Tumor Evolution

• 3525 · PDF Structural variation shapes clonal evolution in pediatric cancer Robert Greenhalgh, Bensheng Ju, Samuel W. Brady, John Easton, Sivaraman Natarajan, Jinghui Zhang
• 3526 · PDF Dynamic evolution of oncogene amplification across 80,000 cancer cell genomes Jake June-Koo Lee, Sohrab Salehi, Matthew Myers, Melissa Yao, Seongmin Choi, Duaa Hassan Al-Rawi, Ignacio Vazquez-Garcia, Eliyahu Havasov, Michelle Wu, Jin Lee, Fathema Uddin, Parvathy Manoj, Pedram Razavi, Samuel Aparicio, Natasha Rekhtman, Kenny Kwok Hei Yu, Helena A. Yu, Charles M. Rudin, Andrea Ventura, Andrew William McPherson, Marc Williams, Sohrab Shah
• 3527 · PDF Clonal evolutionary trajectory of HER2-positive breast cancer with ERBB2 or PIK3CA mutations under neoadjuvant treatment Kang Wang, Ioannis Zerdes, Emmanouil G. Sifakis, Dimitrios Salgkamis, Jonas Bergh, Thomas Hatschek, Alexios Matikas, Theodoros Foukakis
• 3528 · PDF EED drives the small cell lung cancer neuroendocrine phenotype in lung cancer histological transformation Yixiang Li, Yasmin N. Laimon, Hyeonseo Cho, Marina Vivero, Gabriel R. De Oliveira, Andrew Delcea, Varunika Savla, Yuting Chen, Yavuz Durmaz, Xintao Qiu, Shweta Kukreja, Rong Li, Talal El Zarif, Wesley S. Lu, McKayla Van Orden, Jacob E Berchuck, Roderick Bronson, Shuqiang Li, Hongbin Ji, Katerina A. Politi, Matthew L. Freedman, Henry Long, Sabina Signoretti, Matthew Gilbert Oser
• 3529 · PDF Identification of the clonal origin of endometriosis-associated ovarian cancer in normal endometrium Koichi Watanabe, Nobuyuki Kakiuchi, Kosuke Ieiri, Hirona Maeda, Tomonori Hirano, Mana Taki, Koji Yamanoi, Ryusuke Murakami, Masaki Mandai, Seishi Ogawa
• 3530 3530 Drug pressure driven evolution upregulates CIDEA to reprogram lipid metabolism and promote chemoresistance in colorectal cancer Haigui Wan, Yao Shang, Dongwen Chen, Chuling Hu, Yiran Bie, Zhengran Zhou, Zhengyu Wei, Chong Chen, Yifan Zheng, Peishan Hu, Xiaojian Wu
• 3531 · PDF Temporal ordering of genomic events reveals distinct evolutionary trajectories in early-onset breast cancer Sejung Lee, Jeonghyeok Lim, Hyeji Kim, Min-Chae Kang, Eun-Gyeong Lee, Sun-Young Kong, Jinhyuk Bhin
• 3532 · PDF Genetic insights into clonal evolution from normal prostate epithelium to cancer via HighGradePIN Kohsuke Hishiki, Nobuyuki Kakiuchi, Yuki Teramoto, Koichi Watanabe, Kosuke Ieiri, Hirona Maeda, Tomonori Hirano, Yuki Kita, Takashi Kobayashi, Seishi Ogawa
• 3533 · PDF Integrative spatial profiling of protein and chromosomal alterations across normal, precancer, and cancer revealed the presence of aneuploidy in the normal fallopian tube Tanjina Kader, Yu-An Chen, Clemens Hug, Jia-Ren Lin, Jeremy Muhlich, Euihye Jung, Charles Drescher, Ronny I. Drapkin, Peter Karl Sorger, Sandro Santagata
• 3534 · PDF Forecasting oncogene amplification and tumor suppressor deletion Barbara Hernando, Angel Fernandez-Sanroman, Alice Cadiz, Patricia Santamaria, David Gomez Sanchez, Maria Escobar-Rey, Blas Chaves-Urbano, Joe Thompson, Marina Torres, Gorka Ruiz de Garibay, Vera Adradas, Eva Álvarez, The Pan Prostate Cancer Group, Maxime Tarabichi, Tom Lesluyes, Juan Manuel Coya, Jon Zugazagoitia, Luis G. Paz-Ares, Geoff Macintyre
• 3535 · PDF Multi-omics analysis of longitudinal melanoma samples reveals evolutionary transitions and therapy-associated cell-state switching Yourong Bao, Anne Zaremba, Giuseppe Tarantino, Tuulia Vallius, Mark Woodnorth, Mariana Lopez Leon, Yingxiao Shi, Zoltan Maliga, Samira Makhzami, Tyler Aprati, Bojan Karlas, Valerie Glutsch, Bastian Schilling, Jessica Cecile Hassel, Carola Berking, Jochen Utikal, Friedegund Meier, Frank Meiss, Lucie Heinzerling, Katharina Kähler, Jiajia Chen, Lisa Zimmer, Antje Sucker, Elisabeth Livingstone, Eva Hadaschik, Christine G. Lian, George F. Murphy, Yevgeniy R. Semenov, Genevieve Boland, Peter Karl Sorger, Florian Rambow, David Liu, Dirk Schadendorf
• 3536 · PDF Quantifying evolutionary dynamics and tumor heterogeneity in oncogene-addicted advanced non-small cell lung cancer Lyns C. Etienne, Elizabeth E. Martin, Pinar Eser, Kiara Pontious, Junko Tsuji, Natalie Lytell, Nicholas Chevalier, Mandeep Banwait, Jennifer L. Peterson, Michael S. Lawrence, Mari Mino-Kenudsen, Jessica J. Lin, Zofia Piotrowska, Aaron N. Hata, Rebecca Heist, Dejan Juric, Justin Gainor, Gad Getz
• 3537 · PDF Rb1 loss defines distinct migration histories in metastatic prostate cancer subtypes Dawid G. Nowak, Ryan N. Serio, Lise M. Brault, Domenic V. Gargiulo, Rebecca Hassett, Ryan J. Chaffee, Stephen J. Staklinski, Billy Lu, Adam C. Siepel
• 3538 · PDF Clonal landscape of human nephrons Kosuke Ieiri, Nobuyuki Kakiuchi, Koichi Watananbe, Tomonori Hirano, Shun Kawaguchi, Hirona Maeda, Yoshikage Inoue, Tatsuki R. Kataoka, Hiroko Tanaka, Satoru Miyano, Masaki Shiota, Eto Masatoshi, Seishi Ogawa
• 3539 · PDF Spatial profiling of prostate cancer clonal evolution linked to nodal metastases Alastair David Lamb, Joakim Lundeberg, Sandy Figiel, Max Beesley, Mengxiao He
• 3540 · PDF KRAS allelic imbalance reshapes tumor evolution through selective clonal outgrowth and chromosomal instability in NSCLC Li Zhang, Angeliki Bania, Enrico Gurreri, Alessia Savarese, Roberta Rinaldi, Calogero Carlino, Luigi Perelli, Giannicola Genovese
• 3541 · PDF Dynamics of clonal hematopoiesis in ovarian cancer survivors: Correlation with carboplatin and PARP inhibitor exposure Elizabeth M. Swisher, Marc R. Radke, Nithisha Khasnavis, Jennifer Lopez Ochoa, Mayumi Rubin-Saika, Enna Manhardt, Emiko Oshima, Alexandra Bachmann, Roseanne Gamboa, David Wu, Siobán Keel, Sergei Doulatov
• 3542 · PDF Evolving toward precision oncology: Leveraging collateral drug responses for personalized second-line osteosarcoma treatment Elizabeth Nowak, Jarrell Imamura, Arda Durmaz, Masahiro Hitomi, Zachary Burke, Jacob G. Scott
• 3544 · PDF Single-cell multi-omics uncovers coordinated epigenetic and transcriptomic evolution in IDH-mutant glioma Masashi Nomura, Ramya Raviram, Joshua S. Schiffman, Lillian Bussema, Vivian Lu, Noelle Wheeler, John Lee, Yilin Fan, Mian Hua Zheng, Florian Ruiz, Husain Danish, Sorcha Kellett, Labeeba Nusrat, Ronan Chaligne, Jason T. Huse, W. K. Alfred Yung, Shota Tanaka, Nobuhito Saito, Sunit Das, Catherine Potenski, Dan Landau, Mario L. Suva
• 3545 · PDF Integrated genomic and transcriptomic profiling uncovers spatial and evolutionary dynamics in astrocytoma Serafiina Jaatinen, Sonja Mäntylä, Reetta Nätkin, Ismail Hermelo, Anssi Nurminen, Aliisa Tiihonen, Iida Salonen, Elisa M. Vuorinen, Kristiina Nordfors, Hannu Haapasalo, Kirsi Rautajoki, Joonas Haapasalo, Matti Nykter
• 3546 · PDF Quantifying metabolic and clonal dynamics of evolving cancer cells Yi Zhong, Malak Aziz, Gabriel Hemighaus, Richa Mandrekar, Alvin Makohon-Moore

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