Early Detection Biomarkers 1

• 1091 · PDF 利用外周血ctDNA对实性肺结节进行无创诊断:一个多模态平台的开发 Noninvasive diagnosis of solid pulmonary nodules using peripheral blood ctDNA: Development of a multimodality platform Gunangyu Bai, Luyan Shen, Shaohua Ma, Shugeng Gao
• 1092 · PDF 在PLCO队列中基于多分析物血液筛查对HPV相关口咽癌和肛门癌的早期检测 Multi-analyte blood-based screening early detection of HPV-associated oropharyngeal and anal cancer within the PLCO cohort Krystle A. Kuhs, Hilary Robbins, Li Chen, Xiaoshuang Feng, Yana Al-Inaya, Gjystina Lumaj, Samuli Eldorfs, Qin Wang, Tim Waterboer, Dipon Das, Daniel Faden
• 1093 · PDF 在肺癌筛查队列中对一种用于多癌症风险分层的血液检测的验证 Validation of a blood test for multi-cancer risk stratification in a lung cancer screening cohort Ehsan Irajizad, Johannes Fahrmann, Hamid Rudsari, Jody V. Vykoukal, Iakovos Toumazis, Sara Khoramisarvestani, Sara Ansari, Jane Yang, Nicole M. Kettner, Jennifer B. Dennison, Edwin Justin Ostrin, Samir M. Hanash
• 1094 · PDF 循环肿瘤DNA(ctDNA)用于肝细胞癌(HCC)分子残留病灶(MRD)检测与复发监测；COSMOS-HCC01 Circulating tumor DNA (ctDNA) for molecular residual disease (MRD) detection and recurrence monitoring in hepatocellular carcinoma (HCC); COSMOS-HCC01 Masashi Kudo, Mitsuhito Sasaki, Shinji Itoh, Teiichi Sugiura, Tsuyoshi Kobayashi, Keishi Sugimachi, Shinichi Nakanuma, Yuta Abe, Hisashi Kosaka, Nobuhiro Nakamoto, Naoto Yamamoto, Makoto Ueno, Takuji Okusaka, Atsushi Takebe, Minoru Esaki, Kazuyoshi Ohkawa, Hisateru Komatsu, Yu Takahashi, Masatake Tanaka, Takeshi Aramaki, Tomokazu Kawaoka, Rie Sugimoto, Taro Yamashita, Takashi Yamaguchi, Masatoshi Kudo, Masato Ozaka, Chiemi Notake, Hiroshi Uchigata, Masafumi Ikeda, Naoto Gotohda, Yoshiaki Nakamura
• 1095 · PDF ARID1A蛋白表达可增强结直肠息肉监测中的风险分层 ARID1A protein expression enhances risk stratification in colorectal polyp surveillance Aula Ammar, Amna Matly, Kimiya Kabiri Arani, Scott Murray, Mayuri Hendricks, Alexander Winton, Natalie Fisher, Gerard Lynch, Mark Johnstone, Colin Steele, Noori Maka, Jennifer Hay, Philip Dunne, Stephen McSorley, Joanne Edwards
• 1096 · PDF OncoSeek 2.0：一种增强早期检测并辅助癌症诊断的先进多癌种血液检测 OncoSeek 2.0: An advanced multi-cancer blood test enhancing early detection and aiding cancer diagnosis Mao Mao, Yong Shen, Shiyong Li, Wei Wu, Yinyin Chang, PingPing Xing, Chenyu Ding, Dandan Zhu, Qingxia Xu, Wei Cui
• 1097 · PDF 一种基于血液的筛查检测用于晚期癌前病变早期检测的性能 Performance of a blood-based screening test for the early detection of advanced precancerous lesions Prashanthi Natarajan, Preethi Srinivasan, Hsiao-Yun Huang, Alan Selewa, Rebecca Panitch, Caitlin Guccione, Fatemeh Almodaresi, Jayashree Joshi, Su Maw, Misagh Kordi, Yunshu Song, Yu Lin, Osama Khan, Breeana L. Mitchell, Adham Jurdi, Minetta C. Liu, Johannes G. Reiter, Trupti Kawli, Matthew Rabinowitz, Alexey Aleshin
• 1098 · PDF 通过对CDH1驱动的弥漫型胃癌进行时空分析鉴定离散的癌前亚型及癌症进展生物标志物 Discrete precancer subtypes and biomarkers of cancer progression identified with spatiotemporal analysis of CDH1-driven diffuse gastric cancer Jeremy L. Davis, Amber Famiglietti, Yunhe Liu, Rachael Belcher, Sun A Kim, Baktiar O. Karim, Donna Butcher, Linghua Wang
• 1099 · PDF RNA编辑酶ADAR1参与导管内乳头状黏液性肿瘤相关的癌变 The RNA editing enzyme ADAR1 is involved in carcinogenesis associated with intraductal papillary mucinous neoplasm Masashi Kayano, Kunitoshi Shigeyasu, Kazuya Moriwake, Toshiaki Takahashi, Eiki Miyake, Yuhei Kondo, Yuya Sakurai, Shunsuke Nakamura, Masafumi Takahashi, Kaori Nitta, Kazuya Yasui, Tomokazu Fuji, Kosei Takagi, Hiroshi Tazawa, Toshiyoshi Fujiwara
• 1100 · PDF 表观遗传谱分析利用一种基于靶向甲基化的多癌种早期检测(MCED)血液检测鉴定侵袭性癌症亚型的标志物 Epigenetic profiling identifies markers of aggressive cancer subtype using a targeted methylation-based multi-cancer early detection (MCED) blood test Kezhong Chen, Jian Huang, Dahong Zhang, Shu Wang, Hongxu Liu, Wenzhao Zhong, Xiangnan Li, Qiang Zhang, Zhigao Li, Jiaqi Liu, Ziqing Tian, Fei Zhou, Gongsheng Jin, Xudong Xiang, Zhigang Li, Hui Xie, Ya Wei, Guochun Zhang, Guolin Ye, Ming Cai, Junfeng Wang, Yan Zhang, Chao Cheng, Hefei Li, Desong Yang, Jianhong Lian, Sheng Huang, Tao Xu, Zengjun Wang, Xi Guo, Zhuowei Liu, Minfeng Chen, Yang Wang, Yue An, Yanzhan Yang, Min Li, Jing Liu, Baoliang Zhu, Yonghui Li, Xiaohui Wu, Fan Yang, Jun Wang
• 1101 · PDF 一种利用甲基化测序数据估计肿瘤分数的新方法 A novel method for tumor fraction estimation using methylation sequencing data Daokun Sun, Yu Sun, Alex Robertson, Lee A. Albacker, Chang Xu
• 1102 · PDF 揭示肺癌早期转录改变：来自波士顿肺癌跨组学（BOLT）计划的初步见解 Uncovering early transcriptional alterations in lung cancer: Preliminary insights from the Boston Lung Trans-omics (BOLT) Initiative Yu Chen Zhao, Li Su, Lorelei A. Mucci, Timothy R. Rebbeck, Yi Li, David C. Christiani
• 1103 · PDF 易发黑色素瘤皮肤的基因组图景 The genomic landscape of melanoma-prone skin Katie Lee, Yung-Ching Kao, Darren Smit, Marietta K. Saldias Montivero, Joshua Jay Levy, Brock C. Christensen, Quan Nguyen, H. Peter Soyer, Mitchell S. Stark
• 1104 · PDF 使用改良qPCR通过尿液DNA突变和甲基化检测膀胱癌 Detection of bladder cancer via urinary DNA mutation and methylation using modified qPCR Di Jin, Roy Tan, Ruiyun Zhang, Haige Chen
• 1105 · PDF Nestin表达在人类癌症中普遍但高度可变：一项涉及107种肿瘤类型5,917例癌症的组织芯片研究 Nestin expression is prevalent but highly variable in human cancer: A tissue microarray study involving 5,917 cancers from 107 tumor entities Clara von Bargen, Muriel Torzewski, Fiete Gehrisch, Anne Menz, Florian Lutz, Viktoria Chirico, Florian Viehweger, David Dum, Ria Schlichter, Andrea Hinsch, Christoph Fraune, Chrisitan Bernreuther, Seyma Büyücek, Martina Kluth, Claudia Hube-Magg, Georgia Makrypidi-Fraune, Nina Schraps, Katharina Möller, Andreas M Luebke, Patrick Lekok, Guido Sauter, Maximilian Lennartz, Till Clauditz, Andreas H Marx, Ronald Simon, Eike Burandt, Natalia Gorbokon, Maria Chrisitna Tsourlakis, Sarah Minner, Till Krech, Morton Freytag, Viktor Reiswich, Stefan Steurer
• 1106 · PDF 使用新型集成nCounter®工作流程在单张FFPE组织切片上快速鉴定全面的多组学蛋白质和RNA生物标志物 Rapid identification of comprehensive multi-omic protein and RNA biomarkers on a single FFPE tissue section using a novel integrated nCounter® workflow Lakshmi Chandramohan, Kirsteen Maclean, Quratul Ain, Brigitte Lovell, Lisa Duncan, Sergio Hernandez, Christina Bailey, Michael Bailey, Patrick Danaher, Wei Yang, Shanshen He, Joseph M. Beechem
• 1107 · PDF 多组学肺癌筛查血液检测的开发与性能 Development and performance of a multiomics lung cancer screening blood test Ofer Shapira, Alexander F. Lovejoy, Álvaro González, Urvee Desai, Thomas Royce, Gurnit Atwal, Ian Bast, Eric Beraut, Alexandra Buckley, Austin Cauwels, Peter Combs, Nicholas Eisele, G Parker Flowers, Lourdes Gomez, Rebecca Gupte, Johnnie Hahm, Teng-Kuei Hsu, Saiful Islam, Poorval Joshi, Amanda Kahn-Kirby, Phuong Thuy Menchavez, Erene Mina, Jinesh Niroula, Cameron Pospisil, Sodany Son, Rashmi Sriram, Peter Ulz, Russell Williams, Rui Yang, Wilson Zhang, Marian Navratil, C Jimmy Lin, Tanya Moreno, Richard Bourgon
• 1108 · PDF 优化的甲基化-蛋白质多癌种早期检测（MCED）检测分类器的性能 Performance of an optimized methylation-protein multi-cancer early detection (MCED) test classifier Vladimir G. Gainullin, Melissa Gray, Madhav Kumar, Stephen Luebker, Amy Lehman, Darl D. Flake, Avinash Shanmugam, Kevin Cortes, Emily Chang, Philip J. Uren, Amin Mazloom, Jorge Garces, Gerard A. Silvestri, David W. Chesla, Robert W. Given, Tomasz M. Beer, Frank Diehl
• 1109 · PDF 甲基化和蛋白质生物标志物类别在多癌种早期检测（MCED）检测中的互补贡献 The complementary contributions of methylation and protein biomarker classes in a multi-cancer early detection (MCED) test Vladimir G. Gainullin, Melissa Gray, Madhav Kumar, Stephen Luebker, Avinash Shanmugam, Kevin Cortes, Emily Chang, Philip J. Uren, Amin Mazloom, Jorge Garces, Tomasz M. Beer, Frank Diehl
• 1110 · PDF 在NIDCR与NCI的领导和协作下，通过AHEAD和EDRN项目推动头颈部癌症早期检测的生物标志物鉴定 Promote biomarker identification for early detection of head and neck cancers through AHEAD and EDRN programs under the leadership and collaboration between NIDCR and NCI Zhong Chen, Wendy Wang, Guillermo Marquez, Jason Wan, Sudhir Srivastava
• 1111 · PDF 在伊利诺伊州北部代表性不足的少数族裔社区中提高认识并加强低剂量计算机断层扫描筛查的可及性以早期检测肺癌 Promoting awareness and enhancing access to low-dose computed tomography screening for early detection of lung cancer in underrepresented minority communities in Northern Illinois Subaranjana Saravanaguru Vasanthi, Georgia Kapetaneas, Rose Bahari, Shylendra B Sreenivasappa, Nameer Mardini, Sandra Martell, Joseph Ross, Yamilé Molina, Neelu Puri
• 1112 · PDF 循环早期髓源性抑制细胞作为肺癌中肿瘤驱动的髓系生成及疾病进展的指标 Circulating early myeloid-derived suppressor cells as indicators of tumor-driven myelopoiesis and disease progression in lung cancer Anna Zanichelli, Orazio Fortunato, Mara Lecchi, Paolo Verderio, Luigi Rolli, Ugo Pastorino, Gabriella Sozzi, Claudia Chiodoni, Sabina Sangaletti
• 1113 1113 一种利用cfDNA突变及整合基因组特征分析的靶向多癌种早期检测（MCED）检测的临床验证 Clinical validation of a targeted multi-cancer early detection (MCED) test using cfDNA mutation and integrated genomic signatures analysis Chee-Onn Leong, Boon Shing Tan, Hiu Ching Toh, Ee Mun Loo, Anand Mohan, Teryna Thu, Zhi Win Ng, Xin Yi Chew, Chin King Looi, Felicia Fei Lei Chung, Chun Wai Mai
• 1114 · PDF 以信息学驱动整合OpenMRS与iBreastCheck以加强埃塞俄比亚基于社区的癌症筛查 Informatics-Driven Integration of OpenMRS and iBreastCheck to Strengthen Community-Based Cancer Screening in Ethiopia Tsedey Michele Tsegaye, Mukesh kumar Patel, Tulay Soylu
• 1115 · PDF annexin A4在癌症中的表达：一项涉及来自105种肿瘤实体的6,058例癌症的组织微阵列研究 Expression of annexin A4 in cancer: A tissue microarray study involving 6,058 cancers from 105 tumor entities Cosima Völkel, Nayma Malas, Fiete Gehrisch, Nina Schraps, Anne Menz, Florian Lutz, Viktoria Chirico, Florian Viehweger, David Dum, Ria Schlichter, Andrea Hinsch, Christoph Fraune, Christian Bernreuther, Seyma Büyücek, Martina Kluth, Claudia Hube-Magg, Georgia Makrypidi-Fraune, Katharina Möller, Andreas M. Luebke, Patrick Lebok, Guido Sauter, Maximilian Lennartz, Till S. Clauditz, Andreas H. Marx, Ronald Simon, Eike Burandt, Natalia Gorbokon, Maria C. Tsourlakis, Sarah Minner, Till Krech, Morton Freytag, Viktor Reiswich, Stefan Steurer
• 1116 · PDF 一个可扩展的多模态框架用于跨多种癌症类型的无偏倚风险生物标志物发现 A scalable multimodal framework for unbiased risk biomarker discovery across multiple cancer types Constantin Petrescu, Lisa Schmunk, Jack Monahan, Abbas Salami, Thomas M. Stubbs
• LB371 · PDF 血液代谢组的前瞻性研究以识别胆道癌的风险生物标志物 Prospective investigation of the blood metabolome to identify risk biomarkers for biliary tract cancer Valerie Gunchick, Wei Zheng, Chris Haiman, Caroline Um, Roger Milne, Rachel Solomon, Yu Chen, Andrew Chan, Qiuyin Cai, Xiao-Ou Shu, on behalf of the BTC Metabolomic Consortium

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