PO.TB10.08 · 肿瘤生物学
Spatial Niches and Functional Boundaries within the Tumor Microenvironment 1
- 4944 4944 乳腺癌和胃肠道肿瘤的显色三重标记表征用于生物标志物发现和空间图像分析 Chromogenic triplex characterization of breast and gastrointestinal cancers for biomarker discovery and spatial image analysis Andrew Fuller, Stacey Margerrison, Scott J. Anderson, Anne Hellebust
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- 4947 4947 空间组织的转录程序和肿瘤-基质界面塑造微卫星高度不稳定性胃肠道肿瘤的免疫治疗反应 Spatially organized transcriptional programs and tumor-stroma interfaces shape immunotherapy response in microsatellite instability-high gastrointestinal cancers Xueshuai Han, Kohei Yamashita, Melissa Pool Pizzi, Kyung Serk Cho, Enyu Dai, Kai Yu, Yunhe Liu, Yibo Dai, Tian Chu, Matheus Sewastjanow-Silva, Hiro Yoshimura, Yibo Fan, Rebecca Waters, Qiong Gan, Feng Yin, Shilpa S. Dhar, Isadora Martins, Jason Willis, Mariela B. Murphy, Jenny Li, Brian D. Badgwell, Van K. Morris, Michael J. Overman, Linghua Wang, Jaffer A. Ajani
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- 4949 4949 高分辨率空间转录组学揭示前列腺癌进展过程中肿瘤微环境的动态重塑 High resolution spatial transcriptomics reveals dynamic remodeling of the tumor microenvironment during prostate cancer progression Jiayi Zhou, Gabriel Cruz, Somnath Mahapatra, Radha Paturu, Hanbyul Cho, Xuhong Cao, Fengyun Su, Rui Wang, Dan Robinson, Yi-Mi Wu, Rohit Mehra, Kayla Muschong, Christine Caldwell Smith, Chelsea Decker, Chandan Kumar-Sinha, Saravana Mohan Dhanasekaran, Rahul Mannan, Yuping Zhang, Arul Chinnaiyan
- 4950 4950 利用DISS对癌症组织进行空间解析的多组学分析可实现跨组织景观的变异图谱绘制 Spatially resolved multiomic profiling of cancer tissue with DISS enables variant mapping across tissue landscape Vivian Tran Dien, Tyler Lopez, Connor Thompson, Ben Krajacich, Adeline Mah, Andrew Altomare, Mariam Dawood, Neam Dawood, Keerthana Elango, Daniel Honigfort, Ryan Kelley, Michael Kim, Jean Kwon, Seana Lymer, Kyle Metcalfe, Jacob Moreno, Duuluu Naranbat, Evan O'Brien, Tristin Rammel, Carlos Ruiz Perez, Ramreddy Tippana, David White, Kelly Wiseman, Jennifer Wong, Jane Yao, Grace Yeo, Matthew Kellinger, Sinan Arslan, Michael Previte
- 4951 4951 揭示APOE/APOC1/SPP1/TREM2阳性脂质相关巨噬细胞在结直肠癌破坏性静脉侵犯和转移中的作用 Unraveling the role of APOE/APOC1/SPP1/TREM2‑positive lipid‑Associated macrophages in destructive venous invasion and metastasis of colorectal cancer Sanha Hwang
- 4952 4952 空间转录组学揭示区分NSCLC新辅助化学免疫治疗后非MPR与MPR的核心耐药微龛 Spatial Transcriptomics reveals core resistance niches distinguishing non-MPR from MPR in NSCLC after neoadjuvant chemoimmunotherapy Seo Hye Park, Jeongbin Park, Hongyoon Choi, Jaemoon Koh, Taeyoung Yun, Jihyeon Park, Bubse Na, Samina Park, In Kyu Park, Chang Hyun Kang, Young Tae Kim, Kwon Joong Na
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- 4954 4954 侵袭性前列腺腺癌的整合scRNAseq和空间RNAseq分析鉴定出TIGIT-NECTIN 2/3和TIGIT/PVR免疫抑制性相互作用 Integrated scRNAseq andspatial RNAseq analysis of aggressive prostatic adenocarcinoma identifies TIGIT-NECTIN 2/3 and TIGIT/PVR immunosuppressive interactions Jerry A. Ombor, Anurendra Kumar, Jatin Gandhi, Rakesh Shiradkar, Tilak Pathak, Cynthia L. Winham, Ismaheel O. Lawal, Olayinka A. Abiodun-Ojo, Lara Harik, Saurabh Sinha, Martin G. Sanda, David M. Schuster, Adeboye O. Osunkoya, Carlos S. Moreno
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- 4956 4956 空间和血管微环境特征预测胶质母细胞瘤中肿瘤浸润淋巴细胞的扩增 Spatial and vascular microenvironmental features predict tumor-infiltrating lymphocyte expansion in glioblastoma Jodie Jepson, Kenan Zhang, Anna Corcoran, Elizabeth Owens, Kelly M. Hotchkiss, Beth H. Shaz, Kyra Van Batavia, Jose R. Conejo-Garcia, John Hickey, Mustafa Khasraw
- 4957 4957 SMARCB1缺失型上皮样肉瘤肿瘤微环境与治疗反应的空间分辨谱分析 Spatially resolved profiling of the tumor microenvironment and therapeutic response in SMARCB1-deficient epithelioid sarcoma Jiayi Fan, Jeffrey Quinn, Wesley Tansey
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- 4959 4959 Trekker无需分割或去卷积即可实现FFPE肺SCC肿瘤微环境的高灵敏度单细胞空间谱分析 Trekker enables high-sensitivity, single-cell spatial profiling of the FFPE lung SCC tumor microenvironment without segmentation or deconvolution Cedric R. Uytingco, Alec Barret, Julie Wilhelmy, Bryant Ngo, Chenglong Xia, Jonathan Sakkos, Diksha Kool, Wanxin Wang, Christina Chang, Christina Fan, Andrew Farmer
- 4960 4960 在FFPE肺鳞状细胞癌样本中对空间转录组学技术进行跨平台比较 Cross-platform comparison of spatial transcriptomics technologies in an FFPE lung squamous cell carcinoma sample Bryan Bell, Cedric Uytingco, Alec Barrett, Bryant Ngo, Jonathan Sakkos, Diksha Kool, Wanxin Wang, Melissa del Rosario, Christina Chang, Christina Fan, Andrew Farmer
- 4961 4961 高多重空间成像揭示乳腺肿瘤微环境中细胞类型特异性的脂肪因子信号网络 Cell type-specific adipokine signaling networks in the breast tumor microenvironment uncovered by high-plex spatial imaging Samarth Singhal, Amber Rockson, Hanina Hibshoosh, Parin Shah, Fatemeh Derakhshan, Diane Chen, Alireza Salem, Benjamin Izar, Kevin L. Gardner, Coral O. Omene, Daniel Fernandez, Adrienne L. Castillo, Emma Armstrong, Ijeamaka Anyene Fumagalli, Elizabeth M. Cespedes Feliciano, Sandeep K. Singhal, Adana A. M. Llanos
- 4962 4962 空间转录组学揭示晚期前列腺癌中不同的ASCL1和ASCL2基因表达模式 Spatial transcriptomics reveals distinct ASCL1 and ASCL2 gene expression patterns in advanced prostate cancer Fan Wei, Joy C. Yang, Kenneth Iczkowski, Marc A. Dall'Era, Chengfei Liu
- 4963 4963 空间域识别的跨平台验证:整合空间转录组学与多重免疫荧光揭示NSCLC中一致的肿瘤微环境结构 Cross platform validation of spatial domain identification reveals concordant tumor microenvironment architecture in NSCLC using integrated spatial transcriptomics and multiplex immunofluorescence Zeinab Mokhtari, Mint Htun, Debayan Mukherjee, Nima Vakili, Deon Hildebrand, Crysthiane Ishiy, Anna Pasto, Sue Griffin, Paul Barber, Tony NG
- 4964 4964 Gli1高表达肿瘤细胞与M2巨噬细胞之间的空间相互作用可预测胃癌的生存和复发 Spatial interaction between Gli1 high tumor cells and M2 macrophages predicts survival and recurrence in gastric cancer Dae Yeong Kim, Dae-Hee Lee, Sang Cheul Oh
- 4965 4965 肉瘤样转化重塑嫌色细胞肾细胞癌的免疫空间格局与检查点调控 Sarcomatoid transformation rewires the immune spatial landscape and checkpoint regulation in chromophobe renal cell carcinoma Wafaa Bzeih, Yan Tang, Tiegang Han, Andrew J. Sedgewick, Nathan D. Maulding, Carmen Priolo, Katrina Collins, Hadi Mansour, Joelle Chami, Michelle M. Stein, Justin Guinney, Michel Alchoueiry, Jessica F. Williams, Michelle S. Hirsch, Pavlos Msaouel, Elizabeth P. Henske
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- 4968 4968 利用Xenium转录组学与Hyperion XTi成像质谱流式对肿瘤-免疫微环境进行综合多组学分析 Comprehensive multi-omic profiling of the tumor-immune microenvironment using Xenium transcriptomics and Hyperion XTi Imaging Mass Cytometry Wendell Smith, Elim Cheung, JingHao Tian, Qanber Raza, Toby Astill, Daniel Zangrando, Nina Lane, Tommy Tran, Rikita Gakhar, Vidyodhaya Sundaram
- 4969 4969 具有超过100种生物标志物的自动化多组学检测用于多种癌症类型肿瘤微环境的深入空间分析 Automated multiomics assay with over 100 biomarkers for in-depth spatial profiling of the tumor microenvironment in multiple cancer types Marion Bonnet, Cansaran Saygili-Demir, Kim Handel, Pedro Machado, Alix Failletaz, Debia Wakhloo, Anushka Dikshit, Maria Giuseppina Procopio, Saska Brajkovic
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- 4972 4972 KIT外显子9与外显子11突变在胃肠道间质瘤中形成独特的空间及表型免疫微环境 KIT exon 9 versus exon 11 mutations imprint distinct spatial and phenotypic immune microenvironments in gastrointestinal stromal tumors Jean-Philippe Guegan, Jean-Michel Coindre, Carine Ngo, Antoine Bougoüin, Christophe Rey, Catherine SAUTÈS-FRIDMAN, Wolf Herve Fridman, Armelle Dufresne, Alban Bessede, Antoine Italiano
