PO.TB05.02 · 肿瘤生物学
部位特异性肿瘤建模：小鼠中的 DIPG 和脑膜瘤
Site-specific tumor modeling: DIPG and meningioma in mice
作者与单位 Authors & Affiliations
摘要 Abstract
中文摘要
弥漫性内生性脑桥胶质瘤（DIPG）和脑膜瘤是中枢神经系统肿瘤，其解剖位置对疾病行为和治疗反应有关键影响。为研究这一影响，我们开发并比较了使用 SF8628-GFP⁺/Luc⁺（DIPG）和 Ben-Men-1-Luc（脑膜瘤）在三种接种部位的临床前模型：（1）临床相关部位（DIPG 为脑桥；脑膜瘤为颅底），（2）一般颅内部位，以及（3）皮下部位。通过生物发光成像纵向监测肿瘤进展，并经组织病理学确认。本研究旨在确定部位特异的微环境如何影响生长动力学、浸润模式和成像特征。理解这些差异对药物开发至关重要，因为原位模型能更好地再现血脑屏障限制、肿瘤血管化以及影响治疗递送和疗效的局部组织相互作用。
查看英文原文 English abstract
Diffuse intrinsic pontine glioma (DIPG) and meningioma are central nervous system tumors where anatomical location critically influences disease behavior and therapeutic response. To investigate this impact, we have developed and compared preclinical models using SF8628-GFP⁺/Luc⁺ (DIPG) and Ben-Men-1-Luc (meningioma) across three inoculation sites: (1) clinically relevant locations (pons for DIPG; skull base for meningioma), (2) general intracranial sites, and (3) subcutaneous sites. Tumor progression was monitored longitudinally using bioluminescence imaging and confirmed by histopathology. This study sought to determine how site-specific microenvironments affect growth kinetics, infiltration patterns, and imaging characteristics. Understanding these differences is essential for drug development, as orthotopic models better replicate blood-brain barrier constraints, tumor vascularization, and local tissue interactions that influence therapeutic delivery and efficacy.
利益披露 Disclosure
M. Tran, None..
C. Davis, None..
D. McCormick, None..
J. Saurbaugh, None.