PO.IM01.12 · 免疫学
Immunomodulatory Agents
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4297 · PDF COX-2/PGE2驱动的光免疫治疗诱导性水肿在小鼠肿瘤模型中可通过预防性使用NSAIDs而减轻 COX-2/PGE2 driven, photoimmunotherapy-induced edema is reduced by prophylactic NSAIDs in mouse tumor models Christopher M. Amantea, Abram Lozano, Ryosuke Takahashi, Takuya Osada, Shohei Sase, Ryuhei Okada, Amy H. Thorne
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4298 · PDF 高剂量维生素C诱导ROS依赖性钙网蛋白暴露以驱动免疫原性细胞死亡和癌症免疫监视 High-dose vitamin C induces ROS-dependent calreticulin exposure to drive immunogenic cell death and cancer immune surveillance Alessandro Cavaliere, Federica Maione, Marco Macagno, Vito Amodio, Rosaria Chilà, Marcello Turi, Marc Escobosa, Giovanni Germano, Simona Lamba, Chiara Baretta, Anita Brignacca, Valeria Pessei, Elena Perez, Daniela Grases, Alice Bartolini, Fabio Penna, Eduard Porta, Manel Esteller, Dieter Saur, Roland Rad, Annamaria Gullà, Alberto Bardelli, Teresa Troiani, Salvatore Siena, Andrea Sartore-Bianchi, Federica Di Nicolantonio
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4299 · PDF STING通路激活揭示可能限制腺样囊性癌免疫刺激反应的反馈抑制 STING pathway activation reveals feedback inhibition potentially limiting immunostimulatory response in adenoid cystic carcinoma Annie Li, Samantha E. Flynn, Prinjali Kalyan, Dawn R. Mitchell, Chengzhou Gao, Edwin Zhang, Diane Yang, Ross D. Merkin, William C. Faquin, Daniel L. Faden, Xin Gao, Jong Chul Park, Lori J. Wirth, A. John Iafrate
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4300 · PDF 用于治疗胶质母细胞瘤的新型STING激动剂IMGS-203的IND支持性开发 IND-enabling development of a novel STING agonist, IMGS-203, for the treatment of glioblastoma Christine Gagliardi, Paul Blezinger, Ahmad Salameh, Michael A. Curran, James Barlow, Federica Pericle
- 4301 4301 一种全身给药的解毒TLR4激动剂在多种肿瘤模型中显示出强效抗肿瘤活性和良好的临床前耐受性特征 A systemically administered detoxified TLR4 agonist displays potent antitumor activity across multiple tumor models and favorable preclinical tolerance profile Laury-Anne Leroy, Capucine Phelip, Armando Andres Roca Suarez, Sabine Beaumel, Anais Debesset, Abdelkamel Chettab, Martine Caroff, Audrey Diederichs, Alexey Novikov, Barbara Testoni, Frédérique Brune, Fabien Zoulim, Jérôme Kerzerho, Juliette Humeau, Charles Dumontet
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4302 · PDF 新一代STING mRNA疗法:降低毒性并通过增强免疫和诱导肿瘤细胞死亡对抗癌症的双重作用 Next-generation STING mRNA therapy with reduced toxicity and dual action against cancer by boosting immunity and inducing tumor cell death Yong Ho Heo, Youngjin Han, Seung-Hyun Shin, Chang Gyu Lim, Ji Hee Lee, Hocheol Shin, Jooyun Byun, Daejin Kim, In Young Choi
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4303 · PDF 通过靶向EGFL6重编程卵巢癌的肿瘤免疫原性 Reprogramming tumor immunogenicity by targeting EGFL6 in ovarian cancer Weiche Wu, Zonghao Tang, Sujanitha Umamaheswaran, Zhiqiang An, Ningyan Zhang, Lingegowda S. Mangala, Anil K. Sood
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4304 · PDF 通过基于DIRAC-dCas13的筛选鉴定的靶向PD-1前体mRNA的反义寡核苷酸对PD-1阳性淋巴细胞的影响 Effects of antisense oligonucleotides targeting PD-1 pre-mRNA identified by DIRAC-dCas13-based screening on PD-1-positive lymphocytes Yuto Tan, Naoko Kumagai-Takei, Shuya Yano, Yurika Shimizu, Akira Yamasaki, Mari Hara-Yamamoto, Shigeru Mitani, Tatsuo Ito
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4307 · PDF 受妊娠启发的DNA纳米载体可重现由cGAS驱动的促炎单核细胞表型 Pregnancy-inspired DNA nanocarriers reproduce a cGAS-driven pro-inflammatory monocyte phenotype Mathew R. Schnorenberg, Elizabeth Ann L. Enninga, Wendy K. Nevala, Noah A. Stueven, Svetomir N. Markovic
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4308 · PDF 采用工程化癌症激活型启动子的全身性纳米质粒基因治疗可选择性地编程肿瘤细胞表达炎性白细胞介素并驱动抗肿瘤免疫 Systemic nanoplasmid gene therapy with engineered cancer-activated promoters selectively programs tumor cells to express inflammatory interleukins and drive antitumor immunity Evan Bishop, Priyanka Balasubrahmanyam, Ajda Rojc, Trupti Patil, Moataz Reda, Lingyun Li, Dang Dang, Xiaobin Wu, Robby Chandra, Nikki Kimura, Kim Tran, Blaine McCarthy, Sushil Lathwal, Sathyapriva Rajagopal, Badriprasad Ananthanarayanan, Nadege Morisot, David Brian Rosen, David Suhy
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4309 · PDF ARV-6723(一种PROTAC造血祖细胞激酶1(HPK1)降解剂)相较于免疫检查点抑制剂(ICIs)的临床前抗肿瘤及免疫调节活性 Preclinical antitumor and immunomodulatory activity of ARV-6723, a PROTAC hematopoietic progenitor kinase 1 (HPK1) degrader, versus immune checkpoint inhibitors (ICIs) Anna C. Van Acker, William Corwin, Albert DeBerardinis, Emma Rousseau, Rebecca Conrad, Morena Scopel, Christopher Kuhlberg, Gregory Cadelina, Kim Davenport, Wendy Wu, John Corradi, Jennifer Pizzano, Keith R. Hornberger, Angela Cacace, Ignacio J. Juncadella, Sean Landrette, XiaoZhe (Janet) Wang
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4310 · PDF CLD-401,一种通过RedTail病毒疗法递送的IL-15超级激动剂基因药物,实现持续的肿瘤根除 CLD-401, an IL-15 superagonist gene medicine via redtail virotherapy, achieves sustained tumor eradication Duong H. Nguyen, Yunyi Kang, Stephanie Songco, Trevor Smith, David Nguyen, Yan Pang, Lina Schulte, Hongli Zhang, Sinje Tigges, Fabian Kortum, Daniela Kleinholz, Susan Tamraz, Ivelina Minev, Evan Cassavaugh, Travis Clifton, Thomas Herrmann, Barbara Härtl, Antonio F. Santidrian
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4311 · PDF 基于沙粒病毒的非裂解型病毒免疫驱动因子携带嗜肿瘤性突变,作为抗肿瘤T细胞反应的新型放大器 Arenavirus based Non-lytic Viral Immune Drivers with tumor-tropic mutations as new class of amplificators of anti-tumoral T cell responses Philipp A. Lang, Jörg Vollmer, Karl S. Lang
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4312 · PDF 携带新型TLR7激动剂载荷的FAP靶向小分子-免疫刺激剂偶联物在体内诱导肿瘤根除和持久的抗肿瘤免疫 FAP-targeting Small molecule-immunostimulator conjugate bearing a novel TLR7 agonist payload induces tumor eradication and long-lasting antitumor immunity in vivo Matilde Bocci, Matilde Monaci, Marta Mascellani, Dario Neri, Samuele Cazzamalli, Andrea Galbiati
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4313 · PDF 无光照的诱导光化学内化聚合物偶联物引发癌症焦亡以协调宿主免疫反应 Light-free photochemical internalization-inducing polymer conjugate elicits cancer pyroptosis to coordinate host immune responses Torsha Ghosh, Jae Hyung Park, Sol Shin, Soyoung Son
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4314 · PDF 双极脉冲电场消融在同基因PDAC模型中触发局部和远隔肿瘤控制并伴随强劲的免疫激活 Bipolar pulsed field ablation triggers local and abscopal tumor control with robust immune activation in a syngeneic PDAC model MacKenzie Demmel, Lincoln Strickland, Khadija Turabi, Alyssa Waller, Urvinder Kaur Sardarni, Nirav C. Thosani, Raju Viswanathan, Jennifer Bailey-Lundberg
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4315 · PDF Wnt/beta-catenin与c-MET共激活诱导对免疫检查点治疗有反应的炎性肝细胞癌 Co-activation of Wnt/beta-catenin and c-MET induced inflamed hepatocellular carcinoma responsive to immune checkpoint therapy Araceli Selena Bernal, Subash Khadka, Morgana McLaughlin, Ankur Tiwari, Brittany Barre, Francisco Cigarroa, LuZhe Sun
- 4316 4316 一种用于肝癌治疗的体内MAIT细胞激活与再生系统 An in vivo MAIT cell activation and rejuvenation systemfor liver cancer therapy Yan-Ruide Li, Haochen Nan, Zhengyao Shao, Xinyuan Shen, Lili Yang
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4317 · PDF 一种用于低剂量光动力治疗诱导抗肿瘤免疫激活的porphyrin-HDL纳米颗粒 A porphyrin-HDL nanoparticle for low-dose photodynamic therapy-induced antitumor immune activation Yiming Yang, Juan Chen, Gang Zheng
- 4318 4318 Quad Shot方案联合免疫治疗用于不可治愈的复发或转移性头颈癌 Combined Quad Shot regimen and immunotherapy for incurable recurrent or metastatic head and neck cancer Xiao Yang, Zheng Yang, Fei Wang, Lingyi Kong, Chao Wan, Kunyu Yang
- 4319 4319 探索溶瘤病毒疗法靶向骨肉瘤 Exploring oncolytic viral therapy to target osteosarcoma Sumbul Khan, Therasa A. Higgins, Isabella S. Lofano, Payal Agarwal
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4320 · PDF 以IFN-gamma调控为指导对KNP-101重复给药方案的合理设计 Rational design of a repeated-dosing schedule for KNP-101 guided by IFN-gamma regulation Jihoon Chang, Byoung Chul Lee
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4321 · PDF 溶瘤病毒在使用同基因和PDX模型的三阴性乳腺癌中展现出强大的抗肿瘤和免疫调节作用 Oncolytic virus exhibits potent antitumor and immunomodulatory effects in triple-negative breast cancer using syngeneic and PDX models Yelin KIM, Jihye B Lee, Yoonjin Cha, Keunhee Oh, Namhee Lee, Seoyoung Lee, Hei Cheul Jeung, Soong June Bae, Sung Gwe Ahn, Joon JEONG, Jee Hung Kim
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4322 · PDF 肿瘤治疗电场(TTFields)在小鼠肺腺癌模型中克服抗PD-1耐药 Tumor treating fields (TTFields) overcome anti-PD-1 resistance in a murine lung adenocarcinoma model Yun Hu, Fatemeh Maspourour, Qi Wang, Ailing Huang, Carola Leuschner, Jing Wang, James W. Welsh
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4323 · PDF SPHK2抑制剂opaganib在体外增强三阴性乳腺癌的肿瘤内在性STING激活 The SPHK2 inhibitor opaganib potentiates tumor-intrinsic STING activation in triple-negative breast cancer in vitro Colette R. Worcester, Amrita Mitra, Harsh B. Pathak, Shane R. Stecklein
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4324 · PDF 恢复二肽基肽酶4促进KRAS-LKB1突变型肺癌的抗肿瘤免疫 Dipeptidyl peptidase 4 restoration facilitates anti-tumor immunity in KRAS-LKB1-mutant lung cancer Hiraku Yanada
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4326 · PDF 剖析溶瘤病毒在胶质瘤中的抗病毒免疫与抗肿瘤免疫:来自患者来源类器官模型的见解 Dissecting oncolytic virus anti-virus vs anti-tumor immunity in glioma: Insights from a patient derived organoid model C. Zoe Linke, Ethan Chen, Jennifer Gantchev, Aanchalika Chauhan, Christopher Jannotta, Keith L. Ligon, Andres Santos, Nathalie Agar, E Antonio Chiocca, Alexander L. Ling
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4327 · PDF 5-羟色胺受体5-HT2A作为HCC免疫治疗的潜在靶点 Serotonin receptor 5-HT 2A as a potential target for HCC immunotherapy Rong En Tay, Charmaine M. Ho, Nicholas D. Z. Ang, Hui Chien Tay, Daniel Z. Lopez, Qiao Rui Na, Yi Wen Tan, Ser Mei Koh, Kim Peng Tan, Wendy W. L. Lee, Jack Wee Lim, Mai Chan Lau, Han Chong Toh, Olaf Rötzschke, Laurent Rénia