PO.IM02.04 · 免疫学
Adaptive Immunity in Cancer
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4233 · PDF 转录因子c-Maf驱动Th17依赖性的CD8⁺ T细胞活化以维持抗肿瘤免疫 Transcription factor c-Maf drives Th17-dependent activation of CD8⁺ T cells to sustain anti-tumor immunity Ching Tung Wu, Shi-Chuen Miaw
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4234 · PDF 基于聚糖的位点特异性ADC通过改善有效载荷递送和免疫激活实现持续的肿瘤控制 Glycan-based site specific ADC achieves sustained tumor control through Improved payload delivery and immune activation Liu Chih-Chun, Tsai Yi-Chien, Huang Jing-Rong, Lo Fei-Yun, Pei Yu, Hsu Ren-Yu, Tu Tzu-Hsuan, Chen Ya-Chi
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4235 · PDF 通过G4X在细胞水平进行空间转录组学检测结直肠癌复发中微环境STAT1表达的浆细胞 Cell-level spatial transcriptomics detection of microenvironmental STAT1-expressing plasma cells in colorectal cancer recurrence by G4X I-Chuang Liao, Minh-Khang Le, Vivek Pujara, Haley Jun, Devanshi Pratiher, Jane C. Figueiredo, Nathalie Nguyen, Chintda Santiskulvong, Angie Laguna, Yi Zhang, Keluo Yao, Joshua Jay Levy
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4236 · PDF 代谢型谷氨酸受体-1是一个谷氨酸能检查点,与TCR整合以增强抗肿瘤CD8⁺ T细胞的活化、代谢和效应功能 The metabotropic Glutamate receptor-1 is a glutamatergic checkpoint that integrates with TCR to augment anti-tumor CD8⁺ T cell activation, metabolism and effector function Salvador Gonzalez Ochoa, Maria Teresa P. de Aquino, Thomas W. Hodo, Thanigaivelan Kanagasabai, Muna A. Mohammed, Jane Tonello, Alla Ivanova, Anil Shanker
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4237 · PDF 基于免疫荧光的适应性免疫亚型与Carolina乳腺癌研究第三期长期无病间期的关联 Immunofluorescence-based adaptive immune subtypes in an association with long-term disease-free interval in the Carolina Breast Cancer Study Phase III Qichen Wang, Timothy Patrick Sheahan, Alyssa Joy Cozzo, Sarah Christine Van Alsten, Eboneé Nicole Butler, James Stephen Marron, Katherine A. Hoadley, Melissa A. Troester
- 4238 4238 原发性皮肤黑色素瘤中不同类别肿瘤浸润淋巴细胞内的细胞因子表达:一项免疫组织化学研究 Cytokine expression within the different categories of tumor-infiltrating lymphocytes in primary cutaneous melanoma: an immunohistochemical study Thato Ntuli, Benny Mosoane, Tebogo Marutha, Rahaba Marima, Zodwa Dlamini, Meshack Bida
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4239 · PDF 衰老使B细胞成为削弱肿瘤防御的CD8⁺细胞的驱动因素 Aging turns B cells into drivers of CD8⁺ cells that weaken tumor defenses MONICA BODOGAI, Bongsoo Park, Fatima-Zohra Braikia, Kumaraswami Konda, Arya Biragyn
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4240 · PDF 短期和长期缺氧对效应T细胞功能障碍的差异性影响 Differential impact of short and long-term hypoxia on effector T cell dysfunction María Villalba-Esparza, Ana Lledó-Delgado, Shruti S. Desai, Adam Aguirre-Ducler, Daniel Boiarsky, Boyu Huang, Samuel M. DeFina, Javier Ramos-Paradas, Kurt A. Schalper
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4241 · PDF 浸润M3型葡萄膜黑色素瘤转移灶的抗肿瘤抗原CD8 T细胞可在血液中检测到 Anti-tumor antigen CD8 T cells infiltrating M3 uveal melanoma metastases are detectable in the blood Sol Y. Nunez, Rachele Sintini, Camille Jamet, Setareh Aflaki, Abdoulaye Soumare, Pascale Mariani, Manuel Rodrigues, Marc-Henri Stern, Olivier Lantz, Ana I. Lalanne
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4242 · PDF IRF8调控T细胞分化及抗肿瘤效应功能 IRF8 regulates T cell differentiation and anti-tumor effector function Zainab Tiamiyu, Dakota Poschel, Aaron Behdadnia, Kendra Fick, Patrick Czabala, Yang Zhao, Dafeng Yang, Sergie BOMBIN, Kebin LIU
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4243 · PDF 经突变特征校正的模型揭示HLA介导的非小细胞肺癌(NSCLC)抗原性突变耗竭 Mutational-signature adjusted models reveal HLA-mediated depletion of antigenic mutations in non-small cell lung cancer (NSCLC) Amy Lauren Cummings, Andy Han, Seung J. Park, Sai S. Kollapaneni, Daniel Li, Arjan Gower, Maria Antonia Velez Velez, Aaron Lisberg, Jonathan W. Goldman, Edward B. Garon
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4244 · PDF 研究隆突性皮肤纤维肉瘤的空间免疫肿瘤微环境 Investigating the spatial immune tumor microenvironment of dermatofibrosarcoma protuberans Maryam Al-Ghezi, Malia Rettig, Christopher P. Loo, Rashi Yadav, Wesley Yu, Joshua M. Moreau
- 4245 4245 将冷肿瘤转化为热肿瘤并克服耐药的免疫策略 The Immune strategies to convert cold to hot tumors and overcome resistances Yang-Xin Fu
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4248 · PDF ER+乳腺肿瘤及其配对邻近组织中T细胞的表征揭示经典耗竭标志物不能指示T细胞功能 Characterization of T-cells in ER + breast tumors and their matching adjacent tissue reveals that classical exhaustion markers are not indicative of T-cell function Diana Savage, Edward Buchel, Afshin Raouf
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4249 · PDF 利用Jurkat NFAT报告基因-K562抗原呈递细胞系统和单细胞适应性免疫受体分析高通量发现MART1特异性TCR-肽相互作用 High-throughput discovery of MART1-specific TCR-peptide interactions using a Jurkat NFAT Reporter-K562 antigen-presenting cell system and single-cell adaptive immune receptor profiling Alex Chenchik, Debbie Deng, Kitt Paraiso, Guido Stadler, Ben Yellen
- 4250 4250 Sirt2通过对LCK构象状态的翻译后调控决定TCR激活阈值 Sirt2 dictates TCR activation thresholds through post-translational control of LCK conformational state Imene Hamaidi, Pingyan Cheng, Soo Young Jun, Min-Hsuan Wang, Min Zhang, Odesha Taylor, Luis Lopez-bailon, Ismail Can, Bin Fang, Anders Berglund, Bradford Perez, Ben Creelan, Andriy Marusyk, Virginia Shapiro, Haitao Ji, Jose R. Conejo-Garcia, Sungjune Kim
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4251 · PDF Th7R细胞:驱动Tpex介导的肿瘤微环境内抗肿瘤免疫的CD4⁺ T细胞伙伴 Th7R cells: CD4⁺ T-cell partners that drive Tpex-mediated antitumor immunity in the tumor microenvironment Shota Takei, Ou Yamaguchi, Satoshi Yamasaki, Atsuhito Mouri, Ayako Shiono, Yu Miura, Kosuke Hashimoto, Hisao Imai, Kyoichi Kaira, Ichiki Yoshinobu, Hiroyuki Nitanda, Tomoyuki Hishida, Katsuhisa Horimoto, Hiroshi Kagamu
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4252 · PDF 肿瘤细胞外囊泡致敏B细胞,从而促进肿瘤控制及向T细胞新抗原的表位扩展 Tumor extracellular vesicles prime B cells which promote tumor control and epitope spreading to T cell neoantigens Georgia Lattanzi, Zihan Guo, Kendrick Nguyen, Ferdinando Pucci, Daniel Hollern
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4253 · PDF 整合新抗原免疫原性与肿瘤克隆性以预测免疫治疗应答 Integrating neoantigen immunogenicity and tumor clonality for predicting immunotherapy response Ko-Han Lee, Timothy Sears, Maurizio Zanetti, Hannah K. Carter
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4254 · PDF Tapasin抑制低亲和力肽组的MHC I呈递,而该肽组在多种小鼠癌症中激发出一群独特且高效的CD8 T细胞 Tapasin inhibits MHC I-presentation of a low affinity peptidome which elicits a unique population of highly effective CD8 T cells, in multiple mouse cancers Purva Pundeer, Joseph Dempsey, Adam T. Hagymasi, Jeremy Balsbaugh, Tatiana Scheglova, Ion Mandoiu, Pramod K. Srivastava
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4256 · PDF 长读长RNA测序和免疫肽组学揭示转录组异常新抗原作为弥漫性胶质瘤T细胞免疫治疗的靶点 Long-read RNA sequencing and immunopeptidomics reveal transcriptomic aberrationneoantigens as targets for T cell immunotherapy in diffuse glioma Kenan Zhang, Megan Benz, Kelly M. Hotchkiss, Lin Lin, Sarah Quackenbush, Aroa Elortza Payros, Mark Pieterse, Wigard Kloosterman, Jeroen Kneppers, Mustafa Khasraw
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4257 · PDF F5446对T细胞进行表观遗传重编程,增强CEA CAR T细胞免疫治疗对人结直肠癌转移的疗效 F5446 epigenetically reprograms T cells to boost CEA CAR T cell immunotherapy efficacy in human colorectal cancer metastasis Kendra Fick, Patrick Czabala, Zainab Tiamiyu, Dafeng Yang, Kebin Liu
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4258 · PDF 体内全基因组规模增强子筛选解码肿瘤中的T细胞命运决定 In vivo genome-scale enhancer screen decodes T cell fate decisions in the tumor Keely Y. Ji, Alex Chang-Yu Chen, Laura Hinojosa, Bolutito Babatunde, Daniela Martinez, Thomas J. LaSalle, Maria Zschummel, Marc A. Schwartz, Ferhat Ay, Debattama Sen
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4259 · PDF 外周T细胞甲基化组揭示早期肺癌中加速的全身免疫衰老 Peripheral T cell methylome reveals accelerated systemic immune aging in early lung cancer Yu-Ching Wang, Shu-Yung Lin, Yi-Jhen Huang, Sheng-Yao Su, Yi-Chieh Wu, Jin-Shing Chen, Shuenn-Wen Kuo, Mong-Wei Lin, Chong-Jen Yu, Hsing-Chen Tsai
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4260 · PDF 通过微流控技术解析急性髓系白血病中功能失调的免疫突触 Deciphering the dysfunctional immunological synapse in acute myeloid leukemia through microfluidic Sofia Titah, Clara Lewuillon, Faruk Azam Shaik, Aurelie Guillemette, Eva Gez, Nathalie Jouy, Laure Goursaud, Celine Berthon, Salomon Manier, Carine Brinster, William Langue, Tzung Hsuen Khoo, Alexandre Poulain, Sophie Dabo, Dominique Collard, Bruno Quesnel, Loic Lemonnier, Mehmet Cagatay Tarhan, Yasmine Touil
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4261 · PDF 从有限的临床PBMC样本中进行高灵敏度HLA-I免疫肽组分析 High-sensitivity HLA-I immunopeptidome profiling from limited clinical PBMC samples Anamarija Pfeiffer, Lucy Yang, Arthur Viodé, Daniel Redfern, Yuehan Feng, Daniel Green, Cheryl McAlpine