Circulating Tumor Cells, Metastasis, and Dissemination Biology 1

• 1061 1061 肿瘤知情的循环肿瘤DNA可识别出尽管接受了包含原发性肉眼完全切除的最佳一线治疗仍具有最高复发风险的高级别浆液性卵巢癌患者 Tumor-informed circulating tumor DNA identifies high-grade serous ovarian cancer patients at highest risk for recurrence despite optimal first-line treatment with primary macroscopic complete resection Magdalena Postl, Christina Victoria Tauber, Valentina Glueck, Mira Maria Gliga, Nuria Segui, Karen Howarth, Miguel Alcaide, Lucia Oton, Gerda Hofstetter, Isabelle Maurer, Alexander Burges, Sven Mahner, Mirjana Kessler, Melina Danisch, Stephan Polterauer, Nicole Concin, Christoph Grimm, Fabian Trillsch
• 1062 1062 循环肿瘤细胞（CTC）的纵向监测揭示了在ALK阳性NSCLC中与疾病进展和生存相关的动态CTC行为 Longitudinal monitoring of circulating tumor cells (CTC) reveals dynamic CTC behaviors associated with disease progression and survival in ALK-positive NSCLC Yuru Chen, Shamileh Fouladdel, Leah Kidder, Yuehang Tang, Harrison Ball, Habib Serhan, Zhaoping Qin, Albert Liu, Xu Cheng, Liwei Bao, Varun Kathawate, Larua Goo, Mary Horn, Stacy Fry, Aaron N. Hata, Justin Gainor, Jessica J. Lin, Stuart Hinton, Chao H. Huang, Nathan Merrill, Aaron M. Udager, Peter J. Ulintz, Angel Qin, Sofia Merajver, Sunitha Nagrath
• 1063 1063 血清神经元特异性烯醇化酶（NSE）作为中枢神经系统（CNS）转移的生物标志物：来自BrainStorm项目（Oncodistinct 006）的最新结果 Serum neuron-specific enolase (NSE) as a biomarker of central nervous system (CNS) metastases: Updated results from the BrainStorm program (Oncodistinct 006) Soraia Lobo-Martins, Diogo Martins-Branco, Luca Arecco, Guilherme Nader-Marta, Andrea Gombos, Anthony Gonçalves, Eleonora Stephane de Maio D’Esposito, Philippe Barthelemy, Vincent Vanhaudenarde, Florian Clatot, Stéphane Holbrechts, Francois P. Duhoux, Edith Borcoman, Elisabeth Pop, Damien Parlier, Claire Cheymol, Joseph Gligorov, Hannelore Denys, Paul Clement, Caroline Duhem, Lore Decoster, Jean-Luc Canon, Nadège Kindt, Françoise Rothé, Ahmad H. Awada, Nuria Kotecki
• 1064 · PDF 单细胞RNAseq分析评估前列腺穿刺活检标本中癌细胞的新方法 Novel approach of single-cell RNAseq analysis to assess cancer cells in prostate core biopsy specimens Dai Takamatsu, Kelly K. Chong, Gianna Jimenez, David Krasne, Jennifer A. Linehan, Timothy G. Wilson, Dave S. B. Hoon
• 1065 · PDF 循环肿瘤细胞中的有丝分裂与转移性乳腺癌高度侵袭性疾病相关 Mitosis in circulating tumor cells correlates with highly aggressive disease in metastatic breast cancer Alexis B. Duffy, Massimo Cristofanilli, Carolina Reduzzi, Wlliam V. Williams, Giuseppe Del Priore, Saranya Chumsri, Cha-Mei Tang, Toshiaki Iwase, Naoto Ueno, Daniel L. Adams
• 1066 · PDF 利用循环上皮肿瘤细胞（CETC/CTC）数量的轨迹早期检测前列腺癌 Early detection of prostate carcinoma using trajectories of circulating epithelial tumor cell (CETCs/CTCs) numbers Dorothea Schott, Monika Pizon, Joachim Fluhrer, Ulrich Pachmann, Katharina Pachmann, Peter Eng
• 1067 1067 采用新型临床检测方法对多发性骨髓瘤基因组进行全基因组测序，可识别免疫治疗耐药背后的遗传学改变 Whole genome sequencing of multiple myeloma genomes with a novel clinical assay enables identification of genetic alterations underlying immunotherapy resistance Bruno Paiva, Peter Voorhees, Patricia T. Greipp, Danielle Sookiasian, Julian Hess, Marisa DeMeo, Vicki Pounder, Sarah Calkins, Reid Meyer, Linda B. Baughn, Christine-Ivy Liacos, Meletios-Athanasios Dimopoulos, Alexandra Papadimou, Taouxi Konstantina, Efstathios Kastritis, Jesus Berdeja, Daniel Auclair, Valentina Nardi, Thomas Mullen, Francois Aguet, Shaji Kunnathu Kumar
• 1068 1068 联合循环肿瘤细胞和癌症相关巨噬细胞样细胞可增强泛癌种转移性疾病的风险分层模型 Combining circulating tumor cells and cancer associated macrophage-like cells enhances risk stratification models in pan-cancer metastatic disease Daniel L. Adams, Steven H. Lin, Massimo Cristofanilli, Carolina Reduzzi, Saranya Chumsri, Martin J. Edelman, Susan Tsai, Raymond C. Bergan, Mohammed Aldakkak, Thai H. Ho, Cha-Mei Tang
• 1069 1069 利用新型溶瘤病毒系统检测胰腺癌患者活性循环肿瘤细胞(v-CTCs)及PD-L1表达的临床意义 Clinical significance of viable circulating tumor cells (v-CTCs) and PD-L1 expression in pancreatic cancer patients using a novel oncolytic virus system Masahiro Tanemura, Hisataka Ogawa, Yoshiaki Ohmura, Tadafumi Asaoka, Yasuo Urata, Daisaku Yamada, Hirofumi Akita, Hidetoshi Eguchi
• 1070 · PDF 通过液体活检对弥漫性胶质瘤进行分子分型：来自循环肿瘤细胞与ctDNA分析的见解 Molecular profiling of diffuse gliomas via liquid biopsy: Insights from circulating tumor cells and ctDNA analysis Josef Srovnal, Pavel Stejskal, Ondrej Kalita, Marek Slachta, Lumir Hrabalek, Alona Rehulkova, Monika Vidlarova, Marian Hajduch
• 1071 1071 基于Delta样配体3(DLL3)的富集可实现小细胞肺癌免疫治疗期间循环肿瘤细胞的灵敏特异检测 Delta-like ligand 3 (DLL3)-based enrichment enables sensitive and specific detection of circulating tumor cells during immunotherapy in small-cell lung cancer Hyung-Joo Oh, Hyun-Ju Cho, Seung-Hee Song, Yoo-Duk Choi, Woo-Jae Son, Jin-Han Bae, In-Jae Oh, Young-Chul Kim, Hae Ung Lee, Cheol-Kyu Park
• 1072 · PDF 并行微流控平台实现口咽癌p16+循环肿瘤细胞的高效无标记捕获 Parallel microfluidic platform enables efficient label-free capture of p16+ circulating tumor cells in oropharyngeal cancer Chameera E. Weeramange, Jian Zhou, Sreedevi Damodaran, Chiara F. Ghera, Lizbeth Kenny, Brett Hughes, Sarju Vasani, Omar Breik, Rahul Ladwa, Ian Papautsky, Chamindie Punyadeera
• 1073 · PDF 监测mCRPC患者CTCs中雄激素受体及神经内分泌标志物表达动态变化 Monitoring androgen receptor and neuroendocrine marker expression dynamics in CTCs in patients with mCRPC Nobuaki Matsubara, Kentaro Shirai, Hiroyuki Obinata, Hiromichi Nakajima, Chikako Funasaka, Chihiro Kondoh, Kana Kawasaki, Eri Katsumata, Taiga Ajiri, Maharjan Bishnu, Fumie Kato, Masatoshi Yanagida, Reiko Watanabe, Toru Mukohara
• 1074 1074 治疗前循环肿瘤细胞是接受abemaciclib治疗的转移性乳腺癌患者进展的重要预测因子 Pre-treatment circulating tumor cells are a significant predictor of progression in patients with metastatic breast cancer undergoing abemaciclib therapy Qiang Zhang, Justin Zhang, Andrew A. Davis, Natalie Heater, Diana Jaber, Paolo D’Amico, Jianhua Jiao, Weijun Qin, Pan Du, Shading Jia, Akhil Chawla, Janice Lu, Lisa Flaum, William J. Gradishar
• 1075 · PDF 晚期实体瘤组织与液体活检CGP的比较：来自社区癌症中心的见解 Comparison of tissue and liquid biopsy CGP in advanced solid tumors: Insights from a community cancer center Padmapriya Swaminathan, McKenna Perrin, Crystal Hattum, Stephanie B. Hastings, Shakeel Mir, Zachary Wallen, Lucia Speroni, Michelle F. Green, Emily Teslow, Heidi Ko, Rebecca A. Previs, Kalpesh Patel, Shakti Ramkissoon, David Starks, Benjamin Solomon, William Spanos, Tobias Meissner, Rachel Elsey
• 1076 · PDF 癌-神经元相互作用启动EGFR突变型NSCLC的神经模拟及脑定植 Cancer-neuron interaction initiates neural mimicry and brain colonization in EGFR-mutant NSCLC Sam Song, Tomohiro Takehara, Yan Yang, Monique B. Nilsson, Alissa Poteete, Sherise Desiree Ferguson, Xiuning Le, John V. Heymach
• 1077 · PDF 原发性与转移性子宫内膜癌分子分型的不一致性：对精准治疗的意义 Discordance in molecular classification of primary and metastatic endometrial cancer: Implications for precision treatment Mari Kyllesø Halle, Janka Babickova, Hege Fredriksen Berg, Erling Andre Hoivik, Rose M. Gold, Kadri Madissoo, Marta Hjelmeland, Hilde Eide Lien, Jone Trovik, Ingfrid S. Haldorsen, Kathrine Woie, Gema Moreno-Bueno, Rameen Beroukhim, Camilla Krakstad
• 1078 · PDF 从方案到实践：182项肿瘤学试验中获取疾病进展活检的差距 From protocol to practice: The gap in obtaining progression disease biopsies across 182 oncology trials Anjali Vinocha, Kanwal Pratap Singh Raghav, David S. Hong, Christine Parseghian, Joshua P. Hein, Jyotsna Pera, Funda Meric-Bernstam, Scott Kopetz, Alda L. Tam, Michael J. Overman
• 1079 · PDF 前列腺癌患者中过表达PD-L1并伴有细胞簇的循环肿瘤细胞 Over expressing PD-L1 circulating tumor cells with clusters in prostate cancer patients Jayant Khandare, Bharat Bhosale, Gourishankar Aland, Sreeja Jayant, Amrut Ashturkar, Vikas Jadhav, Ashish Joshi, Sourav Mishra, Pradip Kendre, Aravindan Vasudevan, Vashishth Maniar, Jagdeesh Kulkarni
• 1080 · PDF 用于即时检测脑脊液液体活检的小鼠软脑膜病模型的开发 Development of a murine leptomeningeal disease model for a point-of-care cerebrospinal fluid liquid biopsy assay Eileen Shiuan, Jorge Salcedo-Sifuentes, Leilani Pradis, Trinh Phan, Sonia Su, Martin Shum, Daniel T. Kamei, Won Kim, Robert M. Prins
• 1081 1081 用于实时监测循环肿瘤细胞上前列腺特异性膜抗原（PSMA）表达的标准化CELLSEARCH®检测的开发与验证 Development and validation of a standardized CELLSEARCH® assay for real-time monitoring of prostate-specific membrane antigen (PSMA) expression on circulating tumor cells Steven M. Jones, Thai Bui, Damodara Gullipalli, Shemeeakah Powell, Margaret LaCava, Zoltan Simandi
• 1082 · PDF 用于监测结直肠癌患者血液和脑脊液的新型CDH17 CTC检测的开发 Development of a novel CDH17 CTC assay to monitor colorectal patient blood and cerebrospinal fluid Jennifer C. Chow, Casey E. Helmicki, Rachel Ponting, Arturo B. Ramirez, Pashtoon Murtaza Kasi
• 1083 · PDF 转移性胰腺癌中Kras活性关联的糖酵解与免疫抑制 Kras activity-linked glycolysis and immunosuppression in metastatic pancreatic cancer Shuichi Mitsunaga, Mari Masuda, Kota Kato, Hidetaka Suzuki, Mitsuhito Sasaki, Hiroki Yoshimatsu, Yoichi Kamei, Masafumi Ikeda
• 1084 1084 血清蛋白质组学分析揭示三阴性乳腺癌中转移相关的分子特征及早期全身重塑 Serum proteomic profiling reveals metastasis-associated molecular signatures and early systemic remodeling in triple-negative breast cancer Jina Kim, Hyoyoung Kim, Sunao Tanaka, Takeo Fujii, Sungyong You, Hideki Furuya
• 1085 · PDF PHF8是前列腺癌细胞中RIPK2的主要上游调控因子 PHF8 is a major upstream regulator of RIPK2 in prostate cancer cells Jaceline Pires Sanches, Ahmed Elgehama, Lili Guerra, Wei Yang
• 1086 1086 循环肿瘤细胞中的HER2表达作为乳腺癌对trastuzumab deruxtecan治疗反应的微创生物标志物 HER2 expression in circulating tumor cells as a minimally invasive biomarker of therapeutic response to trastuzumab deruxutecan in breast cancer Toru Mukohara, Nobuaki Matsubara, Yusuke Takahashi, Kentaro Shirai, Hiromichi Nakajima, Chikako Funasaka, Chihiro Kondoh, Kana Kawasaki, Maharjan Bishnu Devi, Fumie Kato, Hiroyuki Obinata, Taiga Ajiri, Masatoshi Yanagida, Reiko Watanabe
• 1087 1087 患者来源的乳腺癌和黑色素瘤循环肿瘤细胞（CTC）体外模型作为癌症研究的有前景的新工具 Patient-derived breast and melanoma circulating tumor cell (CTC) in vitro models as encouraging new tools for cancer research Paul Lovell, Karlie Wysong, Fafali Deegbe, Fang Tian

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