PO.CL05.02 · 临床研究
Adoptive Cell Therapy 2
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5183 · PDF 高通量离体TCR-T细胞筛选鉴定出KRAS突变型PDAC中聚集自噬驱动的治疗耐药克隆 High-throughput ex vivo TCR-T cells screening identifies aggrephagy-driven, therapy-resistant clones in KRAS-mutant PDAC Masoumeh Eshaghi, Fei Miao, Ali Abdollahzadeh, Sixing Chen, Jacopo Chiaro, Elahe Kamali G, Joshua Glover, Vineeth Koneru, Michael C. Milone, Miren L Baroja, Gerald P. Linette, Beatriz M. Carreno, Emma E. Furth, Vincenzo Cerullo, Joseph Fraietta, Carl H. June, Friederike Herbst-Nowrouzi
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5184 · PDF 从 tLNP 筛选到体外/体内效率评估:体内 CAR-T 疗法 From tLNP selection to in vitro/vivo efficiency evaluation: In vivo CAR-T therapy Shunchuan Zhang, Qi Xin, Gang Liu, Jingxian Liu, Jun Liu, Pei Wu, Jingwei Huang, Mengwen Huang, Zhongyao Ma, Letian Kuai, Wenji Su
- 5185 5185 基于流式细胞术监测输注前后 CAR-T 细胞的持久性和免疫表型:1/2 期血液恶性肿瘤试验中的挑战 Flow cytometry-based monitoring of CAR-T cell persistence and immune phenotypes pre- and post-infusion: Challenges in Phase 1/2 hematologic malignancy trials Jackie Benko, Bhagyaraj Ella, Samantha Splitt, Angelina Bisconte, Rachel Owen, Deborah J. Phippard
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5186 · PDF 经促炎细胞因子预激的沃顿胶间充质干细胞:一种对抗胰腺癌的强效免疫调节策略 Pro-inflammatory cytokine primed Wharton's jelly mesenchymal stem cells: A potent immunomodulatory strategy to combat pancreatic cancer Sangeeta Choudhury, Poonam Yadav, Mohd Saad, Vikrant Singh, Rohini Tamang
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5187 · PDF IL-21 增强的 NK 细胞:一种针对胶质母细胞瘤干细胞的线粒体健适度增强策略 IL-21-Enhanced NK cells: A mitochondrial fitness enhancement for targeting glioblastoma stem cells Mayra Shanley, Sufang Li, Mandira Manandhar, Giacomo Sferruzza, Rafet Basar, May Daher, Jinzhuang Dou, Joy Gumin, Ana Karen Nunez Cortes, Sunil Acharya, Donghai Xiong, Hila Shaim, Frederick F. Lang, Navin Varadarajan, Ken Chen, Katayoun Rezvani
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5189 · PDF 生成对 EZH2 抑制剂耐药的 CAR-T 细胞以维持功能用于联合疗法 Generating EZH2-inhibitor resistant CAR-T cells to sustain function for combination therapy Katherine Bronson, Daniel Fil, Megan R. Reed, Billie Heflin, Sydnye Shuttlewoth, Brian S. Koss, Alan Tackett
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5190 · PDF 推进 FCRL5 导向的免疫疗法以改善 B 细胞淋巴瘤的治疗 Advancing FCRL5 directed immunotherapy for improved treatment of B cell lymphoma Chakrapani Tripathi, John Nguyen, Fang-chi Hsu, Frank Luh, Yun Yen
- 5191 5191 通过亲和力调谐的结合体和模块化架构优化对 PTPRZ1 CAR T 细胞进行多尺度工程化 Multiscale engineering of PTPRZ1 CAR T cells through affinity-tuned binders and modular architecture optimization Aditya A. Mohan, Barbara Lipes, Rushil Yerrabelli, Kisha Kamini Patel, Charla Gentry, Ariel Gonzalez, John Sampson, Peter E. Fecci, Michael Gunn, Anoop Patel
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5192 · PDF 单细胞图谱揭示 B-ALL 中 CAR-T 复发前的免疫回路紊乱 Single-cell profiling reveals immune circuit disruption preceding CAR-T relapse in B-ALL Zhouting Zhu, Na Li, Zhaoyang Jia, Yufei Deng, Lujing Wu, Hui Hui, Victor Wong, Tariq M. Rana
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5193 · PDF 新型 SynKIR-310 在 B 细胞非霍奇金淋巴瘤异种移植小鼠模型中优于基于 CD3 的第二代 CD28 或 41BB 共刺激 CAR T 细胞,并显示出早期临床信号 Novel SynKIR-310 outperforms CD3-based second-generation CD28 or 41BB co-stimulated CAR T in B-cell non-Hodgkin lymphoma xenograft mice and shows early clinical signal Megan C. Blair, Jun Xu, Nora Yucel, Tony Truong, William Stanley, Michael Tees, Olivia Dermody, Susan K. Howard, Andrea Campanile, Michael Milone, Don L. Siegel, Laura A. Johnson
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5194 · PDF 溶瘤病毒感染的肿瘤驱动 NK 细胞中的 AP-1 和 IRF 信号传导以维持抗肿瘤活性 Oncolytic virus infected tumors drive AP-1 and IRF signaling in NK cells to sustain anti tumor activity Hila Shaim, Cheryl Jiang, Mayra Shanley, Hind Rafei, Jiajinlong Kang, Yu-Sung Hsu, Huihui Fan, Patrick Zhang, Rafet Basar, May Daher, Qingnan Liang, Donghai Xiong, Joy Gumin, Viswakalyan Kotapali, Corry Jones, April Gilbert, Luis Muniz-Feliciano, Gary M. Deyter, Pinaki Banerjee, Madison Moore, Ye Ethan Li, Dexing Fang, Sunil Acharya, Inci Biederstädt, Hong Jiang, Nadima Uprety, Rejeena Shrestha, Byron Jia, Alexander Biederstadt, Paul Daniel, Maliha Munir, Mecit Kaplan, Mayela Mendt, Oluwatosin Banjo, Vakul Mohanty, Jinzhuang Dou, Xianli Jiang, Elizabeth Shpall, Ken Chen, Abhinav Jain, Frederick F. Lang, Candelaria Gomez-Manzano, Juan Fueyo, Katayoun Rezvani
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5195 · PDF 仅靶向肿瘤基质和基质成分的下一代 CAR-T 细胞:表达胶原结合型 IL-12 的 FAP-CAR-T 显示出强效抗肿瘤疗效且安全 Next-generation CAR-T cells that target only tumor stroma and matrix: Collagen-binding IL-12-expressing FAP-CAR-T show strong anti-tumor efficacy but are safe Jun Ishihara, Chiu Po Chaun, Koichi Sasaki
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5197 · PDF 用腺病毒 E4ORF-1 工程化的代谢超级增强型 NK 细胞 Metabolically supercharged NK cells engineered with adenoviral E4ORF-1 Maliha Munir, Madison Moore, Silvia Tiberti, Rafet Basar, Byron Jia, Leen Kheirbek, Nadima Uprety, Francia Reyes Silva, Rejeena Shrestha, Ana K. Nunez Cortes, Mayra Shanley, Sunil Acharya, Jeong-Min Park, Bin Liu, Pinaki Banerjee, Paul Lin, Donghai Xiong, Enli Liu, Alia Ghrayeb, Eyal Gottlieb, Elizabeth Joan Shpall, Katayoun Rezvani, May Daher
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5198 · PDF 用于快速、当日免疫细胞疗法的非病毒 mRNA 工程平台 A non-viral mRNA engineering platform for rapid, same-day immune-cell therapies Chen Wu, Christoph Schaefers, Malvika Gupta, Kevin Regan, Zuoyi Shao, Andre De Menezes Silva Corraes, Virginia Van Keulen, Jacob Hirdler, Tobias Peikert, Timothy D. Wiltshire, Haidong Dong, Yi Lin
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5199 · PDF 靶向 uPAR 的 CAR-NK 细胞增强对急性髓系白血病的细胞毒性 uPAR-targeting CAR-NK cells enhance cytotoxicity against acute myeloid leukemia Xingliang Guo, Nadima Uprety, Rejeena Shrestha, Francia Reyes Silva, Sunil Acharya, Bijender Kumar, Bin Liu, Dexing Fang, Bingqian Hu, Sha Wang, May Daher, Ana K. Nunez Cortes, Corry Jones, LaTretta Harris, Vernikka Woods, Jerrell E. Scott, April Gilbert, Cornelio Santibanez, Katayoun Rezvani, Rafet Basar
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5200 · PDF 装配型 DLL3 双表位复合纳米抗体 CAR T 细胞的临床前评估 Preclinical evaluation of armored DLL3 biepitope compound nanobody CAR T cells Byeong-Hyeok Choi, Ga-Ram Hwang, Morgan Flaherty, Vincent M. DeStefano, Masayuki Wada, Kevin Pinz, Jennifer E. Chow, Nabil Hagag, Yu Ma, Luo Jing, Yupo Ma
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5201 · PDF 调校门控 CAR-T 细胞以增强对急性髓系白血病的活性 Tuning gated CAR-T cells for enhanced activity against acute myeloid leukemia Shawn Barman, Molly Shields, Tatiana Fourfouris, Ki Jun Lee, Naiomi Desai, Devon Bell, Ethan BenDavid, Justin Pfahler, Ayesha Khan, Sanjana Tottempudi, Armita Shadfar, Yong-Mi Kim, BABAK MOGHIMI
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5202 · PDF CAR-T治疗后血液学毒性的预测模型:现有风险评分及未满足的AI需求的系统评价 Predictive models for hematologic toxicity after CAR-T therapy: A systematic review of current risk scores and unmet AI needs Mansha Gupta, Abhijith Vemulapalli, Swathi Cherukuri, Rithish Nimmagadda, Akhil Jain
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5203 · PDF 磷酸化IRF7增强GPC3靶向CAR T细胞在实体瘤中的抗肿瘤活性 Phosphorylated IRF7 enhances antitumor activity of GPC3-targeted CAR T cells in solid tumors Inci Cevher Zeytin, Che-Hsing Li, David de la Cerda, Leidy Diana Caraballo Galva, Andras Attila Heczey
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5204 · PDF CD5靶向CAR5/IL-15 NK细胞作为T细胞恶性肿瘤的治疗平台 CD5-directed CAR5/IL-15 NK cells as a therapeutic platform for T-cell malignancies Rafet Basar, Sunil Acharya, Nadima Uprety, May Daher, Francia Reyes Silva, Rejeena Shrestha, Bin Liu, Mayra Shanley, Merve Dede, Pinaki Banerjee, Ping Li, Paul Lin, Enli Liu, Donghai Xiong, Ken Chen, David Marin, Elizabeth Joan Shpall, Katayoun Rezvani
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5205 · PDF 通过大规模并行混合淋巴细胞反应评估CAR-T细胞中的供者异质性 Assessing donor heterogeneity in CAR-T cells with massively parallel mixed lymphocyte reactions Lujing Wu, Lina Mohamad, Michelle Mantilla, Johnathan Lu, Ansuman T. Satpathy, Theodore Roth
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5206 · PDF 线粒体重塑维持CAR-NK干性以实现卓越的肿瘤控制 Mitochondrial remodeling sustains CAR-NK stemness for superior tumor control Silvia Tiberti, Madison Moore, Maliha Munir, Merve Dede, Byron Jia, Leen Kheirbek, Rejeena Shrestha, Nadima Uprety, Jeong-Min Park, Vernikka Woods, Corry Jones, Patrick Zhang, Dexing Fang, Huihui Fan, Maria Laura Centomo, Francia Reyes Silva, Mayra Shanley, Sunil Acharya, Ye Ethan Li, Bin Liu, Pinaki Banerjee, Rafet Basar, Katayoun Rezvani, May Daher