PO.CL08.02 · 临床研究
Effects of Ionizing Radiation on Normal Tissues and FLASH Radiation Research
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- 5265 5265 FLASH放疗改善小鼠胶质母细胞瘤的生存并保护循环中的抗原反应性CD8+ T细胞 FLASH radiotherapy improves survival in mouse glioblastoma and spares circulating antigen reactive CD8 + T-cells Yanxia Ma, Nhat Nguyen, Xuehong Gui, Edgardo Aguilar, Luke Connell, Denae Neill, Emil Schüler, Chibawanye I. Ene
- 5266 5266 FLASH放疗在乳腺癌PDX模型中维持肿瘤控制并实现安全的再照射，同时保护正常组织 FLASH radiotherapy maintains tumor control and enables safe re-irradiation while preserving normal tissue in breast cancer PDX models Adel Zaid I Mutahar, Banita Verma, Stavros Melemenidis, Suparna Dutt, Kerriann M. Casey, Zhen Qi, Angera Hsiao-Chi Kuo, Kathleen C. Horst, Edward Elliot Graves, Michael F. Clarke, Billy W. Loo, Frederick M. Dirbas
- 5267 5267 丙酮酸代谢的重编程克服肠道干细胞放射敏感性的性别特异性差异并改善腹部照射的治疗比 Reprogramming of pyruvate metabolism overcomes sex-specific differences in intestinal stem cell radiosensitivity and improves the therapeutic ratio for abdominal irradiation Stacey Krepel, Payel Bhanja, Rishi Man Chugh, Shujah Hamid Rehman, Subhrajit Saha
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- 5269 5269 低剂量放射治疗外周关节骨关节炎：美国社区在疼痛、功能和用药结局方面的早期经验 Low-dose radiation therapy for peripheral joint osteoarthritis: Early U.S. community experience with pain, function, and medication outcomes Emily Schwartz, Michael Anderson, Russell Nevins, Kelsey Moakler, Andrew Cohen, Michael Sinopoli, Samuel Francis, Bradley Newby, Matthew Schwartz
- 5270 5270 游离RNA变化先于接受胸部放疗的癌症患者出现症状性放射性肺炎 Cell-free RNA changes precede symptomatic radiation pneumonitis in cancer patients receiving thoracic radiotherapy Isabel Jabara, Noah Kastelowitz, Monica Nesselbush, Nick Phillips, Michael S. Binkley, Rene F. Bonilla, Kevin Liu, Alice Jiang, Nataliya Kovalchuk, Ash A. Alizadeh, Maximilian Diehn
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- 5274 5274 超高剂量率（FLASH）与常规放疗对野生型和cGAS敲除小鼠肿瘤控制的影响 Impact of ultra-high dose rate (FLASH) versus conventional radiotherapy on tumor control in wild-type and cGAS-knockout mice Banita Verma, Adel Mutahar, Stavros Melemenidis, Rohit Verma, Lucy Whitemore, Suparna Dutt, Kathleen C. Horst, Edward Elliot Graves, Michael F. Clarke, Lingyin Li, Billy W. Loo, Frederick M. Dirbas
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- 5276 5276 [123I]CC1，一种用于靶向放射性核素治疗（TRT）的放射性药物，通过PARP结合与捕获来放大人类癌细胞系中的DNA损伤和细胞毒性。 [ 123 I]CC1, a radiopharmaceutical for Targeted radionuclide therapy (TRT), exploits PARP binding and trapping to amplify DNA damage and cytotoxicity in human cancer cell lines. Luis Hernandez Cano, Nerea Delgado Mayenco, Hilleen Kramer, Elmar Diekstra, Francesca Amoroso, Sreelakshmi Unnikrishnan, George Alachouzos, Wiktor Szymanski, Frank A. Kruyt, Bart Cornelissen
- 5277 5277 α和β发射体放射性药物治疗联合双重免疫检查点抑制剂对原发肿瘤和转移肿瘤产生不同的控制效果 Alpha- and beta-emitter radiopharmaceutical therapy combined with dual immune checkpoint inhibitors yields distinct control of primary and metastatic tumors Yujuan Wang, Alexander Wertheim Verona, Bhoomika Raj Pillai, Tracy Berg, Caroline Kerr, Jamey P. Weichert, Reinier Hernandez, Bryan P. Bednarz, Zachary S. Morris
