PO.TB10.03 · 肿瘤生物学
Microenvironmental Determinants of Therapy Response and Resistance 1
- 3429 3429 Macrophages promote immunotherapy resistance of hepatocellular carcinoma through increasing tumor cell lipid availability Zhixian Liang, Xiaohang LONG, ZHEWEN XIONG, PATRICK WONG, Siyuan HUANG, Siyun Chen, Yiling Zhang, Lingyun ZHANG, Chunning Leung, Saiming Ngai, Stephen Lam CHAN, Alfred S. L. Cheng
- 3430 3430 NR4A3 functions as an immuno-metabolic checkpoint in tumor-associated macrophages to mediate radiotherapy sensitivity in rectal cancer​ Xiaowan Guo, Gan Tao, Xiuli Guo, Kehua Hu, Rurui Xue, Yunli Mo, Hui Qiu, Qiuji Wu
- 3431 3431 Neutrophil-like monocytes (NeuMos) with high levels of CXCL2 expression orchestrate systemic granulopoiesis and drive immunotherapy resistance in TNBC Fulya Alkan, Hilmi K. Alkan, Ahmet Caglayan, Aysun Caglayan, Aminah Lawal, Neva Celiker, Huidong Shi, Thomas Vogl, Nouri Neamati, Wicha Max, Hasan Korkaya
-
-
- 3434 3434 Spatially resolved multi-omic profiling reveals BRCA-dependent immune remodeling during PARP inhibition and PD-L1 blockade Kenichi Shimada, Filipa Lynce, Claudine Isaacs, Xue Geng, Edward T. Richardson, Candace Mainor, Mei Wei, Julie M. Collins, Paula R. Pohlmann, Arielle L. Heeke, Kelly F. Zheng, Madeline Townsend, Lauren M. Sloat, Jane Staunton, Stuart J. Schnitt, Hongkun Wang, Joan S. Brugge, Geoffrey I. Shapiro, Jennifer L. Guerriero
- 3435 3435 Spatial transcriptomic profiling reveals distinct tumor microenvironment remodeling patterns associated with immune checkpoint blockade response in lung adenocarcinoma Heesoo Yoon, Jin-Wook Choi, Sejoon Lee, Jin-Haeng Chung, Hyojin Kim
-
-
-
- 3439 3439 Albumin-bound paclitaxel induced stromal reprogramming drives PDAC resistance to AG neoadjuvant chemotherapy Haorui Li, Tiansuo Zhao, Xi Ma, Xiang He, Hongji Dai, Bin Wang
-
-
-
- 3444 3444 Spatial profiling of recurrent glioblastoma in a Phase I clinical trial reveals favorable immune remodeling induced by intracerebroventricular CAR T therapy Wesley V. Wilson, MacLean P. Nasrallah, Nakial Cross, Yael A. Day, Vanessa Gonzalez, Rachel M. Leskowitz, Amy Marshall, Julie K. Jadlowsky, Gabriela Plesa, Donald L. Siegel, Elizabeth O. Hexner, Joseph A. Fraietta, Carl H. June, Stephen J. Bagley, Donald O’Rourke, Zev Binder, Andrew J. Rech
-
-
- 3447 3447 Type III collagen regulated by stress signaling drives chemoresistance in pancreatic cancer by inducing tumor dormancy and remodeling the immunosuppressive niche Haiyan Xu, Yicheng Zhou, Shengbai Xue, Siming Wu, Liwei Wang
-
- 3449 3449 Heterogeneity in outcomes of cytokine blockade identifies plausible role for SPP1+macrophages in colorectal liver metastasis immune suppression Kristin Goodsell, Jason Carter, Sheela Damle, Xiuyun Jiang, Heidi Kenerson, Ian N. Crispe, Venu G. Pillarisetty
-
- 3451 3451 Single-cell transcriptomic insights into tumor and immune dynamics driving resistance to ixazomib combined with gemcitabine and doxorubicin in SMARCB1-deficient renal medullary carcinoma Kai Yu, Rebecca Tidwell, Tharakeswara Bathala, Rahul Sheth, Menuka Karki, Jianfeng Chen, Jing Qian, Fei Duan, Luigi Perelli, Melinda Soeung, Priya Rao, Arlene Siefker-Radtke, Najat Daw, Davis Ingram, Diana Shamsutdinova, Khalida Wani, Wei-Lien Wang, Alexander Lazar, Zilong Zhao, Sabitha Prabhakaran, Neus Bota, Andrew Futreal, Rare Tumor Initiative Team, Patient Mosaic Team, Liuqing Yang, Chunru Lin, Giannicola Genovese, Jianjun Gao, Linghua Wang, Nizar Tannir, Pavlos Msaouel
- 3452 3452 Exploiting stromal vulnerabilities: NFATC2-expressing CAFs enhance chemotherapy sensitivity and reveal a targetable ERBB axis in pancreatic cancer Jiahao Guo, Samuele Cancellieri, Biswajyoti Sahu
-
- 3454 3454 Dynamic alteration of ANXA2 expression as a predictor of response to neoadjuvant bevacizumab in newly diagnosed glioblastoma Taketo Ezaki, Ryota Tamura, Yohei Yamamoto, Jun Takei, Akihiko Teshigawara, Kyoichi Tomoto, Yasuharu Akasaki, Masahiro Toda, Yuichi Murayama, Hikaru Sasaki, Keisuke Miyake, Toshihide Tanaka
- 3455 3455 POSTN-driven mechanotransduction sustains beta-catenin activity in CAFs to promote melanoma progression and drug resistance Jie Wang, Bruna DA SILVA SOLEY, Linli Zhou, Yuhang Zhang
- 3456 3456 Spatial evolution of the tumor immune microenvironment between primary and recurrent serous ovarian cancer using a sixty plex multiplex immuno oncology panel Hayeon Shin, Jue young Kim, Yoon Joo Kim, Yookyung Lee, Jae-Hoon Kim
-
-
