PO.MCB08.04 · 分子与细胞生物学
小细胞神经内分泌癌中全局性mRNA 3'UTR延长
Global mRNA 3'UTR lengthening in small-cell neuroendocrine carcinoma
作者与单位 Authors & Affiliations
摘要 Abstract
中文摘要
小细胞神经内分泌癌（SCNC）是一种罕见但高度恶性的肿瘤亚型，主要发生于肺和前列腺。不同组织来源的SCNC之间的趋同性使其能够通过保守的SCNC特异性分子标志物加以鉴定，从而有助于肿瘤亚型分类。作为一种关键的转录后调控机制，选择性多聚腺苷酸化（APA）参与多种生物学过程，尤其是在肿瘤进展中。然而，其在不同肿瘤亚型中的作用仍不明确。在此，我们揭示了SCNC中由APA导致的全局性3'UTR延长模式。我们鉴定出一组在不同组织来源的SCNC中保守的3'UTR延长事件，其与神经发育及相关信号通路高度关联。更广泛地，我们采用神经网络框架开发了一个预测模型，基于SCNC特异性APA特征作为额外的分子标志物来鉴定SCNC。我们的工作为SCNC的转录后图景提供了新的见解，并确立了APA作为SCNC鉴定的潜在生物标志物。
查看英文原文 English abstract
Small-cell neuroendocrine carcinoma (SCNC) is a rare but highly malignant tumor subtype, primarily arising in the lung and prostate. The convergence of SCNCs across diverse tissues enables their identification through conserved SCNC-specific molecular markers, facilitating tumor subtype classification. As a critical post-transcriptional regulatory mechanism, alternative polyadenylation (APA) is involved in various biological processes, especially in tumor progression. However, its role across tumor subtypes remains unclear. Here, we revealed a global 3'UTR lengthening pattern due to APA in the SCNCs. We identified a set of conserved lengthening 3'UTR events across SCNCs originating from different tissues, showing a high association with neural development and related signaling pathways. More broadly, we developed a prediction model using a neural network framework to identify SCNCs based on the SCNC-specific APA signatures as additional molecular markers. Our work provides new insights into the post-transcriptional landscape of SCNCs and establishes APA as a potential biomarker for SCNC identification.
利益披露 Disclosure
Y. Zhang, None..
X. Zhao, None..
Y. Hu, None.