PO.ET06.04 · 实验与分子治疗

Molecular Targets 1

28 张海报 27 张含资料时间 Apr 20 2026 2:00PM 区域 Section 13

2979 · PDF MAPK驱动的着丝粒不稳定性作为胶质母细胞瘤的生物标志物及治疗易感点 MAPK driven kinetochore instability as a biomarker and therapeutic vulnerability in glioblastoma Jennifer DeLuca, Patrick J. Paddison
2980 · PDF SMARCA2和SMARCA4在癌症中的表达：一项对134种不同肿瘤类型的14,966例肿瘤的组织微阵列研究 SMARCA2 and SMARCA4 expression in cancer: A tissue microarray study on 14,966 tumors from 134 different tumor types Nina Schraps, Anne Menz, Florian Lutz, Viktoria Chirico, Florian Viehweger, David Dum, Ria Schlichter, Andrea Hinsch, Fiete Gehrisch, Christoph Fraune, Christian Bernreuther, Seyma Büyücek, Martina Kluth, Claudia Hube-Magg, Katharina Möller, Viktor Reiswich, Andreas M. Luebke, Patrick Lebok, Baris Mercanoglu, Nathaniel Melling, Thilo Hackert, Guido Sauter, Maximilian Lennartz, Till S. Cauditz, Andreas H Marx, Ronald Simon, Stefan Steurer, Eike Burandt, Natalia Gorbokon, Maria Christina Tsourlakis, Sarah Minner, Till Krech, Morton Freytag
2981 · PDF PM54靶向多种癌症类型中的致癌转录网络 PM54 targets oncogenic transcriptional networks across multiple cancer types Ismael Fernández-Miranda, Javier Robles, Maria José Guillen, Pablo Avilés, Marcelo L. Ribeiro, Carmen Cuevas
2982 · PDF 高迁移率族核小体结合结构域蛋白3（HMGN3）在前列腺癌进展中的作用：一个新型治疗干预靶点 Role of high mobility group nucleosome-binding domain-containing protein 3 (HMGN3) in prostate cancer progression a novel target for therapeutic intervention Vikkram Venkatesan, Jeffrey Mathew, Janani Harikrishnan, Gnanasekar Munirathinam
2983 · PDF 全基因组CRISPRi筛选鉴定RPS27为TP53突变型癌症的新型合成致死靶点 Genome-wide CRISPRi screen identifies RPS27 as a novel synthetic lethal target for TP53 mutant cancers Stephen Paik, Yi Yu, Ashley H. Choi, Samuel R. Meier, Shangtao Liu, Binzhang Shen, Shanchuan Zhao, Xuewen Pan, Jannik N. Andersen, Teng Teng
2984 · PDF 整合素α5的原位与功能分析揭示其在非小细胞肺癌肿瘤进展中的作用 In situ and functional analysis of Integrin-alpha 5 reveals its role in tumor progression in non-small cell lung cancer Mirei Ka, Takahiro Ando, Munetoshi Hinata, Kousuke Watanabe, Akiko Kunita, Masanori Kawakami, Masaaki Sato, Hiroyuki Okada, Hironori Hojo, Tetsuo Ushiku, Cecilia C. Krona, Patrick Micke, Katsutoshi Oda, Hidenori Kage
2985 · PDF TRIB2作为ALK重排非小细胞肺癌的治疗脆弱性靶点 TRIB2 as a therapeutic vulnerability in ALK-rearranged non-small cell lung cancer Jitender Monga, Sudha Sadasivan, Sang-Yoon Lee, Sharad K. Suthar, Craig Rogers, Shirish Gadgeel
2986 · PDF 垂直抑制自噬通路促进胰腺导管腺癌的生长停滞和凋亡性细胞死亡 Vertical inhibition of the autophagy pathway promotes growth arrest and apoptotic cell death in pancreatic ductal adenocarcinoma Mallory K. Roach, Jonathan M. DeLiberty, Seamus Degan, Lily M. Pita, Elyse G. Schechter, Noah L. Pieper, Runying Yang, Mariaelena Pieronon, Clint A. Stalnecker, Emanuel Frank Petricoin, Kirsten L. Bryant
2987 · PDF 虫草素通过靶向NAT10介导的VCAN的ac4C RNA修饰抑制肝内胆管癌进展 Cordycepin inhibits Intrahepatic cholangiocarcinoma progression by targeting NAT10-mediated ac4C RNA modification of VCAN Yuting Zhao, Yinzhao Chen, Yuhan Fang, Kai Luo, Jialin Qu, Dong Shang, Caiming Xu, Guixin Zhang
2988 · PDF 可成药基因组筛选鉴定β-catenin转录靶点为硬纤维瘤细胞的脆弱性 A druggable genome screen identifies b-catenin transcription targets as desmoid cell vulnerabilities Jia Hu, Tianjie Pu, Vladislav Tsiperson, Lakshana Senthilkumar, Katherine Prendergast, Narasimhan P. Agaram, Marco Russo, Sameul Singer, Ralph Garippa, Meera Hameed, Aimee Crago
2989 · PDF ONCO Prime平台助力发现基因分层癌症的合成致死靶点 ONCO Prime platform enables discovery of synthetic lethal targets for genetically stratified cancers Andrzej Mazan, Eliza Zimolag, Joanna Szuszkiewicz, Marcin Serocki, Oleksii Bryzghalov, Izabella Wieckowska, Marcelina Chmiel, Katarzyna Sarad, Julia Wirkijowska, Wiktoria Luczak, Szymon Woroszylo, Dariusz Klonski, Kamil Kus, Andrew Thomason, Michal Mikula, Rafal Dziadziuszko, Krzysztof Brzozka
2990 · PDF PSMA在肿瘤细胞及肿瘤相关血管中的表达：一项评估来自135种不同肿瘤类型的12,409例癌症的组织芯片研究 PSMA expression in neoplastic cells and tumor-associated vasculature: A tissue microarray study evaluating 12,409 cancers from 135 different tumor types Fiete Gehrisch, Alexandra Malinowski, Anne Menz, Florian Lutz, Viktoria Chirico, Florian Viehweger, David Dum, Ria Schlichter, Andrea Hinsch, Christoph Fraune, Christian Bernreuther, Seyma Büyücek, Martina Kluth, Claudia Hube-Magg, Georgia Makrypidi-Fraune, Nina Schraps, Katharina Möller, Andreas M. Luebke, Patrick Lebok, Guido Sauter, Maximilian Lennartz, Frank Jacobsen, Till S. Clauditz, Andreas H. Marx, Ronald Simon, Stefan Steurer, Eike Burandt, Nathalia Gorbokon, Maria C. Tsourlakis, Sarah Minner, Till Krech, Morton Freytag, Viktor Reiswich
2991 2991 与杂交捕获DNA-NGS相比，基于扩增子的DNA和RNA NGS联合检测在中国实体瘤中对NTRK融合具有更优的检出能力 Superior detection of NTRK fusions across Chinese solid tumors using amplicon-based DNA and RNA NGS co-detection compared with hybrid-capture DNA-NGS Mingqian Lu
2992 · PDF FOXD1在甲状腺癌间变性转化中的作用 The role of FOXD1 in the anaplastic transformation of thyroid cancer Aki Inase, Mitsuyoshi Hirokawa, Miyoko Higuchi, Naoyoshi Onoda, Takuya Higashiyama, Taiji Koyama, Shiro Kimbara, Masanori Teshima, Hironobu Minami, Ken-Ichi Nibu, Mitch A. Phelps, Naomi Kiyota
2993 · PDF 解析糖基转移酶GALNT14在骨肉瘤发生中的关键作用 Deciphering the key role of the glycosyltransferase GALNT14 in osteosarcoma tumorigenesis D. Isabel Petrescu, Tajhal D. Patel, Shoshana Leeds, Jeffrey Ritzenthaler, Heath Bradley, Juan Dou, Jason T. Yustein
2994 · PDF I-SPY2 HER2+乳腺癌的整合通路分析揭示药物重定位机会 Integrative pathway analysis of I-SPY2 HER2+ breast cancers reveals drug-repurposing opportunities Kingsley V. Chow, Tam Binh Bui, Denise M. Wolf, Annuska Glas, Zheyun Xu, Gillian L. Hirst, I-SPY2 investigators, Amy Clark, Julia Wulfkhule, Angie DeMichele, Emanuel Frank Petricoin, Laura J. Esserman, Jennifer Rosenbluth, Laura van 't Veer, Rosalyn W. Sayaman
2995 · PDF ATRX框内融合在神经母细胞瘤中促进内源性化疗耐药程序但产生免疫治疗脆弱性 ATRX in-frame fusions promote endogenous chemoresistance programs but yield immunotherapeutic vulnerabilities in neuroblastoma Mohammad Ali Mohammad Nezhady, Sheetal Bhatara, Siarhei Hladyshau, Estevez Prado Daniel, Vernon Ebegboni, Alja Kozulic-Pirher, Arnav Barpujari, Bo Wang, Yuan Feng, Qiqi Jin, Xueying Liu, Paul Geeleher, Xiaotu Ma, Jiyang Yu, Emily Bernstein, Kelly Goldsmith, Hunter Jonus, Adam D. Durbin
2996 · PDF 胆固醇破坏增强食管癌细胞中B7-H3的内化 Internalization of B7-H3 is enhanced by cholesterol disruption in esophageal cancer cells Takashi Imajima, Kenji Tsuchihashi, Takafumi Kitazono, Wataru Kusano, Eishi Baba
2997 · PDF LTA4H通过mTOR激活和T细胞耗竭促进肝内胆管癌进展 LTA4H promotes intrahepatic cholangiocarcinoma progression via mTOR activation and T-cell exhaustion Ganglian Lin, Jinhui Wang, Yizhuo He, Fangkai Feng, Chongming Zheng, Yi Wang
2998 · PDF 谱系可塑性与前列腺癌进展过程中生物钟通路的紊乱 Disrupted clock pathway during lineage plasticity and prostate cancer progression Nishat Manzar, Himisha Beltran
2999 · PDF 靶向p53缺陷型头颈癌中的胆固醇通路 Targeting cholesterol pathways in p53 deficient head and neck cancers Jovanka Gencel-Augusto, Nuo Tian, Akshat Singhal, Hua Li, Liam Woerner, Arthur Goldberg, Daniel E. Johnson, Jennifer Rubin Grandis
3000 · PDF 肿瘤电场治疗（TTFields）可能削弱胶质母细胞瘤网络连接性，对恶性程度具有影响 Tumor Treating Fields (TTFields) may weaken glioblastoma network connectivity, with implications for malignancy Julius Beichert, Jonas A. Kretz, Jena Kim, Xiaoyu Ma, Daniel Dominguez Azorín, Andreas E. Moor, Haikun Liu, Miriam Ratliff
3001 · PDF 靶向致癌性miR-181a加工的癌症治疗性抑制 Therapeutic inhibition of oncogenic miR-181a processing for cancer therapy Grace McIntyre, Jessica Mathew, Zoe Jackson, Meghana Choragudi, Madison Uyemura, Aaron Robida, Renju Jacob, Jose Colina, Jiaming Yao, Hang Yang Wong, Rachel Offenheim, Mark Kunkel, Sriram Chandrasekaran, Peter Toogood, Analisa DiFeo
3002 · PDF 非整倍性作为一种代谢弱点：在鳞状细胞癌中发掘新型治疗靶点 Aneuploidy as a metabolic liability: Exploiting novel therapeutic targets in squamous cell carcinomas Nadja Zhakula, Sejal Jain, Zeinab Amini-Farsani, Jiankang Zhang, Mari Nakamura, Laura Byron, Joan J. Castellano-Perez, Tannishtha Reya, Matthew L. Meyerson, Alison M. Taylor
3003 · PDF 测序技术对肺癌精准肿瘤学中可操作融合检测的影响 Impact of sequencing technology on actionable fusion detection in precision oncology for lung cancer Gabriel Bandeira do Carmo, Rafael Canfield Brianese, Karina Miranda Santiago, Adriano Bonaldi, Marina De Brot Andrade, Giovana Tardin Torrezan, Dirce Maria Carraro
3004 · PDF OXTR靶向局部治疗可能是胸膜间皮瘤的一种有前景的策略 OXTR targeted local therapy could be a promising strategy for pleural mesothelioma Ichidai Tanaka, Hideyuki Itoigawa, Kazumi Hori, Shoichiro Fukuda, Heng Huang, Haruka Takata, Taketo Kato, Mitsuo Sato, Yoshitaka Sekido, Shinobu Shimizu, Tatsuhiro Ishida, Toyofumi Fengshi Yoshikawa, Makoto Ishii
3005 · PDF ODM-212（一种新型泛TEAD抑制剂）在原发性和转移性实体瘤患者中的离体试验 Ex vivo trial of ODM-212, a novel pan-TEAD inhibitor, in patients with primary and metastatic solid tumors Juha K. Rantala, Eetu Välimäki, Janne Suhonen, Reetta Riikonen, Anu-Maarit Moilanen
3006 · PDF PIK3CA突变驱动乳腺癌起始的基因组决定因素 Genomic determinants of PIK3CA mutation driven breast cancer initiation Snehal B. Bhandare, Ruizhong Wang, Poornima Bhat-Nakshatri, Stephanie Adama, Sarah R. Spivak, Farzaneh Behzadnia, Cihat Erdogan, Hongyu Gao, Yunlong Liu, Lylah H. Hutson, Xin Dauterman, George Sandusky, Harikrishna Nakshatri

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