表观遗传谱分析利用一种基于靶向甲基化的多癌种早期检测(MCED)血液检测鉴定侵袭性癌症亚型的标志物

Kezhong Chen¹, Jian Huang², Dahong Zhang³, Shu Wang⁴, Hongxu Liu⁵, Wenzhao Zhong⁶, Xiangnan Li⁷, Qiang Zhang⁵, Zhigao Li⁸, Jiaqi Liu⁹, Ziqing Tian¹⁰, Fei Zhou¹¹, Gongsheng Jin¹², Xudong Xiang¹³, Zhigang Li¹⁴, Hui Xie¹⁵, Ya Wei¹⁶, Guochun Zhang¹⁷, Guolin Ye¹⁸, Ming Cai¹⁹, Junfeng Wang⁸, Yan Zhang²⁰, Chao Cheng²¹, Hefei Li²², Desong Yang²³, Jianhong Lian²⁴, Sheng Huang²⁵, Tao Xu²⁶, Zengjun Wang²⁷, Xi Guo²⁸, Zhuowei Liu²⁹, Minfeng Chen³⁰, Yang Wang³¹, Yue An³¹, Yanzhan Yang³¹, Min Li³¹, Jing Liu³¹, Baoliang Zhu³¹, Yonghui Li³¹, Xiaohui Wu³¹, Fan Yang¹, Jun Wang<sup>1

1</sup>Thoracic Oncology Institute and Department of Thoracic Surgery, Peking University People’s Hospital, Beijing, China,²The Department of Breast Surgery, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China,³Urology & Nephrology Center, Department of Urology, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, China,⁴Breast Disease Center, Peking University People's Hospital, Beijing, China,⁵Liaoning Provincial Cancer Hospital, Shenyang, China,⁶Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China,⁷The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China,⁸Harbin Medical University Cancer Hospital, Harbin, China,⁹Department of Breast Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China,¹⁰Department of Thoracic Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China,¹¹Shanghai Pulmonary Hospital, Shanghai, China,¹²The First Affiliated Hospital of Bengbu Medical College, Bengbu, China,¹³Department of Thoracic Surgery, Yunnan Cancer Hospital, Kunming, China,¹⁴Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University School of medicine, Shanghai, China,¹⁵Department of Breast Cancer Research Center, Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, China,¹⁶Anyang Tumor Hospital, Anyang, China,¹⁷Department of Breast Surgery, Guangdong Provincial People's Hospital, Guangzhou, China,¹⁸Department of Breast Cancer, The First People's Hospital of Foshan, Foshan, China,¹⁹Department of Urology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China,²⁰Department of Oncology, Shijiazhuang People’s Hospital, Shijiazhuang, China,²¹Department of Thoracic Surgery, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China,²²Department of Thoracic Surgery, Affiliated Hospital of Hebei University, Baoding, China,²³Hunan Cancer Hospital & The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China,²⁴Department of General Surgery,Shanxi Cancer Hospital, Taiyuan, China,²⁵Department of Breast Surgical Oncology,Yunnan Cancer Hospital, Kunming, China,²⁶Peking University People's Hospital, Beijing, China,²⁷Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China,²⁸Department of Urology, Hunan Provincial People's Hospital, the First Affiliated Hospital of Hunan Normal University, Changsha, China,²⁹Sun Yat-sen University Cancer Center, Guangzhou, China,³⁰Department of urology, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, China,³¹Shanghai Xiaohe Medical Laboratory Co. Ltd., Shanghai, China