Modifiers of Inflammation and the Tumor Microenvironment

• 2891 · PDF TREM-1阻断起始的特异性与时机影响其在癌症中的治疗疗效 Specificity and timing of TREM-1 blockade initiation impact its therapeutic efficacy in cancer Alexander B. Sigalov
• 2892 · PDF cLRRC15-IFNa（一种将IFNa特异性靶向LRRC15+ CAF的条件激活型生物制剂）的安全性与活性 Safety and activity of cLRRC15-IFNa, a conditionally active biologic targeting IFNa specifically to LRRC15+ CAFs Justin Killebrew, Linda Liang, Shannon Okada, Aelish Guinn, Alton Etheridge, Brett Robison, David Colby, David Jurchen, Jacqueline Pham, Jamie Nguyen, John Skonier, Kendyl Daniels, Kerri Thomas, Laura Carlucci, Lynn Amon, Megan Sprague, Meri Galindo, Remington Lance, Sam Wrenn, Sandra Notonier, Shannon Fallen, Shea McClain, Wendy Curtis, Zane Kraft, John Mulligan, Diane Hollenbaugh
• 2893 · PDF 选择性抑制eIF4A靶向肿瘤相关巨噬细胞以恢复淋巴瘤特异性免疫 Selective inhibition of eIF4A targets tumor-associated macrophages to restore lymphoma-specific immunity Haley Lynn Klimaszewski, A. Douglas Kinghorn, Michael R. Grever, Robert A. Baiocchi, John T. Patton
• 2894 · PDF 表达IL-12的甲病毒复制子重编程肿瘤相关巨噬细胞和中性粒细胞并诱导抗肿瘤免疫 Alphavirus replicon expressing IL-12 reprograms tumor-associated macrophages and neutrophils and induces anti-tumor immunity Forrest Bowling, Momoko Ishikawa, Dhanya Nambiar, Jayalaxmi Sastri, Keiko Ishimoto, Fumiya Tao, Koyo Takahashi, Ivan Stepanek, Hongbin Cao, Davis Leitner, Kenta Matsuda, Fred Baik, John Sunwoo, Quynh Thu Le, Jonathan Smith, Wataru Akahata
• 2895 · PDF JAK抑制通过调节干扰素驱动的耐药增强胶质瘤的病毒治疗 JAK inhibition enhances virotherapy in gliomas by modulating interferon-driven resistance Andres R. Lopez-Rivas, Andrew Gregg Gillard, Akhila Parthasarathy, Dong Ho Shin, Angelis Morales-Rivera, Claudia Solbes-Godina, Alejandra Duran, Joy Gumin, Christopher A. Alvarez-Breckenridge, Marta M Alonso, Frederick F. Lang, Juan Fueyo, Candelaria Gomez-Manzano
• 2896 · PDF 靶向TGR5的治疗消除胆管癌中胆汁酸驱动的髓系细胞免疫抑制 Therapeutic targeting of TGR5 abrogates bile acid driven myeloid cell immunosuppression in cholangiocarcinoma Enis Hikmet Ozmert, Binbin Li, Jingchun Yang, Hannah Elizabeth Stumpf, Jessica R. Willhite, Danielle Carlson, Jennifer L. Tomlinson, Jon Covel, Raghuveer Ramachandra, Steven Olson, Rory L. Smoot, Sumera Ilyas
• 2897 2897 一种患者来源的碎片化肿瘤检测方法，利用scRNAseq详细评估肿瘤微环境（TME）中的药物反应 A patient-derived fragmented tumor assay for detailed evaluation of drug response in the tumor microenvironment (TME) using scRNAseq Daniel C. Rabe, Daniel J. Gorski, Shiyuan Zheng, Mary Flaherty, Tommy Trieu, A'Riane Branch, Terykah Hollis, Lovepreet Singh Chahal, Brian Roberts, Richard A. Klinghoffer, Sonal Khare
• 2898 · PDF 衰老相关的区域淋巴结形态学改变促进结直肠癌免疫抑制性微环境 Aging-related morphological change in regional lymph nodes promotes an immunosuppressive microenvironment in colorectal cancer Kosuke Kanemitsu, Rin Yamada, Daiki Yoshii, Yukio Fujiwara, Yoshiyuki Tagayasu, Teruki Sako, Kota Arima, Kohei Yamashita, Kazuto Harada, Norihisa Hanada, Yoshihiro Komohara, Masaaki Iwatsuki
• 2899 · PDF 溶瘤病毒-化疗联合可改善对PDAC生长和扩散的控制 Oncolytic virus-chemotherapy combination improves control of PDAC growth and spread Biplov Sapkota, Naveen Chintala Ramulu, Shreya Pokharel, Mohammed T. Hussain, Brent Stanfield, Konstantin Kousoulas, Joseph Francis
• 2900 · PDF 激活cGAS-STING信号通路作为胶质母细胞瘤的一种免疫治疗策略 Activation of the cGAS-STING signaling pathway as an immunotherapeutic approach to glioblastoma Louise Leparc, Judit Sanchez Gil, Hiroaki Wakimoto
• 2901 · PDF 对基质CAF驱动的结直肠癌免疫排斥的整合空间、单细胞和体内解析 Integrated spatial, single-cell, and in vivo dissection of matrix CAF-driven immune exclusion in colorectal cancer Yuki Nakanishi, Kosuke Iwane, Yu Muta, Kento Yasumura, Mayuki Omatsu, Naoki Aoyama, Munehiro Ikeda, Yoko Masui, Go Yamakawa, Yasuhiro Fukui, Hiroaki Kasashima, Akihisa Fukuda, Hiroshi Seno
• 2902 · PDF 解析脂质相关巨噬细胞在肝细胞癌免疫治疗耐药中的功能 Deciphering the function of lipid-associated macrophages in immunotherapy resistance of hepatocellular carcinoma Xiaohang Long, Yaxian Wang, Siyuan HUANG, Joaquim Si Long VONG, Joseph Jao-Yiu Sung, Lam, Stephen CHAN, Alfred Sze-Lok Cheng
• 2903 · PDF 利用代谢抑制剂调节肿瘤微环境（TME）以增强抗肿瘤免疫 Modulating the tumor microenvironment (TME) to enhance anti tumor immunity using metabolic inhibitors Takeshi Ito, Shun Kishimoto, Kazutoshi Yamamoto, Jeffrey Brender, Frank Echtenkamp, Daniel Crooks, Murali Cherukuri Krishna, William Marston Linehan
• 2904 2904 传染性法氏囊病病毒（IBDV）作为一种在不同癌症模型中刺激固有和适应性免疫反应的新型病毒疗法 Infectious bursal disease virus (IBDV) as a novel virotherapy for stimulating innate and adaptive immune responses in different cancer models Vicent Tur Planells, Yonina Bykov, Gloria Dawodu, Leticia Perez Rodriguez, Noemi Garcia Romero, Angel Ayuso Sacido, Jordi Cano Ochando, Daniel Lozano Ojalvo, Adolfo Garcia Sastre, Estanislao Nistal Villan, Sara Cuadrado Castano
• 2905 · PDF 胰腺腺癌免疫肿瘤微环境由差异性miRNA表达所塑造 Pancreatic adenocarcinoma immune tumor microenvironment is shaped by differential miRNA expression Maksymilian Jan Pilecki, Shannon M. Wallet, Robert Maile, Gerik Tushoski- Alemán, Song Han, Steven J. Hughes
• 2906 · PDF iRGD肽重编程肿瘤微环境并在晚期人源化PDAC小鼠模型中增强免疫治疗疗效 The iRGD peptide reprograms the tumor microenvironment and potentiates immunotherapy in an advanced humanized PDAC mouse model. Norio Miyamura, Yukihito Kuroda, Kodai Suzuki, Yuki Kunisada, Hotaka Kawai, Henri Havia, Tero Järvinen, Moriya Tsuji, Kazuki N. Sugahara
• 2907 · PDF 肿瘤微环境表型作为免疫浸润潜在生物标志物的特征分析 Characterization of tumor microenvironment phenotypes as potential biomarkers for immune infiltration Iqra A. Arif, Ruchi Shah, Katherine A. Johnson, Cheri A. Pasch, Dustin Deming
• 2908 2908 SR-A拮抗作用重塑肿瘤免疫微环境的髓系细胞群，扩增CD8阳性T细胞，并在体内增强抗肿瘤疗效 SR-A antagonism remodels the myeloid population of tumor immune microenvironment, expands CD8-positive T cells, and enhances antitumor efficacy in vivo Steven R. Post, Fariba Jousheghany, Thomas J. Kelly, Charles M. Quick, Behjatolah M. Karbassi
• 2909 · PDF 靶向USP22重编程肿瘤微环境并使KRAS突变、TP53缺失型肺癌对免疫治疗敏感 Targeting USP22 reprograms the tumor microenvironment and sensitizes KRAS-mutant, TP53-Null Lung cancer to immunotherapy Keqiang Zhang, Ching Ouyang, jinhui Wang, Wendong Li, Walter Tsark, Yuanyuan Gao, Mingxiao Yang, Aimin Li, Colt Egelston, Crystal Marconett, Dan Raz
• 2910 · PDF GRN缺失松解基质屏障并增强MHC-II信号，但降低MHC-I驱动的细胞毒性免疫 GRN deficiency loosens stromal barriers and enhances MHC-II signaling yet reduces MHC-I driven cytotoxic immunity Feng Guo, Boping Jing, Tadahito Yasuda, Mayu Yasuda, Hudie Li, Fabio N. de Mello, Alan Y. Wang
• 2911 · PDF Versican表达与蛋白水解作为跨癌种和分子谱的CD8+ T细胞浸润生物标志物 Versican expression and proteolysis as a biomarker for CD8+ T cell infiltration across cancer types and molecular profiles Ruchi Shah, Elizabeth L. Field, Cheri Pasch, Dustin A. Deming
• 2912 2912 SECN-15：反义寡核苷酸介导的Neuropilin-1抑制增强抗肿瘤免疫并克服实体瘤中的检查点抑制剂耐药 SECN-15: Antisense oligonucleotide-mediated Neuropilin-1 suppression enhances anti-tumor immunity and overcomes checkpoint inhibitor resistance in solid tumors Andre Maaske, Sven Michel, Anne Sadewasser, Julia Festag, Monika Schell, Janani Sekar, Stefanie Raith, Frank Jaschinski, Richard Klar
• 2913 2913 I型干扰素重编程中性粒细胞-T细胞相互作用以增强抗肿瘤免疫并为食管癌的联合策略提供依据 Type I interferon reprograms neutrophil-T cell interactions to enhance antitumor immunity and informs a combinatorial strategy for esophageal cancer Tingxuan Gu, Kun Yu, Zigang Dong
• 2914 · PDF 利用工程化溶瘤单纯疱疹病毒调控肿瘤微环境以促进强效抗肿瘤应答 Modulating the tumor microenvironmentwith an engineered oncolytic herpesvirus facilitates potent antitumor response Joseph Najjar, Geetanjali Geetanjali, Chase Kangas, Vk Gadi, Bin He
• 2915 · PDF 肿瘤内在性METTL5通过损害卵巢癌中ATF4的翻译来限制T细胞诱导的铁死亡 Tumor-intrinsic METTL5 restricts T cell-induced ferroptosis by impairing ATF4 translation in ovarian cancer Jiakai Hou, Cheng-wei Ju, Nicholas A. Egan, Yanjun Wei, Yunfei Wang, Minghao Dang, Tianyi Zhou, Leilei Shi, Ningbo Zheng, Si Chen, Ashley Guerrero, Xiaofang Liang, Wanfu Wu, Areej Akhtar, Chitra Dhiman, Debanwita Roy Burman, Andro Gerges, Mason D. Flores, Han Li, Li-Sheng Zhang, Marleen Kok, Xiaobo Mao, Linghua Wang, Qin Feng, Yiwen Chen, Sanghoon Lee, Daniel McGrail, Nidhi Sahni, Chuan He, Amir A. Jazaeri, Weiyi Peng
• 2916 2916 肿瘤内在性IRE1alpha信号通过上调PD-L1并重塑肿瘤微环境驱动肺癌的免疫逃逸和对免疫检查点抑制剂的抵抗 Tumor-intrinsic IRE1alpha signaling drives immune evasion and resistance to immune checkpoint inhibitor in lung cancer by upregulating PD-L1 and remodeling the tumor microenvironment Youngjoo Jeon, Hyun Kyung Ahn, Hongsoon Kim, Sung-Yup Cho, Jaemoon Koh, Yoon Kyung Jeon
• 2917 · PDF 靶向B7-H3以赋能精准肿瘤学的新型策略 Novel strategies for targeting B7-H3 to empower precision oncology Di Zhao
• 2918 2918 激动剂激活RIG-I+肿瘤相关巨噬细胞可增强胶质母细胞瘤的抗肿瘤免疫和治疗应答 Agonist activation of RIG-I + tumor associated macrophages enhances anti-tumor immunity and therapeutic response in glioblastoma Han Xu, Sungwoon Lee, Felipe Saceanu Leser, Olga Federova, Peiwen Lu, Eric Song, Anne Eichmann, Akiko Iwasaki, Anna Anna Marie Pyle, Jean-Leon Thomas
• 2919 2919 少许STING为三级淋巴结构增添活力：通过STING和淋巴毒素-beta受体激活治疗性诱导成熟TLS可赋予对抗癌症转移的免疫保护 A little STING spices up tertiary lymphoid structures: Therapeutic induction of mature TLS by STING and lymphotoxin-beta receptor activation confers immune protection against cancer metastasis Yasuhiro Kikuchi, Maxwell Duah, Fumiaki Kanamori, Masanobu Komatsu
• 2920 2920 肝巨噬细胞的代谢重编程可在T细胞荒漠型肝细胞癌中恢复CD8+ T细胞免疫 Metabolic reprogramming of hepatic macrophages restores CD8⁺ T cell immunity in T cell-desert hepatocellular carcinoma Liangliang Ji, Delaney Bessel, Sophia Brosnan, Isha Malik, Zijian Xu, Jiaxin Li, Peng Li, Xian Zhang, Jing Zhang, Ting-Wei Tsu, Shengyu Gao, Amaia Lujambio, Ming Li

在会议检索中浏览本分会场