Pediatric Cancer Models

• 6165 · PDF 基质密度塑造尤因肉瘤的早期侵袭与EWSR1::FLI1蛋白动态 Matrix density shapes early invasion and EWSR1::FLI1 protein dynamics in Ewing sarcoma Manon Watzky, James Amatruda
• 6166 · PDF 推进儿童实体瘤治疗的下一代模型 Next-generation models to advance pediatric solid cancer treatments Emon Nasajpour, Dena Panovska, Ruolun Wei, Conrado Soria, Calvin J. Kuo, Rachana Agarwal
• 6167 · PDF 化疗和小分子抑制剂对儿童骨肉瘤3D微环境影响的建模 Modeling the impact of chemotherapy and small molecule inhibitors on the 3D microenvironment of pediatric bone sarcomas Allison Haley Reno, Joshua Kelley, Reid Barker, Jamie Silverman, Jack Hyland, Cameron Bumbleburg, Elizabeth Maahs, Anna Tingler, Denis C. Guttridge, Melinda A. Engevik, Yongren Wu, Casey Langdon
• 6168 · PDF 研究BCOR-CCNB3融合阳性肉瘤的致癌机制 Investigating the mechanism of oncogenesis of BCOR-CCNB3 fusion positive sarcomas Victoria Ann Pete, Ryota Shirai, Sydney Hakim, Joshua Broadman, Naoki Oike, Andrew E. Goodspeed, Masanori Hayashi
• 6169 · PDF 在免疫功能健全的MYCN驱动小鼠神经母细胞瘤同种异体移植模型中评价TCR模拟型CAR T细胞的临床前治疗 Evaluating TCR mimetic CAR T cell preclinical therapeutics in an immunocompetent MYCN-driven murine neuroblastoma allograft model Elisabeth Posthill, Minu Samanta, David Groff, Colleen Casey, Tina Acholla, Anna Maria Giudice, Kristopher R. Bosse, Ruoning Wang, Timothy T. Spear, John M. Maris
• 6170 6170 重现肿瘤异质性和骨微环境的3D骨肉瘤模型的建立与表征 Development and characterization of 3D osteosarcoma models recapitulating tumor heterogeneity and bone microenvironment Margaux Chantoiseau, Pierre Khneisser, Birgit Geoerger, Nathalie Gaspar, Maria Eugénia Marques da Costa, Antonin Marchais
• 6171 · PDF 患者来源的儿童胶质母细胞瘤模型为IDH1驱动的耐药机制提供关键洞见 Patient-derived pediatric glioblastoma models provide key insights into IDH1-driven drug resistance Stephen Friend, Matthew Graziano, Ruby E. Thamert, Heather Branscome, Utsav Sharma, Abhay Andar, Carolina Lucchesi
• 6172 · PDF 转录因子DMRTA2调控儿童高级别胶质瘤的放射状胶质细胞维持和致瘤性 The transcription factor DMRTA2 regulates radial glial maintenance and tumorigenicity of pediatric high-grade glioma Hitomi N. Royston, Autumn B. Hampton, Elissa G. Oliver, Jayden Jackson, Ibukunoluwa Florence Tella, Miriam D. Emerson, Dhruv Bhagat, Daijiro Konno, Kosuke Funato
• 6173 · PDF 开发儿童肉瘤斑马鱼替身模型以支持功能性精准肿瘤学 Developing zebrafish avatars for pediatric sarcomas to support functional precision oncology Karoline Felisbino, Jonathan Tyler Kinder, Colin Williams, Andrew Gaines, Jessica Blackburn
• 6175 · PDF 人类神经母细胞瘤类器官模型的开发 Development of a human neuroblastoma organoid model Simon Tusnady, Eva Bakos, Anna Lovrics, Katalin Monostory, Jozsef Tovari, Andras Furedi, Kornelia Szebenyi
• 6176 · PDF 神经嵴细胞的胚胎重编程驱动尤因肉瘤的发生 Embryonic reprogramming of neural crest cells drives the development of Ewing sarcoma Elena Vasileva, Claire Arata, Yongfeng Luo, Gage Crump, James Amatruda
• 6177 · PDF 使用肿瘤选择性纳米颗粒药物递送方法进行后颅窝A型室管膜瘤的靶向治疗 Targeted posterior fossa A ependymoma therapy using a tumor-selective nanoparticle drug delivery approach Jon D. Larson, Darren Finlay, Yan Yuen Lo, Rabi Murad, Ming Zhao, Antony MichaelRaj, Sachin A. Kumar, Kristen Vogt, Ian Pass, Charles Handley, Bryan K. Li, Robert J. Wechsler-Reya, Michael D. Taylor, Kristiina Vuori, Michael Jackson, Daniel A. Heller, G. Praveen Raju, Lukas Chavez
• 6178 · PDF 尤因肉瘤自发转移PDX模型的建立与分析 Establishment and analysis of spontaneous metastatic PDX models of Ewing sarcoma Ali Mokhtar Mahmoud, Unsun Lee, Arnulfo Mendoza, Christine M. Heske
• 6179 · PDF 在ALK抑制剂治疗前后获得的肿瘤标本所开发的配对FUS-TFCP2+ RMS PDX模型的差异敏感性 Differential sensitivity of paired FUS-TFCP2+ RMS PDX models developed from tumor specimens obtained prior to and after ALK inhibitor therapy Erika Dobrota, M. Reza Saadatzadeh, Barbara Bailey, Keiko Kreklau, Gabe Mervis, Kathy Coy, Felicia Kennedy, Melissa Trowbridge, Anthony Sinn, Christopher Davis, Steven Angus, Michael Ferguson, Pankita Pandya, Karen Pollok
• 6180 · PDF 小鼠基因编辑揭示 ASPS-TFE3 诱导的易位性肾细胞癌的功能机制 Gene editing in the mouse reveals functional mechanisms of ASPS-TFE3 induced translocation renal cell carcinoma Gopinath Prakasam, Alana Christie, Lisa Kinch, Jeffrey Miyata, Quyen Do, Mylinh Nguyen, Robert Hammer, Payal Kapur, James Brugarolas
• 6181 · PDF 建立具有临床相关性的 ETMR 体外模型及其对药物疗效研究的意义 Development of a clinically relevant in vitro model of ETMR and implications for drug efficacy studies Evangelos Liapis, Adele Ponzoni, Lea Anne T. Maristela, Claire L. Carter, Derek Hanson
• 6182 · PDF p14ARF 的转录后沉默驱动 CRISPR 工程化视网膜类器官中视网膜母细胞瘤的恶性转化 Post-transcriptional silencing of p14ARF drives retinoblastoma malignant conversion in CRISPR-engineered retinal organoids Jinlun Bai, David S. Koos, Kevin Stachelek, Bhavana Bhat, Susan Asatrian, Patrick Belen, Sunjum Sanghari, Kayla Stepanian, Scott Fraser, Rex A. Moats, David Cobrinik
• 6183 · PDF MIAC51 细胞在多种大鼠品系中诱导快速起病的白血病：一种新型且可重复的绿色白血病（Chloroleukemia）模型 MIAC51 cells induce rapid-onset leukemia across multiple rat strains: A novel and reproducible model of Chloroleukemia Joel Costoya, Joaquin J. Jimenez
• 6184 · PDF 部位特异性肿瘤建模：小鼠中的 DIPG 和脑膜瘤 Site-specific tumor modeling: DIPG and meningioma in mice Melissa Tran, Cheryl Davis, Ben Hoerner, Victoria Caruso, Helen Ketteringham, Corrine Silvio, Shannan Paul, Chris Holding, Aliccia Koznecki, Dawn Lusk, Shorena Nadaraia-Hoke, Delaney McCormick, Jocelyn Saurbaugh

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