PO.TB10.03 · 肿瘤生物学
Microenvironmental Determinants of Therapy Response and Resistance 1
- 3429 3429 巨噬细胞通过增加肿瘤细胞脂质可用性促进肝细胞癌的免疫治疗耐药 Macrophages promote immunotherapy resistance of hepatocellular carcinoma through increasing tumor cell lipid availability Zhixian Liang, Xiaohang LONG, ZHEWEN XIONG, PATRICK WONG, Siyuan HUANG, Siyun Chen, Yiling Zhang, Lingyun ZHANG, Chunning Leung, Saiming Ngai, Stephen Lam CHAN, Alfred S. L. Cheng
- 3430 3430 NR4A3作为肿瘤相关巨噬细胞中的免疫代谢检查点介导直肠癌的放疗敏感性 NR4A3 functions as an immuno-metabolic checkpoint in tumor-associated macrophages to mediate radiotherapy sensitivity in rectal cancer Xiaowan Guo, Gan Tao, Xiuli Guo, Kehua Hu, Rurui Xue, Yunli Mo, Hui Qiu, Qiuji Wu
- 3431 3431 高表达CXCL2的中性粒细胞样单核细胞（NeuMos）协调全身粒细胞生成并驱动TNBC免疫治疗耐药 Neutrophil-like monocytes (NeuMos) with high levels of CXCL2 expression orchestrate systemic granulopoiesis and drive immunotherapy resistance in TNBC Fulya Alkan, Hilmi K. Alkan, Ahmet Caglayan, Aysun Caglayan, Aminah Lawal, Neva Celiker, Huidong Shi, Thomas Vogl, Nouri Neamati, Wicha Max, Hasan Korkaya
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- 3434 3434 空间分辨多组学分析揭示PARP抑制和PD-L1阻断期间BRCA依赖性免疫重塑 Spatially resolved multi-omic profiling reveals BRCA-dependent immune remodeling during PARP inhibition and PD-L1 blockade Kenichi Shimada, Filipa Lynce, Claudine Isaacs, Xue Geng, Edward T. Richardson, Candace Mainor, Mei Wei, Julie M. Collins, Paula R. Pohlmann, Arielle L. Heeke, Kelly F. Zheng, Madeline Townsend, Lauren M. Sloat, Jane Staunton, Stuart J. Schnitt, Hongkun Wang, Joan S. Brugge, Geoffrey I. Shapiro, Jennifer L. Guerriero
- 3435 3435 空间转录组分析揭示与肺腺癌免疫检查点阻断反应相关的独特肿瘤微环境重塑模式 Spatial transcriptomic profiling reveals distinct tumor microenvironment remodeling patterns associated with immune checkpoint blockade response in lung adenocarcinoma Heesoo Yoon, Jin-Wook Choi, Sejoon Lee, Jin-Haeng Chung, Hyojin Kim
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- 3439 3439 白蛋白结合型紫杉醇诱导的基质重编程驱动PDAC对AG新辅助化疗的耐药 Albumin-bound paclitaxel induced stromal reprogramming drives PDAC resistance to AG neoadjuvant chemotherapy Haorui Li, Tiansuo Zhao, Xi Ma, Xiang He, Hongji Dai, Bin Wang
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- 3444 3444 I期临床试验中复发性胶质母细胞瘤的空间谱分析揭示脑室内CAR T治疗诱导的有利免疫重塑 Spatial profiling of recurrent glioblastoma in a Phase I clinical trial reveals favorable immune remodeling induced by intracerebroventricular CAR T therapy Wesley V. Wilson, MacLean P. Nasrallah, Nakial Cross, Yael A. Day, Vanessa Gonzalez, Rachel M. Leskowitz, Amy Marshall, Julie K. Jadlowsky, Gabriela Plesa, Donald L. Siegel, Elizabeth O. Hexner, Joseph A. Fraietta, Carl H. June, Stephen J. Bagley, Donald O’Rourke, Zev Binder, Andrew J. Rech
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- 3447 3447 由应激信号调控的III型胶原通过诱导肿瘤休眠和重塑免疫抑制性生态位驱动胰腺癌化疗抵抗 Type III collagen regulated by stress signaling drives chemoresistance in pancreatic cancer by inducing tumor dormancy and remodeling the immunosuppressive niche Haiyan Xu, Yicheng Zhou, Shengbai Xue, Siming Wu, Liwei Wang
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- 3449 3449 细胞因子阻断结局的异质性揭示SPP1+巨噬细胞在结直肠癌肝转移免疫抑制中的可能作用 Heterogeneity in outcomes of cytokine blockade identifies plausible role for SPP1+macrophages in colorectal liver metastasis immune suppression Kristin Goodsell, Jason Carter, Sheela Damle, Xiuyun Jiang, Heidi Kenerson, Ian N. Crispe, Venu G. Pillarisetty
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- 3451 3451 单细胞转录组学洞察SMARCB1缺陷型肾髓质癌中驱动对伊沙佐米联合吉西他滨和多柔比星抵抗的肿瘤与免疫动态 Single-cell transcriptomic insights into tumor and immune dynamics driving resistance to ixazomib combined with gemcitabine and doxorubicin in SMARCB1-deficient renal medullary carcinoma Kai Yu, Rebecca Tidwell, Tharakeswara Bathala, Rahul Sheth, Menuka Karki, Jianfeng Chen, Jing Qian, Fei Duan, Luigi Perelli, Melinda Soeung, Priya Rao, Arlene Siefker-Radtke, Najat Daw, Davis Ingram, Diana Shamsutdinova, Khalida Wani, Wei-Lien Wang, Alexander Lazar, Zilong Zhao, Sabitha Prabhakaran, Neus Bota, Andrew Futreal, Rare Tumor Initiative Team, Patient Mosaic Team, Liuqing Yang, Chunru Lin, Giannicola Genovese, Jianjun Gao, Linghua Wang, Nizar Tannir, Pavlos Msaouel
- 3452 3452 利用基质易感性：表达NFATC2的CAF增强化疗敏感性并揭示胰腺癌中可靶向的ERBB轴 Exploiting stromal vulnerabilities: NFATC2-expressing CAFs enhance chemotherapy sensitivity and reveal a targetable ERBB axis in pancreatic cancer Jiahao Guo, Samuele Cancellieri, Biswajyoti Sahu
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- 3454 3454 ANXA2表达的动态改变作为新诊断胶质母细胞瘤对新辅助贝伐珠单抗应答的预测因子 Dynamic alteration of ANXA2 expression as a predictor of response to neoadjuvant bevacizumab in newly diagnosed glioblastoma Taketo Ezaki, Ryota Tamura, Yohei Yamamoto, Jun Takei, Akihiko Teshigawara, Kyoichi Tomoto, Yasuharu Akasaki, Masahiro Toda, Yuichi Murayama, Hikaru Sasaki, Keisuke Miyake, Toshihide Tanaka
- 3455 3455 POSTN驱动的机械转导维持CAFs中beta-catenin活性以促进黑色素瘤进展和耐药 POSTN-driven mechanotransduction sustains beta-catenin activity in CAFs to promote melanoma progression and drug resistance Jie Wang, Bruna DA SILVA SOLEY, Linli Zhou, Yuhang Zhang
- 3456 3456 使用六十重多重免疫肿瘤学面板研究原发性与复发性浆液性卵巢癌之间肿瘤免疫微环境的空间演变 Spatial evolution of the tumor immune microenvironment between primary and recurrent serous ovarian cancer using a sixty plex multiplex immuno oncology panel Hayeon Shin, Jue young Kim, Yoon Joo Kim, Yookyung Lee, Jae-Hoon Kim
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