PO.CL06.02 · 临床研究
Mechanistic Insights for Targeted Therapies in Pediatric Cancer
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- 1154 1154 Multi-omic profiling of cellular heterogeneity and microenvironmental remodeling underlying treatment resistance in neuroblastoma Eun Seop Seo, JI WON LEE, In Woo Hwang, Woong-Yang Park, Jun Sun Kim, Ki Woong Sung
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- 1157 1157 Preclinical evaluation of PEG-[SN22]₄ (PEEL-224), a multivalent polymeric camptothecin prodrug, in pediatric solid tumor patient-derived xenograft models Filemon S. Dela Cruz, Kristina C. Guillan, Samantha Brosius, Armaan H. Siddiquee, Glorife Ibanez Sanchez, Daoqi You, Kristen Victor, Paul Calder, Trent Fowler, Joshua D. Schiffman, Andrew L. Kung
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- 1159 1159 Trans-species analysis of replication repair deficient medulloblastoma and response to immune checkpoint inhibition: An IRRDC report Nicholas R. Fernandez, Anirban Das, Adrian Levine, Kyle Smith, Evan Wang, Melissa Galati, Zoya Aamir, Jiil Chung, Logine Negm, Hope Friedman, Katharine O'Flaherty, Owen Crump, Quang M. Trinh, Nuno M. Nunes, Vanessa Bianchi, Lucie Stengs, Melissa Edwards, Lincoln Stein, Eric Bouffet, Michael D. Taylor, Paul Northcott, Vijay Ramaswamy, Cynthia Hawkins, Uri Tabori
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- 1164 1164 Pacritinib mitigates doxorubicin resistance in osteosarcoma by inhibiting WNT/beta-catenin, efflux proteins and receptor tyrosine kinase network Marina Curcic, Sanjay Kumar Srivastava
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- 1166 1166 Genetic and pharmacologic suppression of pink1 prolongs survival in sonic hedgehog driven medulloblastoma and related mouse model Bahauddeen M. Alrfaei, Amani Almuaysib, Ahmed Aloraidi, Ali Assiri
- 1167 1167 The pan-CLK DYRK inhibitor SM09419 prolongs animal survival times in a subset of pediatric medulloblastoma patient-derived orthotopic xenograft mouse models Xin (Alice) Zhai, Zilu Huang, Milagros Suarez Palacios, Tongchao Jiang, Aalaa Abdallah, Jinnan Chen, Yiming Mei, Emily Ciolak, Nitin Wadhwani, Alicia Lenzen, Yuchen Du, Xiao-Nan Li
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- 1169 1169 Global proteomic analysis of pediatric T-cell acute lymphoblastic leukemia patient samples reveals distinct protein upregulation signature Irina Pushel, Thomas Gremminger, Lisa Lansdon, Michaella Rekowski, Midhat S. Farooqi, Michael Washburn, Keith August
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- 1171 1171 Copy number variation in Sonic hedgehog-medulloblastoma with unique p53 mutations: Inhibition of PI3K/AKT/mTOR pathways with HDAC inhibitors can serve as therapeutic options Austin Carpenter, Mohan Das, Raphael Salles S Medeiros, Sidnei Epelman, Epelman, Nelci Zanon, Chirag D. Gandhi, Meena Jhanwar-Uniyal
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- 1173 1173 Trans-species analysis of mismatch repair deficient IDH1 mutant gliomas reveals a unique genomic and immune landscape resulting in favorable response to combination immune and targeted therapy Vienna Mazzoli, Nicholas R. Fernandez, Zoya Aamir, Olha Kos, Emma Gattoni, Owen Crump, Lucie Stengs, Nuno M. Nunes, Katharine O'Flaherty, Hope Friedman, Olfat Ahmad, Abigail Suwala, Kevin Bielamowicz, Gadi Abebe-Campino, Shani Caspi, Per Nyman, Richard Graham, John Y. H. Kim, Mari Wilhelmsson, Mette Jorgensen, Orli Michaeli, Maria Baro, Alyssa Reddy, Nicolas Jose Llosa, Amanda Li, Adrian Levine, Logine Negm, Melissa Edwards, Vanessa Bianchi, Birgit Ertl-Wagner, Julie Bennett, Stefan M. Pfister, Peter B. Dirks, Eric Bouffet, Cynthia E. Hawkins, Anirban Das, Uri Y. Tabori
