PO.MCB03.02 · 分子与细胞生物学
RTK-ERBB-PI3K and New Targets in Therapeutic Resistance
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- 3296 3296 受体样蛋白酪氨酸磷酸酶PTPRH调节酪氨酸激酶EPHA2和EGFR的去磷酸化，改变细胞形态和黏附，并在非小细胞肺癌细胞中表现为肿瘤抑制因子 The receptor-like protein tyrosine phosphatase PTPRH modulates dephosphorylation of the tyrosine kinases EPHA2 and EGFR, alters cell morphology and adhesion, and behaves as a tumor-suppressor in non-small cell lung cancer cell Mylena Ortiz, Deeya Patel, Jesus Garcia-Lerena, Andrew C. Nelson, Matthew Swiatnicki, Eran Andrechek
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- 3298 3298 TJ106的临床前开发：一种靶向HER2、用于治疗Enhertu耐药肿瘤的强效双互补位双载荷ADC Preclinical development of TJ106, a potent biparatopic dual payload ADC targeting HER2 for the treatment of Enhertu-resistant tumors Siyi Hu, Mao Huang, Xiaobo Cai, Shugaku Takeda, Li Qi, Yangxin Zhang, Haiyan Wu, Yan Zhang, Yanli Mao, Zhaoyuan Chen
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- 3301 3301 TAK1是横纹肌肉瘤中致癌信号和分化阻滞的关键调节因子 TAK1 is a key regulator of oncogenic signaling and differentiation blockade in rhabdomyosarcoma Anh Tuan Vuong, Aniket S. Joshi, Anirban Roy, Kavya Mathukumalli, Phuong T. Ho, Raksha Bhat, Meiricris Tomaz da Silva, Tagari Samanta, Meghana Trivedi, Bin Guo, Benny A. Kaipparettu, Ashok Kumar
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- 3305 3305 利用一种FDA批准药物抑制HUNK作为HER2+乳腺癌潜在治疗策略的生化与细胞学评估 Biochemical and cellular evaluation of HUNK inhibition by an FDA approved drug as potential therapeutic strategy for HER2+ breast cancer Safnas Farwin AbdulSalam, Mia M. Eason, Shuguang Liang, Alison Goupil, Anthony Acinapura, Maia Dominguez, Peter Gallagher, Yuan Wang, Jianghong Wu, Haiching Ma
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- 3322 3322 新一代 FemtoQuest™ 系统实现黑色素瘤血浆样本中活性型与总 HGF 的双分析物超敏定量 Next-Generation FemtoQuest™ system enables dual-analyte ultrasensitive quantitation of active and total HGF in melanoma plasma samples Joseph B. Hwang, Raad Gitan, Matthew Lippold, Brooke Gilliam, Rick Wiese
