Adoptive Cell Therapy 2

• 5183 · PDF High-throughput ex vivo TCR-T cells screening identifies aggrephagy-driven, therapy-resistant clones in KRAS-mutant PDAC Masoumeh Eshaghi, Fei Miao, Ali Abdollahzadeh, Sixing Chen, Jacopo Chiaro, Elahe Kamali G, Joshua Glover, Vineeth Koneru, Michael C. Milone, Miren L Baroja, Gerald P. Linette, Beatriz M. Carreno, Emma E. Furth, Vincenzo Cerullo, Joseph Fraietta, Carl H. June, Friederike Herbst-Nowrouzi
• 5184 · PDF From tLNP selection to in vitro/vivo efficiency evaluation: In vivo CAR-T therapy Shunchuan Zhang, Qi Xin, Gang Liu, Jingxian Liu, Jun Liu, Pei Wu, Jingwei Huang, Mengwen Huang, Zhongyao Ma, Letian Kuai, Wenji Su
• 5185 5185 Flow cytometry-based monitoring of CAR-T cell persistence and immune phenotypes pre- and post-infusion: Challenges in Phase 1/2 hematologic malignancy trials Jackie Benko, Bhagyaraj Ella, Samantha Splitt, Angelina Bisconte, Rachel Owen, Deborah J. Phippard
• 5186 · PDF Pro-inflammatory cytokine primed Wharton's jelly mesenchymal stem cells: A potent immunomodulatory strategy to combat pancreatic cancer Sangeeta Choudhury, Poonam Yadav, Mohd Saad, Vikrant Singh, Rohini Tamang
• 5187 · PDF IL-21-Enhanced NK cells: A mitochondrial fitness enhancement for targeting glioblastoma stem cells Mayra Shanley, Sufang Li, Mandira Manandhar, Giacomo Sferruzza, Rafet Basar, May Daher, Jinzhuang Dou, Joy Gumin, Ana Karen Nunez Cortes, Sunil Acharya, Donghai Xiong, Hila Shaim, Frederick F. Lang, Navin Varadarajan, Ken Chen, Katayoun Rezvani
• 5189 · PDF Generating EZH2-inhibitor resistant CAR-T cells to sustain function for combination therapy Katherine Bronson, Daniel Fil, Megan R. Reed, Billie Heflin, Sydnye Shuttlewoth, Brian S. Koss, Alan Tackett
• 5190 · PDF Advancing FCRL5 directed immunotherapy for improved treatment of B cell lymphoma Chakrapani Tripathi, John Nguyen, Fang-chi Hsu, Frank Luh, Yun Yen
• 5191 5191 Multiscale engineering of PTPRZ1 CAR T cells through affinity-tuned binders and modular architecture optimization Aditya A. Mohan, Barbara Lipes, Rushil Yerrabelli, Kisha Kamini Patel, Charla Gentry, Ariel Gonzalez, John Sampson, Peter E. Fecci, Michael Gunn, Anoop Patel
• 5192 · PDF Single-cell profiling reveals immune circuit disruption preceding CAR-T relapse in B-ALL Zhouting Zhu, Na Li, Zhaoyang Jia, Yufei Deng, Lujing Wu, Hui Hui, Victor Wong, Tariq M. Rana
• 5193 · PDF Novel SynKIR-310 outperforms CD3-based second-generation CD28 or 41BB co-stimulated CAR T in B-cell non-Hodgkin lymphoma xenograft mice and shows early clinical signal Megan C. Blair, Jun Xu, Nora Yucel, Tony Truong, William Stanley, Michael Tees, Olivia Dermody, Susan K. Howard, Andrea Campanile, Michael Milone, Don L. Siegel, Laura A. Johnson
• 5194 · PDF Oncolytic virus infected tumors drive AP-1 and IRF signaling in NK cells to sustain anti tumor activity Hila Shaim, Cheryl Jiang, Mayra Shanley, Hind Rafei, Jiajinlong Kang, Yu-Sung Hsu, Huihui Fan, Patrick Zhang, Rafet Basar, May Daher, Qingnan Liang, Donghai Xiong, Joy Gumin, Viswakalyan Kotapali, Corry Jones, April Gilbert, Luis Muniz-Feliciano, Gary M. Deyter, Pinaki Banerjee, Madison Moore, Ye Ethan Li, Dexing Fang, Sunil Acharya, Inci Biederstädt, Hong Jiang, Nadima Uprety, Rejeena Shrestha, Byron Jia, Alexander Biederstadt, Paul Daniel, Maliha Munir, Mecit Kaplan, Mayela Mendt, Oluwatosin Banjo, Vakul Mohanty, Jinzhuang Dou, Xianli Jiang, Elizabeth Shpall, Ken Chen, Abhinav Jain, Frederick F. Lang, Candelaria Gomez-Manzano, Juan Fueyo, Katayoun Rezvani
• 5195 · PDF Next-generation CAR-T cells that target only tumor stroma and matrix: Collagen-binding IL-12-expressing FAP-CAR-T show strong anti-tumor efficacy but are safe Jun Ishihara, Chiu Po Chaun, Koichi Sasaki
• 5197 · PDF Metabolically supercharged NK cells engineered with adenoviral E4ORF-1 Maliha Munir, Madison Moore, Silvia Tiberti, Rafet Basar, Byron Jia, Leen Kheirbek, Nadima Uprety, Francia Reyes Silva, Rejeena Shrestha, Ana K. Nunez Cortes, Mayra Shanley, Sunil Acharya, Jeong-Min Park, Bin Liu, Pinaki Banerjee, Paul Lin, Donghai Xiong, Enli Liu, Alia Ghrayeb, Eyal Gottlieb, Elizabeth Joan Shpall, Katayoun Rezvani, May Daher
• 5198 · PDF A non-viral mRNA engineering platform for rapid, same-day immune-cell therapies Chen Wu, Christoph Schaefers, Malvika Gupta, Kevin Regan, Zuoyi Shao, Andre De Menezes Silva Corraes, Virginia Van Keulen, Jacob Hirdler, Tobias Peikert, Timothy D. Wiltshire, Haidong Dong, Yi Lin
• 5199 · PDF uPAR-targeting CAR-NK cells enhance cytotoxicity against acute myeloid leukemia Xingliang Guo, Nadima Uprety, Rejeena Shrestha, Francia Reyes Silva, Sunil Acharya, Bijender Kumar, Bin Liu, Dexing Fang, Bingqian Hu, Sha Wang, May Daher, Ana K. Nunez Cortes, Corry Jones, LaTretta Harris, Vernikka Woods, Jerrell E. Scott, April Gilbert, Cornelio Santibanez, Katayoun Rezvani, Rafet Basar
• 5200 · PDF Preclinical evaluation of armored DLL3 biepitope compound nanobody CAR T cells Byeong-Hyeok Choi, Ga-Ram Hwang, Morgan Flaherty, Vincent M. DeStefano, Masayuki Wada, Kevin Pinz, Jennifer E. Chow, Nabil Hagag, Yu Ma, Luo Jing, Yupo Ma
• 5201 · PDF Tuning gated CAR-T cells for enhanced activity against acute myeloid leukemia Shawn Barman, Molly Shields, Tatiana Fourfouris, Ki Jun Lee, Naiomi Desai, Devon Bell, Ethan BenDavid, Justin Pfahler, Ayesha Khan, Sanjana Tottempudi, Armita Shadfar, Yong-Mi Kim, BABAK MOGHIMI
• 5202 · PDF Predictive models for hematologic toxicity after CAR-T therapy: A systematic review of current risk scores and unmet AI needs Mansha Gupta, Abhijith Vemulapalli, Swathi Cherukuri, Rithish Nimmagadda, Akhil Jain
• 5203 · PDF Phosphorylated IRF7 enhances antitumor activity of GPC3-targeted CAR T cells in solid tumors Inci Cevher Zeytin, Che-Hsing Li, David de la Cerda, Leidy Diana Caraballo Galva, Andras Attila Heczey
• 5204 · PDF CD5-directed CAR5/IL-15 NK cells as a therapeutic platform for T-cell malignancies Rafet Basar, Sunil Acharya, Nadima Uprety, May Daher, Francia Reyes Silva, Rejeena Shrestha, Bin Liu, Mayra Shanley, Merve Dede, Pinaki Banerjee, Ping Li, Paul Lin, Enli Liu, Donghai Xiong, Ken Chen, David Marin, Elizabeth Joan Shpall, Katayoun Rezvani
• 5205 · PDF Assessing donor heterogeneity in CAR-T cells with massively parallel mixed lymphocyte reactions Lujing Wu, Lina Mohamad, Michelle Mantilla, Johnathan Lu, Ansuman T. Satpathy, Theodore Roth
• 5206 · PDF Mitochondrial remodeling sustains CAR-NK stemness for superior tumor control Silvia Tiberti, Madison Moore, Maliha Munir, Merve Dede, Byron Jia, Leen Kheirbek, Rejeena Shrestha, Nadima Uprety, Jeong-Min Park, Vernikka Woods, Corry Jones, Patrick Zhang, Dexing Fang, Huihui Fan, Maria Laura Centomo, Francia Reyes Silva, Mayra Shanley, Sunil Acharya, Ye Ethan Li, Bin Liu, Pinaki Banerjee, Rafet Basar, Katayoun Rezvani, May Daher

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