Lidwien Smabers, Hideaki Kyan, Takahiko Kumagai, Yuichi Hikichi, Rene Overmeer, Jeanine Roodhart, Kiyotaka Matsuno, Carla S. Verissimo, Robert G. J. Vries, Sylvia F. Boj
- 2516 2516 印度卵巢癌的基因组图谱及同源重组缺陷模式:对精准治疗的临床意义 Genomic landscape and patterns of homologous recombination deficiency in Indian ovarian cancer: Clinical implications for precision therapy Rahul Katara, Sourabh Kumar, Aditi Agarwal, Kiran Kumar, Deepak K. Sharma, Yuvaraj M, Hardeep Singh, Vipin Kumar, Shivani Sharma
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2517 · PDF 组合式功能性精准平台Optim.AI™在血液系统恶性肿瘤中的真实世界临床表现 Real-world clinical performance of a combinatorial functional precision platform, Optim.AI™, in hematological malignancies Masturah Rashid, Weng Tong Ho, Jhin Jieh Lim, Sharon Pei Yi Chan, William YK Hwang, Edward Kai-Hua Chow
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2518 · PDF 离体功能性精准医疗平台Optim.AI™在指导妇科肿瘤治疗中的可行性研究 Feasibility study of an ex vivo functional precision medicine platform, Optim.AI™, in guiding treatment for gynecological cancers Masturah Rashid, Jhin Jieh Lim, Sharon Pei Yi Chan, Manavi Sachdeva, Hidayah Nabillah Nasit, Natalie Ngoi, John Chia, David Tan, Edward Kai-Hua Chow
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2519 · PDF NSCLC中BRAF融合的特征及其治疗与耐药意义 Characterization of BRAF fusions and their therapeutic and resistance implications in NSCLC Kai Wang, Chao Yi, Xiong Ning, Dalin Xiong, Song Wang, Xiaoying Wu, Hua Bao, Haimeng Tang, Xue Wu, Yuan Jiang, Hongyu Deng, Faqing Tang
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2520 · PDF 个体化医疗对神经母细胞瘤患者的临床影响:PREME项目六年经验 Clinical impact of the personalized medicine for neuroblastoma patients: Six years of experience of the PREME program Francesca Parisi, Eleonora Ciampi, Veronica Bensa, Federica Serafino, Matilde Tirelli, Laura De Rosa, Vito A. Lasorsa, Mario Capasso, Chiara Brignole, Loredana Amoroso, Massimo Conte, Mirco Ponzoni, Fabio Pastorino
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2521 · PDF 通过酪氨酸磷酸化蛋白质组学照亮NSCLC中的激酶星图 Illuminating the kinase starmap in NSCLC via tyrosine phosphoproteomics Jinfeng Yuan, Ying Hu, Yilin Wang, Tianhui Zhang, Aijuan Yu, Yi Liu, Hui Zhou, Chao Zhou, Junjie Hou, Yinyin Xu, Xinxin Xu, Huan Ding, Yuxin Zhang, Rujie Zhong, Mengjia Yang, Chunyan Chang, Hongxuan Yan, Yuanyuan Shang, Weicong Ren, Shanshan Li, Hongdong Zhong, Yun Xiao, Zhang Zhang, Naizhong Zheng, Ming Han, Yu Pang
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2522 · PDF 探讨腹盆腔Rosai-Dorfman病中RAS突变对靶向治疗反应性的影响:一项病例对照研究 Exploring the impact of RAS mutations in abdominopelvic Rosai Dorfman disease on responsiveness to targeted therapies: A case control study Rebecca Denson, Fnu Amisha, David Pottinger, Ling Zhang, Lubomir Sokol, Samuel Benjamin Reynolds