PO.CL08.02 · 临床研究

FTO的基因抑制不会加重C57BL/6小鼠放射诱导性口腔黏膜炎的严重程度

Genetic inhibition of FTO does not exacerbate the severity of radiation-induced oral mucositis in C57BL/6 mice

编号 5268 展板 5 时间 4/21 09:00–12:00 区域 Section 43 主讲 Margaret Pan, BS

分会场 Effects of Ionizing Radiation on Normal Tissues and FLASH Radiation Research

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作者与单位 Authors & Affiliations

Margaret Pan¹, Leighton Pu², Stavros Melemenidis², Edward Elliot Graves³, Kerriann M. Casey², Erinn Rankin³

¹Stanford University School of Medicine, Stanford, CA,²Stanford University School of Medicine, stanford, CA,³Stanford University, Stanford, CA

摘要 Abstract

中文摘要

口腔黏膜炎是头颈癌患者癌症治疗的一种严重副作用。这些溃疡性病变常干扰进食和吞咽，使康复更加困难并可能延误治疗。在本研究中，我们评估了对脂肪量与肥胖相关基因（FTO，一种m6A RNA去甲基化酶）进行基因抑制对C57BL6/J小鼠放射诱导性口腔黏膜炎严重程度的影响。在对头颈部区域给予18 Gy照射后10天采集舌组织。组织病理学显示FTO敲除（KO）小鼠与野生型（WT）小鼠在放射后的损伤相当。因此，FTO抑制不会加重放射后正常组织的损伤，这支持将FTO作为头颈鳞状细胞癌（HNSCC）潜在治疗靶点进行进一步研究。

查看英文原文 English abstract

Oral mucositis is a severe side effect of cancer treatment in patients with head and neck cancer. These ulcerative lesions often interfere with eating and swallowing, making recovery more difficult and potentially delaying treatment. In this study, we evaluated the impact of genetic inhibition of fat-mass and obesity-associated gene (FTO), an m6A RNA demethylase, on the severity of radiation-induced oral mucositis in C57BL6/J mice. Tongues were collected 10 days following administration of 18 Gy irradiation to the head and neck region. Histopathology demonstrated equivalent damage between FTO-knockout (KO) and wild-type (WT) mice following radiation. Thus, FTO inhibition does not exacerbate normal tissue damage following radiation and supports further investigation of FTO as a potential therapeutic target in head and neck squamous cell carcinoma (HNSCC).

利益披露 Disclosure

M. Pan, None.

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