Precision Oncology and Real World Data

• 5333 · PDF 在接受osimertinib治疗的EGFR改变型非小细胞肺癌中对选定抗体-药物偶联物（ADC）靶点的膜抗原表达进行分析 Profiling membrane antigen expression of select antibody-drug conjugate (ADC) targets in EGFR -altered non-small cell lung cancer treated with osimertinib Kevin Lu, Tali Azenkot, Ellen B. Jaeger, Unnati Jariwala, Stamatina Fragkogianni, Jacob Mercer, Jyoti D. Patel, Sandip P. Patel
• 5334 5334 贵州省肺癌的基因组分析以及DNA-NGS与DNA+RNA-NGS在融合检测中的性能比较 Genomic profiling of lung cancer in Guizhou province and comparative performance of DNA-NGS versus DNA+RNA-NGS for fusion detection Weiwei Ouyang, Yichao Geng, Chuang Tian
• 5335 · PDF 整合机器学习与大语言模型揭示KRAS突变型肺癌中生存和治疗反应的分子决定因素 Integrated machine learning and large language models reveal molecular determinants of survival and treatment response in KRAS-mutant lung cancer Qingtian Li, Albert Lee, Wei Wu, Trever G. Bivona
• 5336 · PDF 不同的KRAS突变密码子在结直肠癌中与微卫星不稳定性存在差异关联 Distinct KRAS mutation codons differentially associate with microsatellite instability in colorectal carcinoma Mark Evans, Vishal Chandan, Kenna Shaw, Scott Kopetz, Anirban Maitra, Julian Bryan
• 5337 · PDF MSI结肠腺癌转录组亚型是免疫治疗反应的生物标志物 MSI colon adenocarcinoma transcriptomic subtypes are biomarkers of response to immunotherapy Matthew B. Maxwell, Akul Singhania, Michelle Stein, Radia Johnson, Van K. Morris, Andrew J. Sedgewick, Scott Kopetz, Justin Guinney
• 5338 · PDF 非小细胞肺癌一线免疫检查点抑制剂结局的临床基因组预测因素：来自日本的全国性C-CAT队列 Clinicogenomic predictors of first-line immune checkpoint inhibitor outcomes in non-small cell lung cancer: A nationwide C-CAT cohort from Japan Mika Iwasaki, Takahiro Ando, Koki Fujii, Kousuke Watanabe, Katsutoshi Oda, Hidenori Kage
• 5339 · PDF 真实世界临床基因组数据库揭示小细胞肺癌分子亚型的患病率及其独特的生物学程序 Prevalence and distinct biological programs of small cell lung cancer molecular subtypes revealed by real-world clinico-genomics database Yige Luo, Lujia Wang, Nadine Jahchan, Peter Ansell, Xi Zhao, Weilong Zhao
• 5340 · PDF ALK融合断点与亚型的图谱：DNA-NGS与RNA-NGS的比较分析 Landscape of ALK fusion breakpoints and subtypes: A comparative analysis of DNA-NGS versus RNA-NGSs Yanwei Li, Yanli Chen, Yameng Cui
• 5341 · PDF 中国肺癌和结直肠癌患者中BRAF融合的真实世界图谱：来自26,248例DNA-NGS和RNA-NGS检测的见解 Real-world landscape of BRAF fusions in chinese patients with lung and colorectal cancers: Insights from 26,248 DNA-NGS and RNA-NGS tests Li Wang, Wanpu Wang, Xinyan Pan, Ming Tang, Juanjuan Zhang
• 5342 · PDF 真实世界小细胞肺癌患者中47种细胞表面蛋白的RNA表达分析 Analysis of RNA expression of 47 cell surface proteins in real-world small cell lung cancer patients Sana Parveen, Emma T. Corcoran, Sebastià Franch-Expósito, Prerna Jain, Jacob Mercer, Abdul R. Naqash, Christine M. Lovly, Paul Fields, Hui-Zi Chen
• 5344 · PDF 变异等位基因频率机器学习模型识别出胰腺癌中术后生存较差的独特TP53突变表型 Variant allele frequency machine learning model identifies unique TP53-mutant phenotypes with worse post-operative survival in pancreatic cancer Imaad Said, Eugene Chen, Megan Zeller, Mohammed Aldakkak, Matthew Sochor, Bhabishya Neupane, Kshitij Gaur, Mandana Kamgar, Alexandria Phan, Janice Zhao, Samih Thalji, Beth Erickson, Christina Small-Tom, Callisia Clarke, Kathleen K. Christians, Nikki K. Lytle, Thomas McFall, William A. Hall, Anai N. Kothari, Douglas B. Evans, Yongwoo David Seo
• 5345 · PDF 真实世界患者人群中胰腺癌的大规模基因组分析 Large-scale genomic analysis of pancreatic cancer in a real-world patient population Avinash Ramu, Vasily Aushev, J. Bryce Ortiz, Alyssa Antonopoulos, Maria Diab, Philip A. Philip, David Kwon, Soma Subramaniam, Adham Jurdi, Gregory P. Botta
• 5346 · PDF KRAS突变和CDKN2A缺失在IDH1突变型肝内胆管癌中的预后影响和临床特征 Prognostic impact and clinical characteristics of KRAS mutations and CDKN2A loss in IDH1 -mutant intrahepatic cholangiocarcinoma Eiichiro So, Chigusa Morizane, Kouya Shiraishi, Nobuyoshi Hiraoka, Miyuki Sone, Takafumi Koyama, Rui Kitadai, Yusuke Okuma, Takashi Kohno, Tetsuro Shiraishi, Yuno Goto, Shiho Hakui, Kiyoaki Ochi, Keita Fujisaki, Kazunori Onuma, Yasuhiro Komori, Daiki Yamashige, Mao Okada, Shota Harai, Yuta Maruki, Yasuyuki Kawamoto, Yoshikuni Nagashio, Susumu Hijioka, Hideki Ueno, Kenro Hirata, Takanori Kanai, Takuji Okusaka
• 5347 5347 早发性与平均发病年龄胃癌的真实世界临床基因组比较 Real-world clinicogenomic comparison of early- and average- onset gastric cancer Hannah McDonald, Lilia Turcios, Neelima Hosamani, Abu Saleh Mosa Faisal, Chi Wang, Joseph Kim, Mautin Barry-Hundeyin
• 5348 · PDF 肿瘤重塑通路在肥胖相关结直肠癌的肿瘤微环境中富集 Tumor remodeling pathways are enriched in the tumor microenvironment of obesity-associated colorectal cancer Yu Fujiwara, Sarbajit Mukherjee, Yali Zhang, Jianmin Wang, Emily Baiyee Toegel, Tiago Biachi De Castria, Bodour Salhia, Anne M. Noonan, Michael J. Cavnar, Dae Won Kim, Muneeb Rehman, Patrick B. Boland, Melissa L. Fishel, Carlos H.F. Chan, Michele M. Gage, Hassan Hatoum, Julia White, Robert J. Rounbehler, Michelle Churchman, Deepak Vadehra
• 5349 · PDF 优化肿瘤突变负荷作为pembrolizumab的预测性生物标志物：一项针对1,899例日本患者的真实世界分析 Refining tumor mutational burden as a predictive biomarker for pembrolizumab: A real-world analysis of 1,899 Japanese patients Tomoyo Yasuda, Mio Yumura, Azusa Hamasaki, Tongyi Fei, Takashi Kubo, Hitoshi Ichikawa, Takashi Kohno, Kuniko Sunami
• 5350 · PDF 利用机器学习基于真实世界数据评估晚期上皮性卵巢癌的预后生物标志物 Evaluating prognostic biomarkers in advanced epithelial ovarian carcinoma using machine learning on real-world data Carlos Ronchi, Coryandar Coulomb, Frances Peterson, Danielle Bloch, Kathleen Burke
• 5351 · PDF 在一个基于美国的真实世界临床基因组数据库中，按年龄、种族/族裔和组织学类型分析卵巢癌叶酸受体α表达的流行病学 Epidemiology of folate receptor alpha expression in ovarian cancer by age, race/ethnicity, and histotype in a real-world, US-based clinicogenomic database Rebecca C. Arend, Kent F. Hoskins, Jenny S. Guadamuz, Gregory S. Calip, Megan A. Clarke, Yookyung Christy Choi, Qu Zhang, Ricardo R. Lastra, Amanda L. Strickland, Sarah K. Lynam
• 5352 · PDF 妇科肿瘤生存的基因组和祖源相关决定因素 Genomic and ancestry-associated determinants of survival in gynecologic cancers Laura Chambers, Avinash Ramu, Vasily N. Aushev, Susan Rojahn, Alyssa Antonopoulos, Carly B. Scalise, Faraz Salmasi, Minetta C. Liu, Adam C. ElNaggar, Rebecca C. Arend
• 5354 · PDF 染色体外DNA塑造多发性骨髓瘤的侵袭性转录状态 Extrachromosomal DNA shapes aggressive transcriptional states in multiple myeloma Hi Eun Jung, Saeam Shin, Yu Ri Kim, Ja Min Byun, Youngil Koh, Junshik Hong, Dong-Yeop Shin, Inho Kim, Hoon Kim, Hyunsoo Cho
• 5356 · PDF 利用真实世界临床基因组数据库对实体瘤综合基因组分析（CGP）进行测序后质量评估 Leveraging a real-world clinicogenomic database for post-sequencing quality assessment in solid tumor comprehensive genomic profiling (CGP) Erin N. Newburn, Rebecca A. Previs, Michelle F. Green, Kyle C. Strickland, Heidi Ko, Taylor Jensen, Eric Severson, Hardik Parikh, Maria-Fernanda Senosain, Jie An, Erik Van Roey, Daniel Metzger, R.J. Seager, Mark Sausen, Jennifer Jackson, Kenneth Valkenburg, Brian Caveney, Marcia Eisenberg, Shakti Ramkissoon
• 5357 · PDF 分子肿瘤登记库——真实世界数据（RWD）的学习系统 Molecular tumor registries - A learning system for real world data (RWD) Erik Larsen, Chenbo Sun, Michele Cosi, Rudy Salcido, Sarah Roberts, Nirav Merchant, Justin Starren, Ritu Pandey
• 5358 · PDF 精准肿瘤学中基因组改变与临床试验代表性之间的差异 Disparities between genomic alterations and clinical trial representation in precision oncology Jingyao Zhang, Raoul Santiago, Kamila Bakirhan, Tenzin Tamdin
• 5359 · PDF 精准肿瘤学实践：全面基因组分析在756例临床实体瘤中识别可干预改变并指导治疗选择 Precision oncology in practice: Comprehensive genomic profiling identifies actionable alterations and guides therapeutic selection in 756 clinical solid tumors Sarabjot Pabla, Sushant Khadgi, Anjana N. Bhattacharya, Asia Chang, Mark Gardner

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