In Vitro Models 1: 2D and 3D

• 3396 3396 源自循环肿瘤细胞的三阴性乳腺癌类器官,推进转移性癌症研究与耐药性研究 Triple negative breast cancer organoids derived from circulating tumor cells to advance metastatic cancer research and drug resistance studies Shian-Jiun (SJ) Shih, David HSIEH, Felix Hsieh, Hsiang-Yun Lin, Hui Ren
• 3397 · PDF 利用患者来源类器官建模宫颈癌异质性以推进精准治疗开发 Modeling cervical cancer heterogeneity using patient-derived organoids for precision treatment development Oda Floetre, Hege Fredriksen Berg, Dominika Aleksandra Hawryluk, Marta Espevold Hjelmeland, Stefania Bellone, Alessandro D. Santin, Camilla Krakstad, Mari Kyllesø Halle
• 3398 · PDF 巨噬细胞吞噬作用与胞葬作用:对肿瘤微环境中治疗性调控的启示 Macrophage phagocytosis and efferocytosis: Implications for therapeutic modulation in the tumor microenvironment Veronica Bergo, Carla N. Castro, Arianna Bandini, Tamara Sahner, Sarah Huber, Sandra Moor, Philipp Metzger, Cynthia Obodozie, Holger Weber
• 3399 · PDF 高度多重成像实现肿瘤类器官模型的空间表征 Highly multiplexed imaging allows for spatial characterization of tumor organoid models Anton Luis Villamejor, Joseph Lownik, Daria Mandel, Sinthia Kabir Mumu, Haley Norwood, Madhura Subba Rao, Joshua J. Breunig, Akil A. Merchant
• 3400 · PDF 用于临床前药物测试的基于 3D 生物打印水凝胶的非小细胞肺癌肿瘤模型 A 3D bioprinted hydrogel-based tumor model of non-small cell lung cancer for preclinical drug testing Jan A. Schlegel, Julia Thiel, Kanstantsin Lashuk, Schueler Julia, Thomas E. Mürdter, Matthias Schwab, Meng Dong
• 3401 · PDF 利用PDX来源的胶质母细胞瘤微环境构建多细胞血脑屏障模型：比较人源与鼠源生物芯片系统在肿瘤异质性和药物反应方面的表现 Modeling the multicellular blood-brain barrier with a PDX-derived glioblastoma microenvironment: comparing human and mouse biochip systems for tumor heterogeneity and drug response Michelle Zimmer, Amélie Paillereau, Thomas Sommermann, Lars Winkler, Joshua Alcaniz, Jens Hoffmann, Knut Rennert
• 3402 · PDF THSD7B缺失与结直肠癌患者来源肿瘤类器官的奥沙利铂耐药相关 THSD7B loss is associated with oxaliplatin resistance in colorectal cancer patient-derived tumor organoids Graziana Spoto, Luca Falzone, Marco Fichera, Massimo Libra
• 3403 · PDF 对患者细胞进行高内涵成像以识别可预测药物反应的CLL和AML患者队列 High content imaging of patient cells to identify CLL and AML patient cohorts that predict drug responses David W. Andrews, Mark X. Li, Alla Buzina, Glauber C. Brito, Sila Usta, Brian Leber, Hubert Tsui, David Spaner
• 3404 3404 TR-107，一种新型线粒体ClpP激活剂，在肾上腺皮质癌模型中表现出强效抗肿瘤活性 TR-107, a novel mitochondrial ClpP activator, exhibits potent antitumor activity in adrenocortical carcinoma models George Karadimov, Suresh Kumar, Yoo Sun Kim, Haiqing Fu, Edwin Iwanowicz, Lee M. Graves, Mirit Aladjem, Myriem Boufraqech, Jaydira Del Rivero
• 3405 · PDF ATCC的患者来源二维和三维癌症模型使转化肿瘤学成为科学界的现实 ATCC's patient-derived 2-D & 3-D cancer models make translational oncology a reality for the scientific community Abhay Andar, Ajeet Singh, Changsuk Moon, Stephen Friend, Matthew Graziano, Ruby E. Thamert, Fernanda Ventura, Utsav Sharma, Jonathan Jacobs, Carolina Lucchesi
• 3406 · PDF 建立反映骨微环境的骨肉瘤类器官模型 Establishing an osteosarcoma organoid model reflecting the bone microenvironment Xin Li, Zhi Yang, Ba xuan Hoang, Bo Han
• 3407 · PDF 确保多样化的体外肺癌模型：来自非洲血统个体的肺泡上皮细胞系、患者来源异种移植和肺腺癌细胞系的开发 Ensuring diverse in vitro lung cancer models: Development of alveolar epithelial cell lines, patient-derived xenografts, and lung adenocarcinoma cell lines from individuals of African ancestry Karla E. Gonzalez, Bianca Dal Bo, Chunli Yan, Donna Loza, Matthew A. Gladstone, Anthony W. Kim, Scott M. Atay, Takashi Harano, W. Dean Wallace, Ben Y. Tew, Bodour Salhia, Beiyun Zhou, Kweku Ofosu-Asante, Kyle R. Philips, Benjamin J. Ryder, Desmond Kwakye, Chase A. Lilly, Yong Huang, Nazarius S. Lamango, Ite A. Offringa
• 3408 · PDF 酪氨酸激酶抑制剂诱导的神经内分泌转化型肺癌的患者来源肿瘤模型 Patient-derived tumor models of tyrosine kinase inhibitor-induced neuroendocrine-transformed lung carcinoma Matthew Djan, Sebastiao N. Martins-Filho, Nhu-An Pham, Nikolina Radulovich, Quan Li, Ming Li, Geoffrey Liu, Ming Sound Tsao
• 3409 · PDF 用于表征炎性乳腺癌细胞系淋巴血管间隙浸润的血管化3D微流控乳腺肿瘤平台 A vascularized 3D microfluidic breast tumor platform for characterizing lymphovascular space invasion among inflammatory breast cancer cell lines Melika Mehrabi Dehdezi, Ali Moghaddaszadeh, Zoe Apsel, Surbhi Shivhare, Xiaoding Hu, Bisrat G. Debeb, Wendy A. Woodward, Marissa Nichole Rylander
• 3410 · PDF 通过晶格自组装颗粒环境(GELS)系统构建前列腺肿瘤微环境 Engineering prostate tumor microenvironments via the granular environment for lattice self-assembly (GELS) system Alia Starman, Cris Angeles, Ally Freidholm, Ethan Lin, Gabriel Leonard Galahad Declercq, Hunain Khawaja, Cynthia Miranti, Alexander McGhee
• 3411 · PDF 结直肠癌类器官中生长因子梯度的机械化学效应 Mechanochemical effects of growth factor gradients in colorectal cancer organoids Gabriel L. G. Declercq, Alex Borowiec, Alejandro Moncada, Alia Starman, Surajinder Bharaj, Kevin Pond, Alexander McGhee
• 3412 · PDF 精准癌症医学中的下一代癌症类器官2.0:患者来源的胰腺导管腺癌类器官模型不仅能反映药物敏感性,还能反映肿瘤生物学的复杂性 Next-generation cancer organoids 2.0 in precision cancer medicine: Patient-derived pancreatic ductal adenocarcinoma organoids model tells not only drug sensitivity but also complexity of tumor biology Hyemin Kim, Younghoon Choi, Eun Mi Lee, Jungmyoung Han, Se-Hoon Lee, Kwang Hyuck Lee, Jong Kyun Lee, Kyu Taek Lee, So Jeong Yoon, Hongbeom Kim, Sang Hyun Shin, Jin Seok Heo, In Woong Han, Joo Kyung Park
• 3413 · PDF 利用表达致癌性RET的诱导多能干细胞构建远端肺癌类器官模型 Generation of a distal lung cancer organoid model using oncogenic ret-expressing induced pluripotent stem cells Jinwook Hwang, Christophe Desterke, Paul Marcoux, Mohamed Amin Bani, Frank Griscelli, Annelise Bennaceur Griscelli, Ali G. Turhan
• 3414 · PDF PDO作为NSCLC生物标志物发现的转化模型 PDO as Translational Model for Biomarker Discovery in NSCLC Maria C. Speranza, Anna Pasto, Halh Al-Serori, Elisavet Chatzopoulou, Veronika Yankova, Henrik Hammarén, Patricia Sauer, Kathrin Uhrig, Helena Rannikmae, Lena Eismann, Edward Curry, Tony NG, Kenneth W. Hance
• 3415 · PDF 具有长期可培养性的新型患者来源食管肿瘤类器官的建立与表征 Establishment and characterization of novel patient-derived esophageal tumoroids with long term cultivability Takashi Urano, Etsuko Yokota, Miki Iwai, Takuro Yukawa, Nagio Takigawa, Hideyo Fujiwara, Takashi Akiyama, Minoru Haisa, Takuya Fukazawa, Yoshio Naomoto, Tomoki Yamatsuji
• 3416 · PDF 患者来源胶质母细胞瘤球体所诱导的人血液-肿瘤屏障表型的功能异质性 Functional heterogeneity of the human blood-tumor barrier phenotype induced by patient-derived glioblastoma spheroids Srishti Kala, Luke M. Markowski, Moriah E. Katt
• 3417 · PDF 开发患者来源的胰腺癌类器官-CAF共培养模型以研究肿瘤微环境对放疗反应的影响 Development of a patient-derived pancreatic cancer organoid-CAF coculture model to study tumor microenvironment influence on radiotherapy response Diego Muñoz-Salazar, Carolina Bizama, Paola Caprile, Fernanda Cabrera, Angel Castillo, Victor Manriquez, Macarena Medina, Pablo Munoz-Schuffenegger, Juan Carlos Roa, Patricia Garcia
• 3418 · PDF 治疗前患者来源的食管鳞状细胞癌类器官作为多西他赛、顺铂和氟尿嘧啶新辅助化疗的预测平台 Pre-treatment patient-derived esophageal squamous cell carcinoma organoids as a predictive platform for docetaxel, cisplatin and fluorouracil neoadjuvant chemotherapy Hajime Kashima, Kazuhiro Noma, Akito Shimizu, Yasushige Takeda, Yohei Mizusawa, Tasuku Matsumoto, Hijiri Matsumoto, Tomoyoshi Kunitomo, Masashi Hashimoto, Naoaki Maeda, Satoru Kikuchi, Shunsuke Tanabe, Hotaka Kawai, Toshiaki Ohara, Hiroshi Tazawa, Hiroshi Nakagawa, Toshiyoshi Fujiwara
• 3419 · PDF 利用自发荧光的定量评估分析肿瘤球体的结构异质性 Structural heterogeneity of tumor spheroids using quantitative assessment of autofluorescence Prabhat Suman, Sooraj Kakkat, Joel F. Andrews, Chandrani Sarkar, Dhananjay T. Tambe, Debanjan Chakroborty
• 3420 · PDF 使用Harbor-IN系统对基于转座子的基因插入进行基于DoE的优化 DoE-based optimization of transposon-based gene insertion using the Harbor-IN system Kanstantsin Lashuk, Corey Brizzee, Ina Rohleff, Julia B. Schueler
• 3421 3421 生物打印的结直肠癌类器官作为大规模治疗筛选平台 Bioprinted colorectal cancer organoids as a platform for large-scale therapeutic screening Taehee Kim, Jonathan Levi, Catherine Chen, Lindsay Ng, Alice Soragni
• 3422 · PDF 使用全息断层扫描和生成式跨模态人工智能对小肠类器官进行活体无标记3D虚拟HE成像 Live, label free 3D virtual HE imaging of small intestinal organoids using holotomography and generative cross-modality artificial intelligence Jimin Cho, Juyeon Park, Hyun-Seok Min, YongKeun Park
• 3423 · PDF 整合PDX和PDX来源类器官平台以增强乳腺癌的转化药物发现 Integrating PDX and PDX-derived organoid platforms to enhance translational drug discovery in breast cancer Erin E. Trachet, Liqiang Zhang, Kari Kotlarczyk, Gregg Hirschfeld, Damaris Diaz, Paul Gonzales
• 3424 · PDF 2D和3D细胞培养方法对髓母细胞瘤DNA甲基化模式影响的比较分析 Comparative analysis of 2D and 3D cell culture methods on DNA methylation patterns in medulloblastoma Karen Sperle, Laurel Stell, Micheal Avoseh, Aderonke Ajongbolo, Haozhe Zheng, Darrin Pochan, Sigrid Langhans
• 3425 · PDF 利用生物融合技术提升器官芯片技术并革新药物发现与开发 Leveraging bioconvergence to enhance organ-on-a-chip technology and revolutionize drug discovery and development Shashi K. Tiwari, Stephan Krieg, Fong Cheng Pan, David Austin, Kevin Su, Luisa Marie Pfeifer, Mathab Asadian, Xiaoping Song, Laura Chacon Orellana, Rashmi Ramesh, Alessandra Venz, Bastien Duckert, Mara Lucchetti, Joseph Lento, Sophie Roth, Olivier Henry, Dries Braeken, Laura Braeuninger-Weimer, Philip Hewitt, Steven Johnston, Vi Chu

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