PO.CL01.18 · 临床研究

在NIDCR与NCI的领导和协作下，通过AHEAD和EDRN项目推动头颈部癌症早期检测的生物标志物鉴定

Promote biomarker identification for early detection of head and neck cancers through AHEAD and EDRN programs under the leadership and collaboration between NIDCR and NCI

编号 1110 展板 20 时间 4/19 02:00–05:00 区域 Section 43 主讲 Zhong Chen, MD;PhD

分会场 Early Detection Biomarkers 1

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作者与单位 Authors & Affiliations

Zhong Chen¹, Wendy Wang², Guillermo Marquez², Jason Wan³, Sudhir Srivastava²

¹Oral Mucosa & Cancer Biology Program, Chronic Dental, Oral and Craniofacial Conditions Branch, National Institute of Dental & Craniofacial Research, National Institutes of Health, Bethesda, MD,²Cancer Biomarkers Branch, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD,³Odontogenic Diseases Program, Chronic Dental, Oral and Craniofacial Conditions Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD

摘要 Abstract

中文摘要

美国国立牙科与颅面研究所（NIDCR）的口腔黏膜与癌症生物学项目支持旨在改善口腔、咽部及唾液腺癌症早期检测和治疗的研究活动。美国国立癌症研究所（NCI）的早期检测研究网络（EDRN）支持用于癌症早期检测和风险评估的生物标志物及影像学方法的发现、开发和验证，并将这些发现转化为临床检测手段。NIDCR与NCI长期保持协作关系，并于2023年共同启动了AHEAD项目（推进头颈部癌症早期检测，Advancing Head and Neck Cancer Early Detection）。AHEAD项目共同资助了七个研究课题，旨在发现和开发用于HPV阳性及阴性头颈部癌症（HNC）早期检测和诊断的分子标志。AHEAD领导团队和研究人员积极参与了EDRN肺部及上呼吸消化道癌症协作组，并通过在国内外会议上的报告以及在高影响力期刊上的发表，广泛分享了他们的工作。AHEAD研究人员还在重要学术会议上组织并主持了专题研讨会和工作坊，以提高人们对HNC早期检测和诊断的认识。AHEAD正在进行的活动包括鉴定和验证用于早期检测的生物标志物、建立口腔潜在恶性病变的虚拟肿瘤库、开展空间转录组学分析以识别高优先级生物标志物，以及发表论文以描述AHEAD的活动和进展。在2026年AACR年会上，NIDCR和NCI的项目主管将概述AHEAD项目，重点介绍两所研究所之间的协作努力和资助机会，并着重强调癌症早期检测以及生物标志物的发现和验证。NIDCR与NCI之间的这种协作提供了一个独特而强大的平台，以推进旨在改善头颈部癌症早期检测并最终使患者获益的基础、转化和临床研究。

查看英文原文 English abstract

The Oral Mucosa & Cancer Biology Program at National Institute of Dental and Craniofacial Research (NIDCR) supports research activities that improve early detection and treatment of cancers of the oral cavity, pharynx, and salivary glands. National Cancer Institute (NCI)'s Early Detection Research Network (EDRN) supports discovery, development, and validation of biomarkers and imaging methods for early detection and risk assessment of cancer, translating these discoveries into clinical tests. NIDCR and NCI have a long-standing collaborative relationship and jointly launched the AHEAD Program (Advancing Head and Neck Cancer Early Detection) in 2023. The AHEAD program co-funds seven research projects aimed at discovering and developing molecular signatures of early detection and diagnosis of HPV positive and negative head and neck cancer (HNC). The AHEAD leadership team and investigators actively participated in the EDRN Lung and Upper Aerodigestive Cancers Collaborative Group and have shared their work widely through national and international conference presentations and publications in high-impact journals. AHEAD investigators have also organized and led symposia and workshops at major scientific meetings to raise awareness of early detection and diagnosis of HNC. Ongoing AHEAD activities include identifying and validating biomarkers for early detection, creating a virtual tumor bank of oral potentially malignant disorders, conducting spatial transcriptomics analyses to identify high priority biomarkers, and publishing papers to describe AHEAD activities and progress. At the 2026 AACR Annual Meeting, NIDCR and NCI program directors will present an overview of the AHEAD program, highlighting collaborative efforts and funding opportunities between the two institutes, with an emphasis on early cancer detection and biomarker discovery and validation. This collaboration between NIDCR and NCI provides a unique and powerful platform to advance basic, translational, and clinical research aimed at improving early detection of head and neck cancer and ultimately benefiting patients.

利益披露 Disclosure

Z. Chen, None.. W. Wang, None.. G. Marquez, None.. J. Wan, None.. S. Srivastava, None.

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