Spatial Proteomics and Transcriptomics 3

• 6659 · PDF 胰腺腺癌的空间蛋白-转录组学分析揭示不同恶性亚型相关的免疫和基质功能状态 Spatial proteo-transcriptomic profiling of pancreatic adenocarcinoma unveils distinct malignant subtype-associated immune and stromal functional states Beatrice Wendler Awasthi, Nicole A. Lester, Deniz Guney Olgun, Yi Cui, Gabriel Francisco Pozo Mattos Pereira, Nicholas Caldwell, Mari Mino-Kenudson, Maria Ganci, Manisha Madhavan, Sierra Mckinzie, Jung Woo Bae, Xunqin Yin, Shanshan He, PRAJAN DIVAKAR, Martin Hemberg, Joe Beechem, William L. Hwang
• 6660 · PDF CellScape质量控制（CSQC）：一种组织和蛋白无关的空间蛋白质组学质量评估平台 CellScape Quality Control (CSQC): A tissue- and protein-agnostic platform for spatial proteomics quality assessment Daniel Jimenez-Sanchez, Brian J. Lane, Matthew H. Ingalls, Charles Eldon Jackson, Steven T. Lott, Adam Northcutt, Arne Christians, Anke Brix, Jennifer Brooks, Oliver Braubach
• 6661 · PDF 从具有挑战性的临床样本中获得高质量的全转录组RNA测序 High quality whole transcriptome RNA-sequencing from challenging clinical samples Pieter Mestdagh, Lisa Van Den Bossche, Thomas Van Wunsel, Hilke Spooren, Emmanuel Rivière, Jan Van de Velde, Ana Carolina Elisa Fierro Gutierrez, Nathalie Bernard, Lien Heyrman, Dirk Goossens, Jurgen Del Favero
• 6662 · PDF 空间基因组学揭示前列腺癌中与器官特异性转移倾向相关的微环境程序 Spatial genomics reveals microenvironmental programs associated with organ-specific metastatic propensity in prostate cancer Maryam Ranjpour, Mohamed Omar
• 6663 · PDF 整合空间转录组学和蛋白质组学分析揭示驱动透明细胞肾细胞癌异质性和耐药性的肿瘤-免疫生态位 Integrated spatial transcriptomic and proteomic profiling reveals tumor-immune niches driving heterogeneity and resistance in clear cell renal cell carcinoma Qanber Raza, Nick Zabinyakov, Lauren Tracey, Liang Lim, Christina Loh
• 6664 · PDF 使用GeoMx Discovery Proteome Atlas对多种癌症肿瘤微环境中1200+个蛋白靶点进行单细胞空间蛋白质组学分析 Single-cell spatial proteomics of 1200+ protein targets in tumor microenvironments from diverse cancers using GeoMx Discovery Proteome Atlas Terence C. Theisen, Alexa E. Lasley, Giang Ong, Megan Vandenberg, Brian Filanoski, Lori Hamanishi, Erin Piazza, Sayani Bhattacharjee, Courtney Anderson, Mirko Corselli, Prajan Divakar, Margaret L. Hoang, Joseph M. Beechem
• 6665 · PDF 两种黑色素瘤生物标志物及两组新型即用型多重免疫荧光panel的验证，用于肿瘤微环境中基质与血管区室的空间分析 Validation of two melanoma biomarkers and two novel ready-to-use multiplex immunofluorescence panels for spatial profiling of the stromal and vascular compartments in the tumor microenviroment Paula Juricic, Francois Rivest, Clara Sinthon, Jade Nguyen, Isabelle Blanc, Bastian Nicolai, Alexandre Kehren, Saska Brajkovic
• 6666 6666 从超高多重空间数据中衍生高保真、低多重的临床特征以预测免疫治疗应答 Deriving high-fidelity, low-plex clinical signatures from ultra-high-plex spatial data for immunotherapy response prediction Raymond Yan, Brian Falkenstein, A. Burak Tosun, Filippo Pullara, S. Chakra Chennubhotla
• 6667 · PDF 整合空间转录组学与蛋白质组学工作流程以实现高分辨率多组学分析 Integrated spatial transcriptomics and proteomics workflows for high-resolution multiomics analysis Cindy Pamela Ulloa Guerrero, Michele Bortolomeazzi, Pooja Sant, Laura Schütze, Laura Giese, Denise Keitel, Julia Boehl, Robin Reschke, Jan-Philipp Mallm
• 6668 · PDF 尿路上皮癌新辅助atezolizumab治疗后肿瘤微环境的空间与转录组重塑：来自ABACUS研究的见解 Spatial and transcriptomic remodeling of the tumor microenvironment following neoadjuvant atezolizumab in urothelial carcinoma: Insights from the ABACUS Study Robbin Nameki, Jennifer Kinong, Chao-Hui Huang, Michelle Saul, Aakash Sur, Mehmet Tekman, Alexander Trageser, Wenjing Yang, Daniel Chawla, Greg Szeto, Arne Schmidt, Alberto Megina Gonzalo, Srishti Munjal Mehta, Nina Kozar-Gillan, Rosemarie Krupar, Sophie Laturnus, Cornelius Bohm, Marija Pezer, Gloria H.Y. Lin, Diane Fernandez, Keith Ching, Jadwiga R. Bienkowska, Thomas Powles, Craig B. Davis
• 6669 · PDF 利用AI驱动的端到端工作流程对膀胱癌中抗体-药物偶联物靶点进行空间解析的多重免疫荧光分析 Spatially resolved multiplex immunofluorescence profiling of antibody-drug conjugate targets in bladder cancer using an AI-powered end-to-end workflow Christoph Kuppe, Markus Eckstein, Samaneh Samiei, Katharina Dornblut, Niklas Klümper, Fabian Schneider, Moritz Widmaier, Florian Leiss
• 6670 · PDF 使用Roche DISCOVERY™ULTRA在肿瘤组织中自动化共检测小RNA、RNA和蛋白质 Automated co-detection of small RNAs, RNAs and proteins in tumor tissues with Roche DISCOVERY™ULTRA Renzo S. Adilardi, Rose Delvillar, Manvir Sambhi, Emerald Doolittle, Sonali Deshpande, Anushka Dikshit, Debia Wakhloo, Henry Lamparski
• 6671 · PDF 利用Elucidate空间生物标志物平台揭示骨肉瘤中可干预的耐药机制 Actionable resistance mechanisms in osteosarcoma uncovered by the elucidate spatial biomarker platform Gulpreet Kaur, Jason Weirather, James Perna, Sizun Jiang, Will Singleterry
• 6672 · PDF 通过通用抗体标记策略和EpicIF™多重化学扩展空间蛋白质组学的边界 Expanding the boundaries of spatial proteomics with a universal antibody labeling strategy and EpicIF™ multiplexing chemistry Thore Boettke, Jannik Boog, Charles Eldon Jackson, Matthew H. Ingalls, Arne Christians, Oliver Braubach
• 6673 · PDF MERFISH 2.0实现高灵敏度、可定制的空间转录组学，用于解析人类癌症中的免疫和肿瘤程序 MERFISH 2.0 enables high-sensitivity, customizable spatial transcriptomics for resolving immune and tumor programs in human cancers Renchao Chen, Bin Wang, Bing Yang, Manisha Ray, Justin He, Timothy Wiggin, Lizi Maziashvili, Alexander Genshaft, Peter Reinhold, Angela Vasaturo, Jiang He
• 6674 · PDF 晚期肾肿瘤中的代谢重编程导致肿瘤微环境内出现功能失调的免疫反应和免疫耗竭 Metabolic reprogramming in advanced renal tumors contributes to a dysfunctional immune response and immune exhaustion within the tumor microenvironment Lakshmi Chandramohan, Kirsteen Maclean, Sergio Hernandez, Brigitte Lovell, Courtney Todorov, Harry Nunns, Jiong Fei, Judy Kuo, Erinn A. Parnell, Qingyan Au
• 6675 · PDF 用于多组学SpaceIQ™平台中空间解析分子成像数据的端到端质量控制流程 An end-to-end quality control pipeline for spatially resolved molecular imaging data in the multi-omic SpaceIQ™ platform Brian Falkenstein, A. Burak Tosun, Raymond Yan, S. Chakra Chennubhotla, Filippo Pullara
• 6676 · PDF 空间蛋白质组学与AI驱动的分析揭示胶质母细胞瘤微环境内的治疗图景 Spatial proteomics and AI-driven analysis uncover therapeutic landscapes within the glioblastoma microenvironment Nadine Nelson, Hoyin Lai, Sophie Struble, Richard A. Heil-Chapdelaine, Natasha F. Diaz Granados, Arindam Bose
• 6677 · PDF 多重成像与AI引导的分析揭示多种癌症类型间免疫图景的多样性 Multiplexed imaging and AI-guided analysis reveal immune landscape diversity across multiple cancer types Lynne Turnbull, Michael J. Smith, Sophie Struble, Vasundhara Agrawal, Debayon Paul, Richard A. Heil-Chapdelaine, Natasha F. Diaz Granados, Arindam Bose
• 6678 · PDF 在CellScape平台上利用EpicIF技术对肿瘤-免疫微环境进行超高重数免疫荧光分析 Ultra-high-plex immunofluorescence analysis of the tumor-immune microenvironment with EpicIF technology on the CellScape platform Arne Christians, Thore Boettke, Jannik Boog, Charles Eldon Jackson, Matt Ingalls, Brian J. Lane, Daniel Jimenez Sanchez, Christoph Rocken, Niclas Christian Blessin, Oliver Braubach
• 6679 · PDF 通过高重数空间多组学解码人类癌症组织中的免疫和肿瘤生态位 Decoding immune and tumor niches through high-plex spatial multi-omics in human cancer tissues Bin Wang, Kevin Hwang, Yijia Sun, Cassandra Kysilovsky, Angela Vasaturo, Jiang He
• 6680 · PDF 用三组学解码肿瘤微环境：在同一切片上对蛋白-蛋白相互作用、RNA和蛋白标志物进行自动化空间分析 Decoding the tumor microenvironment with triple-omics: Automated spatial analysis of protein-protein interactions, RNA, and protein markers on the same section Alice Comberlato, Arec Manoukian, Pino Bordignon, Ge-Ah Kim, Sonali Deshpande, Florent Jeanpetit, Alix Failletaz, Li-chong Wang, Alexandre Kehren, Saska Brajkovic
• 6681 · PDF 创新的10x Genomics技术助力临床规模的癌症研究与AI驱动的生物标志物发现 Innovative 10x Genomics technologies enable clinical-scale cancer research and AI-driven biomarker discovery Hiroshi M. Sasaki, Seayar H. Mohabbet, Ian T. Fiddes, Francesca Meschi, 10x Genomics Development Team
• 6682 · PDF 肿瘤学研究中的嵌合抗体：特性及其在低重（low-multiplexing）检测中的应用 Chimeric antibodies in oncology research: Properties and application in low-multiplexing assays Tom Bright, Nadine Nelson, Antonella Galli, Will Howat, Silvia Sbacchi
• 6683 · PDF 利用InSituPlex®和ZEISS Axioscan 7实现精简的高重成像用于空间表型分析 Streamlined high-plex imaging with InSituPlex®and ZEISS Axioscan 7 for spatial phenotyping Kevin Hwang, Mike Woerdemann, Lars Loetgering, Moritz Widmaier, Cassandra Kysilovsky, Sherry Derakhshani, Jiang He, Angela Vasaturo
• 6684 · PDF 透明细胞肾细胞癌（ccRCC）免疫治疗前后的空间多组学分析鉴定出新的可成药靶点 Spatial multi-omics profiling of clear cell renal cell carcinoma (ccRCC) pre-and post-immunotherapy identifies new druggable targets Navneet Kaur, Wadih Issa, Ze Yu, Hua Zhong, Aleksandra Weronika Nielsen, Jay Jasti, Shahed Abdullah, Libin Yan, Damla Gunenc, Qinhan Zhou, Andrew DeVilbiss, Satwik Rajaram, Payal Kapur, Chao Xing, Liwei Jia, Andrew Z. Wang, Tian Zhang
• 6685 · PDF 利用G4X™空间测序仪对FFPE切片中RNA、蛋白和形态学进行整合式高通量多模态空间分析 Integrated high-throughput multimodal spatial profiling of RNA, protein, and morphology in FFPE sections with the G4X™ Spatial Sequencer Michael Lawson, Kenneth Gouin, Sabrina Shore, Yuji Ishitsuka, Richard Que, Eli Glezer, Daan Witters
• 6686 · PDF Direct-Seq™实现在FFPE组织中以亚细胞分辨率对IgH和TCRbeta转录本进行空间分辨的原位测序 Direct-Seq™ enables spatially resolved in situ sequencing of IgH and TCRbeta transcripts in FFPE tissue at subcellular resolution Michael Lawson, Tung T. Le, Ryan Shultzaberger, Ashley Tsue, Zane Hiatt, Nathan Ing, Kenneth Gouin, Eli Glezer, Daan Witters

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