LBPO.CH01 · 化学 · Late-Breaking

Late-Breaking Research: Chemistry

21 张海报 20 张含资料时间 Apr 19 2026 2:00PM 区域 Section 51

LB021 · PDF ApoA1-抗CD99抗体融合蛋白增强对尤文肉瘤的治疗疗效 Enhanced therapeutic efficacy of ApoA1-Anti CD99 antibody fusion protein for treatment of Ewing sarcoma HyungGyoo Kang, Bryon Upton, Jon Nagy, Timothy Triche
LB022 · PDF 前沿的无药靶向抗癌疗法：智能叶酸偶联共聚物本征性地失活YAP/TAZ-HIPPO癌蛋白并遏制胰腺癌进展与转移 Cutting-edge, drug-free targeted cancer therapeutic: Smart folate-conjugated copolymer intrinsically disables the YAP/TAZ-HIPPO oncoproteins and abrogates pancreatic cancer progression and metastasis Reza Bayat Mokhtari, Nicole Mendonza, Daniel Leon Moshe, Yunfan Li, Daniella Ghokasian, Razieh Salahandish, Narges Baluch, Myron R. Szewczuk
LB023 · PDF 用于治疗骨转移的配体靶向放射治疗的设计 Design of a ligand targeted radiotherapy for treatment of bone metastasis Losha D. Jung, Neel T. Parekh, Nithin R. S. Raj, Lauren K. Thompson, Philip S. Low
LB025 · PDF 用于靶向抗癌治疗的DNA损伤化学邻近诱导剂（DD-CIP） DNA damage chemical inducers of proximity (DD-CIP) for targeted cancer therapy Tian Qiu, Yeuan Ting Lee, Brendan G. Dwyer, Yi Jer Tan, Ting Chen, Bryan A. Romero, Yanlan Wang, Jiehui Deng, Tinghu Zhang, Gerald R. Crabtree, Stephen M. Hinshaw, Kwok-Kin Wong, Nathanael S. Gray
LB027 · PDF AI引导的pH响应性抗体工程改造实现肿瘤选择性靶向并改善治疗指数 AI guided engineering of pH responsive antibodies enables tumor selective targeting and improves the therapeutic index Qilin Yu, Mingchen Chen, Ying Lu, Yuxi Wang
LB028 LB028 LN019，一种新型HER2靶向亲和体-药物偶联物，在异种移植模型中展现出优于T-DXd的抗肿瘤疗效 LN019, a novel HER2-targeting affibody-drug conjugate, demonstrates superior antitumor efficacy compared to T-DXd in xenograft models Xuelin Xia, Ning Sun, Wei Huang, Zhigang Yan, Zhao Sun, Yong Liu, Wenming Li, Xiaobo Li, Xiaoxia Xia, Deyue Yan
LB029 · PDF 用于单个肿瘤细胞增殖表型及组学分析的一体化高通量检测 An integrated high-throughput assay for proliferative phenotypic and omics profiling of single tumor cells Shiska Raut, Karoliina Stefanius, Bryan Presley, Digant P. Dave
LB030 · PDF 化学蛋白质组学发现变构共价GSTO1抑制剂揭示一种此前未被认识、具有抗炎活性的结合模式 Chemoproteomic discovery of allosteric covalent GSTO1 inhibitors reveals a previously unrecognized binding mode with anti-inflammatory activity Nan Chen, Fengying Zhang, Wenchao Lu
LB031 · PDF 一种强效三氟甲基苯乙酰胺衍生物抗癌作用的转录组学评价 Transcriptomic evaluation of a potent trifluoromethyl phenyl acetamide derivative for its anticancer effect Mohamed A. Eltokhy, Ahmed Ragab, Eman A. Fayed, Moustafa S. Abusaif, Aya Thabet, Yousry A. Ammar, Sahar Radwan, Sanjay Srivastava
LB032 · PDF 天然化合物KH617通过调控MGMT逆转胶质母细胞瘤对烷化剂的耐药性 The natural compound KH617 reverses glioblastoma resistance to alkylating agents via MGMT modulation Chun-Jie Li, Xue Yang, Ling-Min Lin, Qiao-Xin Tang, Yun Feng, Yong Zhu, Man-Xi Zhao, Xiao Ke
LB033 · PDF KH617原料药生产：一种合成生物学方法 KH617 API manufacturing: A synthetic biology approach Yi Zhou, Jiong-Qin Liu, Cheng-Guo Gao, Hao Luo, Man-Xi Zhao, Xiao Ke
LB034 · PDF 生物合成来源分子KHN705的广谱抗肿瘤活性 Broad-spectrum antitumor activity of the biosynthetically derived molecule KHN705 Yun Feng, Wang-Wei Mao, Yu-Jie Yuan, Hong Chen, Qiao-Xin Tang, Yong Zhu, Hao Luo, Man-Xi Zhao, Xiao Ke
LB035 · PDF 天然化合物KH617：一种靶向GBM代谢重编程的安全且选择性的治疗药物 The natural compound KH617: A safe and selective therapeutic agent targeting GBM metabolic reprogramming Chun-Jie Li, Xue Yang, Li-Tao Liu, Yun Feng, Ling-Min Lin, Qiao-Xin Tang, Yong Zhu, Man-Xi Zhao, Zhuang Kang, Wen-Bin Li, Xiao Ke
LB036 · PDF BLU-448的表征：一种用于治疗HR+/HER2-乳腺癌的强效选择性CDK4降解剂 Characterization of BLU-448: A potent and selective degrader of CDK4 for the treatment of HR+/HER2- breast cancers Zhihu (Jeff) Ding*, Xiang Liu*, Barbara K. Robens, Jeff Keats, Suzanne Spong, Fereidoon Daryaee, Michael R. Wasserman, Benjamin Barlock, Jian Guo, James Baker, Kenneth Kearney, Gramoz Kondakci, Camila Medrano-Trochez, Christophe Lemetre, Emily Erickson, Hana von der Linden, Dean Zhang, Sheng Sun, Rentian Wu, Lakshimi Muthuswamy, Jie Ge, Luis Torres, Kevin Barvian, Thiwanka Mudiyanselage, Winston L. Chow, Deborah G. Conrady, Yunxing (Stella) Li, Xavier Fradera, Yinghui Dai, Caitlin Kinkema, Jason Brubaker, Robert Meissner, Thomas A. Dineen, Chiara Conti, Kerrie Faia, Scott Ribich
LB037 · PDF 一种系统性的基于质谱的化学蛋白质组学平台（chomiXdegrade TM），用于分子胶降解剂的发现和机制解析 A systematic mass spectrometry-based chemoproteomic platform (chomiXdegrade TM ) for molecular glue degrade discovery and mechanistic dissection Nan Chen, Fengying Zhang, Xin Yuan, Hao Hu
LB038 · PDF 一种新型口服生物可利用MDM2 PROTAC（NW-8-461）在急性白血病和骨髓纤维化中的临床前评价 Preclinical evaluation of a novel orally bioavailable MDM2 PROTAC, NW-8-461, in acute leukemia and myelofibrosis Qinhong Zhang, Yajing Xu, Qiong Wu, Cecilia Z. Tu, Shijia Wang, Kai Yin, Xuesong Xu, Zhang Zhang, Bing Dai, Fenlai Tan, Yi Chen
LB039 · PDF 具有新型CRBN配体的口服可利用BCL6降解剂HSK47977在NHL中显示出强效抗肿瘤活性及与BCL2抑制的协同作用 Orally bioavailable BCL6 degrader HSK47977 featuring a novel CRBN ligand demonstrates potent antitumor activity and synergy with BCL2 inhibition in NHL Jun Xu, Qingyuan Meng, Yuting Liao, Chen Zhang, Jing Wei, Ruofeng Tang, Caixia Dou, Jie Yang, Pingming Tang, Zhen Chen, Yao Lu, Ju Wang, Pangke Yan
LB040 · PDF 从Cereblon调节剂文库中鉴定出一种具有治疗潜力的强效选择性PPIL4降解剂 Identification of a potent and selective PPIL4 degrader with therapeutic potential from a library of Cereblon modulators Yunchao Chang, Vanshita Goel, Gisele Nishiguchi, Vyoma Sheth, Zhe Shi, Pankaj Ghate, Joy Mondal, Irin Tom, Xiaoming Zhong, Kevin McGowan, Anup Aggarwal, Jason Ochoada, Jeanine Price, DongGeun Lee, Lei Yang, Francisca N. de Luna Vitorino, Sarah M. Young, Renee Dean, Joanna Lempiainen, Lauren Mascibroda, Josi Lott, Jamila Moore, Dixie Brewington, Paula Perez Sanchez, Suiping Zhou, Vishwajeeth Pagala, Yingxue Fu, Zuo-Fei Yuan, Anthony High, Benjamin Leslie, Vibhor Mishra, Sandi Radko-Juettner, Baranda Hansen, Shondra Pruett-Miller, Benjamin Garcia, Jeffery Klco, Madan Babu, Marcus Fischer, Martine F. Roussel, Zoran Rankovic, Charles G. Mullighan
LB041 · PDF 利用邻近网络分析(Proximity Network Assay)解码CAR T细胞的单细胞蛋白互作组 Decoding single-cell protein interactomes of CAR T cells with the Proximity Network Assay Filip Karlsson, Michele Simonetti, Christina Galonska, Hanna van Ooijen, Tomasz Kallas, Divya Thiagarajan, Maud Schweitzer, Ludvig Larsson, Vincent van Hoef, William Love, Jerell Aguila, Simon Fredriksson, Michael Forster
LB042 · PDF 阐明上皮性卵巢癌特有的血浆细菌源性及宿主源性代谢物 Elucidating plasma bacterial and host derived metabolites unique to epithelial ovarian cancer Diane E. Mahoney, Ilce Medina-Meza
LB044 · PDF 一个化学蛋白质组学光亲和平台(PAfBPP)实现马兜铃酸诱导肾毒性的靶点鉴定和机制解析 A chemoproteomic photoaffinity platform(PAfBPP) enables target identification and mechanistic dissection of aristolochic acid-induced nephrotoxicity Nan Chen, Biwei Liu, Wenqi Meng

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