In Vitro Models 1: 2D and 3D

• 3396 3396 Triple negative breast cancer organoids derived from circulating tumor cells to advance metastatic cancer research and drug resistance studies Shian-Jiun (SJ) Shih, David HSIEH, Felix Hsieh, Hsiang-Yun Lin, Hui Ren
• 3397 · PDF Modeling cervical cancer heterogeneity using patient-derived organoids for precision treatment development Oda Floetre, Hege Fredriksen Berg, Dominika Aleksandra Hawryluk, Marta Espevold Hjelmeland, Stefania Bellone, Alessandro D. Santin, Camilla Krakstad, Mari Kyllesø Halle
• 3398 · PDF Macrophage phagocytosis and efferocytosis: Implications for therapeutic modulation in the tumor microenvironment Veronica Bergo, Carla N. Castro, Arianna Bandini, Tamara Sahner, Sarah Huber, Sandra Moor, Philipp Metzger, Cynthia Obodozie, Holger Weber
• 3399 · PDF Highly multiplexed imaging allows for spatial characterization of tumor organoid models Anton Luis Villamejor, Joseph Lownik, Daria Mandel, Sinthia Kabir Mumu, Haley Norwood, Madhura Subba Rao, Joshua J. Breunig, Akil A. Merchant
• 3400 · PDF A 3D bioprinted hydrogel-based tumor model of non-small cell lung cancer for preclinical drug testing Jan A. Schlegel, Julia Thiel, Kanstantsin Lashuk, Schueler Julia, Thomas E. Mürdter, Matthias Schwab, Meng Dong
• 3401 · PDF Modeling the multicellular blood-brain barrier with a PDX-derived glioblastoma microenvironment: comparing human and mouse biochip systems for tumor heterogeneity and drug response Michelle Zimmer, Amélie Paillereau, Thomas Sommermann, Lars Winkler, Joshua Alcaniz, Jens Hoffmann, Knut Rennert
• 3402 · PDF THSD7B loss is associated with oxaliplatin resistance in colorectal cancer patient-derived tumor organoids Graziana Spoto, Luca Falzone, Marco Fichera, Massimo Libra
• 3403 · PDF High content imaging of patient cells to identify CLL and AML patient cohorts that predict drug responses David W. Andrews, Mark X. Li, Alla Buzina, Glauber C. Brito, Sila Usta, Brian Leber, Hubert Tsui, David Spaner
• 3404 3404 TR-107, a novel mitochondrial ClpP activator, exhibits potent antitumor activity in adrenocortical carcinoma models George Karadimov, Suresh Kumar, Yoo Sun Kim, Haiqing Fu, Edwin Iwanowicz, Lee M. Graves, Mirit Aladjem, Myriem Boufraqech, Jaydira Del Rivero
• 3405 · PDF ATCC's patient-derived 2-D & 3-D cancer models make translational oncology a reality for the scientific community Abhay Andar, Ajeet Singh, Changsuk Moon, Stephen Friend, Matthew Graziano, Ruby E. Thamert, Fernanda Ventura, Utsav Sharma, Jonathan Jacobs, Carolina Lucchesi
• 3406 · PDF Establishing an osteosarcoma organoid model reflecting the bone microenvironment Xin Li, Zhi Yang, Ba xuan Hoang, Bo Han
• 3407 · PDF Ensuring diverse in vitro lung cancer models: Development of alveolar epithelial cell lines, patient-derived xenografts, and lung adenocarcinoma cell lines from individuals of African ancestry Karla E. Gonzalez, Bianca Dal Bo, Chunli Yan, Donna Loza, Matthew A. Gladstone, Anthony W. Kim, Scott M. Atay, Takashi Harano, W. Dean Wallace, Ben Y. Tew, Bodour Salhia, Beiyun Zhou, Kweku Ofosu-Asante, Kyle R. Philips, Benjamin J. Ryder, Desmond Kwakye, Chase A. Lilly, Yong Huang, Nazarius S. Lamango, Ite A. Offringa
• 3408 · PDF Patient-derived tumor models of tyrosine kinase inhibitor-induced neuroendocrine-transformed lung carcinoma Matthew Djan, Sebastiao N. Martins-Filho, Nhu-An Pham, Nikolina Radulovich, Quan Li, Ming Li, Geoffrey Liu, Ming Sound Tsao
• 3409 · PDF A vascularized 3D microfluidic breast tumor platform for characterizing lymphovascular space invasion among inflammatory breast cancer cell lines Melika Mehrabi Dehdezi, Ali Moghaddaszadeh, Zoe Apsel, Surbhi Shivhare, Xiaoding Hu, Bisrat G. Debeb, Wendy A. Woodward, Marissa Nichole Rylander
• 3410 · PDF Engineering prostate tumor microenvironments via the granular environment for lattice self-assembly (GELS) system Alia Starman, Cris Angeles, Ally Freidholm, Ethan Lin, Gabriel Leonard Galahad Declercq, Hunain Khawaja, Cynthia Miranti, Alexander McGhee
• 3411 · PDF Mechanochemical effects of growth factor gradients in colorectal cancer organoids Gabriel L. G. Declercq, Alex Borowiec, Alejandro Moncada, Alia Starman, Surajinder Bharaj, Kevin Pond, Alexander McGhee
• 3412 · PDF Next-generation cancer organoids 2.0 in precision cancer medicine: Patient-derived pancreatic ductal adenocarcinoma organoids model tells not only drug sensitivity but also complexity of tumor biology Hyemin Kim, Younghoon Choi, Eun Mi Lee, Jungmyoung Han, Se-Hoon Lee, Kwang Hyuck Lee, Jong Kyun Lee, Kyu Taek Lee, So Jeong Yoon, Hongbeom Kim, Sang Hyun Shin, Jin Seok Heo, In Woong Han, Joo Kyung Park
• 3413 · PDF Generation of a distal lung cancer organoid model using oncogenic ret-expressing induced pluripotent stem cells Jinwook Hwang, Christophe Desterke, Paul Marcoux, Mohamed Amin Bani, Frank Griscelli, Annelise Bennaceur Griscelli, Ali G. Turhan
• 3414 · PDF PDO as Translational Model for Biomarker Discovery in NSCLC Maria C. Speranza, Anna Pasto, Halh Al-Serori, Elisavet Chatzopoulou, Veronika Yankova, Henrik Hammarén, Patricia Sauer, Kathrin Uhrig, Helena Rannikmae, Lena Eismann, Edward Curry, Tony NG, Kenneth W. Hance
• 3415 · PDF Establishment and characterization of novel patient-derived esophageal tumoroids with long term cultivability Takashi Urano, Etsuko Yokota, Miki Iwai, Takuro Yukawa, Nagio Takigawa, Hideyo Fujiwara, Takashi Akiyama, Minoru Haisa, Takuya Fukazawa, Yoshio Naomoto, Tomoki Yamatsuji
• 3416 · PDF Functional heterogeneity of the human blood-tumor barrier phenotype induced by patient-derived glioblastoma spheroids Srishti Kala, Luke M. Markowski, Moriah E. Katt
• 3417 · PDF Development of a patient-derived pancreatic cancer organoid-CAF coculture model to study tumor microenvironment influence on radiotherapy response Diego Muñoz-Salazar, Carolina Bizama, Paola Caprile, Fernanda Cabrera, Angel Castillo, Victor Manriquez, Macarena Medina, Pablo Munoz-Schuffenegger, Juan Carlos Roa, Patricia Garcia
• 3418 · PDF Pre-treatment patient-derived esophageal squamous cell carcinoma organoids as a predictive platform for docetaxel, cisplatin and fluorouracil neoadjuvant chemotherapy Hajime Kashima, Kazuhiro Noma, Akito Shimizu, Yasushige Takeda, Yohei Mizusawa, Tasuku Matsumoto, Hijiri Matsumoto, Tomoyoshi Kunitomo, Masashi Hashimoto, Naoaki Maeda, Satoru Kikuchi, Shunsuke Tanabe, Hotaka Kawai, Toshiaki Ohara, Hiroshi Tazawa, Hiroshi Nakagawa, Toshiyoshi Fujiwara
• 3419 · PDF Structural heterogeneity of tumor spheroids using quantitative assessment of autofluorescence Prabhat Suman, Sooraj Kakkat, Joel F. Andrews, Chandrani Sarkar, Dhananjay T. Tambe, Debanjan Chakroborty
• 3420 · PDF DoE-based optimization of transposon-based gene insertion using the Harbor-IN system Kanstantsin Lashuk, Corey Brizzee, Ina Rohleff, Julia B. Schueler
• 3421 3421 Bioprinted colorectal cancer organoids as a platform for large-scale therapeutic screening Taehee Kim, Jonathan Levi, Catherine Chen, Lindsay Ng, Alice Soragni
• 3422 · PDF Live, label free 3D virtual HE imaging of small intestinal organoids using holotomography and generative cross-modality artificial intelligence Jimin Cho, Juyeon Park, Hyun-Seok Min, YongKeun Park
• 3423 · PDF Integrating PDX and PDX-derived organoid platforms to enhance translational drug discovery in breast cancer Erin E. Trachet, Liqiang Zhang, Kari Kotlarczyk, Gregg Hirschfeld, Damaris Diaz, Paul Gonzales
• 3424 · PDF Comparative analysis of 2D and 3D cell culture methods on DNA methylation patterns in medulloblastoma Karen Sperle, Laurel Stell, Micheal Avoseh, Aderonke Ajongbolo, Haozhe Zheng, Darrin Pochan, Sigrid Langhans
• 3425 · PDF Leveraging bioconvergence to enhance organ-on-a-chip technology and revolutionize drug discovery and development Shashi K. Tiwari, Stephan Krieg, Fong Cheng Pan, David Austin, Kevin Su, Luisa Marie Pfeifer, Mathab Asadian, Xiaoping Song, Laura Chacon Orellana, Rashmi Ramesh, Alessandra Venz, Bastien Duckert, Mara Lucchetti, Joseph Lento, Sophie Roth, Olivier Henry, Dries Braeken, Laura Braeuninger-Weimer, Philip Hewitt, Steven Johnston, Vi Chu

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