PO.CL06.02 · 临床研究
Mechanistic Insights for Targeted Therapies in Pediatric Cancer
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- 1154 1154 多组学分析揭示神经母细胞瘤治疗耐药背后的细胞异质性与微环境重塑 Multi-omic profiling of cellular heterogeneity and microenvironmental remodeling underlying treatment resistance in neuroblastoma Eun Seop Seo, JI WON LEE, In Woo Hwang, Woong-Yang Park, Jun Sun Kim, Ki Woong Sung
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- 1157 1157 多价聚合物喜树碱前药PEG-[SN22]₄（PEEL-224）在儿童实体瘤患者来源异种移植模型中的临床前评价 Preclinical evaluation of PEG-[SN22]₄ (PEEL-224), a multivalent polymeric camptothecin prodrug, in pediatric solid tumor patient-derived xenograft models Filemon S. Dela Cruz, Kristina C. Guillan, Samantha Brosius, Armaan H. Siddiquee, Glorife Ibanez Sanchez, Daoqi You, Kristen Victor, Paul Calder, Trent Fowler, Joshua D. Schiffman, Andrew L. Kung
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- 1159 1159 复制修复缺陷型髓母细胞瘤及其对免疫检查点抑制反应的跨物种分析：一份IRRDC报告 Trans-species analysis of replication repair deficient medulloblastoma and response to immune checkpoint inhibition: An IRRDC report Nicholas R. Fernandez, Anirban Das, Adrian Levine, Kyle Smith, Evan Wang, Melissa Galati, Zoya Aamir, Jiil Chung, Logine Negm, Hope Friedman, Katharine O'Flaherty, Owen Crump, Quang M. Trinh, Nuno M. Nunes, Vanessa Bianchi, Lucie Stengs, Melissa Edwards, Lincoln Stein, Eric Bouffet, Michael D. Taylor, Paul Northcott, Vijay Ramaswamy, Cynthia Hawkins, Uri Tabori
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- 1164 1164 Pacritinib通过抑制WNT/beta-catenin、外排蛋白及受体酪氨酸激酶网络减轻骨肉瘤对多柔比星的耐药 Pacritinib mitigates doxorubicin resistance in osteosarcoma by inhibiting WNT/beta-catenin, efflux proteins and receptor tyrosine kinase network Marina Curcic, Sanjay Kumar Srivastava
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- 1166 1166 从遗传学和药理学角度抑制pink1可延长音猬因子（Sonic Hedgehog）驱动的髓母细胞瘤及相关小鼠模型的生存期 Genetic and pharmacologic suppression of pink1 prolongs survival in sonic hedgehog driven medulloblastoma and related mouse model Bahauddeen M. Alrfaei, Amani Almuaysib, Ahmed Aloraidi, Ali Assiri
- 1167 1167 泛CLK/DYRK抑制剂SM09419延长一部分儿童髓母细胞瘤患者来源原位异种移植小鼠模型的动物生存期 The pan-CLK DYRK inhibitor SM09419 prolongs animal survival times in a subset of pediatric medulloblastoma patient-derived orthotopic xenograft mouse models Xin (Alice) Zhai, Zilu Huang, Milagros Suarez Palacios, Tongchao Jiang, Aalaa Abdallah, Jinnan Chen, Yiming Mei, Emily Ciolak, Nitin Wadhwani, Alicia Lenzen, Yuchen Du, Xiao-Nan Li
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- 1169 1169 儿童T细胞急性淋巴细胞白血病患者样本的全局蛋白质组分析揭示独特的蛋白上调特征 Global proteomic analysis of pediatric T-cell acute lymphoblastic leukemia patient samples reveals distinct protein upregulation signature Irina Pushel, Thomas Gremminger, Lisa Lansdon, Michaella Rekowski, Midhat S. Farooqi, Michael Washburn, Keith August
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- 1171 1171 具有独特p53突变的Sonic hedgehog型髓母细胞瘤中的拷贝数变异：用HDAC抑制剂抑制PI3K/AKT/mTOR通路可作为治疗选择 Copy number variation in Sonic hedgehog-medulloblastoma with unique p53 mutations: Inhibition of PI3K/AKT/mTOR pathways with HDAC inhibitors can serve as therapeutic options Austin Carpenter, Mohan Das, Raphael Salles S Medeiros, Sidnei Epelman, Epelman, Nelci Zanon, Chirag D. Gandhi, Meena Jhanwar-Uniyal
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- 1173 1173 错配修复缺陷型IDH1突变胶质瘤的跨物种分析揭示了独特的基因组和免疫格局，从而对免疫联合靶向治疗产生良好反应 Trans-species analysis of mismatch repair deficient IDH1 mutant gliomas reveals a unique genomic and immune landscape resulting in favorable response to combination immune and targeted therapy Vienna Mazzoli, Nicholas R. Fernandez, Zoya Aamir, Olha Kos, Emma Gattoni, Owen Crump, Lucie Stengs, Nuno M. Nunes, Katharine O'Flaherty, Hope Friedman, Olfat Ahmad, Abigail Suwala, Kevin Bielamowicz, Gadi Abebe-Campino, Shani Caspi, Per Nyman, Richard Graham, John Y. H. Kim, Mari Wilhelmsson, Mette Jorgensen, Orli Michaeli, Maria Baro, Alyssa Reddy, Nicolas Jose Llosa, Amanda Li, Adrian Levine, Logine Negm, Melissa Edwards, Vanessa Bianchi, Birgit Ertl-Wagner, Julie Bennett, Stefan M. Pfister, Peter B. Dirks, Eric Bouffet, Cynthia E. Hawkins, Anirban Das, Uri Y. Tabori
