Tumor Evolution

• 3525 · PDF 结构变异塑造儿童癌症中的克隆演化 Structural variation shapes clonal evolution in pediatric cancer Robert Greenhalgh, Bensheng Ju, Samuel W. Brady, John Easton, Sivaraman Natarajan, Jinghui Zhang
• 3526 · PDF 跨越80,000个癌症细胞基因组的致癌基因扩增动态演化 Dynamic evolution of oncogene amplification across 80,000 cancer cell genomes Jake June-Koo Lee, Sohrab Salehi, Matthew Myers, Melissa Yao, Seongmin Choi, Duaa Hassan Al-Rawi, Ignacio Vazquez-Garcia, Eliyahu Havasov, Michelle Wu, Jin Lee, Fathema Uddin, Parvathy Manoj, Pedram Razavi, Samuel Aparicio, Natasha Rekhtman, Kenny Kwok Hei Yu, Helena A. Yu, Charles M. Rudin, Andrea Ventura, Andrew William McPherson, Marc Williams, Sohrab Shah
• 3527 · PDF 携带ERBB2或PIK3CA突变的HER2阳性乳腺癌在新辅助治疗下的克隆演化轨迹 Clonal evolutionary trajectory of HER2-positive breast cancer with ERBB2 or PIK3CA mutations under neoadjuvant treatment Kang Wang, Ioannis Zerdes, Emmanouil G. Sifakis, Dimitrios Salgkamis, Jonas Bergh, Thomas Hatschek, Alexios Matikas, Theodoros Foukakis
• 3528 · PDF EED在肺癌组织学转化中驱动小细胞肺癌神经内分泌表型 EED drives the small cell lung cancer neuroendocrine phenotype in lung cancer histological transformation Yixiang Li, Yasmin N. Laimon, Hyeonseo Cho, Marina Vivero, Gabriel R. De Oliveira, Andrew Delcea, Varunika Savla, Yuting Chen, Yavuz Durmaz, Xintao Qiu, Shweta Kukreja, Rong Li, Talal El Zarif, Wesley S. Lu, McKayla Van Orden, Jacob E Berchuck, Roderick Bronson, Shuqiang Li, Hongbin Ji, Katerina A. Politi, Matthew L. Freedman, Henry Long, Sabina Signoretti, Matthew Gilbert Oser
• 3529 · PDF 在正常子宫内膜中鉴定子宫内膜异位症相关卵巢癌的克隆起源 Identification of the clonal origin of endometriosis-associated ovarian cancer in normal endometrium Koichi Watanabe, Nobuyuki Kakiuchi, Kosuke Ieiri, Hirona Maeda, Tomonori Hirano, Mana Taki, Koji Yamanoi, Ryusuke Murakami, Masaki Mandai, Seishi Ogawa
• 3530 3530 药物压力驱动的进化上调CIDEA以重编程脂质代谢并促进结直肠癌的化疗耐药 Drug pressure driven evolution upregulates CIDEA to reprogram lipid metabolism and promote chemoresistance in colorectal cancer Haigui Wan, Yao Shang, Dongwen Chen, Chuling Hu, Yiran Bie, Zhengran Zhou, Zhengyu Wei, Chong Chen, Yifan Zheng, Peishan Hu, Xiaojian Wu
• 3531 · PDF 基因组事件的时序排列揭示早发性乳腺癌中不同的进化轨迹 Temporal ordering of genomic events reveals distinct evolutionary trajectories in early-onset breast cancer Sejung Lee, Jeonghyeok Lim, Hyeji Kim, Min-Chae Kang, Eun-Gyeong Lee, Sun-Young Kong, Jinhyuk Bhin
• 3532 · PDF 从正常前列腺上皮经高级别PIN到癌的克隆进化的遗传学见解 Genetic insights into clonal evolution from normal prostate epithelium to cancer via HighGradePIN Kohsuke Hishiki, Nobuyuki Kakiuchi, Yuki Teramoto, Koichi Watanabe, Kosuke Ieiri, Hirona Maeda, Tomonori Hirano, Yuki Kita, Takashi Kobayashi, Seishi Ogawa
• 3533 · PDF 跨正常、癌前和癌组织的蛋白质与染色体改变的整合空间分析揭示正常输卵管中存在非整倍体 Integrative spatial profiling of protein and chromosomal alterations across normal, precancer, and cancer revealed the presence of aneuploidy in the normal fallopian tube Tanjina Kader, Yu-An Chen, Clemens Hug, Jia-Ren Lin, Jeremy Muhlich, Euihye Jung, Charles Drescher, Ronny I. Drapkin, Peter Karl Sorger, Sandro Santagata
• 3534 · PDF 预测癌基因扩增和抑癌基因缺失 Forecasting oncogene amplification and tumor suppressor deletion Barbara Hernando, Angel Fernandez-Sanroman, Alice Cadiz, Patricia Santamaria, David Gomez Sanchez, Maria Escobar-Rey, Blas Chaves-Urbano, Joe Thompson, Marina Torres, Gorka Ruiz de Garibay, Vera Adradas, Eva Álvarez, The Pan Prostate Cancer Group, Maxime Tarabichi, Tom Lesluyes, Juan Manuel Coya, Jon Zugazagoitia, Luis G. Paz-Ares, Geoff Macintyre
• 3535 · PDF 纵向黑色素瘤样本的多组学分析揭示进化转变和治疗相关的细胞状态转换 Multi-omics analysis of longitudinal melanoma samples reveals evolutionary transitions and therapy-associated cell-state switching Yourong Bao, Anne Zaremba, Giuseppe Tarantino, Tuulia Vallius, Mark Woodnorth, Mariana Lopez Leon, Yingxiao Shi, Zoltan Maliga, Samira Makhzami, Tyler Aprati, Bojan Karlas, Valerie Glutsch, Bastian Schilling, Jessica Cecile Hassel, Carola Berking, Jochen Utikal, Friedegund Meier, Frank Meiss, Lucie Heinzerling, Katharina Kähler, Jiajia Chen, Lisa Zimmer, Antje Sucker, Elisabeth Livingstone, Eva Hadaschik, Christine G. Lian, George F. Murphy, Yevgeniy R. Semenov, Genevieve Boland, Peter Karl Sorger, Florian Rambow, David Liu, Dirk Schadendorf
• 3536 · PDF 量化癌基因成瘾性晚期非小细胞肺癌的进化动态和肿瘤异质性 Quantifying evolutionary dynamics and tumor heterogeneity in oncogene-addicted advanced non-small cell lung cancer Lyns C. Etienne, Elizabeth E. Martin, Pinar Eser, Kiara Pontious, Junko Tsuji, Natalie Lytell, Nicholas Chevalier, Mandeep Banwait, Jennifer L. Peterson, Michael S. Lawrence, Mari Mino-Kenudsen, Jessica J. Lin, Zofia Piotrowska, Aaron N. Hata, Rebecca Heist, Dejan Juric, Justin Gainor, Gad Getz
• 3537 · PDF Rb1缺失定义了转移性前列腺癌亚型中不同的迁移历史 Rb1 loss defines distinct migration histories in metastatic prostate cancer subtypes Dawid G. Nowak, Ryan N. Serio, Lise M. Brault, Domenic V. Gargiulo, Rebecca Hassett, Ryan J. Chaffee, Stephen J. Staklinski, Billy Lu, Adam C. Siepel
• 3538 · PDF 人类肾单位的克隆图谱 Clonal landscape of human nephrons Kosuke Ieiri, Nobuyuki Kakiuchi, Koichi Watananbe, Tomonori Hirano, Shun Kawaguchi, Hirona Maeda, Yoshikage Inoue, Tatsuki R. Kataoka, Hiroko Tanaka, Satoru Miyano, Masaki Shiota, Eto Masatoshi, Seishi Ogawa
• 3539 · PDF 与淋巴结转移相关的前列腺癌克隆演进的空间分析 Spatial profiling of prostate cancer clonal evolution linked to nodal metastases Alastair David Lamb, Joakim Lundeberg, Sandy Figiel, Max Beesley, Mengxiao He
• 3540 · PDF KRAS等位基因失衡通过选择性克隆增生和染色体不稳定性重塑NSCLC的肿瘤演进 KRAS allelic imbalance reshapes tumor evolution through selective clonal outgrowth and chromosomal instability in NSCLC Li Zhang, Angeliki Bania, Enrico Gurreri, Alessia Savarese, Roberta Rinaldi, Calogero Carlino, Luigi Perelli, Giannicola Genovese
• 3541 · PDF 卵巢癌幸存者中克隆性造血的动态：与卡铂和PARP抑制剂暴露的相关性 Dynamics of clonal hematopoiesis in ovarian cancer survivors: Correlation with carboplatin and PARP inhibitor exposure Elizabeth M. Swisher, Marc R. Radke, Nithisha Khasnavis, Jennifer Lopez Ochoa, Mayumi Rubin-Saika, Enna Manhardt, Emiko Oshima, Alexandra Bachmann, Roseanne Gamboa, David Wu, Siobán Keel, Sergei Doulatov
• 3542 · PDF 迈向精准肿瘤学的演进：利用附带药物反应实现个体化二线骨肉瘤治疗 Evolving toward precision oncology: Leveraging collateral drug responses for personalized second-line osteosarcoma treatment Elizabeth Nowak, Jarrell Imamura, Arda Durmaz, Masahiro Hitomi, Zachary Burke, Jacob G. Scott
• 3544 · PDF 单细胞多组学揭示IDH突变型胶质瘤中协调的表观遗传和转录组演化 Single-cell multi-omics uncovers coordinated epigenetic and transcriptomic evolution in IDH-mutant glioma Masashi Nomura, Ramya Raviram, Joshua S. Schiffman, Lillian Bussema, Vivian Lu, Noelle Wheeler, John Lee, Yilin Fan, Mian Hua Zheng, Florian Ruiz, Husain Danish, Sorcha Kellett, Labeeba Nusrat, Ronan Chaligne, Jason T. Huse, W. K. Alfred Yung, Shota Tanaka, Nobuhito Saito, Sunit Das, Catherine Potenski, Dan Landau, Mario L. Suva
• 3545 · PDF 整合基因组和转录组分析揭示星形细胞瘤的空间和演化动态 Integrated genomic and transcriptomic profiling uncovers spatial and evolutionary dynamics in astrocytoma Serafiina Jaatinen, Sonja Mäntylä, Reetta Nätkin, Ismail Hermelo, Anssi Nurminen, Aliisa Tiihonen, Iida Salonen, Elisa M. Vuorinen, Kristiina Nordfors, Hannu Haapasalo, Kirsi Rautajoki, Joonas Haapasalo, Matti Nykter
• 3546 · PDF 量化演进中癌细胞的代谢与克隆动态 Quantifying metabolic and clonal dynamics of evolving cancer cells Yi Zhong, Malak Aziz, Gabriel Hemighaus, Richa Mandrekar, Alvin Makohon-Moore

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