PO.CL05.03 · 临床研究
Combination Immunotherapies
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3786 · PDF 多塔利单抗(dostarlimab)在标准治疗根治性放疗基础上用于医学上无法手术的子宫内膜癌患者的外周免疫特征 Peripheral immune signature of dostarlimab in addition to standard of care definitive radiation in patients with medically inoperable endometrial cancer Liyun Chen, Rachel Furuya, Linda Odibo, Lulu Sun, David Mutch, Carolyn McCourt, Matthew A. Powell, Julie K. Schwarz, Jessika A. Contreras, Premal H. Thaker, Stephanie Markovina
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3787 · PDF PARP抑制剂联合免疫检查点抑制剂与免疫检查点抑制剂单药治疗的安全性比较:一项随机对照试验的系统评价、meta分析和试验序贯分析 The safety of PARP inhibitors combined with immune checkpoint inhibitors versus immune checkpoint inhibitor monotherapy: A systematic review, meta-analysis, and trial sequential analysis of randomized controlled trials Mus'ab Theeb Mustafa, Aws Khalid Abushanab, Ahmad Yousef Alazzam, Mahmoud Taysir Mousa, Ahmad Sa'ed, Noor N. Al-Bzour, Osama Wadah Rammaha, Zaher Mutaz Ashour, Hamza Muneer Alakhras, Yihea Mohammad Al-Mashaqbah, Ahmad Sami Othman, Nour Maher Mustafa, Renad Fawwaz Al Banawi, Anwaar Saeed
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3788 · PDF 整合单细胞分析识别与PD-L1阳性晚期NSCLC患者接受SBRT序贯阿替利珠单抗(atezolizumab)联合替瑞利尤单抗(tiragolumab)治疗临床获益相关的生物标志物 Integrated single-cell analysis identifies biomarkers associated with clinical benefit in patients with PD-L1 positive, advanced NSCLC treated with SBRT followed by atezolizumab plus tiragolumab Jii Bum Lee, Dong Kwon Kim, Sang Hoon Lee, Kyung Hwan Kim, Su-Jin Choi, Min Hee Hong, Byoung Chul Cho, Sun Min Lim
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3789 · PDF 以ACR-2316(一种潜在的首创及同类最佳WEE1/PKMYT1抑制剂)联合抗PD-L1治疗可诱导完全肿瘤消退并产生持久免疫记忆 Treatment with ACR-2316, a potential first- and best-in-class WEE1/PKMYT1 inhibitor, combined with anti-PD-L1 induces complete tumor regression with durable immune memory Taronish Dubash, Joelle Baddour-Sousounis, Amira Elbakry, Jessica Hopkins, Subodh Kumar, Yingchun Spring Liu, Ahmed Youssef, Kate Rappard, Ignacio Arribas Diez, Georgia Mista, Marc Isaksson, Francisco Santana, Luka Romero, Zachary Best, Nina Lipjankic, Anna-Maria Alves, Daphne García-López, Portia Lombardo, Calvin Yang, Emma Ahrman, Valentina Siino, Magnus E. Jakobsson, Helen Nilsson, Ayesha Murshid, Lei Shi, Caroline Wigerup, Michail Shipitsin, Joon Jung, David Proia, Kristina Masson, Peter Blume-Jensen
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3790 · PDF 联合抑制髓系细胞PI3Kgamma和调节性T细胞整合素alphavbeta8可促进持久的肿瘤抑制 Combined inhibition of myeloid cell PI3Kgamma and regulatory T cell integrin alphavbeta8 promotes durable tumor suppression Erpei Wang, Giuliana Mognol, MOHAMMAD AMJAD, Hui Chen, Mark Paradise, Dean Sheppard, judith Varner
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3791 · PDF 抑制Cry1通过促进抗肿瘤免疫逆转对基于T细胞的免疫治疗的耐药性 Cry1 inhibition reverses resistance to T cell-based immunotherapy by promoting anti-tumor immunity Tae Woo Kim, Oh Se Jin
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3792 · PDF EGFR促进NF1突变型黑色素瘤的免疫逃逸和免疫治疗耐药 EGFR promotes immune evasion and resistance to immunotherapy in NF1 mutant melanoma Milad Ibrahim, Irineu Illa-Bochaca, Tara Muijlwijk, Ines Delclaux, KATHERINE VENTRE, George Jour, Shi Qiu, Agrima Dutt, Paola Angulo salgado, Amanda W. Lund, Markus Schober, Iman Osman
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3793 · PDF 在cabozantinib/PD-1阻断诱导的受损肝脏中阻止NK细胞活化可提高肝细胞癌模型的生存率 Preventing nk cell activation in the damaged liver induced by cabozantinib/pd-1 blockade increases survival in hepatocellular carcinoma models Satoru Morita, Tomofumi Ando, Hiroto Kikuchi, Atsuyo Morita, Tatsuya Kobayashi, Grace Birch, Ryota Tanaka, Aya Matsui, Zhiping Ruan, Peigen Huang, Alexei Hernandez, Erin M. Coyne, Sarah M. Shin, Robin Kate Kelley, Mark Yarchoan, Stefan Halvorsen, Slim Sassi, Mari Mino Kenudson, Shadmehr Demehri, Rizwan Romee, Won Jin Ho, Dan Duda
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3794 · PDF ACR246,一种首创的5T4抗体药物偶联物(ADC),在临床前模型和食管癌患者中显示出可喜的抗癌疗效 ACR246, a first-in-class 5T4 antibody-drug conjugate (ADC), showed promising anticancer efficacy in preclinical models and patient with esophageal cancer Xi Jiao, Zhenwei Miao, Na Zhuo, Panpan Zhang, Jifang Gong, Feng Wang, Yan Dai, Li Yang, Wu Yao, Shanhui Weng, Johannes Nippgen, Lin Shen
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3795 · PDF CREPT-618:首个靶向CREPT的GalNAc-siRNA逆转HCC免疫逃逸并与抗PD-1协同 Crept-618: First GalNAc-siRNA targeting CREPT reverses HCC immune evasion and synergizes with anti-PD-1 Jianghua Li, Alex Zou, He Yang, Jiayu Wang, Weihua Yang, Zhijie Chang, Jun Li
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3796 · PDF 用HBS-101靶向midkine通过免疫激活和致癌通路抑制增强TNBC对化疗和免疫治疗的应答 Targeting midkine with HBS-101 enhances chemotherapy and immunotherapy response in TNBC via immune activation and oncogenic pathway suppression Baskaran Subramani, Megharani R. Mahajan, Panneerdoss Subbarayalu, Zhenming Xu, Neelam Mukherjee, Gangadhara R. Sareddy, Hareesh B. Nair, Ratna K. Vadlamudi, Suryavathi Viswanadhapalli
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3797 · PDF 一种新型三联疗法克服免疫抑制性肿瘤微环境并引发强劲的抗肿瘤活性 A novel tritherapy overcoming the immune suppressive tumor microenvironment elicits robust antitumor activity Brian G. Morreale, Andrea Monell, Han Yu, David B. Sykes, Jonathan F. Lovell, Michael J. Nemeth, Scott I. Abrams
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3798 · PDF AGX101(一种TM4SF1靶向的微管蛋白抑制剂偶联物)与免疫检查点抑制剂联合的体内结果 In vivo results of AGX101, a TM4SF1-directed tubulin inhibitor conjugate, in combination with immune checkpoint inhibitors Shou-Ching Jaminet, Paul Jaminet, Glen J. Weiss
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3799 · PDF 抑制HER3使转移性结直肠癌和胰腺癌对免疫治疗敏感 HER3 inhibition sensitizes metastatic colorectal and pancreatic cancer to immunotherapy Chao Wei, Moeez Ghani Rathore, Elizabeth Bryson, Kimberly Curry, Jennifer Baek, Jordan M. Winter, Rui Wang
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3800 · PDF VC2-GM-CSF溶瘤病毒与紫杉醇联合治疗在终末期乳腺癌动物模型中的协同效应 Combinational effects of VC2-GMCSF oncolytic virus and paclitaxel in end-stage breast cancer animal model Reza Ghavimi, Leila Rahimian, Vladimir Chouljenko, Harikrishnan Mohan, Ojasvi Dutta, Md Mehedi Hasan, Jeongha Lee, Minori Kojima, Jose Sezar Menk, Konstantin Kousoulas
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3801 · PDF 植物病毒免疫调节剂与IL-12联合治疗小鼠卵巢癌的协同疗效 Synergistic therapy by combination of a plant virus immunomodulator and IL-12 against murine ovarian cancer Xinyi Deng, Jessica Fernanda Affonso de Oliveira, Nicole F. Steinmetz
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3802 · PDF 适应性CD73上调削弱PARP抑制剂疗效并为晚期前列腺癌联合阻断创造治疗机会 Adaptive cd73 upregulation undermines parp inhibitor efficacy and creates a therapeutic opportunity for combined blockade in advanced prostate cancer Ping xie, Jie Fan, Hui Tang, Longzhen Song, Bin Zhang
- 3803 3803 单例患者中四种免疫治疗毒性的独特表现 The unique presentation of four immunotherapy toxicities in a single patient Orianna Guarisma-Lugo, Roderick Brice, Samuel Ramirez, Winston W. Tan
- 3804 3804 工程化CAR巨噬细胞联合抗肿瘤疗法以抑制脑转移 Engineering CAR macrophages in combination with anti-tumor therapies to suppress brain metastasis Shih-Ying Wu, Abhishek Tyagi, Eleanor Cecile Smith, Ravindra Pramod Deshpande, Jee Won Kim, Kounosuke Watabe
- 3805 3805 通过体内LNP递送通用嵌合适配体蛋白经T细胞衔接器激活固有免疫细胞以增强抗肿瘤免疫 Enhancing anti-tumor immunity via in vivo LNP delivery of a universal chimeric adapter protein to activate innate immune cells through T cell engagers Kevin Carbajal, Warren Anderson, Matthias Schroff, Maximilian Richter
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3807 · PDF 用于实体瘤靶向治疗的差异化EGFR/PDL1双特异性ADC的工程化设计与临床前开发 Engineering and preclinical development of a differentiated EGFR/PDL1 bispecific ADC for the targeted therapy of solid tumors Liang Zhu, Chen Chuan, Mei Tian, Dandan Liu, Jiyuan Tian, Lisha Dong, Yongxin Shang, Rongmei Yan, Kezhen Ye, Liang Tian, Jian Peng, Zhenping Zhu
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3808 · PDF 内分泌耐药乳腺癌中表达胶原的myCAFs和腔上皮祖细胞对PD-L1+肿瘤相关巨噬细胞的调控 Regulation of PD-L1 + tumor associated macrophages by collagen expressing myCAFs and luminal progenitors in endocrine-resistant breast cancer Nirmal Das, Cheng-Han Hsieh, Rumela Chakrabarti
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3809 · PDF Bax激活促进免疫活性并与PD-L1阻断免疫疗法协同对抗突变KRAS驱动的肺癌 Bax activation promotes immune activity and synergizes with PD-L1 blockade immunotherapy against mutant KRAS-driven lung cancer Abu Syed Md Anisuzzaman, Xingming Deng
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3810 · PDF 瘤内(IT)注射ruxotemitide(LTX-315)联合pembrolizumab治疗对PD-1/PD-L1疗法难治的不可切除晚期黑色素瘤患者:ATLAS-IT-05研究的最终结果 Intratumoral (IT) ruxotemitide (LTX‑315) in combination with pembrolizumab in patients with unresectable advanced melanoma refractory to PD-1/PD-L1 therapy: Final results from the ATLAS-IT-05 study Stéphane Dalle, Adi Diab, John M. Kirkwood, Miguel F. Sanmamed, Laurent Mortier, Marta Nyakas, Thomas Urban Marron, Maciej Gil, Øystein Rekdal, Karim A. Benhadji, Caroline Robert
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3811 · PDF 探索靶向三阴性乳腺癌细胞的免疫调节型肿瘤来源疫苗 Exploring immunomodulatory tumor-derived vaccines targeting triple negative breast cancer cells Marcio C. Bajgelman, Karina Thomaz, Daniela Mizobuti, Susana Ramalho, Sophie Derchain
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3812 · PDF 一种新型"播种与增强(Seed-and-Boost)"免疫疗法驱动强效TCR-T细胞扩增、肿瘤浸润和持久的肿瘤控制 A novel 'Seed-and-Boost' immunotherapy drives potent TCR-T cell expansion, tumor infiltration, and durable tumor control Kar Wai Tan, Kan Xing Wu, Jin Wei Tan, Melissa Wirawan, Yovita Purwanti, Ana Dios, Fan Zhao, Natasha Girgis, Alessandra Nardin, Evan W. Newell, Anish Suri, Steven N. Quayle, Michael Fehlings
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3813 · PDF 肿瘤治疗电场联合免疫疗法在实体瘤中的协同免疫调节:一项对胰腺导管腺癌具有转化意义的系统评价 Synergistic immunomodulation by Tumor Treating Fields combined with immunotherapy across solid tumors: A systematic review with translational relevance to pancreatic ductal adenocarcinoma. Douaa Albelal, Hari Krishnareddy Rachamala, Hani Babiker