PO.ET02.08 · 实验与分子治疗
Nanocarriers and Drug Delivery Systems
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3010 · PDF LIN-T(脂质整合标签):一种用于靶向治疗性mRNA递送的优化标签-脂质纳米颗粒设计 LIN-T (lipid integrated tag): An optimized tag-lipid nanoparticle design for targeted therapeutic mRNA delivery Tommy Lidström, Alexandros Kostakis, Rosanne Veerman, Venera Emruli, Safia Guleed, Tina Furebring, Jonas A. Nilsson, Sara Mangsbo
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3011 · PDF 一种STING增强的脂质纳米颗粒mRNA疫苗用于治疗性癌症疫苗接种 A STING-boosted lipid nanoparticle mRNA vaccine for therapeutic cancer vaccination Alessia Marrocu, Osama W. M. Hassuneh, Victor M. Moreno Zafra, Alaa Zam, Emre Demirel, Meriem Bahri, Adam Walters, James N. Arnold, Khuloud T. Al-Jamal
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3012 · PDF 脂质纳米颗粒在原代人T细胞中实现高效的CRISPR HDR介导的基因插入 Lipid nanoparticles enable high efficiency CRISPR HDR mediated gene insertions in primary human T cells Reka Geczy, Meenakshi Swaminathan, Hannah Ly, Mana Novin, Bernice Thommandru, Sijo Chemmannur, Sadik Kassim, Samuel Clarke
- 3013 3013 仿生外泌体递送的STAT3抑制剂用于口腔鳞状细胞癌细胞的放射增敏 Biomimetic exosome-delivered STAT3 inhibitor for radiosensitization in oral squamous cell carcinoma cells Kehua Hu, Sisi Yan, Xiaowan Guo, Rurui Xue, Yunli Mo, Hui Qiu, Linlin Bu, Qiuji Wu
- 3014 3014 在晚期前列腺癌中使用RNA生物工程技术和定制化脂质纳米颗粒靶向PLXND1 Targeting PLXND1 using RNA bioengineering technologies and customized lipid nanoparticles in advanced prostate cancer Huan Qu, Menghuan Tang, Qiufang Zong, Sohaib Mahri, Pengfei Xu, Joy C. Yang, Fan Wei, Junwei Zhao, Meijuan Tu, Neelu Bartra, Leyi Wang, Allen C. Gao, Kit Lam, Marc A. Dall'Era, Aiming Yu, Yuanpei Li, Chengfei Liu
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3015 · PDF 推动mRNA疗法迈向免疫肿瘤学应用:脂质纳米颗粒在正常小鼠和荷瘤小鼠中重复给药mRNA时展现出良好的安全性和有效性特征 Advancing mRNA therapeutics towards immuno-oncology applications: Lipid nanoparticles demonstrate favorable safety and efficacy profile with repeated mRNA administration in normal and tumor-bearing mice Sams MA Sadat, Avisek Deyati, Leanna Yee, Zhengyu Chen, Kalyan Golla, Tony Wu, Richard Jiang, Jay Paquette, Malathi Anantha, Noorjahan Aibani, Nikita Jain, Anitha Thomas
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3016 · PDF 通过脂质体递送和ATR抑制剂联合增强CX-5461在TNBC中的疗效 Enhancing CX-5461 therapy in TNBC through liposomal delivery and ATR inhibitor combination Henos S. Negash, Rachel K. Myrick, Sandro R.P. da Rocha, J. Chuck Harrell
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3017 · PDF 长春瑞滨与多柔比星在游离溶液和脂质体中于多细胞球体模型的联合效应 Combination effect of vinorelbine and doxorubicin in free solutions and liposomes in a multicellular spheroids model Yong Zhu, Zizhao Xu, Yifan Lu, Shen Zhao, Md Delowar Hossain, Xin Guo
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3018 · PDF 脂聚合物介导的融合癌基因靶向siRNA递送在血液系统恶性肿瘤临床前模型中减轻白血病负荷并改善生存 Lipopolymer-mediated delivery of fusion oncogene-targeting siRNAs attenuates leukemia burden and improves survival in preclinical models of hematologic malignancies Mohammad Nasrullah, Remant KC, Spencer B. Gibson, Xiaoyan Jiang, Olaf Heidenreich, Joseph Brandwein, Hasan Uludag
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3019 · PDF 首个基于凝聚层的递送系统用于干细胞中高效且安全的基因工程 The first coacervate based delivery system for efficient and safe genetic engineering in stem cells Peipei Zhu, Manman Lu, Qing Zhang, Renxia Zhang, Lihong Jiang, Xiaowen Fei, Xiaofei Gao
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3020 · PDF 淋巴细胞拟态药物载体实现向淋巴结的靶向治疗递送以增强免疫调节 Lymphocyte-mimetic drug carriers enable targeted therapeutic delivery to lymph nodes for enhanced immunomodulation Michael J. Donzanti, Luisa A. Fink, Bahar Bahramimeimandi, Kayla Katz, Dylan T. Ngo, Ana Obradovic, Ryan Zurakowski, Jason P. Gleghorn
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3021 · PDF ONM-421,一种pH响应型聚合物-药物偶联物纳米颗粒,将MMAE递送至实体瘤并在小鼠中展现出抗原非依赖性的抗肿瘤疗效 ONM-421, a pH-responsive polymer-drug conjugate nanoparticle, delivers MMAE to solid tumors and shows antigen-independent antitumor efficacy in mice Jason B. Miller, Stephen Gutowski, Qingtai Su, Bhargavi Allu, Austin Burcham, Zirong Chen, Ruolan Han, Tian Zhao
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3022 · PDF 一种基于肽的药物递送系统用于靶向转移性前列腺癌 A peptide-based drug delivery system to target metastatic prostate cancer Yukihito Kuroda, Norio Miyamura, Chisato M. Yamazaki, Erkki Ruoslahti, Tambet Teesalu, Kazuki Sugahara
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3023 · PDF 辣椒素纳米颗粒在人类NSCLC中表现出强效的生长抑制活性 Capsaicin nanoparticles display robust growth-inhibitory activity in human NSCLC Kushal Jignesh Modi, Reagan S. Light, Kaitlyn B. Conley, Sarah L. Miles, Piyali Dasgupta
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3024 · PDF 通过新型NCI-H929脂质提取物修饰纳米脂质体增强多发性骨髓瘤的靶向递送 Enhancing targeted delivery in multiple myeloma via novel NCI-H929 lipid-extracted-modified nanoliposomes Kenny D. Pham, Shivmani Barve, Robert B. Campbell
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3025 · PDF 用于癌症治疗的自协同互向前药脂质体共靶向氧化还原稳态与PIN1 Self-synergizing mutual prodrug liposomes co-targeting redox homeostasis and PIN1 for cancer therapy Nuri Kim, Dongwon Lee
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3026 · PDF 用于肿瘤特异性药物递送的聚合物-药物偶联物平台:一种经临床验证的超pH敏感胶束技术的进展 A polymer-drug conjugate platform for tumor specific drug delivery: Advancement of a clinically validated ultra pH-sensitive micelle technology Qingtai Su, Stephen Gutowski, Bhargavi Allu, Austin Burcham, Zirong Chen, Ruolan Han, Jason B. Miller, Tian Zhao
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3027 · PDF 具有优化胆固醇浓度和源自模型低级别浆液性卵巢癌细胞系脂质提取物的纳米脂质体的细胞摄取 Cellular uptake of nanoliposomes with optimized cholesterol concentration and lipid extract derived from a model low grade serous ovarian carcinoma cell line Sofia Orlando, Krishna Panchal, Heer Patel, Robert B. Campbell
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3028 · PDF 研究常规及新型阳离子纳米脂质体中的磷脂酰胆碱和磷脂酰乙醇胺磷脂与慢性髓性白血病细胞体外相互作用 Investigating phosphatidylcholine and phosphoethanolamine phospholipids in conventional and novel cationic nanoliposomes for interactions with chronic myeloid leukemia cells in vitro Shivmani Y. Barve, Robert B. Campbell
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3029 · PDF 用于乳腺癌精准联合化疗的模块化脂质基口服药物递送系统 A modular lipid-based oral drug delivery system for precision combination chemotherapy in breast cancer Shailvi Soni, Terrick Andey
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3030 · PDF SU-CCS-1脂质提取物修饰纳米脂质体及模型透明细胞肉瘤靶细胞系的特征性生长谱 SU-CCS-1 lipid extract-modified nanoliposomes and characteristic growth profile of a model clear cell sarcoma target cell line Ashley Silva, Abigail Chan, Simoun Banoud, Charloote Bouchard, Robert B. Campbell
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3031 · PDF 通过乳源性细胞外囊泡增强多柔比星在肺癌细胞中的递送 Enhanced delivery of doxorubicin via milk-derived extracellular vesicles in lung cancer cells Cayden Xuanzhang Xia, Elise Copeland, Akhil Srivastava
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3032 · PDF 电穿孔增强的靶向博来霉素递送用于治疗犬肛周肿瘤 Electroporation-enhanced targeted bleomycin delivery for the treatment of canine perianal tumors Sergio Fernando Salgado, Josmell David Mestanza, Andrea Hatsumi Bazan, Micaela Vizquerra, Mitzi Westreicher, Nandi Ken Candela
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3033 · PDF 电化学疗法治疗直肠腺癌:通过电穿孔推进药物递送 Electrochemotherapy for rectal adenocarcinoma: Advancing drug delivery through electroporation Sergio Fernando Salgado, Josmell David Mestanza, Micaela Vizquerra, Mitzi Westreicher, Nandi Ken Candela, Andrea Hatsumi Bazan
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3034 · PDF 电穿孔增强博来霉素递送治疗犬猫实质性器官肿瘤的可行性与安全性 Feasibility and safety of electroporation-enhanced bleomycin delivery for the treatment of parenchymal tumors in dogs and cats Sergio Fernando Salgado, Andrea Hatsumi Bazan, Josmell David Mestanza, Nandi Ken Candela, Mitzi Westreicher, Micaela Vizquerra
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3035 · PDF 电化学疗法作为局部控制犬棘皮瘤型成釉细胞瘤的创新药物递送方式 Electrochemotherapy as an innovative drug delivery modality for local control of canine acanthomatous ameloblastoma Sergio Fernando Salgado, Andrea Hatsumi Bazan, Josmell David Mestanza, Micaela Vizquerra, Nandi Ken Candela, Mitzi Westreicher
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3036 · PDF 用于高效有效地向实体瘤递送治疗药物的Intellipulse平台 Intellipulse platform for efficient and effective delivery of therapeutics to solid tumors Richard Heller, Loree Heller, Jody Synowiec, Julie Singh, Alex Otten, Mark J. Jaroszeski
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3037 · PDF 研究纳米晶PRMT5抑制剂在胰腺导管腺癌中的治疗潜力 Investigating the therapeutic potential of a nanocrystal PRMT5 inhibitor in pancreatic ductal adenocarcinoma Faranak Alipourgivi, Zhongyue (Claire) Yuan, Rahaf Habboub, Yoon Yeo, Tao Lu